Q9HN91 - HALSA - GREMLIN Contacts

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Q9HN91 - Uncharacterized protein

UniProt:	Q9HN91	Sequences: MCGPLVTMYADRIGTDDRRGPSTRALRQHALFNGGRTVSYAAVGGLMGAVGGVLVDAGGVLAVAHLVRGVAGVVAGAAIVAAGVGYAAGGGSRLAAGAVPGLGRAFSAVTGRLTDHVDDWATGPRIAVLGAAHGALPCPLIYPGYVYAVATASPVEGAAALGALGLGTFPTLFAYGTAVDAVSATTRRRVHRALGVAFVVAGTIPLAKGLAALGWPVPQVPLPMPPLPT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	229 (195)
Sequences:	1269 (977)
Seq/√Len:	70.0

HALSA - Q9HN91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
45_G	158_A	5.326	1.00
80_V	202_G	5.239	1.00
83_G	195_G	4.643	1.00
38_V	127_A	4.397	1.00
41_A	162_G	4.117	1.00
83_G	199_V	4.075	1.00
76_G	202_G	4.027	1.00
76_G	206_L	2.923	1.00
121_A	125_R	2.881	1.00
111_G	115_D	2.781	1.00
43_V	145_Y	2.760	1.00
90_G	95_A	2.654	1.00
43_V	135_A	2.609	1.00
76_G	205_P	2.176	1.00
134_G	165_G	2.127	1.00
45_G	154_P	2.102	1.00
154_P	157_G	2.081	1.00
80_V	199_V	2.045	1.00
72_G	205_P	2.043	1.00
35_G	127_A	2.006	1.00
70_V	74_V	1.991	1.00
48_G	152_A	1.978	1.00
204_I	208_K	1.972	1.00
111_G	114_T	1.919	1.00
33_N	176_G	1.899	1.00
133_H	172_L	1.870	1.00
39_S	134_G	1.825	1.00
37_T	165_G	1.789	1.00
41_A	158_A	1.781	1.00
98_A	101_G	1.743	1.00
153_S	156_E	1.709	1.00
69_G	209_G	1.691	1.00
117_V	128_V	1.641	0.99
33_N	36_R	1.612	0.99
141_I	145_Y	1.597	0.99
151_T	160_A	1.586	0.99
32_F	133_H	1.545	0.99
79_I	198_F	1.528	0.99
34_G	38_V	1.490	0.99
38_V	131_A	1.487	0.99
169_F	173_F	1.459	0.99
33_N	79_I	1.445	0.99
49_A	154_P	1.418	0.98
7_T	179_V	1.415	0.98
144_G	160_A	1.415	0.98
73_V	77_A	1.409	0.98
83_G	198_F	1.399	0.98
6_V	172_L	1.370	0.98
10_A	33_N	1.369	0.98
72_G	208_K	1.356	0.98
77_A	81_A	1.346	0.98
134_G	141_I	1.337	0.98
37_T	162_G	1.334	0.98
83_G	202_G	1.325	0.97
151_T	157_G	1.320	0.97
158_A	162_G	1.285	0.97
25_A	29_H	1.281	0.97
45_G	153_S	1.271	0.97
96_A	102_L	1.270	0.97
183_S	187_R	1.268	0.97
51_G	76_G	1.248	0.96
108_A	111_G	1.244	0.96
141_I	165_G	1.234	0.96
49_A	157_G	1.233	0.96
39_S	127_A	1.231	0.96
47_M	145_Y	1.214	0.96
66_L	70_V	1.199	0.95
40_Y	134_G	1.159	0.94
11_D	29_H	1.158	0.94
107_S	119_D	1.156	0.94
146_V	150_A	1.152	0.94
40_Y	142_Y	1.136	0.94
147_Y	160_A	1.101	0.93
142_Y	165_G	1.087	0.92
39_S	131_A	1.083	0.92
4_P	144_G	1.077	0.92
6_V	9_Y	1.071	0.92
133_H	165_G	1.043	0.91
77_A	108_A	1.037	0.90
145_Y	161_L	1.021	0.90
21_P	24_R	1.017	0.90
64_A	114_T	1.014	0.89
37_T	169_F	1.013	0.89
128_V	131_A	0.995	0.88
80_V	206_L	0.994	0.88
8_M	11_D	0.978	0.88
39_S	135_A	0.975	0.87
102_L	105_A	0.974	0.87
36_R	137_P	0.972	0.87
2_C	40_Y	0.972	0.87
139_P	164_L	0.972	0.87
185_T	189_R	0.970	0.87
27_R	41_A	0.966	0.87
109_V	113_L	0.964	0.87
133_H	145_Y	0.946	0.86
42_A	70_V	0.941	0.86
1_M	40_Y	0.923	0.84
33_N	172_L	0.922	0.84
122_T	125_R	0.921	0.84
39_S	43_V	0.909	0.84
167_G	170_P	0.906	0.83
6_V	29_H	0.902	0.83
54_L	172_L	0.902	0.83
144_G	205_P	0.900	0.83
39_S	195_G	0.899	0.83
46_L	113_L	0.898	0.83
43_V	102_L	0.885	0.82
147_Y	205_P	0.884	0.82
37_T	172_L	0.875	0.81
163_A	174_A	0.874	0.81
100_P	107_S	0.874	0.81
89_G	199_V	0.872	0.81
45_G	157_G	0.869	0.81
124_P	155_V	0.863	0.80
86_Y	198_F	0.850	0.79
120_W	126_I	0.849	0.79
72_G	76_G	0.848	0.79
96_A	100_P	0.843	0.79
4_P	147_Y	0.838	0.78
9_Y	29_H	0.818	0.76
10_A	147_Y	0.818	0.76
76_G	209_G	0.814	0.76
27_R	30_A	0.813	0.76
73_V	206_L	0.812	0.76
38_V	41_A	0.812	0.76
135_A	197_A	0.811	0.76
97_G	100_P	0.806	0.75
153_S	157_G	0.804	0.75
143_P	147_Y	0.804	0.75
44_G	157_G	0.799	0.75
68_R	72_G	0.796	0.75
26_L	33_N	0.787	0.74
103_G	112_R	0.784	0.73
19_R	115_D	0.784	0.73
42_A	135_A	0.779	0.73
82_A	149_V	0.771	0.72
114_T	150_A	0.768	0.72
119_D	125_R	0.764	0.71
72_G	141_I	0.761	0.71
145_Y	165_G	0.757	0.71
39_S	176_G	0.751	0.70
107_S	112_R	0.751	0.70
133_H	141_I	0.747	0.70
22_S	26_L	0.745	0.70
103_G	140_L	0.743	0.69
10_A	160_A	0.740	0.69
51_G	149_V	0.739	0.69
103_G	107_S	0.736	0.69
80_V	89_G	0.736	0.69
120_W	129_L	0.732	0.68
65_H	159_A	0.727	0.68
133_H	209_G	0.725	0.67
37_T	120_W	0.725	0.67
178_A	181_A	0.724	0.67
127_A	131_A	0.721	0.67
35_G	39_S	0.721	0.67
45_G	124_P	0.719	0.67
120_W	128_V	0.719	0.67
108_A	112_R	0.718	0.67
41_A	144_G	0.716	0.66
22_S	74_V	0.715	0.66
32_F	126_I	0.707	0.66
120_W	125_R	0.706	0.65
4_P	72_G	0.705	0.65
87_A	199_V	0.702	0.65
166_L	170_P	0.696	0.64
110_T	114_T	0.693	0.64
30_A	105_A	0.693	0.64
21_P	80_V	0.692	0.64
125_R	193_A	0.692	0.64
113_L	124_P	0.681	0.63
6_V	32_F	0.677	0.62
29_H	37_T	0.676	0.62
174_A	177_T	0.674	0.62
47_M	121_A	0.671	0.61
207_A	210_L	0.671	0.61
4_P	205_P	0.669	0.61
174_A	182_V	0.668	0.61
5_L	134_G	0.667	0.61
112_R	135_A	0.664	0.61
40_Y	165_G	0.664	0.61
4_P	143_P	0.663	0.61
105_A	108_A	0.660	0.60
134_G	172_L	0.659	0.60
2_C	134_G	0.651	0.59
157_G	188_R	0.649	0.59
126_I	133_H	0.648	0.59
36_R	140_L	0.647	0.59
134_G	142_Y	0.646	0.59
8_M	79_I	0.644	0.58
31_L	126_I	0.642	0.58
84_V	185_T	0.638	0.58
156_E	159_A	0.636	0.57
39_S	133_H	0.636	0.57
132_A	200_V	0.629	0.57
140_L	165_G	0.627	0.56
42_A	46_L	0.626	0.56
65_H	68_R	0.625	0.56
53_V	83_G	0.624	0.56
110_T	197_A	0.620	0.55
23_T	77_A	0.617	0.55
118_D	141_I	0.614	0.55
64_A	68_R	0.613	0.55
5_L	201_A	0.609	0.54
51_G	144_G	0.608	0.54
82_A	160_A	0.607	0.54
45_G	52_G	0.607	0.54
28_Q	122_T	0.606	0.54
50_V	132_A	0.601	0.53
134_G	168_T	0.601	0.53
122_T	166_L	0.596	0.53
5_L	35_G	0.595	0.52
106_F	111_G	0.594	0.52
73_V	210_L	0.590	0.52
133_H	144_G	0.588	0.52
32_F	40_Y	0.585	0.51
65_H	70_V	0.585	0.51
38_V	189_R	0.584	0.51
75_A	84_V	0.583	0.51
33_N	135_A	0.583	0.51
1_M	134_G	0.583	0.51
193_A	197_A	0.582	0.51
134_G	187_R	0.580	0.51
133_H	192_R	0.577	0.50
187_R	196_V	0.576	0.50
74_V	84_V	0.574	0.50
4_P	86_Y	0.573	0.50
140_L	143_P	0.570	0.49
32_F	134_G	0.569	0.49
154_P	191_H	0.568	0.49
29_H	33_N	0.566	0.49
6_V	10_A	0.566	0.49
1_M	32_F	0.565	0.49
151_T	191_H	0.565	0.49
21_P	25_A	0.563	0.49
75_A	202_G	0.561	0.48
69_G	208_K	0.561	0.48
34_G	159_A	0.559	0.48
132_A	197_A	0.558	0.48
165_G	169_F	0.555	0.48
136_L	182_V	0.555	0.48
205_P	209_G	0.554	0.47
48_G	52_G	0.552	0.47
75_A	205_P	0.546	0.47
33_N	173_F	0.546	0.47
51_G	160_A	0.544	0.46
52_G	157_G	0.543	0.46
80_V	84_V	0.542	0.46
189_R	192_R	0.542	0.46
63_V	67_V	0.541	0.46
155_V	159_A	0.541	0.46
5_L	211_A	0.541	0.46
145_Y	151_T	0.540	0.46
40_Y	144_G	0.539	0.46
208_K	211_A	0.530	0.45
45_G	127_A	0.529	0.44
112_R	119_D	0.529	0.44
99_V	105_A	0.529	0.44
101_G	104_R	0.529	0.44
52_G	153_S	0.528	0.44
34_G	127_A	0.527	0.44
63_V	153_S	0.526	0.44
39_S	179_V	0.525	0.44
78_A	147_Y	0.524	0.44
22_S	25_A	0.524	0.44
187_R	207_A	0.520	0.43
154_P	166_L	0.520	0.43
103_G	119_D	0.519	0.43
44_G	48_G	0.518	0.43
50_V	149_V	0.518	0.43
51_G	208_K	0.517	0.43
126_I	136_L	0.516	0.43
69_G	72_G	0.515	0.43
44_G	51_G	0.514	0.43
40_Y	141_I	0.514	0.43
107_S	133_H	0.514	0.43
75_A	143_P	0.513	0.43
198_F	208_K	0.512	0.42
42_A	155_V	0.512	0.42
79_I	169_F	0.511	0.42
43_V	177_T	0.511	0.42
46_L	193_A	0.507	0.42
5_L	127_A	0.507	0.42
109_V	166_L	0.506	0.42
195_G	205_P	0.505	0.42
44_G	130_G	0.505	0.42
188_R	203_T	0.504	0.42
81_A	156_E	0.503	0.41
38_V	187_R	0.501	0.41
76_G	199_V	0.501	0.41
84_V	87_A	0.501	0.41
202_G	205_P	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4m64A	1	0.9258	30.8	0.941	Contact Map
3wdoA	1	0.8821	27.1	0.942	Contact Map
3o7qA	1	0.9563	26.1	0.943	Contact Map
2gfpA	2	0.8646	21.3	0.945	Contact Map
1pw4A	1	0.8821	20.1	0.946	Contact Map
2cfqA	1	0.8952	18.9	0.947	Contact Map
3dh4A	3	0.7293	11.2	0.952	Contact Map
4j05A	3	0.8559	9.5	0.953	Contact Map
4tphA	2	0.8428	6.6	0.957	Contact Map
4pypA	1	0.8908	5.1	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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