GREMLIN Database
Q9HN91 - Uncharacterized protein
UniProt: Q9HN91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (195)
Sequences: 1269 (977)
Seq/√Len: 70.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_G158_A5.3261.00
80_V202_G5.2391.00
83_G195_G4.6431.00
38_V127_A4.3971.00
41_A162_G4.1171.00
83_G199_V4.0751.00
76_G202_G4.0271.00
76_G206_L2.9231.00
121_A125_R2.8811.00
111_G115_D2.7811.00
43_V145_Y2.7601.00
90_G95_A2.6541.00
43_V135_A2.6091.00
76_G205_P2.1761.00
134_G165_G2.1271.00
45_G154_P2.1021.00
154_P157_G2.0811.00
80_V199_V2.0451.00
72_G205_P2.0431.00
35_G127_A2.0061.00
70_V74_V1.9911.00
48_G152_A1.9781.00
204_I208_K1.9721.00
111_G114_T1.9191.00
33_N176_G1.8991.00
133_H172_L1.8701.00
39_S134_G1.8251.00
37_T165_G1.7891.00
41_A158_A1.7811.00
98_A101_G1.7431.00
153_S156_E1.7091.00
69_G209_G1.6911.00
117_V128_V1.6410.99
33_N36_R1.6120.99
141_I145_Y1.5970.99
151_T160_A1.5860.99
32_F133_H1.5450.99
79_I198_F1.5280.99
34_G38_V1.4900.99
38_V131_A1.4870.99
169_F173_F1.4590.99
33_N79_I1.4450.99
49_A154_P1.4180.98
7_T179_V1.4150.98
144_G160_A1.4150.98
73_V77_A1.4090.98
83_G198_F1.3990.98
6_V172_L1.3700.98
10_A33_N1.3690.98
72_G208_K1.3560.98
77_A81_A1.3460.98
134_G141_I1.3370.98
37_T162_G1.3340.98
83_G202_G1.3250.97
151_T157_G1.3200.97
158_A162_G1.2850.97
25_A29_H1.2810.97
45_G153_S1.2710.97
96_A102_L1.2700.97
183_S187_R1.2680.97
51_G76_G1.2480.96
108_A111_G1.2440.96
141_I165_G1.2340.96
49_A157_G1.2330.96
39_S127_A1.2310.96
47_M145_Y1.2140.96
66_L70_V1.1990.95
40_Y134_G1.1590.94
11_D29_H1.1580.94
107_S119_D1.1560.94
146_V150_A1.1520.94
40_Y142_Y1.1360.94
147_Y160_A1.1010.93
142_Y165_G1.0870.92
39_S131_A1.0830.92
4_P144_G1.0770.92
6_V9_Y1.0710.92
133_H165_G1.0430.91
77_A108_A1.0370.90
145_Y161_L1.0210.90
21_P24_R1.0170.90
64_A114_T1.0140.89
37_T169_F1.0130.89
128_V131_A0.9950.88
80_V206_L0.9940.88
8_M11_D0.9780.88
39_S135_A0.9750.87
102_L105_A0.9740.87
36_R137_P0.9720.87
2_C40_Y0.9720.87
139_P164_L0.9720.87
185_T189_R0.9700.87
27_R41_A0.9660.87
109_V113_L0.9640.87
133_H145_Y0.9460.86
42_A70_V0.9410.86
1_M40_Y0.9230.84
33_N172_L0.9220.84
122_T125_R0.9210.84
39_S43_V0.9090.84
167_G170_P0.9060.83
6_V29_H0.9020.83
54_L172_L0.9020.83
144_G205_P0.9000.83
39_S195_G0.8990.83
46_L113_L0.8980.83
43_V102_L0.8850.82
147_Y205_P0.8840.82
37_T172_L0.8750.81
163_A174_A0.8740.81
100_P107_S0.8740.81
89_G199_V0.8720.81
45_G157_G0.8690.81
124_P155_V0.8630.80
86_Y198_F0.8500.79
120_W126_I0.8490.79
72_G76_G0.8480.79
96_A100_P0.8430.79
4_P147_Y0.8380.78
9_Y29_H0.8180.76
10_A147_Y0.8180.76
76_G209_G0.8140.76
27_R30_A0.8130.76
73_V206_L0.8120.76
38_V41_A0.8120.76
135_A197_A0.8110.76
97_G100_P0.8060.75
153_S157_G0.8040.75
143_P147_Y0.8040.75
44_G157_G0.7990.75
68_R72_G0.7960.75
26_L33_N0.7870.74
103_G112_R0.7840.73
19_R115_D0.7840.73
42_A135_A0.7790.73
82_A149_V0.7710.72
114_T150_A0.7680.72
119_D125_R0.7640.71
72_G141_I0.7610.71
145_Y165_G0.7570.71
39_S176_G0.7510.70
107_S112_R0.7510.70
133_H141_I0.7470.70
22_S26_L0.7450.70
103_G140_L0.7430.69
10_A160_A0.7400.69
51_G149_V0.7390.69
103_G107_S0.7360.69
80_V89_G0.7360.69
120_W129_L0.7320.68
65_H159_A0.7270.68
133_H209_G0.7250.67
37_T120_W0.7250.67
178_A181_A0.7240.67
127_A131_A0.7210.67
35_G39_S0.7210.67
45_G124_P0.7190.67
120_W128_V0.7190.67
108_A112_R0.7180.67
41_A144_G0.7160.66
22_S74_V0.7150.66
32_F126_I0.7070.66
120_W125_R0.7060.65
4_P72_G0.7050.65
87_A199_V0.7020.65
166_L170_P0.6960.64
110_T114_T0.6930.64
30_A105_A0.6930.64
21_P80_V0.6920.64
125_R193_A0.6920.64
113_L124_P0.6810.63
6_V32_F0.6770.62
29_H37_T0.6760.62
174_A177_T0.6740.62
47_M121_A0.6710.61
207_A210_L0.6710.61
4_P205_P0.6690.61
174_A182_V0.6680.61
5_L134_G0.6670.61
112_R135_A0.6640.61
40_Y165_G0.6640.61
4_P143_P0.6630.61
105_A108_A0.6600.60
134_G172_L0.6590.60
2_C134_G0.6510.59
157_G188_R0.6490.59
126_I133_H0.6480.59
36_R140_L0.6470.59
134_G142_Y0.6460.59
8_M79_I0.6440.58
31_L126_I0.6420.58
84_V185_T0.6380.58
156_E159_A0.6360.57
39_S133_H0.6360.57
132_A200_V0.6290.57
140_L165_G0.6270.56
42_A46_L0.6260.56
65_H68_R0.6250.56
53_V83_G0.6240.56
110_T197_A0.6200.55
23_T77_A0.6170.55
118_D141_I0.6140.55
64_A68_R0.6130.55
5_L201_A0.6090.54
51_G144_G0.6080.54
82_A160_A0.6070.54
45_G52_G0.6070.54
28_Q122_T0.6060.54
50_V132_A0.6010.53
134_G168_T0.6010.53
122_T166_L0.5960.53
5_L35_G0.5950.52
106_F111_G0.5940.52
73_V210_L0.5900.52
133_H144_G0.5880.52
32_F40_Y0.5850.51
65_H70_V0.5850.51
38_V189_R0.5840.51
75_A84_V0.5830.51
33_N135_A0.5830.51
1_M134_G0.5830.51
193_A197_A0.5820.51
134_G187_R0.5800.51
133_H192_R0.5770.50
187_R196_V0.5760.50
74_V84_V0.5740.50
4_P86_Y0.5730.50
140_L143_P0.5700.49
32_F134_G0.5690.49
154_P191_H0.5680.49
29_H33_N0.5660.49
6_V10_A0.5660.49
1_M32_F0.5650.49
151_T191_H0.5650.49
21_P25_A0.5630.49
75_A202_G0.5610.48
69_G208_K0.5610.48
34_G159_A0.5590.48
132_A197_A0.5580.48
165_G169_F0.5550.48
136_L182_V0.5550.48
205_P209_G0.5540.47
48_G52_G0.5520.47
75_A205_P0.5460.47
33_N173_F0.5460.47
51_G160_A0.5440.46
52_G157_G0.5430.46
80_V84_V0.5420.46
189_R192_R0.5420.46
63_V67_V0.5410.46
155_V159_A0.5410.46
5_L211_A0.5410.46
145_Y151_T0.5400.46
40_Y144_G0.5390.46
208_K211_A0.5300.45
45_G127_A0.5290.44
112_R119_D0.5290.44
99_V105_A0.5290.44
101_G104_R0.5290.44
52_G153_S0.5280.44
34_G127_A0.5270.44
63_V153_S0.5260.44
39_S179_V0.5250.44
78_A147_Y0.5240.44
22_S25_A0.5240.44
187_R207_A0.5200.43
154_P166_L0.5200.43
103_G119_D0.5190.43
44_G48_G0.5180.43
50_V149_V0.5180.43
51_G208_K0.5170.43
126_I136_L0.5160.43
69_G72_G0.5150.43
44_G51_G0.5140.43
40_Y141_I0.5140.43
107_S133_H0.5140.43
75_A143_P0.5130.43
198_F208_K0.5120.42
42_A155_V0.5120.42
79_I169_F0.5110.42
43_V177_T0.5110.42
46_L193_A0.5070.42
5_L127_A0.5070.42
109_V166_L0.5060.42
195_G205_P0.5050.42
44_G130_G0.5050.42
188_R203_T0.5040.42
81_A156_E0.5030.41
38_V187_R0.5010.41
76_G199_V0.5010.41
84_V87_A0.5010.41
202_G205_P0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4m64A 1 0.9258 30.8 0.941 Contact Map
3wdoA 1 0.8821 27.1 0.942 Contact Map
3o7qA 1 0.9563 26.1 0.943 Contact Map
2gfpA 2 0.8646 21.3 0.945 Contact Map
1pw4A 1 0.8821 20.1 0.946 Contact Map
2cfqA 1 0.8952 18.9 0.947 Contact Map
3dh4A 3 0.7293 11.2 0.952 Contact Map
4j05A 3 0.8559 9.5 0.953 Contact Map
4tphA 2 0.8428 6.6 0.957 Contact Map
4pypA 1 0.8908 5.1 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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