GREMLIN Database
Q9HN94 - Cytochrome c oxidase subunit II
UniProt: Q9HN94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (113)
Sequences: 5077 (2484)
Seq/√Len: 233.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R124_V3.1041.00
125_P128_E2.9441.00
58_T126_Q2.7871.00
64_V84_V2.7591.00
126_Q130_T2.6071.00
40_R45_S2.4771.00
35_V52_I2.4191.00
96_F123_V2.3841.00
56_A123_V2.1911.00
54_V96_F2.0181.00
56_A99_A1.9581.00
62_F94_V1.9561.00
51_P122_E1.9241.00
99_A125_P1.9031.00
36_Y47_G1.8361.00
34_D61_T1.7981.00
101_T120_S1.7351.00
81_N108_E1.6691.00
32_S58_T1.5691.00
40_R67_G1.5631.00
40_R43_A1.5461.00
38_E65_T1.5411.00
74_E107_H1.5411.00
36_Y63_H1.5111.00
54_V121_I1.5001.00
124_V128_E1.4851.00
39_A84_V1.4781.00
106_C110_C1.4711.00
34_D63_H1.4621.00
104_I119_G1.4571.00
59_N95_N1.4451.00
72_G81_N1.4291.00
38_E47_G1.4161.00
61_T91_Q1.3901.00
101_T122_E1.3621.00
72_G107_H1.3471.00
78_T121_I1.3241.00
51_P120_S1.3231.00
83_M108_E1.3171.00
71_H106_C1.3031.00
99_A123_V1.2911.00
56_A126_Q1.2871.00
82_T92_L1.2731.00
53_R122_E1.2351.00
71_H110_C1.2061.00
110_C114_H1.1831.00
63_H89_V1.1811.00
32_S59_N1.1781.00
64_V82_T1.1681.00
128_E131_P1.1591.00
78_T96_F1.1381.00
33_Y129_F1.1351.00
72_G108_E1.1221.00
37_V62_F1.1201.00
60_V96_F1.0851.00
46_P52_I1.0771.00
36_Y65_T1.0651.00
79_N94_V1.0501.00
106_C114_H1.0311.00
46_P119_G1.0051.00
54_V60_V0.9951.00
105_V118_E0.9861.00
134_Q137_A0.9731.00
106_C117_M0.9691.00
81_N107_H0.9591.00
29_D32_S0.9541.00
103_H120_S0.9501.00
56_A125_P0.9421.00
103_H118_E0.9411.00
35_V62_F0.9391.00
75_L121_I0.9341.00
130_T134_Q0.9171.00
82_T90_A0.9000.99
102_H123_V0.8850.99
51_P101_T0.8820.99
35_V54_V0.8770.99
54_V94_V0.8560.99
113_A116_A0.8390.99
29_D93_T0.8390.99
65_T89_V0.8390.99
59_N93_T0.8300.99
50_E136_A0.8280.99
63_H91_Q0.8170.99
131_P135_A0.8070.99
131_P134_Q0.8040.99
29_D59_N0.8020.99
42_F69_V0.7850.99
104_I121_I0.7600.98
46_P104_I0.7550.98
68_D71_H0.7550.98
46_P73_F0.7500.98
37_V46_P0.7460.98
48_T129_F0.7390.98
54_V123_V0.7340.98
41_Q68_D0.7320.98
61_T93_T0.7300.98
68_D86_P0.7280.98
99_A128_E0.7170.98
41_Q109_Y0.7160.97
41_Q69_V0.7150.97
83_M107_H0.7150.97
74_E80_V0.7060.97
79_N104_I0.6990.97
66_S84_V0.6860.97
62_F92_L0.6790.97
73_F121_I0.6740.96
35_V48_T0.6650.96
110_C117_M0.6630.96
68_D106_C0.6610.96
99_A102_H0.6590.96
69_V108_E0.6550.96
32_S126_Q0.6520.96
57_D97_D0.6510.96
37_V64_V0.6480.96
71_H114_H0.6450.95
75_L78_T0.6440.95
85_I88_Q0.6430.95
25_V29_D0.6410.95
80_V92_L0.6400.95
25_V28_A0.6400.95
62_F73_F0.6390.95
45_S67_G0.6380.95
37_V73_F0.6310.95
43_A113_A0.6290.95
127_S131_P0.6190.94
57_D95_N0.6180.94
74_E105_V0.6180.94
78_T123_V0.6080.94
66_S70_T0.6060.94
114_H117_M0.6060.94
55_P60_V0.6030.93
39_A44_F0.6010.93
109_Y112_P0.5930.93
99_A124_V0.5930.93
26_Y29_D0.5810.92
44_F104_I0.5740.92
28_A93_T0.5710.91
44_F84_V0.5600.91
129_F133_Q0.5580.91
80_V94_V0.5560.90
80_V104_I0.5540.90
42_F112_P0.5510.90
74_E81_N0.5510.90
42_F105_V0.5490.90
73_F80_V0.5460.90
31_D58_T0.5460.90
31_D61_T0.5440.89
124_V129_F0.5410.89
46_P51_P0.5410.89
57_D123_V0.5390.89
107_H114_H0.5390.89
132_P136_A0.5380.89
33_Y58_T0.5380.89
79_N90_A0.5360.89
28_A59_N0.5340.89
74_E115_H0.5310.88
48_T132_P0.5300.88
29_D57_D0.5250.88
68_D114_H0.5230.88
70_T85_I0.5230.88
52_I62_F0.5200.87
56_A96_F0.5180.87
33_Y60_V0.5180.87
133_Q137_A0.5160.87
39_A71_H0.5080.86
60_V94_V0.5070.86
75_L100_R0.5020.85
25_V59_N0.5020.85
108_E114_H0.5020.85
132_P135_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1fftB 1 0.9931 100 0.193 Contact Map
4txvB 1 0.8276 100 0.204 Contact Map
1cyxA 1 0.7931 100 0.208 Contact Map
3hb3B 1 0.9793 100 0.225 Contact Map
1v54B 1 0.9448 100 0.23 Contact Map
2gsmB 1 0.9586 100 0.255 Contact Map
2yevB 1 1 100 0.294 Contact Map
2cuaA 1 0.8276 100 0.433 Contact Map
3s8fB 1 0.8414 100 0.46 Contact Map
3sbqA 2 0.8345 99.9 0.539 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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