KPRS - HALSA - GREMLIN Contacts

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KPRS - Ribose-phosphate pyrophosphokinase

UniProt:	Q9HN88	Sequences: MLLSGSSSQSLAAALAAATGERLGDVTYDSFPDGEQLVTVPPAVDGERAVIVASTPTSDAHIEVLQLQDAARDAGASEIITVLPYMGYARQDDAFDPGQPVSARAVARAISTGTDRVLTVNPHEDGVLECFDVPAAGVDAAPQLAAPLPADLTDPVFLSPDHGATDLATSVRDAYGTGVTDHFQKVRHSGSDVTVEPSEIQTAGRDVVVTDDIVATGTTMSEAITALDDPARVFVATVHPLLAGSARLKLARAGVEAVYGTDTIECAVSEVSAAPAIADAL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	281 (279)
Sequences:	3961 (2030)
Seq/√Len:	121.5

ECOLI - KPRS
BACSU - KPRS
HALSA - KPRS
SULSO - KPRS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
14_A	262_D	4.595	1.00
232_R	256_E	4.540	1.00
262_D	272_S	3.609	1.00
68_Q	114_T	3.305	1.00
206_D	232_R	3.132	1.00
248_L	252_R	3.069	1.00
61_H	106_V	2.937	1.00
3_L	24_G	2.872	1.00
245_S	249_K	2.731	1.00
157_F	168_A	2.700	1.00
18_A	278_A	2.661	1.00
25_D	41_P	2.528	1.00
2_L	16_A	2.512	1.00
66_Q	102_S	2.507	1.00
206_D	231_A	2.466	1.00
240_P	260_G	2.454	1.00
9_Q	13_A	2.416	1.00
48_R	78_E	2.381	1.00
222_E	225_T	2.251	1.00
225_T	229_D	2.247	1.00
7_S	54_S	2.224	1.00
228_D	256_E	2.163	1.00
120_V	277_I	2.119	1.00
30_S	59_D	2.091	1.00
220_M	235_V	2.090	1.00
214_V	237_T	2.066	1.00
156_V	205_R	2.029	1.00
120_V	263_T	2.025	1.00
120_V	273_A	2.010	1.00
15_L	52_V	1.992	1.00
13_A	17_A	1.983	1.00
110_I	114_T	1.969	1.00
55_T	87_G	1.964	1.00
12_A	23_L	1.957	1.00
215_A	243_A	1.908	1.00
225_T	254_G	1.900	1.00
108_R	132_D	1.879	1.00
158_L	207_V	1.842	1.00
11_L	277_I	1.837	1.00
51_I	71_A	1.818	1.00
155_P	177_T	1.795	1.00
159_S	164_A	1.781	1.00
263_T	273_A	1.757	1.00
121_N	238_V	1.750	1.00
10_S	14_A	1.709	1.00
242_L	258_V	1.670	1.00
146_A	150_A	1.664	1.00
27_T	41_P	1.644	1.00
214_V	258_V	1.644	1.00
234_F	257_A	1.644	1.00
235_V	255_V	1.634	1.00
217_G	221_S	1.594	1.00
26_V	67_L	1.592	1.00
152_L	155_P	1.586	1.00
204_G	231_A	1.585	1.00
234_F	256_E	1.585	1.00
2_L	52_V	1.537	1.00
164_A	167_L	1.517	1.00
11_L	15_L	1.476	1.00
33_D	85_Y	1.476	1.00
245_S	248_L	1.466	1.00
105_A	112_T	1.461	1.00
83_L	117_V	1.456	1.00
6_S	28_Y	1.453	1.00
138_V	280_A	1.448	1.00
267_A	270_E	1.447	1.00
250_L	258_V	1.442	1.00
189_S	192_D	1.439	1.00
206_D	234_F	1.435	1.00
148_L	259_Y	1.431	1.00
214_V	220_M	1.417	1.00
144_L	271_V	1.415	1.00
266_C	269_S	1.395	1.00
147_P	259_Y	1.393	1.00
80_I	116_R	1.391	1.00
228_D	233_V	1.384	1.00
27_T	39_T	1.375	1.00
158_L	180_T	1.367	1.00
193_V	222_E	1.359	1.00
14_A	274_A	1.346	1.00
16_A	23_L	1.333	1.00
237_T	260_G	1.324	1.00
207_V	227_L	1.298	1.00
4_S	12_A	1.295	1.00
49_A	71_A	1.284	1.00
83_L	110_I	1.284	1.00
10_S	13_A	1.275	1.00
19_T	278_A	1.260	1.00
18_A	275_P	1.256	0.99
151_D	154_D	1.253	0.99
29_D	37_L	1.237	0.99
104_R	108_R	1.230	0.99
209_V	223_A	1.222	0.99
163_G	187_R	1.222	0.99
228_D	254_G	1.220	0.99
44_V	71_A	1.218	0.99
147_P	257_A	1.217	0.99
40_V	71_A	1.211	0.99
92_D	126_G	1.210	0.99
6_S	30_S	1.209	0.99
224_I	255_V	1.202	0.99
48_R	80_I	1.177	0.99
104_R	132_D	1.177	0.99
5_G	53_A	1.166	0.99
8_S	54_S	1.160	0.99
155_P	208_V	1.158	0.99
51_I	68_Q	1.155	0.99
157_F	175_Y	1.141	0.99
195_V	226_A	1.141	0.99
148_L	208_V	1.137	0.99
158_L	227_L	1.127	0.99
15_L	281_L	1.127	0.99
57_T	60_A	1.125	0.99
16_A	22_R	1.121	0.99
161_D	187_R	1.120	0.99
95_F	99_Q	1.120	0.99
14_A	272_S	1.118	0.99
51_I	67_L	1.110	0.99
69_D	73_D	1.106	0.99
152_L	206_D	1.103	0.99
65_L	109_A	1.101	0.99
39_T	99_Q	1.091	0.99
214_V	217_G	1.086	0.99
163_G	185_K	1.082	0.98
12_A	16_A	1.076	0.98
240_P	266_C	1.071	0.98
103_A	127_V	1.064	0.98
78_E	115_D	1.056	0.98
37_L	99_Q	1.054	0.98
56_P	60_A	1.052	0.98
143_Q	271_V	1.045	0.98
155_P	206_D	1.045	0.98
2_L	21_E	1.040	0.98
156_V	207_V	1.036	0.98
110_I	117_V	1.024	0.98
154_D	205_R	1.022	0.98
226_A	229_D	1.020	0.98
111_S	132_D	1.019	0.98
161_D	185_K	1.017	0.98
162_H	166_D	1.010	0.98
242_L	260_G	1.010	0.98
4_S	7_S	1.003	0.98
144_L	236_A	0.990	0.97
224_I	254_G	0.986	0.97
8_S	265_E	0.978	0.97
230_P	233_V	0.974	0.97
183_F	223_A	0.973	0.97
147_P	271_V	0.973	0.97
147_P	236_A	0.969	0.97
122_P	137_G	0.968	0.97
145_A	171_V	0.966	0.97
108_R	111_S	0.965	0.97
148_L	234_F	0.956	0.97
217_G	245_S	0.954	0.97
235_V	253_A	0.940	0.96
169_T	184_Q	0.940	0.96
58_S	62_I	0.939	0.96
217_G	249_K	0.937	0.96
3_L	67_L	0.937	0.96
33_D	87_G	0.932	0.96
30_S	36_Q	0.924	0.96
32_P	215_A	0.920	0.96
221_S	249_K	0.915	0.96
180_T	183_F	0.915	0.96
61_H	65_L	0.910	0.96
36_Q	58_S	0.910	0.96
170_S	173_D	0.908	0.96
10_S	265_E	0.908	0.96
18_A	279_D	0.908	0.96
48_R	77_S	0.897	0.95
266_C	270_E	0.892	0.95
6_S	63_E	0.890	0.95
5_G	67_L	0.886	0.95
13_A	23_L	0.886	0.95
120_V	276_A	0.885	0.95
39_T	96_D	0.879	0.95
71_A	76_A	0.879	0.95
237_T	240_P	0.871	0.94
25_D	42_P	0.869	0.94
40_V	67_L	0.869	0.94
94_A	101_V	0.866	0.94
225_T	228_D	0.866	0.94
144_L	261_T	0.864	0.94
96_D	99_Q	0.862	0.94
140_A	238_V	0.858	0.94
121_N	167_L	0.855	0.94
35_E	91_Q	0.850	0.94
157_F	171_V	0.848	0.94
163_G	218_T	0.847	0.94
161_D	212_D	0.844	0.93
81_T	114_T	0.841	0.93
275_P	278_A	0.840	0.93
33_D	93_D	0.835	0.93
241_L	264_I	0.832	0.93
148_L	236_A	0.829	0.93
250_L	253_A	0.825	0.93
58_S	66_Q	0.824	0.93
160_P	219_T	0.821	0.92
188_H	193_V	0.821	0.92
220_M	237_T	0.815	0.92
202_T	227_L	0.815	0.92
6_S	9_Q	0.815	0.92
140_A	144_L	0.810	0.92
35_E	213_I	0.810	0.92
187_R	218_T	0.809	0.92
146_A	149_P	0.807	0.92
14_A	17_A	0.806	0.92
4_S	8_S	0.797	0.91
185_K	193_V	0.793	0.91
188_H	194_T	0.792	0.91
105_A	109_A	0.792	0.91
45_D	50_V	0.784	0.91
32_P	244_G	0.784	0.91
207_V	233_V	0.778	0.90
224_I	253_A	0.775	0.90
68_Q	81_T	0.775	0.90
28_Y	38_V	0.769	0.90
9_Q	25_D	0.766	0.90
185_K	218_T	0.764	0.90
153_T	206_D	0.764	0.90
171_V	210_T	0.762	0.89
221_S	225_T	0.761	0.89
207_V	230_P	0.760	0.89
188_H	192_D	0.759	0.89
32_P	191_S	0.758	0.89
171_V	271_V	0.757	0.89
64_V	110_I	0.755	0.89
224_I	235_V	0.755	0.89
143_Q	276_A	0.753	0.89
111_S	133_V	0.753	0.89
79_I	115_D	0.752	0.89
14_A	18_A	0.752	0.89
155_P	205_R	0.749	0.89
116_R	136_A	0.748	0.89
225_T	252_R	0.741	0.88
172_R	177_T	0.740	0.88
45_D	75_G	0.738	0.88
6_S	26_V	0.736	0.88
5_G	162_H	0.736	0.88
221_S	224_I	0.735	0.88
70_A	74_A	0.730	0.87
123_H	212_D	0.726	0.87
55_T	64_V	0.726	0.87
114_T	133_V	0.720	0.87
122_P	127_V	0.717	0.86
107_A	131_F	0.715	0.86
247_R	251_A	0.714	0.86
69_D	104_R	0.713	0.86
65_L	112_T	0.713	0.86
4_S	9_Q	0.713	0.86
91_Q	213_I	0.712	0.86
191_S	215_A	0.707	0.86
154_D	206_D	0.704	0.85
248_L	251_A	0.703	0.85
16_A	21_E	0.703	0.85
214_V	260_G	0.700	0.85
122_P	135_A	0.698	0.85
154_D	231_A	0.697	0.85
100_P	105_A	0.696	0.85
139_D	170_S	0.694	0.84
138_V	276_A	0.689	0.84
187_R	219_T	0.686	0.84
45_D	98_G	0.683	0.84
119_T	122_P	0.683	0.84
191_S	216_T	0.679	0.83
94_A	98_G	0.678	0.83
189_S	193_V	0.677	0.83
141_A	171_V	0.674	0.83
62_I	66_Q	0.671	0.82
188_H	191_S	0.668	0.82
190_G	193_V	0.665	0.82
83_L	87_G	0.663	0.82
39_T	214_V	0.661	0.82
125_D	166_D	0.658	0.81
251_A	254_G	0.658	0.81
184_Q	199_E	0.658	0.81
69_D	105_A	0.658	0.81
4_S	26_V	0.656	0.81
148_L	171_V	0.653	0.81
162_H	179_V	0.650	0.80
11_L	52_V	0.649	0.80
188_H	195_V	0.647	0.80
262_D	273_A	0.644	0.80
165_T	182_H	0.643	0.80
224_I	228_D	0.642	0.80
20_G	149_P	0.642	0.80
209_V	255_V	0.641	0.80
151_D	206_D	0.641	0.80
86_M	89_A	0.639	0.79
236_A	259_Y	0.638	0.79
90_R	161_D	0.636	0.79
237_T	258_V	0.635	0.79
90_R	215_A	0.633	0.79
159_S	163_G	0.632	0.79
202_T	230_P	0.630	0.78
34_G	216_T	0.628	0.78
24_G	42_P	0.620	0.77
214_V	242_L	0.619	0.77
5_G	8_S	0.618	0.77
147_P	150_A	0.616	0.77
69_D	108_R	0.612	0.76
221_S	253_A	0.610	0.76
2_L	19_T	0.609	0.76
43_A	47_E	0.608	0.76
68_Q	112_T	0.607	0.76
60_A	64_V	0.606	0.76
190_G	218_T	0.606	0.76
119_T	137_G	0.605	0.76
76_A	79_I	0.603	0.75
65_L	105_A	0.603	0.75
126_G	129_E	0.603	0.75
168_A	179_V	0.602	0.75
3_L	26_V	0.602	0.75
114_T	117_V	0.601	0.75
138_V	277_I	0.599	0.75
18_A	274_A	0.598	0.75
273_A	277_I	0.595	0.74
123_H	161_D	0.594	0.74
165_T	169_T	0.593	0.74
95_F	125_D	0.592	0.74
228_D	232_R	0.591	0.74
163_G	219_T	0.590	0.74
63_E	66_Q	0.590	0.74
37_L	96_D	0.589	0.74
54_S	87_G	0.589	0.74
169_T	173_D	0.588	0.73
145_A	174_A	0.588	0.73
58_S	88_Y	0.583	0.73
194_T	222_E	0.582	0.73
40_V	44_V	0.581	0.73
120_V	138_V	0.579	0.72
164_A	168_A	0.578	0.72
36_Q	63_E	0.577	0.72
126_G	130_C	0.576	0.72
139_D	145_A	0.575	0.72
16_A	19_T	0.575	0.72
184_Q	197_P	0.573	0.72
33_D	241_L	0.572	0.71
27_T	37_L	0.572	0.71
92_D	124_E	0.570	0.71
259_Y	271_V	0.569	0.71
55_T	61_H	0.568	0.71
171_V	236_A	0.567	0.71
77_S	115_D	0.567	0.71
86_M	131_F	0.567	0.71
7_S	53_A	0.567	0.71
260_G	266_C	0.563	0.70
183_F	226_A	0.561	0.70
221_S	250_L	0.560	0.70
71_A	79_I	0.560	0.70
86_M	107_A	0.560	0.70
3_L	44_V	0.559	0.70
170_S	174_A	0.559	0.70
185_K	219_T	0.558	0.70
187_R	195_V	0.557	0.69
105_A	108_R	0.556	0.69
92_D	161_D	0.554	0.69
92_D	187_R	0.551	0.69
161_D	217_G	0.551	0.69
45_D	136_A	0.550	0.68
217_G	235_V	0.550	0.68
178_G	205_R	0.549	0.68
50_V	98_G	0.546	0.68
94_A	125_D	0.546	0.68
156_V	202_T	0.546	0.68
63_E	67_L	0.545	0.68
74_A	94_A	0.545	0.68
17_A	23_L	0.545	0.68
140_A	261_T	0.545	0.68
261_T	271_V	0.544	0.68
92_D	123_H	0.542	0.67
169_T	186_V	0.542	0.67
217_G	247_R	0.541	0.67
117_V	131_F	0.541	0.67
193_V	220_M	0.539	0.67
124_E	127_V	0.539	0.67
118_L	280_A	0.538	0.67
96_D	189_S	0.535	0.66
2_L	24_G	0.535	0.66
4_S	23_L	0.534	0.66
168_A	210_T	0.533	0.66
34_G	213_I	0.532	0.66
160_P	185_K	0.532	0.66
207_V	236_A	0.529	0.65
66_Q	105_A	0.529	0.65
32_P	97_P	0.526	0.65
80_I	118_L	0.525	0.65
198_S	226_A	0.524	0.65
61_H	109_A	0.522	0.64
14_A	275_P	0.521	0.64
47_E	99_Q	0.521	0.64
183_F	195_V	0.519	0.64
185_K	211_D	0.518	0.64
186_V	197_P	0.518	0.64
151_D	155_P	0.516	0.64
191_S	243_A	0.515	0.63
249_K	252_R	0.515	0.63
182_H	199_E	0.515	0.63
161_D	211_D	0.514	0.63
3_L	71_A	0.514	0.63
218_T	245_S	0.513	0.63
159_S	167_L	0.512	0.63
95_F	102_S	0.511	0.63
161_D	218_T	0.511	0.63
128_L	136_A	0.510	0.63
35_E	88_Y	0.509	0.63
122_P	129_E	0.508	0.62
21_E	275_P	0.508	0.62
58_S	61_H	0.508	0.62
195_V	222_E	0.507	0.62
68_Q	76_A	0.507	0.62
78_E	118_L	0.506	0.62
15_L	277_I	0.505	0.62
137_G	166_D	0.505	0.62
91_Q	102_S	0.504	0.62
15_L	18_A	0.504	0.62
72_R	115_D	0.503	0.62
209_V	224_I	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4twbA	2	0.9573	100	0.156	Contact Map
3s5jB	2	0.9715	100	0.157	Contact Map
2ji4A	5	0.9324	100	0.158	Contact Map
1dkuA	5	0.9537	100	0.165	Contact Map
1u9yA	3	0.9609	100	0.167	Contact Map
3dahA	5	0.9715	100	0.189	Contact Map
3lrtA	2	0.9822	100	0.192	Contact Map
3dezA	2	0.6157	100	0.691	Contact Map
1o57A	2	0.8505	99.9	0.729	Contact Map
3m3hA	2	0.5943	99.9	0.748	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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