GREMLIN Database
Q9HNA0 - Histidine triad protein
UniProt: Q9HNA0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (113)
Sequences: 5439 (3288)
Seq/√Len: 309.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_C8_C3.0901.00
22_E45_K3.0381.00
46_T58_D2.9241.00
25_D61_A2.5051.00
8_C47_H2.4971.00
5_C47_H2.3891.00
18_R30_L2.1761.00
26_T65_T2.1761.00
13_D19_V2.1271.00
55_P58_D2.0911.00
80_D91_A2.0291.00
56_G67_H2.0281.00
23_D61_A2.0011.00
29_F43_I2.0011.00
86_F101_G1.9901.00
66_L101_G1.9681.00
19_V27_L1.8101.00
20_V40_T1.7511.00
9_Q14_E1.7051.00
27_L45_K1.6681.00
60_T64_E1.6461.00
54_T99_V1.5991.00
17_A27_L1.5451.00
59_A67_H1.5321.00
26_T61_A1.4901.00
19_V22_E1.4691.00
56_G64_E1.4571.00
91_A108_A1.4331.00
8_C12_A1.4261.00
83_T106_R1.3771.00
46_T55_P1.3621.00
21_H65_T1.3531.00
40_T69_L1.3521.00
62_V101_G1.3481.00
48_A55_P1.3351.00
72_T76_A1.3291.00
42_V103_I1.3091.00
10_I17_A1.2551.00
50_T53_D1.2221.00
28_A40_T1.2021.00
67_H71_P1.1861.00
50_T89_G1.1821.00
59_A63_F1.1771.00
48_A58_D1.1741.00
52_A82_T1.1521.00
52_A74_E1.1061.00
30_L40_T1.1051.00
50_T88_N1.0611.00
4_D8_C1.0391.00
74_E82_T1.0311.00
25_D64_E1.0301.00
63_F101_G1.0041.00
56_G60_T1.0041.00
48_A54_T0.9991.00
49_A53_D0.9951.00
50_T97_P0.9791.00
70_A74_E0.9771.00
38_G105_P0.9651.00
27_L43_I0.9641.00
49_A89_G0.9501.00
61_A65_T0.9331.00
6_V96_V0.9241.00
4_D9_Q0.9201.00
62_V99_V0.9171.00
83_T87_N0.9131.00
9_Q15_I0.9071.00
81_A91_A0.9051.00
36_A107_F0.9011.00
70_A82_T0.8991.00
86_F99_V0.8961.00
11_I27_L0.8921.00
62_V66_L0.8911.00
48_A99_V0.8861.00
64_E68_A0.8691.00
36_A104_I0.8671.00
7_F96_V0.8551.00
35_M104_I0.8551.00
35_M95_E0.8531.00
63_F66_L0.8481.00
68_A71_P0.8441.00
4_D12_A0.8341.00
49_A97_P0.8341.00
76_A79_A0.8301.00
25_D58_D0.8301.00
37_P107_F0.8231.00
113_G116_H0.8231.00
54_T59_A0.8201.00
90_T97_P0.8181.00
23_D68_A0.8101.00
112_G115_L0.8071.00
51_L63_F0.7861.00
28_A69_L0.7831.00
28_A42_V0.7740.99
82_T103_I0.7620.99
73_V77_V0.7610.99
58_D61_A0.7600.99
6_V32_A0.7500.99
77_V105_P0.7440.99
50_T74_E0.7400.99
81_A92_A0.7400.99
85_G104_I0.7320.99
79_A107_F0.7310.99
42_V66_L0.7260.99
30_L38_G0.7220.99
66_L84_I0.7220.99
23_D65_T0.7220.99
107_F110_D0.7200.99
23_D64_E0.7150.99
106_R109_D0.7140.99
23_D26_T0.7120.99
89_G92_A0.7080.99
80_D108_A0.7080.99
48_A53_D0.7050.99
54_T58_D0.7010.99
40_T103_I0.6930.99
20_V30_L0.6900.99
94_Q97_P0.6870.99
80_D107_F0.6840.99
6_V9_Q0.6800.99
18_R32_A0.6780.99
51_L86_F0.6770.99
106_R110_D0.6730.99
51_L84_I0.6730.99
11_I43_I0.6690.98
11_I45_K0.6680.98
71_P75_A0.6670.98
64_E67_H0.6650.98
74_E79_A0.6500.98
84_I88_N0.6470.98
21_H68_A0.6460.98
83_T104_I0.6360.98
28_A65_T0.6300.98
10_I32_A0.6280.98
68_A72_T0.6220.98
6_V15_I0.6180.97
51_L67_H0.6160.97
25_D46_T0.6150.97
52_A103_I0.6120.97
26_T62_V0.6060.97
13_D17_A0.5970.97
10_I29_F0.5920.97
19_V45_K0.5910.97
66_L73_V0.5770.96
15_I32_A0.5770.96
73_V103_I0.5760.96
13_D22_E0.5750.96
56_G59_A0.5740.96
71_P74_E0.5680.96
46_T57_D0.5680.96
5_C98_H0.5590.95
61_A64_E0.5580.95
40_T72_T0.5510.95
111_D114_P0.5510.95
83_T92_A0.5500.95
8_C11_I0.5460.95
90_T108_A0.5460.95
54_T62_V0.5440.95
35_M85_G0.5370.94
31_D87_N0.5330.94
52_A88_N0.5320.94
72_T75_A0.5300.94
40_T73_V0.5250.94
92_A95_E0.5250.94
47_H98_H0.5160.93
14_E22_E0.5150.93
11_I17_A0.5130.93
10_I43_I0.5110.93
7_F43_I0.5050.92
74_E89_G0.5050.92
62_V65_T0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ksvA 2 0.9648 100 0.188 Contact Map
3lb5A 2 0.9507 100 0.231 Contact Map
3imiA 2 0.993 100 0.237 Contact Map
3l7xA 2 0.9718 100 0.238 Contact Map
1y23A 2 0.9789 100 0.249 Contact Map
2eo4A 2 0.9648 100 0.258 Contact Map
3o0mA 2 0.9225 100 0.267 Contact Map
3anoA 4 0.9789 100 0.272 Contact Map
1emsA 3 0.8873 100 0.273 Contact Map
1fitA 2 0.8873 100 0.296 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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