GREMLIN Database
Q9HN80 - Pre-mRNA splicing helicase
UniProt: Q9HN80 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 779 (629)
Sequences: 3582 (2632)
Seq/√Len: 105.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
145_V174_A4.7391.00
228_R231_T3.4551.00
467_T471_L3.3651.00
120_D124_R3.3551.00
431_D434_D3.3531.00
142_I161_V3.3521.00
463_R467_T3.2651.00
39_A50_L3.2261.00
228_R233_L3.2191.00
228_R232_A3.2171.00
228_R235_L3.1471.00
303_A326_I3.1431.00
78_K81_E3.1071.00
91_S108_R2.9701.00
226_Y233_L2.8911.00
207_D212_V2.8771.00
204_R207_D2.8451.00
226_Y231_T2.8271.00
436_M440_E2.6741.00
206_V212_V2.6591.00
146_H370_Q2.6531.00
227_R233_L2.6441.00
443_F447_R2.6191.00
191_A194_D2.5511.00
203_Y206_V2.5361.00
227_R231_T2.5191.00
648_I653_D2.5171.00
206_V209_H2.4841.00
259_A330_F2.4341.00
225_K231_T2.4321.00
140_V164_L2.4311.00
205_P209_H2.4061.00
27_V31_L2.3531.00
400_T405_G2.2991.00
225_K228_R2.2691.00
55_I65_A2.2381.00
178_T370_Q2.1961.00
124_R127_D2.1951.00
197_F200_D2.1901.00
209_H212_V2.1851.00
204_R209_H2.1741.00
199_F204_R2.1511.00
229_L233_L2.1371.00
370_Q374_R2.1291.00
123_T126_H2.1251.00
667_L670_G2.0811.00
225_K230_F2.0531.00
205_P212_V1.9921.00
469_D473_D1.9851.00
658_G661_G1.9821.00
204_R208_L1.9771.00
227_R230_F1.9721.00
433_G437_A1.9651.00
230_F235_L1.9511.00
63_G138_E1.9341.00
176_S181_N1.9221.00
209_H383_V1.9151.00
498_Y503_T1.9141.00
231_T234_D1.9131.00
468_L485_L1.8981.00
190_D193_P1.8961.00
207_D211_G1.8961.00
564_I569_M1.8781.00
464_V467_T1.8681.00
230_F234_D1.8661.00
231_T235_L1.8491.00
228_R238_P1.8471.00
647_G650_T1.7941.00
34_D57_Q1.7901.00
235_L238_P1.7751.00
694_D698_A1.7701.00
225_K233_L1.7651.00
209_H213_R1.7641.00
629_L632_I1.7641.00
695_S699_G1.7631.00
203_Y209_H1.7601.00
672_A676_H1.7571.00
71_L337_W1.7481.00
542_A549_H1.7411.00
470_D474_Q1.7391.00
232_A236_A1.7271.00
415_N419_H1.7241.00
695_S698_A1.7221.00
581_A584_I1.7211.00
144_E374_R1.7191.00
692_F695_S1.7181.00
430_R434_D1.7111.00
690_G694_D1.7061.00
205_P211_G1.7031.00
319_Q323_E1.7021.00
338_G374_R1.6781.00
691_D694_D1.6751.00
144_E338_G1.6701.00
682_L685_V1.6681.00
559_R562_Y1.6651.00
230_F233_L1.6591.00
465_R468_L1.6411.00
640_A643_L1.6381.00
205_P208_L1.6361.00
462_D466_A1.6301.00
419_H422_A1.6281.00
120_D123_T1.6191.00
394_D397_T1.6151.00
41_A45_S1.6131.00
469_D472_I1.6131.00
424_I477_V1.6111.00
204_R212_V1.6101.00
432_L465_R1.6101.00
82_W111_V1.6091.00
694_D699_G1.6081.00
229_L235_L1.6051.00
454_A457_F1.6001.00
153_R158_E1.5861.00
79_E94_V1.5821.00
250_V256_T1.5711.00
441_T446_Q1.5701.00
550_S554_M1.5491.00
442_T447_R1.5481.00
648_I659_V1.5391.00
608_A611_A1.5351.00
610_A615_E1.5341.00
203_Y212_V1.5331.00
374_R377_R1.5241.00
437_A440_E1.5191.00
696_V699_G1.5171.00
639_R644_H1.5151.00
491_G495_S1.5071.00
344_R381_D1.4961.00
252_S255_D1.4941.00
663_V672_A1.4921.00
528_G531_D1.4821.00
683_P688_D1.4761.00
413_D416_L1.4701.00
250_V330_F1.4681.00
676_H679_A1.4651.00
551_G554_M1.4531.00
471_L475_G1.4481.00
580_D584_I1.4481.00
226_Y230_F1.4471.00
611_A615_E1.4451.00
237_E241_R1.4411.00
421_N425_A1.4371.00
43_T376_G1.4361.00
667_L671_V1.4261.00
562_Y569_M1.4241.00
109_A112_L1.4231.00
636_A639_R1.4211.00
691_D695_S1.4211.00
59_L90_Y1.4171.00
527_A530_F1.4161.00
43_T144_E1.4161.00
661_G664_D1.4151.00
203_Y207_D1.4021.00
400_T404_E1.3981.00
671_V676_H1.3951.00
668_A672_A1.3851.00
461_R467_T1.3771.00
505_R509_A1.3731.00
435_V447_R1.3721.00
686_A690_G1.3701.00
527_A531_D1.3681.00
647_G654_V1.3671.00
228_R236_A1.3671.00
117_E334_T1.3671.00
642_K646_E1.3621.00
627_V631_A1.3611.00
73_A117_E1.3591.00
651_P657_A1.3571.00
685_V700_D1.3510.99
416_L419_H1.3490.99
491_G503_T1.3480.99
368_V372_L1.3450.99
668_A671_V1.3420.99
566_R569_M1.3370.99
557_G560_K1.3370.99
648_I657_A1.3330.99
200_D203_Y1.3270.99
205_P210_A1.3240.99
688_D698_A1.3200.99
419_H423_E1.3110.99
197_F207_D1.3070.99
30_L37_V1.3030.99
204_R210_A1.2950.99
686_A689_W1.2940.99
526_A529_E1.2940.99
154_G158_E1.2920.99
204_R211_G1.2920.99
679_A683_P1.2910.99
52_E371_M1.2900.99
565_L588_A1.2890.99
683_P687_V1.2880.99
206_V213_R1.2870.99
305_H334_T1.2780.99
588_A592_L1.2770.99
652_G655_R1.2760.99
24_R28_P1.2760.99
429_I435_V1.2750.99
659_V662_L1.2750.99
656_D663_V1.2700.99
680_A685_V1.2690.99
670_G679_A1.2690.99
69_A75_T1.2660.99
681_G686_A1.2640.99
263_T330_F1.2610.99
238_P242_E1.2590.99
438_W442_T1.2590.99
50_L54_A1.2510.99
468_L479_T1.2490.99
681_G688_D1.2470.99
231_T238_P1.2460.99
621_G626_A1.2450.99
694_D697_P1.2430.99
475_G478_E1.2350.99
561_V567_A1.2330.99
434_D439_L1.2320.99
205_P213_R1.2300.99
305_H318_E1.2270.99
332_T374_R1.2190.99
557_G561_V1.2160.99
559_R563_A1.2150.99
679_A687_V1.2150.99
651_P654_V1.2100.99
43_T373_G1.2060.99
675_V679_A1.2030.99
260_A302_V1.2010.99
117_E121_S1.2000.99
498_Y501_L1.1980.99
144_E370_Q1.1970.99
48_T82_W1.1960.99
332_T376_G1.1960.99
542_A546_V1.1930.99
680_A684_A1.1910.99
93_Y109_A1.1910.99
519_A522_R1.1900.99
609_N617_R1.1900.99
674_S677_E1.1900.99
693_P696_V1.1820.99
678_Q681_G1.1820.99
207_D210_A1.1810.99
435_V446_Q1.1810.99
587_N590_R1.1800.99
418_E422_A1.1770.99
423_E426_M1.1760.99
418_E421_N1.1750.99
229_L232_A1.1710.99
435_V438_W1.1700.99
550_S553_E1.1690.99
183_G187_D1.1690.99
74_L338_G1.1690.99
394_D398_Y1.1680.99
525_A528_G1.1670.98
637_A643_L1.1580.98
192_T195_T1.1550.98
671_V677_E1.1540.98
683_P689_W1.1540.98
422_A425_A1.1500.98
560_K564_I1.1420.98
226_Y229_L1.1400.98
75_T94_V1.1390.98
643_L654_V1.1380.98
552_D555_A1.1370.98
491_G497_Y1.1360.98
684_A692_F1.1350.98
262_K266_E1.1340.98
42_P376_G1.1340.98
687_V695_S1.1310.98
432_L435_V1.1300.98
673_E676_H1.1300.98
190_D194_D1.1270.98
613_R618_I1.1190.98
228_R234_D1.1180.98
468_L472_I1.1160.98
666_G671_V1.1160.98
520_I524_V1.1140.98
577_L581_A1.1130.98
206_V210_A1.1110.98
68_V114_M1.1070.98
604_D607_G1.0980.98
580_D583_V1.0960.98
620_T631_A1.0930.98
71_L117_E1.0930.98
121_S124_R1.0910.98
470_D473_D1.0890.98
688_D692_F1.0880.98
253_R308_G1.0880.98
425_A428_T1.0850.98
685_V688_D1.0800.97
434_D443_F1.0800.97
204_R213_R1.0770.97
435_V445_Y1.0720.97
520_I525_A1.0710.97
230_F236_A1.0700.97
438_W447_R1.0640.97
158_E162_S1.0640.97
200_D207_D1.0640.97
200_D204_R1.0630.97
507_F514_A1.0610.97
562_Y568_S1.0610.97
199_F207_D1.0600.97
226_Y235_L1.0600.97
654_V657_A1.0580.97
491_G498_Y1.0570.97
637_A641_H1.0570.97
424_I428_T1.0570.97
206_V211_G1.0530.97
409_E412_L1.0530.97
146_H337_W1.0500.97
684_A695_S1.0480.97
420_L429_I1.0460.97
522_R526_A1.0460.97
641_H646_E1.0420.97
198_E204_R1.0400.97
436_M439_L1.0360.97
591_L595_L1.0320.97
455_Y459_T1.0290.97
317_V326_I1.0290.97
303_A320_W1.0250.97
316_H320_W1.0250.97
628_G635_V1.0250.97
479_T482_D1.0230.97
666_G669_P1.0220.97
544_H547_L1.0210.96
644_H655_R1.0180.96
639_R655_R1.0130.96
676_H688_D1.0120.96
233_L238_P1.0120.96
200_D209_H1.0100.96
599_F609_N1.0100.96
545_T548_G1.0090.96
257_V304_F1.0060.96
210_A213_R1.0050.96
584_I591_L1.0050.96
464_V469_D1.0040.96
51_A175_L1.0040.96
648_I651_P1.0020.96
445_Y448_A0.9970.96
246_S347_V0.9940.96
686_A691_D0.9920.96
225_K229_L0.9920.96
315_S319_Q0.9900.96
452_P455_Y0.9900.96
615_E618_I0.9870.96
197_F202_D0.9780.96
22_M41_A0.9760.95
203_Y213_R0.9750.95
372_L386_G0.9750.95
697_P700_D0.9730.95
583_V587_N0.9720.95
685_V693_P0.9700.95
491_G499_L0.9680.95
620_T624_E0.9680.95
640_A644_H0.9680.95
416_L420_L0.9680.95
522_R529_E0.9670.95
43_T74_L0.9660.95
464_V468_L0.9650.95
693_P700_D0.9650.95
689_W692_F0.9630.95
355_D361_V0.9620.95
646_E650_T0.9610.95
679_A691_D0.9610.95
200_D213_R0.9600.95
432_L440_E0.9600.95
617_R624_E0.9590.95
610_A613_R0.9590.95
488_T491_G0.9580.95
650_T654_V0.9530.95
57_Q60_A0.9480.95
536_R539_E0.9470.95
664_D675_V0.9460.95
423_E429_I0.9450.95
675_V683_P0.9440.95
693_P698_A0.9430.95
401_L405_G0.9380.94
692_F698_A0.9350.94
97_G115_T0.9350.94
677_E681_G0.9350.94
511_I514_A0.9340.94
685_V690_G0.9330.94
233_L236_A0.9310.94
641_H647_G0.9290.94
68_V119_A0.9270.94
226_Y234_D0.9260.94
606_M609_N0.9250.94
376_G384_G0.9220.94
468_L471_L0.9220.94
117_E335_L0.9170.94
21_A123_T0.9150.94
562_Y570_R0.9150.94
672_A682_L0.9150.94
638_G645_D0.9150.94
74_L144_E0.9090.93
197_F203_Y0.9090.93
447_R451_A0.9080.93
117_E120_D0.9070.93
413_D417_A0.9050.93
412_L420_L0.9030.93
655_R662_L0.9020.93
642_K645_D0.9020.93
417_A420_L0.9020.93
433_G446_Q0.9010.93
650_T656_D0.9010.93
652_G657_A0.8980.93
42_P45_S0.8970.93
650_T655_R0.8960.93
618_I631_A0.8960.93
683_P691_D0.8950.93
68_V140_V0.8950.93
648_I655_R0.8950.93
191_A196_T0.8930.93
334_T340_N0.8840.92
649_D653_D0.8830.92
675_V678_Q0.8820.92
229_L234_D0.8810.92
691_D700_D0.8800.92
436_M444_Y0.8800.92
685_V691_D0.8780.92
674_S678_Q0.8770.92
52_E78_K0.8750.92
199_F203_Y0.8740.92
228_R237_E0.8740.92
227_R235_L0.8730.92
635_V640_A0.8720.92
233_L237_E0.8710.92
210_A368_V0.8710.92
338_G377_R0.8700.92
318_E335_L0.8680.92
497_Y501_L0.8680.92
632_I678_Q0.8660.92
691_D699_G0.8660.92
444_Y448_A0.8660.92
49_A52_E0.8650.92
471_L479_T0.8650.92
692_F699_G0.8640.92
541_D545_T0.8610.91
43_T309_L0.8600.91
667_L675_V0.8560.91
639_R647_G0.8540.91
148_L174_A0.8520.91
487_A492_V0.8510.91
432_L439_L0.8510.91
525_A529_E0.8480.91
66_L137_V0.8460.91
443_F450_S0.8450.91
471_L474_Q0.8450.91
685_V689_W0.8450.91
551_G555_A0.8440.91
48_T52_E0.8440.91
672_A687_V0.8440.91
451_A454_A0.8430.91
444_Y447_R0.8430.91
441_T447_R0.8430.91
433_G461_R0.8430.91
646_E655_R0.8420.90
52_E82_W0.8420.90
197_F204_R0.8410.90
560_K565_L0.8410.90
474_Q481_A0.8400.90
414_G417_A0.8380.90
573_V576_E0.8380.90
22_M45_S0.8380.90
471_L476_F0.8380.90
646_E649_D0.8340.90
558_S562_Y0.8340.90
232_A237_E0.8290.90
670_G674_S0.8290.90
591_L594_A0.8290.90
464_V472_I0.8280.90
535_A540_Q0.8280.90
563_A568_S0.8250.90
692_F696_V0.8250.90
202_D206_V0.8240.89
200_D206_V0.8240.89
490_L504_A0.8240.89
500_R504_A0.8240.89
501_L504_A0.8230.89
583_V591_L0.8220.89
438_W444_Y0.8210.89
244_G344_R0.8200.89
559_R567_A0.8200.89
693_P697_P0.8170.89
590_R593_A0.8130.89
641_H644_H0.8120.89
559_R566_R0.8120.89
525_A531_D0.8110.89
667_L672_A0.8100.89
521_L524_V0.8090.89
141_V175_L0.8060.88
598_F605_P0.8060.88
336_A342_P0.8020.88
467_T470_D0.8010.88
647_G657_A0.8010.88
546_V549_H0.8000.88
670_G678_Q0.7980.88
682_L687_V0.7980.88
617_R623_P0.7970.88
669_P672_A0.7940.88
648_I662_L0.7940.88
234_D237_E0.7930.88
77_E153_R0.7920.88
671_V678_Q0.7920.88
669_P679_A0.7920.88
414_G420_L0.7910.88
542_A548_G0.7900.87
689_W698_A0.7900.87
587_N591_L0.7900.87
651_P655_R0.7900.87
674_S691_D0.7900.87
608_A612_A0.7890.87
201_D212_V0.7870.87
578_R583_V0.7860.87
226_Y232_A0.7850.87
619_D632_I0.7850.87
677_E685_V0.7840.87
583_V586_Q0.7830.87
495_S498_Y0.7810.87
543_I547_L0.7800.87
419_H425_A0.7790.87
442_T449_Q0.7780.87
207_D213_R0.7780.87
470_D475_G0.7770.87
676_H681_G0.7760.86
676_H680_A0.7760.86
678_Q687_V0.7750.86
680_A686_A0.7730.86
680_A687_V0.7710.86
564_I580_D0.7670.86
414_G419_H0.7650.86
627_V630_T0.7650.86
438_W441_T0.7650.86
690_G696_V0.7650.86
153_R334_T0.7650.86
334_T376_G0.7640.86
201_D207_D0.7630.86
394_D405_G0.7620.85
596_G602_Y0.7620.85
523_A533_V0.7620.85
636_A648_I0.7610.85
203_Y211_G0.7610.85
689_W694_D0.7610.85
621_G628_G0.7600.85
616_A621_G0.7600.85
689_W693_P0.7580.85
672_A679_A0.7580.85
669_P676_H0.7570.85
310_S313_D0.7550.85
491_G494_A0.7530.85
539_E546_V0.7530.85
209_H385_Y0.7520.85
465_R478_E0.7520.85
612_A633_E0.7510.85
497_Y504_A0.7500.85
476_F479_T0.7490.85
636_A640_A0.7490.85
197_F206_V0.7490.85
311_T315_S0.7460.84
617_R626_A0.7440.84
659_V663_V0.7440.84
44_G47_K0.7430.84
696_V700_D0.7420.84
498_Y505_R0.7410.84
90_Y110_D0.7400.84
240_L245_Q0.7400.84
675_V687_V0.7390.84
255_D259_A0.7360.83
100_D103_P0.7350.83
199_F205_P0.7350.83
494_A499_L0.7340.83
636_A643_L0.7340.83
399_R405_G0.7340.83
435_V439_L0.7330.83
336_A371_M0.7320.83
318_E334_T0.7310.83
64_T136_D0.7300.83
368_V388_V0.7290.83
77_E340_N0.7290.83
416_L423_E0.7280.83
658_G665_A0.7280.83
420_L423_E0.7260.83
177_A373_G0.7250.83
564_I568_S0.7240.82
493_L501_L0.7240.82
123_T127_D0.7240.82
29_A37_V0.7230.82
507_F527_A0.7230.82
499_L591_L0.7230.82
471_L477_V0.7200.82
474_Q501_L0.7200.82
95_V106_A0.7200.82
463_R471_L0.7200.82
679_A685_V0.7180.82
466_A469_D0.7180.82
43_T256_T0.7180.82
81_E84_R0.7180.82
684_A688_D0.7180.82
599_F604_D0.7170.82
346_V349_R0.7170.82
504_A508_R0.7150.82
687_V690_G0.7140.82
612_A620_T0.7140.82
615_E629_L0.7120.81
232_A235_L0.7120.81
165_R190_D0.7110.81
669_P673_E0.7110.81
199_F202_D0.7110.81
434_D441_T0.7100.81
644_H649_D0.7100.81
413_D421_N0.7090.81
39_A175_L0.7090.81
199_F209_H0.7090.81
436_M441_T0.7080.81
599_F613_R0.7060.81
373_G384_G0.7060.81
119_A164_L0.7040.81
52_E81_E0.7030.81
662_L676_H0.7000.80
639_R651_P0.6970.80
671_V679_A0.6970.80
73_A335_L0.6960.80
671_V680_A0.6960.80
77_E373_G0.6950.80
197_F213_R0.6950.80
439_L449_Q0.6940.80
73_A334_T0.6940.80
362_D394_D0.6930.80
660_S663_V0.6930.80
653_D657_A0.6920.80
673_E684_A0.6910.79
412_L419_H0.6910.79
585_T589_L0.6900.79
436_M443_F0.6890.79
442_T446_Q0.6890.79
596_G614_L0.6890.79
305_H335_L0.6880.79
520_I523_A0.6870.79
78_K82_W0.6870.79
639_R646_E0.6870.79
640_A646_E0.6860.79
538_S543_I0.6860.79
460_L477_V0.6850.79
614_L617_R0.6840.79
434_D448_A0.6820.79
577_L584_I0.6820.79
424_I429_I0.6820.79
674_S685_V0.6820.79
542_A545_T0.6810.78
153_R305_H0.6810.78
683_P698_A0.6810.78
309_L373_G0.6790.78
490_L493_L0.6780.78
672_A680_A0.6770.78
176_S179_M0.6770.78
642_K648_I0.6760.78
538_S542_A0.6760.78
472_I477_V0.6760.78
415_N420_L0.6750.78
678_Q683_P0.6740.78
668_A678_Q0.6720.78
500_R506_E0.6710.77
638_G642_K0.6690.77
688_D699_G0.6680.77
669_P687_V0.6680.77
247_L331_S0.6680.77
670_G684_A0.6670.77
475_G479_T0.6660.77
253_R331_S0.6650.77
668_A675_V0.6640.77
515_A523_A0.6640.77
540_Q544_H0.6630.77
613_R625_A0.6630.77
40_S45_S0.6620.76
472_I475_G0.6620.76
71_L334_T0.6620.76
537_H545_T0.6610.76
464_V475_G0.6600.76
673_E686_A0.6590.76
608_A615_E0.6590.76
495_S500_R0.6570.76
526_A530_F0.6570.76
638_G648_I0.6570.76
71_L77_E0.6550.76
198_E202_D0.6550.76
464_V481_A0.6550.76
490_L495_S0.6540.76
440_E445_Y0.6540.76
488_T494_A0.6530.76
368_V386_G0.6530.76
677_E688_D0.6530.76
557_G566_R0.6530.76
414_G418_E0.6530.76
418_E423_E0.6500.75
564_I570_R0.6500.75
609_N615_E0.6490.75
412_L416_L0.6490.75
663_V666_G0.6490.75
464_V473_D0.6490.75
153_R318_E0.6480.75
665_A690_G0.6480.75
73_A370_Q0.6470.75
498_Y504_A0.6470.75
489_R502_D0.6460.75
415_N418_E0.6450.75
432_L441_T0.6440.75
556_D560_K0.6440.75
225_K232_A0.6430.74
683_P690_G0.6420.74
652_G656_D0.6420.74
203_Y210_A0.6410.74
562_Y566_R0.6410.74
203_Y208_L0.6400.74
401_L409_E0.6400.74
644_H648_I0.6400.74
114_M119_A0.6400.74
534_S543_I0.6400.74
626_A630_T0.6390.74
616_A619_D0.6390.74
416_L422_A0.6390.74
686_A699_G0.6380.74
408_I411_R0.6370.74
117_E337_W0.6370.74
443_F446_Q0.6370.74
603_D623_P0.6360.74
577_L580_D0.6350.73
688_D693_P0.6350.73
664_D686_A0.6350.73
411_R415_N0.6340.73
79_E83_E0.6340.73
197_F205_P0.6320.73
256_T260_A0.6320.73
558_S566_R0.6310.73
433_G436_M0.6300.73
77_E337_W0.6290.73
332_T340_N0.6280.73
78_K344_R0.6270.73
577_L583_V0.6250.72
669_P678_Q0.6230.72
26_A50_L0.6230.72
400_T403_D0.6220.72
641_H645_D0.6220.72
417_A421_N0.6220.72
78_K371_M0.6220.72
557_G562_Y0.6220.72
668_A686_A0.6220.72
435_V442_T0.6200.72
625_A628_G0.6200.72
24_R27_V0.6200.72
408_I412_L0.6200.72
632_I635_V0.6170.71
230_F238_P0.6170.71
255_D258_Q0.6160.71
628_G631_A0.6150.71
680_A689_W0.6150.71
417_A423_E0.6140.71
685_V696_V0.6120.71
687_V694_D0.6110.71
208_L212_V0.6110.71
493_L496_T0.6110.71
612_A617_R0.6100.70
140_V172_V0.6090.70
460_L463_R0.6090.70
467_T477_V0.6090.70
199_F211_G0.6080.70
567_A573_V0.6080.70
563_A566_R0.6070.70
678_Q691_D0.6060.70
639_R643_L0.6050.70
235_L387_W0.6050.70
521_L529_E0.6030.70
301_G324_G0.6030.70
431_D435_V0.6020.69
199_F210_A0.6020.69
591_L599_F0.6020.69
125_K128_S0.6010.69
561_V565_L0.6000.69
197_F209_H0.5990.69
507_F510_V0.5980.69
435_V440_E0.5980.69
460_L464_V0.5980.69
405_G409_E0.5980.69
665_A669_P0.5970.69
661_G665_A0.5960.69
43_T342_P0.5940.68
227_R237_E0.5940.68
139_C171_R0.5930.68
560_K570_R0.5920.68
671_V674_S0.5920.68
690_G698_A0.5910.68
660_S664_D0.5910.68
553_E559_R0.5910.68
512_D516_D0.5900.68
512_D518_R0.5900.68
638_G654_V0.5890.68
531_D538_S0.5870.68
610_A614_L0.5860.67
43_T177_A0.5860.67
584_I588_A0.5860.67
71_L366_L0.5840.67
598_F604_D0.5830.67
678_Q682_L0.5820.67
463_R466_A0.5820.67
437_A441_T0.5810.67
690_G695_S0.5810.67
540_Q547_L0.5800.67
248_V347_V0.5800.67
425_A429_I0.5790.67
499_L504_A0.5790.67
684_A691_D0.5780.66
644_H647_G0.5770.66
679_A682_L0.5750.66
630_T640_A0.5740.66
538_S576_E0.5740.66
683_P686_A0.5740.66
658_G663_V0.5710.65
419_H424_I0.5710.65
587_N596_G0.5710.65
512_D515_A0.5700.65
511_I515_A0.5700.65
43_T306_H0.5700.65
565_L568_S0.5690.65
528_G532_S0.5670.65
672_A685_V0.5660.65
442_T445_Y0.5660.65
429_I447_R0.5650.65
373_G376_G0.5640.65
537_H540_Q0.5630.64
75_T113_V0.5630.64
612_A627_V0.5630.64
577_L594_A0.5630.64
597_A603_D0.5630.64
432_L479_T0.5630.64
397_T402_L0.5620.64
462_D467_T0.5620.64
636_A647_G0.5610.64
673_E679_A0.5590.64
473_D481_A0.5590.64
314_K336_A0.5590.64
555_A564_I0.5580.64
659_V664_D0.5570.64
612_A618_I0.5570.64
616_A623_P0.5560.63
675_V699_G0.5560.63
524_V529_E0.5550.63
550_S556_D0.5540.63
537_H544_H0.5540.63
471_L488_T0.5540.63
562_Y572_A0.5530.63
423_E428_T0.5520.63
161_V189_L0.5520.63
146_H308_G0.5510.63
91_S95_V0.5500.63
20_N24_R0.5490.62
491_G507_F0.5490.62
667_L680_A0.5480.62
560_K575_S0.5470.62
451_A455_Y0.5470.62
200_D205_P0.5460.62
686_A692_F0.5450.62
465_R469_D0.5450.62
73_A146_H0.5450.62
613_R617_R0.5440.62
65_A328_V0.5440.62
462_D470_D0.5420.61
260_A264_R0.5420.61
438_W443_F0.5420.61
674_S681_G0.5420.61
579_S582_W0.5420.61
96_T342_P0.5410.61
680_A683_P0.5410.61
440_E451_A0.5400.61
525_A561_V0.5400.61
438_W446_Q0.5390.61
463_R473_D0.5380.61
684_A694_D0.5380.61
679_A684_A0.5380.61
618_I634_G0.5380.61
421_N428_T0.5370.61
522_R525_A0.5350.60
681_G684_A0.5340.60
662_L689_W0.5340.60
662_L667_L0.5340.60
413_D419_H0.5330.60
689_W699_G0.5330.60
43_T332_T0.5330.60
43_T335_L0.5330.60
69_A369_L0.5330.60
488_T496_T0.5330.60
561_V564_I0.5300.60
447_R452_P0.5300.60
177_A376_G0.5290.60
502_D506_E0.5290.60
450_S459_T0.5280.59
402_L405_G0.5270.59
490_L499_L0.5270.59
407_E410_S0.5260.59
529_E533_V0.5260.59
552_D560_K0.5250.59
529_E532_S0.5250.59
435_V443_F0.5240.59
73_A340_N0.5230.59
36_N55_I0.5230.59
672_A677_E0.5230.59
397_T404_E0.5220.59
650_T657_A0.5210.58
334_T341_L0.5200.58
595_L598_F0.5200.58
55_I59_L0.5190.58
416_L421_N0.5180.58
201_D205_P0.5170.58
639_R645_D0.5160.58
335_L371_M0.5150.58
618_I623_P0.5150.58
680_A694_D0.5150.58
210_A369_L0.5140.57
421_N424_I0.5130.57
582_W591_L0.5130.57
566_R573_V0.5120.57
496_T504_A0.5110.57
524_V531_D0.5110.57
666_G670_G0.5110.57
342_P376_G0.5100.57
657_A662_L0.5100.57
483_L511_I0.5100.57
681_G685_V0.5090.57
472_I478_E0.5090.57
245_Q345_C0.5080.57
201_D206_V0.5080.57
577_L591_L0.5080.57
578_R581_A0.5070.56
460_L465_R0.5060.56
198_E213_R0.5060.56
157_L161_V0.5050.56
569_M576_E0.5050.56
488_T501_L0.5040.56
657_A661_G0.5040.56
636_A644_H0.5040.56
542_A547_L0.5040.56
155_S159_V0.5030.56
675_V682_L0.5020.56
62_G110_D0.5020.56
318_E340_N0.5020.56
519_A524_V0.5020.56
554_M563_A0.5010.56
503_T507_F0.5010.56
335_L349_R0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f92B 1 0.9872 100 0.279 Contact Map
4bgdA 1 0.9859 100 0.307 Contact Map
2zj8A 2 0.8485 100 0.328 Contact Map
2p6rA 1 0.8306 100 0.336 Contact Map
2va8A 1 0.8241 100 0.338 Contact Map
5agaA 4 0.8858 100 0.371 Contact Map
4bujA 1 0.7612 100 0.468 Contact Map
4qu4A 1 0.7522 100 0.51 Contact Map
4nhoA 1 0.4583 100 0.513 Contact Map
4u4cA 1 0.7766 100 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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