GREMLIN Database
KPRS - Ribose-phosphate pyrophosphokinase
UniProt: Q9HN88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (279)
Sequences: 3961 (2030)
Seq/√Len: 121.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_A262_D4.5951.00
232_R256_E4.5401.00
262_D272_S3.6091.00
68_Q114_T3.3051.00
206_D232_R3.1321.00
248_L252_R3.0691.00
61_H106_V2.9371.00
3_L24_G2.8721.00
245_S249_K2.7311.00
157_F168_A2.7001.00
18_A278_A2.6611.00
25_D41_P2.5281.00
2_L16_A2.5121.00
66_Q102_S2.5071.00
206_D231_A2.4661.00
240_P260_G2.4541.00
9_Q13_A2.4161.00
48_R78_E2.3811.00
222_E225_T2.2511.00
225_T229_D2.2471.00
7_S54_S2.2241.00
228_D256_E2.1631.00
120_V277_I2.1191.00
30_S59_D2.0911.00
220_M235_V2.0901.00
214_V237_T2.0661.00
156_V205_R2.0291.00
120_V263_T2.0251.00
120_V273_A2.0101.00
15_L52_V1.9921.00
13_A17_A1.9831.00
110_I114_T1.9691.00
55_T87_G1.9641.00
12_A23_L1.9571.00
215_A243_A1.9081.00
225_T254_G1.9001.00
108_R132_D1.8791.00
158_L207_V1.8421.00
11_L277_I1.8371.00
51_I71_A1.8181.00
155_P177_T1.7951.00
159_S164_A1.7811.00
263_T273_A1.7571.00
121_N238_V1.7501.00
10_S14_A1.7091.00
242_L258_V1.6701.00
146_A150_A1.6641.00
27_T41_P1.6441.00
214_V258_V1.6441.00
234_F257_A1.6441.00
235_V255_V1.6341.00
217_G221_S1.5941.00
26_V67_L1.5921.00
152_L155_P1.5861.00
204_G231_A1.5851.00
234_F256_E1.5851.00
2_L52_V1.5371.00
164_A167_L1.5171.00
11_L15_L1.4761.00
33_D85_Y1.4761.00
245_S248_L1.4661.00
105_A112_T1.4611.00
83_L117_V1.4561.00
6_S28_Y1.4531.00
138_V280_A1.4481.00
267_A270_E1.4471.00
250_L258_V1.4421.00
189_S192_D1.4391.00
206_D234_F1.4351.00
148_L259_Y1.4311.00
214_V220_M1.4171.00
144_L271_V1.4151.00
266_C269_S1.3951.00
147_P259_Y1.3931.00
80_I116_R1.3911.00
228_D233_V1.3841.00
27_T39_T1.3751.00
158_L180_T1.3671.00
193_V222_E1.3591.00
14_A274_A1.3461.00
16_A23_L1.3331.00
237_T260_G1.3241.00
207_V227_L1.2981.00
4_S12_A1.2951.00
49_A71_A1.2841.00
83_L110_I1.2841.00
10_S13_A1.2751.00
19_T278_A1.2601.00
18_A275_P1.2560.99
151_D154_D1.2530.99
29_D37_L1.2370.99
104_R108_R1.2300.99
209_V223_A1.2220.99
163_G187_R1.2220.99
228_D254_G1.2200.99
44_V71_A1.2180.99
147_P257_A1.2170.99
40_V71_A1.2110.99
92_D126_G1.2100.99
6_S30_S1.2090.99
224_I255_V1.2020.99
48_R80_I1.1770.99
104_R132_D1.1770.99
5_G53_A1.1660.99
8_S54_S1.1600.99
155_P208_V1.1580.99
51_I68_Q1.1550.99
157_F175_Y1.1410.99
195_V226_A1.1410.99
148_L208_V1.1370.99
158_L227_L1.1270.99
15_L281_L1.1270.99
57_T60_A1.1250.99
16_A22_R1.1210.99
161_D187_R1.1200.99
95_F99_Q1.1200.99
14_A272_S1.1180.99
51_I67_L1.1100.99
69_D73_D1.1060.99
152_L206_D1.1030.99
65_L109_A1.1010.99
39_T99_Q1.0910.99
214_V217_G1.0860.99
163_G185_K1.0820.98
12_A16_A1.0760.98
240_P266_C1.0710.98
103_A127_V1.0640.98
78_E115_D1.0560.98
37_L99_Q1.0540.98
56_P60_A1.0520.98
143_Q271_V1.0450.98
155_P206_D1.0450.98
2_L21_E1.0400.98
156_V207_V1.0360.98
110_I117_V1.0240.98
154_D205_R1.0220.98
226_A229_D1.0200.98
111_S132_D1.0190.98
161_D185_K1.0170.98
162_H166_D1.0100.98
242_L260_G1.0100.98
4_S7_S1.0030.98
144_L236_A0.9900.97
224_I254_G0.9860.97
8_S265_E0.9780.97
230_P233_V0.9740.97
183_F223_A0.9730.97
147_P271_V0.9730.97
147_P236_A0.9690.97
122_P137_G0.9680.97
145_A171_V0.9660.97
108_R111_S0.9650.97
148_L234_F0.9560.97
217_G245_S0.9540.97
235_V253_A0.9400.96
169_T184_Q0.9400.96
58_S62_I0.9390.96
217_G249_K0.9370.96
3_L67_L0.9370.96
33_D87_G0.9320.96
30_S36_Q0.9240.96
32_P215_A0.9200.96
221_S249_K0.9150.96
180_T183_F0.9150.96
61_H65_L0.9100.96
36_Q58_S0.9100.96
170_S173_D0.9080.96
10_S265_E0.9080.96
18_A279_D0.9080.96
48_R77_S0.8970.95
266_C270_E0.8920.95
6_S63_E0.8900.95
5_G67_L0.8860.95
13_A23_L0.8860.95
120_V276_A0.8850.95
39_T96_D0.8790.95
71_A76_A0.8790.95
237_T240_P0.8710.94
25_D42_P0.8690.94
40_V67_L0.8690.94
94_A101_V0.8660.94
225_T228_D0.8660.94
144_L261_T0.8640.94
96_D99_Q0.8620.94
140_A238_V0.8580.94
121_N167_L0.8550.94
35_E91_Q0.8500.94
157_F171_V0.8480.94
163_G218_T0.8470.94
161_D212_D0.8440.93
81_T114_T0.8410.93
275_P278_A0.8400.93
33_D93_D0.8350.93
241_L264_I0.8320.93
148_L236_A0.8290.93
250_L253_A0.8250.93
58_S66_Q0.8240.93
160_P219_T0.8210.92
188_H193_V0.8210.92
220_M237_T0.8150.92
202_T227_L0.8150.92
6_S9_Q0.8150.92
140_A144_L0.8100.92
35_E213_I0.8100.92
187_R218_T0.8090.92
146_A149_P0.8070.92
14_A17_A0.8060.92
4_S8_S0.7970.91
185_K193_V0.7930.91
188_H194_T0.7920.91
105_A109_A0.7920.91
45_D50_V0.7840.91
32_P244_G0.7840.91
207_V233_V0.7780.90
224_I253_A0.7750.90
68_Q81_T0.7750.90
28_Y38_V0.7690.90
9_Q25_D0.7660.90
185_K218_T0.7640.90
153_T206_D0.7640.90
171_V210_T0.7620.89
221_S225_T0.7610.89
207_V230_P0.7600.89
188_H192_D0.7590.89
32_P191_S0.7580.89
171_V271_V0.7570.89
64_V110_I0.7550.89
224_I235_V0.7550.89
143_Q276_A0.7530.89
111_S133_V0.7530.89
79_I115_D0.7520.89
14_A18_A0.7520.89
155_P205_R0.7490.89
116_R136_A0.7480.89
225_T252_R0.7410.88
172_R177_T0.7400.88
45_D75_G0.7380.88
6_S26_V0.7360.88
5_G162_H0.7360.88
221_S224_I0.7350.88
70_A74_A0.7300.87
123_H212_D0.7260.87
55_T64_V0.7260.87
114_T133_V0.7200.87
122_P127_V0.7170.86
107_A131_F0.7150.86
247_R251_A0.7140.86
69_D104_R0.7130.86
65_L112_T0.7130.86
4_S9_Q0.7130.86
91_Q213_I0.7120.86
191_S215_A0.7070.86
154_D206_D0.7040.85
248_L251_A0.7030.85
16_A21_E0.7030.85
214_V260_G0.7000.85
122_P135_A0.6980.85
154_D231_A0.6970.85
100_P105_A0.6960.85
139_D170_S0.6940.84
138_V276_A0.6890.84
187_R219_T0.6860.84
45_D98_G0.6830.84
119_T122_P0.6830.84
191_S216_T0.6790.83
94_A98_G0.6780.83
189_S193_V0.6770.83
141_A171_V0.6740.83
62_I66_Q0.6710.82
188_H191_S0.6680.82
190_G193_V0.6650.82
83_L87_G0.6630.82
39_T214_V0.6610.82
125_D166_D0.6580.81
251_A254_G0.6580.81
184_Q199_E0.6580.81
69_D105_A0.6580.81
4_S26_V0.6560.81
148_L171_V0.6530.81
162_H179_V0.6500.80
11_L52_V0.6490.80
188_H195_V0.6470.80
262_D273_A0.6440.80
165_T182_H0.6430.80
224_I228_D0.6420.80
20_G149_P0.6420.80
209_V255_V0.6410.80
151_D206_D0.6410.80
86_M89_A0.6390.79
236_A259_Y0.6380.79
90_R161_D0.6360.79
237_T258_V0.6350.79
90_R215_A0.6330.79
159_S163_G0.6320.79
202_T230_P0.6300.78
34_G216_T0.6280.78
24_G42_P0.6200.77
214_V242_L0.6190.77
5_G8_S0.6180.77
147_P150_A0.6160.77
69_D108_R0.6120.76
221_S253_A0.6100.76
2_L19_T0.6090.76
43_A47_E0.6080.76
68_Q112_T0.6070.76
60_A64_V0.6060.76
190_G218_T0.6060.76
119_T137_G0.6050.76
76_A79_I0.6030.75
65_L105_A0.6030.75
126_G129_E0.6030.75
168_A179_V0.6020.75
3_L26_V0.6020.75
114_T117_V0.6010.75
138_V277_I0.5990.75
18_A274_A0.5980.75
273_A277_I0.5950.74
123_H161_D0.5940.74
165_T169_T0.5930.74
95_F125_D0.5920.74
228_D232_R0.5910.74
163_G219_T0.5900.74
63_E66_Q0.5900.74
37_L96_D0.5890.74
54_S87_G0.5890.74
169_T173_D0.5880.73
145_A174_A0.5880.73
58_S88_Y0.5830.73
194_T222_E0.5820.73
40_V44_V0.5810.73
120_V138_V0.5790.72
164_A168_A0.5780.72
36_Q63_E0.5770.72
126_G130_C0.5760.72
139_D145_A0.5750.72
16_A19_T0.5750.72
184_Q197_P0.5730.72
33_D241_L0.5720.71
27_T37_L0.5720.71
92_D124_E0.5700.71
259_Y271_V0.5690.71
55_T61_H0.5680.71
171_V236_A0.5670.71
77_S115_D0.5670.71
86_M131_F0.5670.71
7_S53_A0.5670.71
260_G266_C0.5630.70
183_F226_A0.5610.70
221_S250_L0.5600.70
71_A79_I0.5600.70
86_M107_A0.5600.70
3_L44_V0.5590.70
170_S174_A0.5590.70
185_K219_T0.5580.70
187_R195_V0.5570.69
105_A108_R0.5560.69
92_D161_D0.5540.69
92_D187_R0.5510.69
161_D217_G0.5510.69
45_D136_A0.5500.68
217_G235_V0.5500.68
178_G205_R0.5490.68
50_V98_G0.5460.68
94_A125_D0.5460.68
156_V202_T0.5460.68
63_E67_L0.5450.68
74_A94_A0.5450.68
17_A23_L0.5450.68
140_A261_T0.5450.68
261_T271_V0.5440.68
92_D123_H0.5420.67
169_T186_V0.5420.67
217_G247_R0.5410.67
117_V131_F0.5410.67
193_V220_M0.5390.67
124_E127_V0.5390.67
118_L280_A0.5380.67
96_D189_S0.5350.66
2_L24_G0.5350.66
4_S23_L0.5340.66
168_A210_T0.5330.66
34_G213_I0.5320.66
160_P185_K0.5320.66
207_V236_A0.5290.65
66_Q105_A0.5290.65
32_P97_P0.5260.65
80_I118_L0.5250.65
198_S226_A0.5240.65
61_H109_A0.5220.64
14_A275_P0.5210.64
47_E99_Q0.5210.64
183_F195_V0.5190.64
185_K211_D0.5180.64
186_V197_P0.5180.64
151_D155_P0.5160.64
191_S243_A0.5150.63
249_K252_R0.5150.63
182_H199_E0.5150.63
161_D211_D0.5140.63
3_L71_A0.5140.63
218_T245_S0.5130.63
159_S167_L0.5120.63
95_F102_S0.5110.63
161_D218_T0.5110.63
128_L136_A0.5100.63
35_E88_Y0.5090.63
122_P129_E0.5080.62
21_E275_P0.5080.62
58_S61_H0.5080.62
195_V222_E0.5070.62
68_Q76_A0.5070.62
78_E118_L0.5060.62
15_L277_I0.5050.62
137_G166_D0.5050.62
91_Q102_S0.5040.62
15_L18_A0.5040.62
72_R115_D0.5030.62
209_V224_I0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4twbA 2 0.9573 100 0.156 Contact Map
3s5jB 2 0.9715 100 0.157 Contact Map
2ji4A 5 0.9324 100 0.158 Contact Map
1dkuA 5 0.9537 100 0.165 Contact Map
1u9yA 3 0.9609 100 0.167 Contact Map
3dahA 5 0.9715 100 0.189 Contact Map
3lrtA 2 0.9822 100 0.192 Contact Map
3dezA 2 0.6157 100 0.691 Contact Map
1o57A 2 0.8505 99.9 0.729 Contact Map
3m3hA 2 0.5943 99.9 0.748 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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