GREMLIN Database
SYI - Isoleucine--tRNA ligase
UniProt: Q9HN97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 1070 (843)
Sequences: 4453 (2423)
Seq/√Len: 83.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_D31_E5.3961.00
247_R278_E5.3471.00
242_D284_S4.9361.00
22_S26_A4.8121.00
262_S282_D4.7711.00
74_H79_Y4.2091.00
25_E138_Q3.8201.00
244_Q262_S3.7661.00
32_Q801_D3.7611.00
131_D134_Q3.6991.00
167_E170_D3.6081.00
432_D442_R3.5331.00
369_A377_D3.5301.00
366_Y381_D3.5081.00
342_G347_L3.3871.00
677_D680_V3.2631.00
242_D262_S3.2611.00
109_D112_E3.2411.00
219_L314_V3.2411.00
289_I316_H3.1981.00
209_R256_D3.0581.00
241_G322_A3.0581.00
703_E817_A2.8961.00
235_V327_L2.8861.00
35_D38_A2.8591.00
77_Q717_T2.8281.00
490_E494_A2.7901.00
605_R611_K2.7351.00
121_E124_R2.7271.00
97_K100_E2.7131.00
430_N433_T2.6651.00
37_R40_A2.6531.00
319_W341_R2.6451.00
773_L777_A2.6361.00
289_I345_L2.6271.00
694_A697_D2.6271.00
242_D282_D2.6061.00
184_C404_C2.6041.00
561_D591_E2.5991.00
435_E592_E2.5421.00
264_C267_D2.5361.00
623_E647_W2.4831.00
23_Y27_V2.4811.00
72_R784_P2.4691.00
715_D731_A2.4581.00
257_V280_V2.4521.00
426_E586_G2.4341.00
315_Y341_R2.4321.00
365_K381_D2.4051.00
244_Q265_V2.4031.00
249_T255_T2.3901.00
319_W330_S2.3731.00
602_P648_D2.3641.00
130_L151_K2.2981.00
134_Q147_D2.2711.00
23_Y792_S2.2611.00
381_D385_R2.2601.00
779_L787_T2.2491.00
219_L327_L2.2431.00
43_F723_F2.2331.00
664_F790_L2.2241.00
134_Q138_Q2.1671.00
202_T395_E2.1641.00
263_E322_A2.1561.00
235_V293_Y2.1531.00
32_Q35_D2.1491.00
145_D148_N2.1471.00
200_D397_S2.1371.00
34_V80_D2.1311.00
680_V691_V2.1281.00
12_D15_G2.1101.00
184_C187_C2.1081.00
317_G341_R2.1011.00
705_L771_V2.0871.00
425_D429_A2.0821.00
114_G117_A2.0821.00
234_F315_Y2.0821.00
200_D395_E2.0581.00
120_E124_R2.0571.00
619_E623_E2.0521.00
19_R22_S2.0291.00
268_V272_G2.0221.00
473_P520_D2.0201.00
474_E525_T2.0181.00
339_F343_A2.0141.00
39_D80_D2.0061.00
712_V731_A1.9811.00
245_Q281_A1.9761.00
210_F232_N1.9631.00
718_A722_D1.9591.00
707_S821_E1.9591.00
55_A132_G1.9571.00
562_L594_L1.9531.00
337_E340_E1.9521.00
247_R257_V1.9501.00
370_F373_D1.9501.00
377_D380_A1.9481.00
436_W593_V1.9421.00
187_C404_C1.9261.00
419_T422_D1.9131.00
717_T808_W1.9041.00
211_D387_A1.8971.00
219_L235_V1.8901.00
426_E429_A1.8641.00
21_F785_F1.8641.00
497_D500_V1.8421.00
354_G358_V1.8181.00
41_E79_Y1.8171.00
55_A136_D1.8051.00
246_V265_V1.8041.00
284_S287_D1.7981.00
361_D367_A1.7971.00
429_A432_D1.7851.00
562_L592_E1.7851.00
101_Q121_E1.7831.00
236_A330_S1.7801.00
56_A140_F1.7791.00
218_S256_D1.7731.00
248_A256_D1.7711.00
229_I297_L1.7691.00
245_Q257_V1.7631.00
76_M780_A1.7501.00
473_P476_W1.7501.00
266_E270_S1.7481.00
42_T80_D1.7481.00
380_A384_A1.7461.00
236_A341_R1.7451.00
73_Y721_E1.7431.00
709_L774_E1.7341.00
429_A433_T1.7341.00
244_Q282_D1.7251.00
476_W520_D1.7251.00
163_W497_D1.7211.00
202_T393_T1.7131.00
292_S311_T1.7101.00
834_G876_L1.7081.00
101_Q128_D1.7011.00
31_E35_D1.6851.00
652_N656_D1.6851.00
211_D218_S1.6811.00
714_A718_A1.6741.00
221_V235_V1.6731.00
705_L740_L1.6661.00
859_D863_D1.6641.00
619_E622_D1.6631.00
380_A383_E1.6501.00
824_V827_L1.6491.00
247_R255_T1.6481.00
713_K774_E1.6431.00
711_H821_E1.6421.00
89_M153_V1.6411.00
73_Y77_Q1.6401.00
714_A813_E1.6381.00
23_Y788_E1.6341.00
211_D294_T1.6331.00
866_D869_G1.6331.00
708_R739_D1.6311.00
238_D241_G1.6311.00
127_D153_V1.6291.00
602_P646_S1.6241.00
281_A287_D1.6211.00
269_L277_H1.6081.00
717_T721_E1.6071.00
16_V19_R1.6011.00
271_A392_Q1.5961.00
827_L831_E1.5891.00
151_K154_D1.5841.00
820_L827_L1.5811.00
167_E171_N1.5771.00
236_A317_G1.5771.00
546_N585_L1.5731.00
831_E835_S1.5711.00
74_H721_E1.5701.00
299_D365_K1.5681.00
828_R831_E1.5671.00
430_N582_T1.5651.00
244_Q279_I1.5631.00
551_E554_F1.5581.00
168_V583_A1.5481.00
483_V487_G1.5471.00
490_E493_A1.5461.00
162_W496_A1.5451.00
69_A634_L1.5411.00
436_W446_F1.5391.00
166_S170_D1.5341.00
176_R472_T1.5321.00
220_V389_L1.5311.00
496_A500_V1.5301.00
507_L511_T1.5301.00
776_V790_L1.5301.00
213_D292_S1.5251.00
71_I81_V1.5130.99
22_S25_E1.5090.99
206_I229_I1.4970.99
802_T805_M1.4950.99
405_D610_S1.4920.99
862_V866_D1.4900.99
700_T823_D1.4860.99
83_D144_M1.4790.99
237_V314_V1.4750.99
484_L495_L1.4720.99
333_G352_P1.4630.99
15_G18_E1.4520.99
369_A374_A1.4470.99
260_V268_V1.4370.99
800_Y806_A1.4360.99
209_R218_S1.4330.99
141_G785_F1.4310.99
157_Y540_A1.4310.99
29_A143_W1.4280.99
237_V327_L1.4240.99
381_D384_A1.4230.99
824_V831_E1.4210.99
619_E647_W1.4100.99
551_E555_D1.4030.99
316_H345_L1.3940.99
288_L291_W1.3920.99
187_C401_C1.3900.99
772_L794_L1.3880.99
652_N655_R1.3870.99
66_L564_M1.3860.99
297_L381_D1.3850.99
212_L291_W1.3840.99
215_R247_R1.3830.99
27_V801_D1.3760.99
850_T880_A1.3750.99
15_G19_R1.3730.99
853_V884_V1.3720.99
58_M614_T1.3710.99
216_E257_V1.3690.99
777_A806_A1.3650.99
517_I520_D1.3640.99
238_D318_D1.3560.99
74_H77_Q1.3540.99
245_Q283_H1.3490.99
220_V258_L1.3490.99
491_E495_L1.3480.99
493_A497_D1.3470.99
838_R841_A1.3420.99
488_T491_E1.3410.99
838_R843_R1.3390.99
474_E523_E1.3360.99
720_W728_A1.3310.99
499_D503_A1.3260.99
157_Y543_G1.3260.99
166_S487_G1.3190.99
117_A120_E1.3070.98
246_V279_I1.3020.98
724_E727_R1.3000.98
599_A643_M1.2980.98
431_M450_V1.2940.98
77_Q721_E1.2920.98
755_D760_S1.2900.98
420_I423_V1.2900.98
358_V373_D1.2830.98
204_P374_A1.2790.98
186_R404_C1.2740.98
352_P360_T1.2730.98
229_I385_R1.2710.98
788_E802_T1.2660.98
213_D294_T1.2660.98
231_A359_Y1.2650.98
239_E316_H1.2650.98
558_W587_D1.2610.98
330_S342_G1.2610.98
432_D447_R1.2580.98
578_L589_P1.2500.98
827_L875_R1.2480.98
37_R75_R1.2480.98
233_Q350_F1.2460.98
620_V650_T1.2410.98
780_A804_H1.2380.98
317_G340_E1.2370.98
450_V575_W1.2360.98
38_A41_E1.2330.98
240_D286_S1.2260.98
58_M620_V1.2250.98
713_K778_L1.2250.98
160_A163_W1.2230.98
767_T771_V1.2230.98
265_V269_L1.2220.98
182_S410_Q1.2200.98
163_W493_A1.2190.98
168_V580_M1.2180.98
376_D391_S1.2140.97
240_D284_S1.2110.97
217_G257_V1.2100.97
437_H592_E1.2090.97
720_W782_Y1.2060.97
376_D380_A1.2060.97
878_T881_I1.2060.97
427_L579_G1.2050.97
369_A373_D1.2050.97
833_A836_H1.2020.97
336_E340_E1.1960.97
850_T882_E1.1950.97
575_W579_G1.1930.97
184_C401_C1.1920.97
262_S279_I1.1910.97
139_S622_D1.1900.97
487_G491_E1.1890.97
430_N588_V1.1890.97
496_A515_I1.1890.97
204_P391_S1.1880.97
701_V748_V1.1870.97
558_W585_L1.1870.97
823_D867_A1.1850.97
820_L823_D1.1850.97
482_D486_V1.1840.97
618_N622_D1.1820.97
283_H287_D1.1820.97
170_D483_V1.1790.97
383_E391_S1.1730.97
710_Q713_K1.1730.97
64_K137_F1.1680.97
651_E654_Q1.1640.97
236_A315_Y1.1640.97
539_V580_M1.1640.97
488_T492_L1.1630.97
698_L706_L1.1590.97
493_A499_D1.1580.97
717_T810_T1.1580.97
363_G367_A1.1580.97
353_V371_V1.1570.97
188_E356_D1.1490.96
863_D866_D1.1490.96
179_R457_N1.1480.96
31_E147_D1.1460.96
372_R375_N1.1440.96
37_R807_D1.1430.96
491_E494_A1.1420.96
486_V495_L1.1420.96
317_G330_S1.1370.96
820_L824_V1.1330.96
166_S489_R1.1300.96
611_K614_T1.1300.96
838_R844_K1.1290.96
293_Y312_H1.1260.96
444_N448_D1.1240.96
20_V792_S1.1220.96
418_I458_V1.1200.96
249_T256_D1.1190.96
23_Y29_A1.1180.96
473_P517_I1.1170.96
435_E722_D1.1160.96
587_D591_E1.1160.96
237_V288_L1.1110.96
447_R451_E1.1110.96
245_Q259_Y1.1090.96
636_V643_M1.1070.96
236_A319_W1.1010.96
333_G349_V1.1010.96
49_P157_Y1.1010.96
36_H807_D1.0990.95
533_V536_D1.0980.95
492_L500_V1.0980.95
496_A499_D1.0950.95
820_L831_E1.0950.95
592_E723_F1.0910.95
823_D827_L1.0910.95
366_Y377_D1.0910.95
564_M596_H1.0900.95
482_D487_G1.0810.95
269_L274_Y1.0790.95
698_L767_T1.0760.95
217_G245_Q1.0740.95
499_D506_D1.0730.95
161_A531_F1.0720.95
207_Y271_A1.0710.95
818_P822_A1.0690.95
844_K847_W1.0680.95
707_S816_R1.0660.95
234_F342_G1.0660.95
242_D263_E1.0650.95
358_V370_F1.0640.95
827_L835_S1.0630.95
229_I378_I1.0620.95
446_F593_V1.0610.95
283_H288_L1.0600.94
354_G360_T1.0580.94
693_I698_L1.0540.94
862_V885_E1.0520.94
831_E834_G1.0460.94
492_L496_A1.0450.94
663_V745_V1.0450.94
691_V758_S1.0440.94
508_H511_T1.0430.94
751_R764_A1.0430.94
482_D485_V1.0410.94
819_A823_D1.0390.94
211_D216_E1.0390.94
164_A584_A1.0370.94
493_A500_V1.0360.94
364_G367_A1.0320.94
248_A258_L1.0310.94
196_V408_I1.0310.94
541_S580_M1.0290.94
776_V787_T1.0290.94
728_A782_Y1.0270.94
651_E656_D1.0260.93
279_I282_D1.0260.93
237_V316_H1.0230.93
131_D135_S1.0200.93
70_Y725_Q1.0190.93
42_T557_L1.0170.93
173_L423_V1.0160.93
708_R825_A1.0150.93
233_Q348_P1.0150.93
495_L500_V1.0140.93
184_C520_D1.0140.93
32_Q805_M1.0130.93
56_A60_T1.0130.93
199_E405_D1.0120.93
164_A535_L1.0100.93
581_G585_L1.0090.93
473_P477_S1.0080.93
117_A121_E1.0050.93
695_D698_L1.0020.93
648_D652_N1.0000.93
231_A352_P0.9990.93
495_L499_D0.9980.93
776_V803_V0.9970.92
145_D553_D0.9970.92
212_L219_L0.9960.92
247_R280_V0.9960.92
706_L770_R0.9950.92
290_G345_L0.9930.92
209_R258_L0.9920.92
239_E286_S0.9920.92
168_V418_I0.9900.92
493_A496_A0.9900.92
371_V409_I0.9870.92
833_A837_A0.9870.92
169_H174_V0.9860.92
360_T363_G0.9840.92
434_S588_V0.9830.92
473_P524_Y0.9830.92
399_G410_Q0.9760.92
491_E500_V0.9760.92
484_L487_G0.9750.92
165_F174_V0.9750.92
377_D381_D0.9750.92
176_R414_D0.9740.92
268_V389_L0.9730.92
353_V409_I0.9710.91
219_L259_Y0.9690.91
116_E120_E0.9690.91
732_V779_L0.9680.91
127_D130_L0.9680.91
698_L766_A0.9670.91
886_P889_A0.9650.91
366_Y369_A0.9640.91
33_T75_R0.9630.91
698_L763_A0.9630.91
286_S289_I0.9630.91
143_W804_H0.9610.91
401_C404_C0.9590.91
832_E835_S0.9580.91
334_H351_C0.9580.91
72_R804_H0.9580.91
58_M599_A0.9580.91
541_S544_T0.9570.91
206_I379_I0.9560.91
693_I766_A0.9560.91
77_Q808_W0.9550.91
379_I391_S0.9520.91
44_F557_L0.9470.90
519_E522_T0.9460.90
712_V735_F0.9460.90
58_M645_F0.9440.90
148_N154_D0.9440.90
495_L498_Q0.9430.90
340_E343_A0.9430.90
474_E522_T0.9420.90
711_H818_P0.9390.90
779_L783_A0.9370.90
676_F766_A0.9360.90
486_V489_R0.9330.90
623_E651_E0.9330.90
135_S138_Q0.9300.90
503_A507_L0.9290.90
713_K811_V0.9290.90
869_G873_A0.9280.90
635_S729_L0.9270.89
76_M804_H0.9250.89
653_M656_D0.9240.89
713_K809_P0.9230.89
17_E626_A0.9220.89
189_T404_C0.9200.89
550_Q553_D0.9180.89
204_P393_T0.9180.89
330_S341_R0.9170.89
677_D691_V0.9170.89
492_L495_L0.9170.89
404_C520_D0.9170.89
666_F670_Y0.9150.89
664_F793_H0.9150.89
834_G852_V0.9150.89
221_V296_P0.9110.89
708_R711_H0.9100.89
352_P359_Y0.9100.89
774_E778_L0.9090.89
494_A497_D0.9080.88
508_H512_V0.9080.88
492_L497_D0.9080.88
99_E118_F0.9070.88
770_R809_P0.9060.88
761_K765_Y0.9010.88
239_E289_I0.9000.88
290_G313_E0.9000.88
292_S313_E0.8990.88
232_N312_H0.8980.88
373_D376_D0.8970.88
615_I620_V0.8950.88
29_A805_M0.8940.88
271_A390_A0.8940.88
248_A255_T0.8930.88
461_Q529_D0.8920.88
791_Y806_A0.8860.87
545_L560_A0.8860.87
828_R832_E0.8850.87
716_A778_L0.8840.87
824_V832_E0.8830.87
265_V279_I0.8830.87
520_D524_Y0.8820.87
834_G837_A0.8810.87
115_E509_K0.8810.87
405_D611_K0.8800.87
616_E619_E0.8760.87
495_L503_A0.8750.87
542_W546_N0.8740.87
428_L447_R0.8740.87
873_A881_I0.8740.87
826_V831_E0.8730.86
259_Y283_H0.8730.86
34_V75_R0.8720.86
171_N426_E0.8710.86
489_R492_L0.8710.86
446_F450_V0.8710.86
819_A822_A0.8700.86
709_L771_V0.8690.86
719_H727_R0.8670.86
602_P647_W0.8670.86
516_T523_E0.8670.86
448_D451_E0.8650.86
431_M436_W0.8620.86
674_D765_Y0.8620.86
471_W509_K0.8610.86
234_F347_L0.8610.86
261_A322_A0.8610.86
241_G261_A0.8580.85
427_L575_W0.8580.85
486_V492_L0.8570.85
784_P804_H0.8570.85
58_M616_E0.8570.85
204_P375_N0.8570.85
46_V540_A0.8540.85
707_S711_H0.8540.85
824_V835_S0.8540.85
515_I518_T0.8530.85
872_L881_I0.8520.85
843_R849_V0.8490.85
124_R128_D0.8470.85
219_L293_Y0.8460.85
206_I388_M0.8460.85
578_L588_V0.8450.85
274_Y277_H0.8450.85
826_V864_A0.8430.84
341_R345_L0.8430.84
558_W581_G0.8430.84
876_L881_I0.8420.84
743_Y828_R0.8420.84
599_A614_T0.8410.84
218_S258_L0.8410.84
315_Y347_L0.8410.84
359_Y374_A0.8390.84
217_G259_Y0.8360.84
72_R143_W0.8340.84
120_E502_P0.8340.84
490_E499_D0.8330.84
442_R447_R0.8310.84
670_Y768_M0.8310.84
132_G136_D0.8310.84
776_V794_L0.8310.84
484_L488_T0.8300.84
620_V629_M0.8280.83
38_A80_D0.8250.83
76_M808_W0.8240.83
476_W522_T0.8230.83
184_C476_W0.8230.83
705_L735_F0.8230.83
127_D131_D0.8210.83
431_M446_F0.8200.83
645_F650_T0.8200.83
476_W517_I0.8190.83
570_T595_M0.8180.83
249_T276_D0.8160.83
128_D132_G0.8150.82
488_T495_L0.8150.82
490_E497_D0.8150.82
674_D761_K0.8140.82
184_C473_P0.8120.82
294_T299_D0.8110.82
76_M777_A0.8090.82
246_V269_L0.8080.82
780_A787_T0.8080.82
318_D344_E0.8080.82
234_F313_E0.8060.82
313_E345_L0.8050.82
210_F221_V0.8030.81
715_D727_R0.7990.81
869_G883_V0.7990.81
780_A803_V0.7980.81
853_V882_E0.7970.81
774_E777_A0.7970.81
186_R406_T0.7970.81
241_G263_E0.7950.81
289_I344_E0.7950.81
212_L217_G0.7940.81
219_L237_V0.7940.81
795_T799_G0.7930.81
293_Y314_V0.7920.81
491_E497_D0.7910.81
820_L828_R0.7900.80
404_C473_P0.7900.80
718_A721_E0.7890.80
213_D311_T0.7880.80
104_F109_D0.7880.80
513_D517_I0.7880.80
475_D523_E0.7840.80
499_D502_P0.7840.80
822_A826_V0.7830.80
428_L432_D0.7830.80
315_Y319_W0.7830.80
807_D810_T0.7830.80
770_R773_L0.7820.80
420_I453_A0.7820.80
648_D651_E0.7820.80
710_Q714_A0.7810.80
165_F531_F0.7810.80
40_A807_D0.7790.79
235_V314_V0.7780.79
827_L832_E0.7780.79
210_F235_V0.7760.79
791_Y800_Y0.7760.79
693_I697_D0.7760.79
231_A334_H0.7760.79
136_D616_E0.7760.79
576_S590_Y0.7760.79
420_I454_P0.7750.79
352_P362_A0.7740.79
190_A461_Q0.7730.79
138_Q147_D0.7730.79
35_D39_D0.7720.79
764_A767_T0.7720.79
700_T824_V0.7710.79
163_W490_E0.7710.79
692_G766_A0.7700.79
125_F129_N0.7700.79
692_G770_R0.7700.79
773_L799_G0.7670.78
491_E496_A0.7660.78
812_E815_L0.7660.78
472_T483_V0.7650.78
719_H728_A0.7640.78
113_F121_E0.7640.78
404_C476_W0.7630.78
817_A820_L0.7630.78
32_Q802_T0.7620.78
763_A767_T0.7620.78
333_G351_C0.7610.78
245_Q280_V0.7610.78
315_Y345_L0.7600.78
695_D703_E0.7600.78
18_E622_D0.7590.78
212_L293_Y0.7590.78
233_Q347_L0.7560.77
360_T367_A0.7560.77
813_E816_R0.7550.77
426_E430_N0.7550.77
119_I505_V0.7540.77
29_A801_D0.7530.77
664_F668_R0.7520.77
489_R493_A0.7490.77
66_L596_H0.7470.77
473_P522_T0.7460.76
162_W469_P0.7450.76
129_N132_G0.7450.76
820_L826_V0.7450.76
425_D428_L0.7450.76
713_K717_T0.7440.76
205_S394_V0.7430.76
838_R847_W0.7430.76
563_I577_Q0.7430.76
185_P370_F0.7420.76
27_V802_T0.7420.76
499_D507_L0.7410.76
617_P620_V0.7410.76
822_A825_A0.7400.76
379_I393_T0.7400.76
428_L451_E0.7390.76
47_D64_K0.7370.76
730_D734_E0.7370.76
453_A579_G0.7370.76
376_D379_I0.7360.76
520_D523_E0.7360.76
847_W879_R0.7360.76
73_Y717_T0.7350.75
272_G389_L0.7350.75
872_L876_L0.7340.75
351_C355_E0.7290.75
567_H570_T0.7280.75
845_L848_P0.7260.75
261_A264_C0.7260.75
120_E506_D0.7260.75
707_S815_L0.7250.74
111_Q463_Y0.7240.74
168_V174_V0.7240.74
164_A542_W0.7240.74
497_D502_P0.7230.74
446_F570_T0.7220.74
75_R81_V0.7210.74
824_V828_R0.7200.74
487_G492_L0.7190.74
473_P523_E0.7190.74
567_H598_Y0.7190.74
123_K127_D0.7190.74
202_T394_V0.7180.74
317_G321_E0.7180.74
861_V864_A0.7180.74
698_L770_R0.7160.74
315_Y342_G0.7150.73
668_R793_H0.7150.73
748_V764_A0.7130.73
380_A391_S0.7130.73
830_A834_G0.7110.73
828_R835_S0.7090.73
849_V878_T0.7090.73
246_V260_V0.7090.73
290_G316_H0.7080.73
435_E442_R0.7070.73
477_S525_T0.7060.72
33_T143_W0.7060.72
493_A498_Q0.7060.72
434_S589_P0.7060.72
714_A811_V0.7040.72
267_D323_D0.7040.72
482_D488_T0.7020.72
293_Y327_L0.7010.72
19_R789_E0.7010.72
233_Q310_G0.7000.72
870_D873_A0.7000.72
552_D556_E0.7000.72
415_Q457_N0.6990.72
488_T496_A0.6970.72
631_M729_L0.6970.72
221_V327_L0.6970.72
187_C406_T0.6960.71
246_V277_H0.6960.71
184_C406_T0.6950.71
856_A865_L0.6940.71
156_S497_D0.6940.71
860_S863_D0.6930.71
218_S387_A0.6920.71
108_K112_E0.6920.71
40_A80_D0.6920.71
85_P146_W0.6910.71
634_L782_Y0.6910.71
841_A844_K0.6900.71
540_A544_T0.6890.71
267_D270_S0.6880.71
818_P821_E0.6880.71
566_A596_H0.6870.70
827_L834_G0.6870.70
711_H715_D0.6860.70
474_E521_G0.6860.70
615_I643_M0.6850.70
136_D618_N0.6840.70
754_E758_S0.6840.70
859_D885_E0.6830.70
542_W585_L0.6830.70
869_G881_I0.6830.70
441_A595_M0.6820.70
113_F118_F0.6820.70
359_Y366_Y0.6820.70
647_W651_E0.6810.70
433_T587_D0.6810.70
73_Y808_W0.6800.70
342_G345_L0.6800.70
244_Q283_H0.6800.70
366_Y378_I0.6780.69
476_W524_Y0.6780.69
423_V583_A0.6770.69
249_T278_E0.6760.69
97_K129_N0.6760.69
212_L259_Y0.6750.69
615_I647_W0.6740.69
773_L776_V0.6730.69
678_A769_Q0.6730.69
849_V852_V0.6730.69
550_Q554_F0.6720.69
743_Y875_R0.6710.69
714_A816_R0.6710.69
598_Y606_G0.6700.69
25_E135_S0.6700.69
651_E655_R0.6680.68
294_T298_A0.6680.68
33_T804_H0.6680.68
472_T527_V0.6670.68
155_P489_R0.6660.68
202_T391_S0.6660.68
709_L713_K0.6650.68
699_E760_S0.6640.68
205_S392_Q0.6640.68
131_D138_Q0.6630.68
358_V371_V0.6630.68
747_V874_D0.6620.68
434_S578_L0.6610.67
436_W442_R0.6600.67
780_A802_T0.6600.67
366_Y384_A0.6590.67
854_V881_I0.6580.67
715_D719_H0.6570.67
710_Q815_L0.6570.67
486_V491_E0.6560.67
770_R812_E0.6560.67
233_Q312_H0.6560.67
693_I696_A0.6560.67
716_A732_V0.6560.67
664_F776_V0.6550.67
300_A310_G0.6550.67
161_A164_A0.6540.67
507_L512_V0.6520.66
710_Q816_R0.6520.66
27_V31_E0.6520.66
28_D35_D0.6500.66
361_D364_G0.6490.66
728_A738_E0.6480.66
169_H483_V0.6480.66
362_A367_A0.6480.66
359_Y363_G0.6460.66
762_T766_A0.6460.66
298_A312_H0.6450.66
699_E764_A0.6450.66
846_R877_N0.6440.65
201_V400_H0.6440.65
471_W513_D0.6440.65
666_F745_V0.6430.65
700_T703_E0.6430.65
695_D815_L0.6420.65
42_T553_D0.6410.65
752_M768_M0.6410.65
229_I381_D0.6410.65
855_D884_V0.6410.65
214_D292_S0.6400.65
783_A787_T0.6390.65
839_Q842_G0.6390.65
111_Q114_G0.6390.65
241_G321_E0.6380.65
116_E506_D0.6370.65
660_L779_L0.6370.65
16_V20_V0.6360.64
884_V887_G0.6350.64
212_L314_V0.6340.64
491_E499_D0.6330.64
350_F362_A0.6330.64
719_H731_A0.6330.64
298_A365_K0.6310.64
137_F146_W0.6310.64
838_R842_G0.6300.64
51_Y64_K0.6290.64
96_T118_F0.6290.64
797_D800_Y0.6290.64
885_E888_A0.6290.64
803_V806_A0.6290.64
820_L834_G0.6280.64
21_F139_S0.6280.64
884_V888_A0.6270.63
488_T493_A0.6260.63
490_E495_L0.6260.63
8_P11_Y0.6250.63
207_Y268_V0.6230.63
135_S622_D0.6220.63
861_V865_L0.6220.63
450_V579_G0.6210.63
657_L783_A0.6210.63
87_Y134_Q0.6200.63
823_D828_R0.6200.63
427_L582_T0.6200.63
58_M618_N0.6180.62
826_V861_V0.6180.62
134_Q146_W0.6170.62
128_D131_D0.6170.62
142_V146_W0.6160.62
36_H805_M0.6160.62
258_L389_L0.6160.62
13_P657_L0.6160.62
349_V352_P0.6130.62
500_V503_A0.6130.62
546_N558_W0.6120.62
388_M391_S0.6120.62
490_E500_V0.6120.62
76_M806_A0.6110.61
319_W337_E0.6110.61
155_P158_M0.6110.61
396_H399_G0.6100.61
864_A867_A0.6100.61
820_L835_S0.6090.61
675_D765_Y0.6080.61
607_M613_I0.6080.61
398_Y410_Q0.6070.61
53_S60_T0.6070.61
750_E754_E0.6060.61
751_R760_S0.6060.61
699_E748_V0.6060.61
55_A129_N0.6060.61
130_L134_Q0.6050.61
272_G390_A0.6050.61
96_T100_E0.6050.61
374_A378_I0.6050.61
856_A859_D0.6050.61
354_G361_D0.6040.61
51_Y94_I0.6030.60
783_A786_V0.6030.60
702_D751_R0.6030.60
437_H446_F0.6030.60
97_K101_Q0.6020.60
614_T620_V0.6020.60
709_L778_L0.6010.60
204_P376_D0.6000.60
421_T424_K0.5990.60
60_T130_L0.5990.60
64_K85_P0.5990.60
210_F312_H0.5980.60
220_V268_V0.5980.60
832_E836_H0.5980.60
120_E123_K0.5980.60
434_S593_V0.5970.60
158_M453_A0.5960.60
695_D814_S0.5960.60
624_Y650_T0.5960.60
123_K153_V0.5950.59
886_P890_W0.5950.59
439_E442_R0.5940.59
61_T65_T0.5940.59
492_L498_Q0.5940.59
52_T89_M0.5940.59
45_F144_M0.5930.59
69_A782_Y0.5930.59
235_V296_P0.5920.59
41_E74_H0.5920.59
171_N343_A0.5910.59
823_D831_E0.5910.59
566_A598_Y0.5910.59
820_L832_E0.5910.59
262_S265_V0.5890.59
29_A802_T0.5890.59
52_T60_T0.5860.58
112_E117_A0.5860.58
824_V834_G0.5850.58
237_V289_I0.5840.58
215_R257_V0.5840.58
602_P644_S0.5830.58
755_D759_A0.5830.58
174_V418_I0.5830.58
660_L736_V0.5830.58
735_F771_V0.5820.58
753_W765_Y0.5820.58
56_A614_T0.5820.58
209_R389_L0.5820.58
554_F557_L0.5820.58
60_T600_N0.5810.58
239_E319_W0.5810.58
846_R849_V0.5810.58
424_K451_E0.5800.57
655_R658_N0.5790.57
101_Q125_F0.5790.57
260_V272_G0.5780.57
869_G880_A0.5780.57
831_E836_H0.5780.57
859_D862_V0.5780.57
366_Y385_R0.5780.57
351_C359_Y0.5770.57
77_Q810_T0.5770.57
431_M593_V0.5770.57
475_D522_T0.5770.57
244_Q260_V0.5760.57
365_K384_A0.5760.57
473_P518_T0.5760.57
127_D151_K0.5750.57
796_G799_G0.5750.57
58_M615_I0.5750.57
18_E22_S0.5750.57
215_R291_W0.5740.57
701_V747_V0.5740.57
823_D868_H0.5740.57
509_K526_R0.5740.57
132_G135_S0.5740.57
294_T311_T0.5730.57
490_E498_Q0.5730.57
581_G587_D0.5720.56
171_N586_G0.5720.56
600_N642_D0.5720.56
203_D398_Y0.5720.56
822_A860_S0.5710.56
260_V265_V0.5700.56
56_A136_D0.5700.56
483_V488_T0.5700.56
29_A32_Q0.5700.56
96_T186_R0.5690.56
470_I527_V0.5690.56
34_V37_R0.5680.56
41_E80_D0.5680.56
703_E820_L0.5680.56
453_A575_W0.5680.56
321_E330_S0.5680.56
42_T82_T0.5680.56
720_W725_Q0.5670.56
789_E793_H0.5670.56
488_T512_V0.5660.56
817_A823_D0.5660.56
168_V590_Y0.5660.56
792_S795_T0.5660.56
69_A720_W0.5660.56
698_L703_E0.5660.56
113_F117_A0.5650.55
98_V125_F0.5650.55
208_V221_V0.5650.55
216_E256_D0.5650.55
541_S558_W0.5640.55
382_L387_A0.5640.55
718_A829_A0.5640.55
852_V878_T0.5630.55
527_V530_V0.5630.55
556_E559_P0.5620.55
339_F412_V0.5610.55
770_R774_E0.5610.55
819_A860_S0.5610.55
42_T79_Y0.5610.55
514_D518_T0.5610.55
297_L385_R0.5600.55
290_G346_D0.5600.55
167_E584_A0.5600.55
20_V788_E0.5600.55
554_F559_P0.5600.55
190_A457_N0.5600.55
166_S491_E0.5590.55
7_V793_H0.5580.55
492_L499_D0.5580.55
56_A617_P0.5580.55
296_P312_H0.5570.54
157_Y539_V0.5570.54
139_S626_A0.5570.54
64_K142_V0.5560.54
137_F142_V0.5560.54
352_P374_A0.5560.54
704_W708_R0.5550.54
518_T521_G0.5550.54
693_I763_A0.5550.54
76_M807_D0.5550.54
54_G87_Y0.5540.54
665_R668_R0.5540.54
601_M614_T0.5530.54
376_D393_T0.5530.54
74_H717_T0.5530.54
614_T617_P0.5530.54
79_Y721_E0.5520.54
237_V285_G0.5520.54
160_A550_Q0.5510.54
697_D759_A0.5510.54
14_A622_D0.5510.54
788_E792_S0.5510.54
334_H352_P0.5500.54
496_A502_P0.5500.54
236_A347_L0.5500.54
710_Q811_V0.5500.54
553_D556_E0.5480.53
715_D718_A0.5480.53
332_P342_G0.5470.53
353_V357_G0.5470.53
190_A468_V0.5470.53
855_D886_P0.5470.53
728_A779_L0.5470.53
40_A77_Q0.5470.53
863_D867_A0.5470.53
447_R575_W0.5470.53
276_D279_I0.5460.53
23_Y26_A0.5460.53
204_P238_D0.5460.53
58_M65_T0.5460.53
204_P379_I0.5450.53
153_V161_A0.5450.53
44_F82_T0.5450.53
258_L274_Y0.5450.53
838_R849_V0.5450.53
764_A768_M0.5440.53
748_V752_M0.5440.53
259_Y314_V0.5440.53
208_V229_I0.5430.53
233_Q342_G0.5430.53
739_D828_R0.5420.52
610_S614_T0.5420.52
826_V830_A0.5420.52
672_A675_D0.5420.52
539_V543_G0.5420.52
164_A168_V0.5410.52
37_R41_E0.5400.52
66_L70_Y0.5400.52
374_A377_D0.5390.52
273_G390_A0.5390.52
336_E410_Q0.5390.52
39_D42_T0.5390.52
614_T645_F0.5390.52
8_P793_H0.5380.52
363_G366_Y0.5380.52
820_L830_A0.5380.52
85_P149_P0.5380.52
56_A618_N0.5370.52
265_V277_H0.5370.52
541_S545_L0.5370.52
632_F649_E0.5370.52
590_Y593_V0.5370.52
707_S817_A0.5360.52
420_I579_G0.5360.52
756_D759_A0.5350.52
56_A616_E0.5350.52
268_V271_A0.5350.52
880_A883_V0.5350.52
104_F113_F0.5350.52
884_V889_A0.5350.52
156_S160_A0.5350.52
508_H513_D0.5350.52
114_G506_D0.5340.51
313_E316_H0.5340.51
507_L513_D0.5340.51
79_Y82_T0.5340.51
837_A841_A0.5330.51
607_M614_T0.5320.51
437_H593_V0.5320.51
27_V792_S0.5320.51
62_W643_M0.5310.51
269_L389_L0.5300.51
325_T593_V0.5300.51
712_V716_A0.5300.51
427_L453_A0.5280.51
678_A795_T0.5280.51
231_A363_G0.5270.50
134_Q149_P0.5270.50
801_D805_M0.5270.50
788_E796_G0.5260.50
567_H594_L0.5260.50
796_G800_Y0.5260.50
814_S817_A0.5260.50
753_W761_K0.5250.50
11_Y14_A0.5250.50
856_A861_V0.5250.50
129_N189_T0.5250.50
751_R755_D0.5250.50
31_E36_H0.5240.50
295_P298_A0.5240.50
166_S490_E0.5240.50
708_R821_E0.5240.50
841_A847_W0.5240.50
34_V39_D0.5240.50
263_E282_D0.5240.50
826_V829_A0.5230.50
844_K849_V0.5230.50
430_N587_D0.5230.50
469_P485_V0.5230.50
529_D533_V0.5220.50
207_Y220_V0.5220.50
210_F347_L0.5220.50
596_H639_Q0.5210.50
84_R149_P0.5210.50
256_D386_D0.5210.50
483_V486_V0.5200.50
444_N447_R0.5200.50
497_D503_A0.5200.50
746_Q877_N0.5200.50
221_V400_H0.5200.50
71_I76_M0.5200.50
664_F667_P0.5190.49
350_F363_G0.5190.49
184_C517_I0.5190.49
513_D518_T0.5180.49
671_M674_D0.5180.49
542_W584_A0.5180.49
634_L729_L0.5180.49
599_A602_P0.5180.49
719_H722_D0.5180.49
168_V584_A0.5170.49
182_S408_I0.5170.49
19_R23_Y0.5170.49
138_Q146_W0.5160.49
85_P137_F0.5160.49
772_L790_L0.5160.49
264_C323_D0.5160.49
670_Y753_W0.5160.49
339_F359_Y0.5160.49
553_D557_L0.5150.49
367_A371_V0.5150.49
119_I502_P0.5140.49
96_T113_F0.5140.49
47_D137_F0.5140.49
165_F175_E0.5130.49
360_T366_Y0.5130.49
28_D32_Q0.5130.49
754_E757_A0.5130.49
614_T619_E0.5130.49
568_D598_Y0.5120.48
621_I627_D0.5110.48
720_W808_W0.5110.48
220_V260_V0.5110.48
432_D451_E0.5110.48
356_D370_F0.5110.48
491_E498_Q0.5100.48
312_H350_F0.5100.48
766_A770_R0.5100.48
428_L431_M0.5100.48
339_F351_C0.5100.48
705_L767_T0.5090.48
397_S400_H0.5090.48
694_A698_L0.5080.48
698_L701_V0.5080.48
727_R731_A0.5080.48
12_D16_V0.5070.48
401_C406_T0.5070.48
675_D757_A0.5070.48
431_M442_R0.5060.48
280_V830_A0.5060.48
488_T500_V0.5060.48
71_I75_R0.5060.48
96_T182_S0.5060.48
378_I381_D0.5050.48
199_E400_H0.5050.48
165_F420_I0.5050.48
488_T517_I0.5050.48
269_L273_G0.5050.48
310_G313_E0.5050.48
316_H319_W0.5050.48
43_F70_Y0.5030.47
769_Q773_L0.5030.47
862_V883_V0.5030.47
260_V395_E0.5030.47
163_W167_E0.5030.47
38_A829_A0.5030.47
148_N553_D0.5030.47
825_A840_Q0.5030.47
581_G588_V0.5020.47
16_V789_E0.5020.47
787_T803_V0.5020.47
518_T524_Y0.5020.47
843_R847_W0.5020.47
186_R401_C0.5020.47
214_D291_W0.5010.47
440_W444_N0.5010.47
269_L272_G0.5010.47
234_F330_S0.5010.47
166_S469_P0.5000.47
238_D316_H0.5000.47
545_L553_D0.5000.47
493_A503_A0.5000.47
173_L424_K0.5000.47
564_M594_L0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ffyA 1 0.8252 100 0.318 Contact Map
1gaxA 1 0.7935 100 0.391 Contact Map
1ileA 1 0.7523 100 0.398 Contact Map
1wz2A 1 0.8206 100 0.418 Contact Map
1wkbA 1 0.6729 100 0.495 Contact Map
2v0cA 1 0.6327 100 0.53 Contact Map
4arcA 1 0.6514 100 0.547 Contact Map
3ziuA 1 0.5495 100 0.638 Contact Map
1rqgA 2 0.5093 100 0.716 Contact Map
4qreA 1 0.472 100 0.723 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0209 seconds.