GREMLIN Database
Q9HN95 - Cytochrome c oxidase subunit I
UniProt: Q9HN95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 463 (384)
Sequences: 4350 (1456)
Seq/√Len: 74.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
333_M372_I4.9921.00
146_I295_G4.3461.00
301_V393_T4.2731.00
139_A292_T4.0231.00
262_N277_V3.7631.00
239_K315_A3.7371.00
321_V382_S3.7221.00
71_P74_R3.7141.00
81_M165_F3.6301.00
239_K312_R3.5591.00
158_D162_R3.3831.00
84_A169_V3.3211.00
151_A216_L3.3131.00
142_A296_V3.1321.00
63_Y83_L3.0951.00
77_L155_L2.9701.00
283_L327_T2.7331.00
328_L375_G2.6951.00
72_D75_I2.6941.00
64_R72_D2.6161.00
31_F120_T2.5751.00
312_R316_A2.4901.00
298_Y318_Q2.4801.00
38_H41_F2.4481.00
171_L201_L2.4411.00
216_L241_S2.4311.00
325_G378_L2.4271.00
149_K299_W2.3791.00
150_L299_W2.3601.00
147_L249_G2.2651.00
313_T317_I2.2141.00
366_S370_L2.2131.00
182_T272_H2.1871.00
127_F131_V2.0781.00
314_L385_L2.0691.00
246_A323_V2.0621.00
294_M386_F2.0491.00
202_L260_M2.0101.00
314_L388_A2.0031.00
328_L371_Q1.9551.00
84_A166_V1.9271.00
261_I276_W1.9251.00
106_P111_W1.9111.00
321_V385_L1.9101.00
92_S173_T1.9001.00
314_L317_I1.8561.00
243_S318_Q1.8531.00
392_G396_S1.8451.00
45_A100_V1.8381.00
374_I378_L1.8361.00
152_G236_P1.8331.00
128_G131_V1.8131.00
318_Q386_F1.7991.00
311_H392_G1.7901.00
318_Q322_W1.7901.00
279_G334_H1.7761.00
136_L140_Y1.7481.00
267_I271_I1.7361.00
140_Y205_S1.6811.00
392_G398_P1.6611.00
148_P155_L1.6511.00
336_G368_M1.6401.00
303_Q416_P1.6321.00
142_A300_L1.6251.00
307_K397_R1.6171.00
27_V36_Q1.6140.99
30_T124_F1.6000.99
121_R273_N1.5990.99
235_L241_S1.5980.99
325_G375_G1.5840.99
377_T381_V1.5800.99
318_Q382_S1.5610.99
142_A146_I1.5600.99
298_Y315_A1.5530.99
150_L240_P1.5510.99
144_Y212_V1.5380.99
63_Y79_T1.5370.99
331_N335_R1.5320.99
388_A392_G1.5280.99
294_M318_Q1.5130.99
146_I296_V1.5100.99
414_S418_D1.4880.99
216_L245_M1.4840.99
244_A295_G1.4840.99
297_A386_F1.4790.99
89_W93_S1.4690.99
64_R83_L1.4680.99
161_A165_F1.4680.99
56_G86_F1.4510.99
251_V327_T1.4480.99
105_I111_W1.4380.99
388_A391_V1.4350.99
414_S422_I1.4030.99
327_T331_N1.3980.99
37_A41_F1.3970.99
147_L216_L1.3970.99
95_G126_Y1.3840.98
63_Y75_I1.3840.98
283_L331_N1.3810.98
318_Q383_L1.3750.98
56_G90_Y1.3750.98
60_F83_L1.3610.98
46_A101_V1.3520.98
67_R70_N1.3460.98
135_W285_V1.3430.98
27_V31_F1.3360.98
76_P79_T1.3320.98
243_S294_M1.3270.98
199_F263_A1.3220.98
168_F208_T1.3150.98
268_N277_V1.3130.98
321_V381_V1.3010.98
70_N74_R1.2990.98
64_R87_V1.2980.98
421_R424_D1.2940.98
307_K393_T1.2890.97
60_F90_Y1.2890.97
329_M379_L1.2860.97
99_E120_T1.2720.97
31_F41_F1.2680.97
84_A165_F1.2640.97
33_P120_T1.2640.97
384_A388_A1.2600.97
262_N271_I1.2560.97
329_M376_G1.2460.97
242_F319_P1.2290.97
161_A164_V1.2270.97
292_T295_G1.2260.97
397_R400_M1.2250.97
246_A319_P1.2230.97
146_I240_P1.2180.96
287_T326_M1.2120.96
162_R165_F1.2080.96
335_R368_M1.2030.96
92_S134_F1.2000.96
415_G419_S1.1990.96
333_M336_G1.1990.96
318_Q385_L1.1920.96
125_W128_G1.1910.96
46_A100_V1.1900.96
72_D83_L1.1830.96
133_Y138_P1.1770.96
367_E371_Q1.1680.96
84_A87_V1.1670.95
16_F19_E1.1520.95
318_Q389_V1.1500.95
322_W379_L1.1480.95
239_K316_A1.1400.95
341_L369_Q1.1360.95
297_A390_M1.1360.95
49_I97_A1.1340.95
387_L391_V1.1300.95
67_R74_R1.1280.95
195_M265_M1.1280.95
315_A389_V1.1250.94
240_P299_W1.1230.94
414_S423_L1.1200.94
317_I385_L1.1170.94
260_M263_A1.1120.94
52_S89_W1.1090.94
33_P103_F1.1000.94
198_T262_N1.0980.94
275_I341_L1.0960.94
39_P107_W1.0880.93
78_Q82_V1.0870.93
391_V395_L1.0700.93
150_L241_S1.0690.93
243_S298_Y1.0690.93
332_A368_M1.0680.93
322_W382_S1.0670.93
416_P419_S1.0660.93
146_I244_A1.0630.93
380_F384_A1.0570.92
313_T316_A1.0570.92
132_V138_P1.0520.92
415_G418_D1.0500.92
136_L289_F1.0490.92
58_D62_T1.0490.92
30_T272_H1.0380.92
301_V305_T1.0350.92
131_V135_W1.0330.92
182_T269_Y1.0230.91
342_P345_T1.0190.91
216_L235_L1.0190.91
177_F186_I1.0170.91
130_P133_Y1.0130.91
152_G406_N1.0110.91
25_A31_F1.0100.91
403_L406_N1.0060.90
322_W383_L1.0060.90
75_I79_T1.0060.90
46_A104_L1.0060.90
312_R315_A0.9940.90
148_P154_K0.9930.90
283_L334_H0.9930.90
85_T134_F0.9920.90
403_L407_G0.9890.90
45_A48_L0.9780.89
255_G284_T0.9780.89
19_E22_F0.9770.89
198_T263_A0.9630.88
143_W244_A0.9630.88
407_G410_P0.9600.88
374_I377_T0.9600.88
294_M383_L0.9590.88
144_Y208_T0.9440.87
370_L374_I0.9330.87
242_F316_A0.9320.87
140_Y212_V0.9280.86
31_F36_Q0.9280.86
27_V38_H0.9230.86
369_Q373_A0.9220.86
91_L173_T0.9180.86
181_Y265_M0.9090.85
324_I378_L0.9000.85
118_L184_P0.8980.85
60_F87_V0.8970.85
130_P138_P0.8940.84
172_S273_N0.8940.84
68_A426_L0.8930.84
279_G333_M0.8930.84
325_G382_S0.8900.84
93_S97_A0.8890.84
202_L208_T0.8870.84
238_G316_A0.8850.84
301_V394_W0.8840.84
294_M322_W0.8790.83
164_V167_L0.8770.83
208_T212_V0.8750.83
46_A97_A0.8740.83
135_W289_F0.8660.82
205_S208_T0.8660.82
55_V99_E0.8650.82
59_Y63_Y0.8650.82
305_T393_T0.8630.82
237_W241_S0.8590.82
398_P401_G0.8580.82
150_L405_V0.8540.82
59_Y82_V0.8540.82
216_L233_R0.8520.81
122_T334_H0.8520.81
73_E163_V0.8410.81
33_P36_Q0.8390.80
385_L388_A0.8360.80
244_A249_G0.8350.80
154_K159_P0.8340.80
396_S399_G0.8320.80
42_Y104_L0.8320.80
17_A371_Q0.8310.80
128_G135_W0.8290.80
341_L350_F0.8290.80
127_F135_W0.8270.79
276_W351_R0.8220.79
140_Y208_T0.8210.79
87_V169_V0.8200.79
394_W397_R0.8190.79
155_L158_D0.8170.79
116_D344_R0.8170.79
258_S334_H0.8150.78
242_F320_F0.8150.78
311_H388_A0.8150.78
257_F260_M0.8080.78
140_Y206_L0.8060.78
307_K394_W0.8030.77
212_V247_L0.8010.77
291_L319_P0.8000.77
418_D423_L0.7970.77
184_P273_N0.7960.77
48_L52_S0.7950.77
208_T211_T0.7940.77
307_K396_S0.7930.77
321_V378_L0.7920.76
385_L389_V0.7910.76
136_L288_A0.7900.76
253_A257_F0.7880.76
38_H231_W0.7850.76
191_K290_A0.7830.76
104_L108_S0.7830.76
294_M298_Y0.7820.76
279_G332_A0.7810.75
394_W398_P0.7800.75
53_W97_A0.7730.75
143_W292_T0.7720.75
22_F25_A0.7710.74
31_F38_H0.7700.74
326_M379_L0.7680.74
301_V310_Q0.7670.74
105_I109_M0.7670.74
77_L342_P0.7640.74
143_W147_L0.7610.74
93_S131_V0.7610.74
59_Y86_F0.7560.73
81_M137_L0.7550.73
16_F22_F0.7550.73
275_I369_Q0.7540.73
150_L238_G0.7530.73
180_Q273_N0.7530.73
75_I158_D0.7510.73
101_V104_L0.7500.72
389_V393_T0.7480.72
87_V101_V0.7470.72
178_H280_H0.7460.72
19_E40_A0.7450.72
161_A211_T0.7450.72
239_K246_A0.7440.72
236_P406_N0.7440.72
149_K405_V0.7440.72
301_V307_K0.7420.72
84_A162_R0.7410.72
15_G19_E0.7350.71
129_H178_H0.7350.71
136_L139_A0.7350.71
148_P404_S0.7350.71
112_I116_D0.7350.71
239_K242_F0.7340.71
19_E38_H0.7330.71
25_A120_T0.7310.71
73_E155_L0.7290.70
77_L161_A0.7260.70
191_K269_Y0.7230.70
266_N285_V0.7230.70
73_E158_D0.7220.70
345_T369_Q0.7200.69
171_L174_P0.7190.69
160_L272_H0.7180.69
257_F287_T0.7170.69
69_D426_L0.7150.69
99_E124_F0.7120.68
373_A377_T0.7120.68
176_G194_A0.7060.68
159_P163_V0.7040.68
122_T180_Q0.7010.67
129_H132_V0.6990.67
17_A20_L0.6970.67
67_R75_I0.6960.67
44_G101_V0.6950.67
410_P429_W0.6950.67
402_R416_P0.6940.67
240_P310_Q0.6930.66
93_S102_A0.6920.66
136_L212_V0.6920.66
372_I375_G0.6850.66
27_V41_F0.6840.65
143_W247_L0.6840.65
37_A40_A0.6830.65
161_A207_L0.6830.65
195_M264_G0.6770.65
48_L93_S0.6750.64
109_M150_L0.6740.64
298_Y389_V0.6740.64
56_G92_S0.6740.64
140_Y164_V0.6730.64
121_R184_P0.6700.64
289_F293_M0.6700.64
266_N271_I0.6690.64
202_L210_F0.6680.64
146_I292_T0.6680.64
156_F211_T0.6680.64
122_T273_N0.6680.64
89_W128_G0.6650.63
253_A288_A0.6650.63
177_F197_N0.6650.63
81_M155_L0.6640.63
237_W245_M0.6630.63
139_A143_W0.6600.63
156_F168_F0.6590.63
187_A191_K0.6590.63
124_F132_V0.6530.62
109_M418_D0.6530.62
250_L254_A0.6520.62
277_V281_F0.6510.62
335_R339_A0.6510.62
371_Q375_G0.6500.61
156_F215_S0.6500.61
43_V101_V0.6480.61
147_L384_A0.6480.61
328_L378_L0.6480.61
352_G366_S0.6470.61
240_P312_R0.6460.61
18_P22_F0.6440.61
193_I197_N0.6440.61
140_Y144_Y0.6440.61
400_M416_P0.6430.61
136_L284_T0.6420.61
147_L244_A0.6420.61
306_G417_A0.6420.61
404_S407_G0.6400.60
311_H317_I0.6390.60
88_M198_T0.6390.60
239_K243_S0.6380.60
68_A74_R0.6350.60
184_P205_S0.6340.60
50_V54_I0.6340.60
400_M404_S0.6330.59
51_G116_D0.6330.59
49_I208_T0.6300.59
118_L122_T0.6260.59
106_P115_V0.6250.58
203_L207_L0.6250.58
285_V290_A0.6220.58
19_E23_G0.6220.58
398_P402_R0.6220.58
46_A49_I0.6210.58
15_G44_G0.6210.58
271_I277_V0.6210.58
182_T291_L0.6200.58
246_A291_L0.6200.58
285_V289_F0.6190.58
232_L236_P0.6160.57
67_R105_I0.6160.57
89_W127_F0.6160.57
109_M234_A0.6140.57
130_P175_V0.6140.57
87_V167_L0.6130.57
98_V102_A0.6130.57
251_V323_V0.6120.57
93_S127_F0.6120.57
36_Q103_F0.6110.57
337_G340_G0.6100.57
324_I384_A0.6080.56
284_T288_A0.6080.56
95_G99_E0.6060.56
423_L427_K0.6040.56
74_R429_W0.6040.56
424_D428_V0.6010.56
243_S319_P0.6010.56
311_H398_P0.5990.55
387_L420_P0.5990.55
133_Y175_V0.5990.55
26_N287_T0.5980.55
117_P121_R0.5980.55
49_I100_V0.5980.55
302_P400_M0.5960.55
167_L170_L0.5960.55
185_G252_F0.5960.55
209_A284_T0.5940.55
91_L95_G0.5930.55
423_L426_L0.5910.54
350_F365_I0.5910.54
261_I267_I0.5900.54
311_H314_L0.5890.54
144_Y202_L0.5890.54
412_A417_A0.5880.54
73_E159_P0.5870.54
67_R296_V0.5870.54
118_L273_N0.5850.54
196_T267_I0.5840.53
93_S162_R0.5820.53
88_M135_W0.5820.53
100_V104_L0.5810.53
18_P21_P0.5780.53
64_R231_W0.5770.53
150_L422_I0.5750.52
48_L51_G0.5740.52
65_A279_G0.5740.52
135_W162_R0.5740.52
42_Y120_T0.5730.52
303_Q412_A0.5730.52
136_L208_T0.5730.52
69_D158_D0.5720.52
102_A368_M0.5710.52
99_E142_A0.5700.52
202_L205_S0.5690.52
205_S211_T0.5690.52
171_L204_P0.5680.51
182_T374_I0.5680.51
310_Q397_R0.5670.51
181_Y275_I0.5670.51
162_R406_N0.5670.51
86_F134_F0.5670.51
106_P201_L0.5640.51
374_I399_G0.5630.51
21_P25_A0.5620.51
279_G326_M0.5620.51
316_A319_P0.5620.51
392_G395_L0.5600.50
84_A127_F0.5600.50
285_V288_A0.5590.50
52_S116_D0.5590.50
205_S209_A0.5570.50
73_E170_L0.5560.50
81_M160_L0.5560.50
140_Y168_F0.5560.50
251_V258_S0.5540.50
181_Y195_M0.5540.50
414_S417_A0.5530.50
261_I271_I0.5520.49
396_S400_M0.5510.49
243_S315_A0.5510.49
89_W131_V0.5510.49
425_N428_V0.5500.49
415_G423_L0.5490.49
119_L123_L0.5490.49
302_P314_L0.5480.49
293_M297_A0.5480.49
51_G100_V0.5470.49
397_R405_V0.5470.49
121_R124_F0.5470.49
335_R338_L0.5460.49
96_V181_Y0.5460.49
233_R315_A0.5450.49
199_F341_L0.5430.48
189_G193_I0.5430.48
27_V33_P0.5400.48
399_G415_G0.5390.48
136_L141_L0.5380.48
60_F86_F0.5370.48
353_E380_F0.5340.47
414_S419_S0.5340.47
52_S165_F0.5340.47
23_G167_L0.5330.47
413_L424_D0.5330.47
70_N76_P0.5320.47
21_P67_R0.5320.47
67_R72_D0.5320.47
154_K365_I0.5310.47
161_A208_T0.5310.47
102_A106_P0.5300.47
129_H280_H0.5290.47
160_L164_V0.5290.47
301_V304_I0.5290.47
233_R405_V0.5280.46
405_V416_P0.5270.46
389_V392_G0.5270.46
39_P108_S0.5270.46
79_T83_L0.5270.46
391_V400_M0.5270.46
58_D208_T0.5250.46
420_P423_L0.5250.46
324_I328_L0.5250.46
156_F208_T0.5230.46
109_M335_R0.5220.46
30_T198_T0.5220.46
419_S424_D0.5220.46
345_T350_F0.5210.46
233_R298_Y0.5210.46
33_P104_L0.5200.45
272_H305_T0.5200.45
327_T334_H0.5200.45
156_F336_G0.5200.45
189_G192_F0.5200.45
52_S198_T0.5190.45
77_L272_H0.5160.45
16_F21_P0.5150.45
380_F400_M0.5150.45
68_A71_P0.5140.45
43_V112_I0.5140.45
27_V365_I0.5120.44
198_T396_S0.5120.44
240_P298_Y0.5120.44
75_I83_L0.5110.44
17_A40_A0.5110.44
397_R401_G0.5110.44
381_V385_L0.5110.44
43_V47_L0.5100.44
322_W391_V0.5100.44
172_S287_T0.5100.44
133_Y137_L0.5090.44
114_Q185_G0.5080.44
274_T429_W0.5070.44
140_Y143_W0.5060.44
414_S420_P0.5060.44
82_V86_F0.5060.44
49_I58_D0.5050.44
67_R412_A0.5050.44
264_G287_T0.5040.43
207_L311_H0.5040.43
182_T281_F0.5040.43
149_K233_R0.5030.43
314_L389_V0.5020.43
170_L174_P0.5010.43
32_Y252_F0.5000.43
317_I388_A0.5000.43
187_A287_T0.5000.43
136_L144_Y0.5000.43
93_S128_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftA 1 0.8488 100 0.209 Contact Map
3s8fA 1 0.9719 100 0.223 Contact Map
2yevA 1 0.9417 100 0.225 Contact Map
2gsmA 1 0.8488 100 0.241 Contact Map
1v54A 1 0.8683 100 0.251 Contact Map
3ayfA 2 0.784 100 0.419 Contact Map
3mk7A 1 0.7775 100 0.425 Contact Map
3wfdB 1 0.7451 100 0.451 Contact Map
3pcvA 3 0.3045 4.6 0.984 Contact Map
4px7A 1 0.4449 4.3 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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