GREMLIN Database
Q9HN85 - Phosphomannomutase
UniProt: Q9HN85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 455 (437)
Sequences: 10907 (6690)
Seq/√Len: 320.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
224_L228_A4.1471.00
307_R310_E4.1261.00
180_G240_A3.7931.00
172_A230_A3.5761.00
223_A227_A3.3961.00
248_E357_S3.2881.00
170_T194_D2.8511.00
156_S190_E2.8501.00
46_T205_H2.8441.00
27_K62_I2.8361.00
224_L227_A2.7371.00
284_V296_L2.7081.00
37_R65_D2.6991.00
434_H438_E2.6671.00
272_T293_T2.6651.00
295_E307_R2.6461.00
83_R150_D2.6281.00
186_T190_E2.5511.00
31_S124_A2.5371.00
289_R362_P2.4571.00
52_E68_R2.4511.00
264_E290_T2.4441.00
149_R153_A2.4131.00
219_G223_A2.3291.00
236_H343_G2.3121.00
354_T358_E2.2881.00
38_V59_L2.2721.00
19_P50_M2.2561.00
222_G226_R2.2431.00
26_A55_A2.2381.00
245_F346_F2.1861.00
55_A89_V2.1821.00
170_T196_V2.1691.00
40_V56_V2.1551.00
59_L89_V2.1491.00
41_A77_T2.1271.00
197_T200_A2.1041.00
442_E446_A2.0981.00
29_A87_P2.0731.00
285_D288_D2.0591.00
386_D390_A2.0561.00
433_D436_R2.0311.00
267_L292_A2.0241.00
30_G59_L2.0211.00
39_A86_V2.0051.00
42_R52_E2.0011.00
264_E362_P2.0001.00
42_R48_G1.9901.00
49_R53_N1.9741.00
12_V99_Q1.9691.00
30_G62_I1.9601.00
264_E268_D1.9591.00
123_R127_T1.9441.00
172_A224_L1.9371.00
438_E442_E1.9251.00
124_A127_T1.8961.00
120_R123_R1.8691.00
31_S62_I1.8561.00
284_V288_D1.8231.00
199_N220_D1.8071.00
79_A83_R1.8031.00
307_R316_D1.7621.00
37_R67_D1.7511.00
152_R187_F1.7501.00
149_R186_T1.7461.00
261_A349_L1.7351.00
285_D366_Y1.7311.00
12_V100_Y1.7221.00
436_R439_S1.7221.00
113_L121_V1.7191.00
29_A105_L1.7091.00
234_I343_G1.6951.00
27_K31_S1.6821.00
196_V228_A1.6811.00
23_L54_A1.6571.00
287_C292_A1.6531.00
122_E126_T1.5971.00
356_A360_V1.5881.00
429_A441_A1.5331.00
439_S443_A1.5261.00
225_V233_G1.5241.00
12_V15_E1.5231.00
185_P189_R1.5161.00
175_P200_A1.5051.00
223_A226_R1.5051.00
186_T189_R1.5021.00
153_A190_E1.4971.00
306_T310_E1.4961.00
389_E401_T1.4851.00
248_E355_P1.4741.00
437_A441_A1.4731.00
435_E439_S1.4591.00
23_L57_A1.4471.00
22_V103_V1.4411.00
369_V438_E1.4411.00
185_P200_A1.4411.00
23_L61_S1.4351.00
59_L64_V1.4321.00
272_T295_E1.4271.00
446_A449_R1.4261.00
275_S294_L1.4171.00
32_V117_D1.4091.00
149_R190_E1.3951.00
204_G207_P1.3851.00
220_D223_A1.3831.00
44_T71_V1.3831.00
445_A449_R1.3761.00
297_T307_R1.3741.00
22_V51_L1.3721.00
171_V232_V1.3701.00
39_A80_Y1.3681.00
262_L330_F1.3601.00
383_A387_A1.3581.00
79_A154_Q1.3541.00
251_E361_A1.3501.00
221_L235_A1.3461.00
304_I321_A1.3431.00
13_A47_T1.3381.00
30_G64_V1.3341.00
219_G222_G1.3221.00
441_A445_A1.3141.00
42_R49_R1.3141.00
32_V124_A1.3031.00
387_A391_R1.3031.00
9_T25_V1.3021.00
46_T204_G1.2971.00
221_L246_V1.2961.00
259_L322_G1.2951.00
26_A103_V1.2941.00
431_S437_A1.2861.00
403_D406_R1.2861.00
249_T357_S1.2791.00
170_T228_A1.2731.00
56_V60_Q1.2691.00
123_R126_T1.2681.00
263_A273_T1.2581.00
282_R359_V1.2531.00
358_E361_A1.2501.00
169_L231_D1.2411.00
232_V347_L1.2371.00
155_L341_Y1.2361.00
226_R249_T1.2251.00
32_V120_R1.2201.00
438_E441_A1.2181.00
386_D389_E1.2171.00
158_A345_R1.2121.00
355_P358_E1.2121.00
42_R68_R1.2101.00
232_V350_L1.2081.00
72_V76_A1.2051.00
191_L344_A1.2021.00
310_E316_D1.2001.00
59_L66_V1.2001.00
170_T229_D1.1981.00
155_L344_A1.1901.00
150_D153_A1.1901.00
293_T316_D1.1731.00
154_Q157_D1.1711.00
26_A59_L1.1681.00
40_V55_A1.1591.00
268_D352_D1.1491.00
146_S149_R1.1471.00
153_A157_D1.1441.00
148_G183_T1.1441.00
148_G186_T1.1241.00
260_A282_R1.1241.00
220_D224_L1.1181.00
275_S279_V1.1171.00
234_I245_F1.1141.00
139_G142_R1.1091.00
352_D355_P1.1081.00
120_R124_A1.1051.00
38_V87_P1.1001.00
222_G252_Y1.0951.00
89_V103_V1.0921.00
52_E56_V1.0921.00
218_L252_Y1.0921.00
160_D348_E1.0901.00
56_V68_R1.0901.00
81_A88_A1.0841.00
173_L188_Y1.0841.00
83_R154_Q1.0771.00
371_V445_A1.0771.00
188_Y343_G1.0761.00
267_L271_D1.0761.00
275_S296_L1.0711.00
119_E122_E1.0701.00
369_V441_A1.0701.00
371_V442_E1.0681.00
29_A89_V1.0671.00
79_A150_D1.0671.00
286_V290_T1.0671.00
379_A383_A1.0651.00
9_T105_L1.0641.00
295_E316_D1.0641.00
198_V220_D1.0631.00
405_Y440_L1.0591.00
152_R183_T1.0581.00
436_R440_L1.0571.00
198_V224_L1.0541.00
117_D120_R1.0541.00
152_R190_E1.0541.00
84_A147_A1.0531.00
260_A286_V1.0521.00
77_T88_A1.0511.00
19_P54_A1.0511.00
73_P76_A1.0441.00
180_G236_H1.0411.00
54_A58_G1.0381.00
55_A91_V1.0371.00
247_D251_E1.0321.00
21_F25_V1.0311.00
279_V283_L1.0241.00
77_T90_M1.0231.00
388_A416_V1.0231.00
41_A90_M1.0221.00
154_Q158_A1.0171.00
177_H209_R1.0131.00
284_V294_L1.0121.00
225_V246_V1.0111.00
196_V230_A1.0071.00
196_V224_L1.0061.00
267_L290_T1.0051.00
382_G386_D1.0051.00
27_K61_S1.0051.00
181_A200_A1.0021.00
189_R197_T1.0021.00
114_A117_D1.0011.00
407_L414_V1.0011.00
55_A59_L0.9971.00
188_Y347_L0.9971.00
173_L180_G0.9941.00
44_T202_P0.9921.00
199_N213_P0.9901.00
107_G117_D0.9881.00
181_A185_P0.9821.00
259_L283_L0.9801.00
221_L233_G0.9781.00
47_T50_M0.9761.00
287_C294_L0.9751.00
303_Q306_T0.9741.00
406_R413_W0.9721.00
173_L236_H0.9681.00
153_A156_S0.9661.00
403_D407_L0.9661.00
69_L72_V0.9661.00
308_I318_V0.9641.00
28_A125_F0.9621.00
57_A61_S0.9581.00
432_T436_R0.9571.00
257_A365_D0.9551.00
350_L359_V0.9551.00
28_A124_A0.9511.00
115_V303_Q0.9491.00
52_E91_V0.9461.00
134_A137_G0.9431.00
218_L244_I0.9431.00
65_D143_E0.9421.00
119_E123_R0.9421.00
172_A196_V0.9411.00
53_N57_A0.9411.00
442_E445_A0.9381.00
285_D289_R0.9371.00
257_A360_V0.9321.00
116_A120_R0.9291.00
330_F345_R0.9271.00
170_T231_D0.9241.00
60_Q141_D0.9221.00
272_T316_D0.9191.00
48_G101_N0.9191.00
33_W87_P0.9181.00
272_T318_V0.9171.00
317_H331_P0.9141.00
377_T380_Q0.9141.00
156_S191_L0.9121.00
258_T346_F0.9081.00
177_H199_N0.9021.00
320_V328_I0.9021.00
118_L121_V0.9021.00
171_V193_C0.8951.00
151_Y155_L0.8921.00
273_T287_C0.8911.00
289_R363_Y0.8901.00
169_L350_L0.8881.00
203_D211_P0.8851.00
184_S236_H0.8851.00
286_V289_R0.8831.00
39_A69_L0.8821.00
172_A228_A0.8781.00
174_D221_L0.8771.00
259_L273_T0.8751.00
67_D86_V0.8751.00
41_A72_V0.8731.00
273_T283_L0.8721.00
380_Q383_A0.8721.00
26_A58_G0.8701.00
138_V142_R0.8671.00
42_R71_V0.8671.00
258_T328_I0.8661.00
243_A342_T0.8661.00
25_V125_F0.8641.00
147_A150_D0.8561.00
162_A167_A0.8561.00
234_I243_A0.8531.00
183_T340_A0.8521.00
268_D290_T0.8511.00
171_V347_L0.8511.00
400_T408_D0.8491.00
375_Y378_E0.8481.00
184_S340_A0.8481.00
80_Y147_A0.8471.00
442_E449_R0.8471.00
19_P23_L0.8441.00
70_G182_L0.8431.00
245_F258_T0.8421.00
113_L117_D0.8401.00
345_R348_E0.8361.00
222_G246_V0.8361.00
266_E345_R0.8341.00
271_D317_H0.8311.00
427_I445_A0.8301.00
373_V445_A0.8301.00
435_E438_E0.8291.00
122_E125_F0.8291.00
134_A138_V0.8291.00
271_D292_A0.8261.00
288_D294_L0.8211.00
383_A386_D0.8191.00
265_A349_L0.8191.00
35_A124_A0.8191.00
246_V252_Y0.8151.00
81_A87_P0.8141.00
35_A120_R0.8101.00
169_L347_L0.8091.00
148_G182_L0.8091.00
37_R86_V0.8071.00
72_V90_M0.8061.00
83_R147_A0.8051.00
188_Y193_C0.8021.00
391_R394_D0.8011.00
135_W138_V0.7991.00
328_I342_T0.7991.00
260_A280_S0.7971.00
261_A360_V0.7971.00
221_L225_V0.7961.00
354_T362_P0.7961.00
234_I347_L0.7951.00
236_H339_G0.7931.00
26_A30_G0.7911.00
429_A437_A0.7911.00
274_V307_R0.7911.00
71_V179_A0.7911.00
152_R186_T0.7891.00
130_F133_A0.7881.00
264_E286_V0.7851.00
275_S284_V0.7851.00
274_V321_A0.7851.00
216_E219_G0.7821.00
20_G24_R0.7811.00
41_A69_L0.7811.00
387_A390_A0.7811.00
80_Y84_A0.7781.00
298_P303_Q0.7771.00
44_T179_A0.7761.00
440_L443_A0.7751.00
57_A132_N0.7731.00
146_S150_D0.7721.00
411_D432_T0.7711.00
118_L122_E0.7691.00
264_E363_Y0.7681.00
243_A339_G0.7671.00
262_L345_R0.7650.99
169_L232_V0.7640.99
280_S322_G0.7630.99
398_D408_D0.7610.99
408_D443_A0.7610.99
390_A393_L0.7580.99
347_L350_L0.7580.99
251_E257_A0.7570.99
168_D194_D0.7560.99
225_V230_A0.7550.99
54_A57_A0.7530.99
271_D319_P0.7520.99
388_A392_A0.7500.99
319_P332_E0.7500.99
244_I252_Y0.7480.99
431_S436_R0.7480.99
159_V344_A0.7430.99
305_M329_I0.7420.99
7_S276_A0.7410.99
105_L121_V0.7400.99
39_A84_A0.7390.99
258_T262_L0.7380.99
226_R229_D0.7330.99
277_V415_L0.7330.99
60_Q142_R0.7320.99
327_G337_R0.7310.99
401_T404_G0.7300.99
288_D293_T0.7290.99
5_G8_G0.7270.99
67_D145_A0.7270.99
367_H433_D0.7260.99
149_R152_R0.7250.99
145_A149_R0.7250.99
56_V66_V0.7240.99
218_L246_V0.7230.99
400_T404_G0.7230.99
385_L389_E0.7230.99
132_N135_W0.7220.99
177_H213_P0.7220.99
281_Q430_E0.7210.99
356_A359_V0.7210.99
283_L322_G0.7200.99
414_V444_F0.7180.99
173_L184_S0.7170.99
182_L186_T0.7170.99
6_S420_G0.7150.99
69_L76_A0.7150.99
154_Q333_Y0.7150.99
290_T363_Y0.7150.99
262_L349_L0.7130.99
172_A198_V0.7130.99
154_Q334_R0.7130.99
24_R125_F0.7080.99
167_A194_D0.7070.99
56_V141_D0.6980.99
185_P197_T0.6960.99
76_A148_G0.6920.99
247_D357_S0.6910.99
406_R415_L0.6900.99
267_L287_C0.6900.99
373_V449_R0.6900.99
443_A447_D0.6880.99
251_E360_V0.6880.99
172_A233_G0.6870.99
232_V245_F0.6870.99
138_V141_D0.6860.99
152_R156_S0.6850.99
26_A89_V0.6830.99
259_L320_V0.6790.99
136_D139_G0.6790.99
354_T359_V0.6780.99
32_V121_V0.6770.99
95_H104_K0.6760.99
93_A96_N0.6760.99
31_S127_T0.6750.99
443_A446_A0.6730.99
384_L387_A0.6700.99
369_V445_A0.6700.99
98_S205_H0.6700.99
379_A418_P0.6680.99
198_V223_A0.6680.99
396_D400_T0.6680.99
69_L77_T0.6670.99
253_I356_A0.6670.99
375_Y380_Q0.6660.99
111_V309_R0.6650.99
381_R385_L0.6650.99
14_N18_T0.6640.99
128_E131_D0.6630.99
31_S131_D0.6620.99
48_G52_E0.6620.99
15_E99_Q0.6610.99
372_N424_V0.6610.99
181_A202_P0.6570.98
133_A138_V0.6550.98
29_A33_W0.6520.98
367_H434_H0.6510.98
46_T98_S0.6500.98
84_A150_D0.6500.98
243_A343_G0.6470.98
401_T405_Y0.6470.98
169_L351_A0.6430.98
385_L418_P0.6410.98
22_V54_A0.6400.98
262_L342_T0.6380.98
23_L58_G0.6380.98
349_L352_D0.6370.98
281_Q366_Y0.6350.98
7_S370_R0.6340.98
137_G140_A0.6340.98
67_D144_V0.6310.98
263_A283_L0.6310.98
433_D437_A0.6290.98
389_E393_L0.6280.98
436_R443_A0.6280.98
12_V16_E0.6270.98
233_G246_V0.6270.98
14_N50_M0.6260.98
72_V148_G0.6260.98
260_A363_Y0.6250.98
379_A382_G0.6240.98
256_D368_N0.6230.98
188_Y192_G0.6180.98
282_R366_Y0.6170.98
50_M54_A0.6160.98
18_T21_F0.6150.98
218_L221_L0.6150.98
148_G152_R0.6140.98
374_D424_V0.6140.98
109_D309_R0.6130.98
184_S343_G0.6120.98
278_N299_I0.6120.98
346_F356_A0.6100.98
224_L230_A0.6100.98
116_A119_E0.6090.97
375_Y381_R0.6080.97
283_L294_L0.6070.97
195_V200_A0.6070.97
253_I261_A0.6070.97
271_D293_T0.6050.97
439_S442_E0.6050.97
263_A320_V0.6050.97
94_S104_K0.6040.97
295_E318_V0.6030.97
416_V448_L0.6030.97
444_F447_D0.6030.97
49_R70_G0.6030.97
281_Q408_D0.6020.97
29_A38_V0.6020.97
121_V125_F0.5990.97
24_R128_E0.5990.97
184_S188_Y0.5960.97
113_L118_L0.5940.97
135_W139_G0.5940.97
96_N421_T0.5930.97
231_D248_E0.5930.97
17_L25_V0.5930.97
440_L444_F0.5920.97
404_G407_L0.5920.97
36_D108_S0.5920.97
412_A440_L0.5920.97
17_L22_V0.5900.97
320_V330_F0.5900.97
376_D379_A0.5900.97
265_A352_D0.5890.97
60_Q66_V0.5880.97
24_R126_T0.5880.97
380_Q384_L0.5880.97
57_A60_Q0.5880.97
275_S281_Q0.5870.97
375_Y418_P0.5870.97
21_F125_F0.5860.97
437_A440_L0.5850.97
7_S112_E0.5850.97
159_V166_A0.5850.97
371_V441_A0.5810.97
25_V105_L0.5800.97
274_V297_T0.5790.97
96_N100_Y0.5790.97
5_G420_G0.5780.97
175_P198_V0.5780.97
38_V64_V0.5780.97
22_V26_A0.5760.96
17_L21_F0.5760.96
434_H437_A0.5740.96
162_A166_A0.5740.96
226_R251_E0.5740.96
68_R143_E0.5730.96
441_A444_F0.5730.96
170_T230_A0.5710.96
350_L356_A0.5690.96
413_W430_E0.5690.96
274_V304_I0.5680.96
199_N212_E0.5660.96
281_Q285_D0.5640.96
11_G16_E0.5630.96
22_V55_A0.5620.96
83_R153_A0.5620.96
226_R250_G0.5590.96
371_V449_R0.5580.96
55_A103_V0.5580.96
19_P57_A0.5570.96
53_N138_V0.5560.96
251_E365_D0.5550.96
24_R27_K0.5540.96
184_S195_V0.5540.96
155_L158_A0.5530.96
378_E382_G0.5530.96
10_R95_H0.5520.96
262_L346_F0.5520.96
172_A221_L0.5520.96
330_F342_T0.5510.95
211_P215_R0.5500.95
174_D235_A0.5480.95
243_A346_F0.5450.95
211_P214_V0.5440.95
249_T361_A0.5440.95
203_D207_P0.5430.95
65_D140_A0.5410.95
395_A398_D0.5410.95
181_A195_V0.5400.95
129_Q134_A0.5400.95
187_F190_E0.5390.95
151_Y338_D0.5390.95
173_L195_V0.5380.95
258_T326_G0.5370.95
409_Y412_A0.5370.95
78_Q335_M0.5370.95
260_A264_E0.5370.95
167_A231_D0.5370.95
357_S361_A0.5360.95
251_E357_S0.5360.95
266_E319_P0.5360.95
81_A86_V0.5360.95
21_F24_R0.5340.95
187_F340_A0.5340.95
209_R217_H0.5340.95
285_D432_T0.5340.95
138_V143_E0.5330.95
23_L27_K0.5330.95
360_V363_Y0.5320.95
330_F341_Y0.5310.95
27_K130_F0.5300.94
412_A431_S0.5300.94
248_E358_E0.5290.94
235_A246_V0.5270.94
76_A183_T0.5270.94
168_D351_A0.5260.94
286_V363_Y0.5240.94
96_N104_K0.5240.94
218_L233_G0.5220.94
402_I416_V0.5220.94
416_V427_I0.5210.94
444_F448_L0.5210.94
115_V118_L0.5180.94
218_L222_G0.5180.94
95_H241_D0.5160.94
301_S337_R0.5160.94
374_D422_E0.5150.94
13_A51_L0.5150.94
138_V144_V0.5150.94
218_L235_A0.5130.93
189_R194_D0.5130.93
189_R192_G0.5130.93
384_L425_V0.5120.93
254_E257_A0.5120.93
158_A341_Y0.5110.93
36_D120_R0.5110.93
106_V112_E0.5100.93
39_A88_A0.5100.93
253_I360_V0.5080.93
37_R84_A0.5080.93
412_A436_R0.5080.93
215_R252_Y0.5060.93
408_D439_S0.5060.93
188_Y236_H0.5050.93
131_D134_A0.5040.93
376_D380_Q0.5040.93
59_L87_P0.5040.93
168_D193_C0.5030.93
202_P206_F0.5030.93
310_E317_H0.5030.93
184_S192_G0.5020.93
283_L287_C0.5000.93
278_N428_Y0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wqaA 3 0.978 100 0.086 Contact Map
2f7lA 4 0.978 100 0.087 Contact Map
1tuoA 1 0.9143 100 0.132 Contact Map
3pdkA 2 0.9495 100 0.141 Contact Map
1p5dX 1 0.9648 100 0.148 Contact Map
3uw2A 1 0.9516 100 0.151 Contact Map
3i3wA 2 0.9473 100 0.154 Contact Map
3na5A 2 0.9758 100 0.17 Contact Map
2z0fA 2 0.9319 100 0.173 Contact Map
4hjhA 2 0.956 100 0.186 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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