GREMLIN Database
Q9HN79 - DNA damage-inducible protein
UniProt: Q9HN79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (424)
Sequences: 18607 (14140)
Seq/√Len: 686.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_D90_A4.6891.00
147_F211_V3.9431.00
136_T200_F3.3341.00
55_G283_T3.2001.00
349_V364_T3.1371.00
80_A308_G3.0991.00
118_P135_A3.0561.00
344_S347_T3.0271.00
315_N318_R2.9301.00
243_R247_S2.8921.00
116_L119_D2.7711.00
163_D166_M2.7611.00
118_P122_G2.7121.00
140_V200_F2.5061.00
75_C98_A2.4821.00
135_A139_T2.4571.00
177_T212_A2.4421.00
239_R243_R2.4401.00
184_F189_W2.4291.00
42_W186_V2.4191.00
82_H90_A2.4031.00
49_N129_A2.3251.00
42_W183_P2.2881.00
127_D276_S2.2361.00
174_A213_G2.2321.00
53_A133_L2.2201.00
16_R20_V2.2141.00
303_V326_A2.1991.00
133_L136_T2.1351.00
93_S238_S2.1081.00
170_I216_V2.1021.00
324_W328_G2.0651.00
150_M214_F2.0621.00
393_K447_Y2.0371.00
366_A427_H1.9961.00
345_P369_Q1.9831.00
140_V203_A1.9641.00
356_F360_E1.9621.00
281_A363_Y1.9511.00
132_Q136_T1.9471.00
39_D206_T1.9371.00
144_G207_A1.9361.00
425_P428_A1.9321.00
310_N318_R1.9181.00
43_L202_A1.9151.00
346_A365_V1.9091.00
82_H87_D1.9031.00
200_F204_L1.8981.00
47_S50_A1.8971.00
26_V298_A1.8821.00
186_V202_A1.8651.00
357_S360_E1.8641.00
102_V153_T1.8481.00
197_Y204_L1.8231.00
42_W182_D1.7971.00
165_R169_L1.7781.00
184_F188_G1.7481.00
82_H85_A1.7481.00
48_R355_T1.7411.00
23_A27_V1.7291.00
122_G131_I1.7211.00
117_A135_A1.7131.00
345_P365_V1.7121.00
311_V391_A1.6891.00
277_A357_S1.6701.00
189_W196_G1.6571.00
140_V204_L1.6551.00
170_I217_A1.6511.00
215_T219_A1.6451.00
377_A438_V1.6371.00
143_V146_V1.6351.00
176_L180_V1.6321.00
342_Y369_Q1.6311.00
346_A350_S1.6161.00
306_I322_A1.6141.00
321_R324_W1.6061.00
22_T302_A1.6001.00
323_T384_I1.5981.00
147_F214_F1.5951.00
321_R325_L1.5911.00
183_P189_W1.5801.00
320_T324_W1.5771.00
119_D122_G1.5761.00
188_G196_G1.5751.00
78_L94_T1.5721.00
129_A276_S1.5711.00
310_N315_N1.5451.00
113_V142_T1.5411.00
330_T379_G1.5361.00
311_V319_A1.5191.00
238_S241_T1.5061.00
129_A132_Q1.5011.00
38_V179_V1.4971.00
268_A272_G1.4941.00
181_L205_A1.4881.00
182_D202_A1.4871.00
117_A139_T1.4841.00
131_I135_A1.4801.00
338_G342_Y1.4731.00
90_A93_S1.4721.00
128_E132_Q1.4711.00
323_T387_G1.4601.00
393_K396_V1.4591.00
183_P187_V1.4501.00
347_T350_S1.4491.00
140_V207_A1.4471.00
154_I217_A1.4361.00
424_V428_A1.4311.00
365_V369_Q1.4281.00
15_P325_L1.4281.00
219_A223_V1.4261.00
88_A92_R1.4161.00
110_A146_V1.4111.00
317_D321_R1.4101.00
328_G332_A1.4071.00
185_L189_W1.3921.00
122_G128_E1.3861.00
180_V183_P1.3741.00
370_I431_W1.3721.00
82_H94_T1.3721.00
118_P132_Q1.3721.00
14_L306_I1.3711.00
177_T181_L1.3681.00
57_V138_L1.3641.00
169_L173_V1.3581.00
446_A450_A1.3561.00
81_Q85_A1.3471.00
43_L54_V1.3461.00
121_V131_I1.3441.00
89_A93_S1.3401.00
39_D178_N1.3381.00
350_S359_I1.3301.00
180_V184_F1.3261.00
415_L419_V1.3211.00
200_F203_A1.3181.00
52_S280_A1.3161.00
27_V168_M1.3051.00
347_T351_V1.2991.00
83_V309_Q1.2951.00
342_Y372_A1.2831.00
316_P320_T1.2721.00
50_A133_L1.2661.00
31_V172_V1.2651.00
84_G312_G1.2591.00
330_T383_P1.2521.00
119_D123_V1.2501.00
185_L197_Y1.2481.00
90_A241_T1.2481.00
118_P131_I1.2431.00
114_L139_T1.2321.00
446_A449_W1.2241.00
81_Q308_G1.2191.00
408_V439_A1.2071.00
339_V343_S1.2011.00
403_L407_G1.1981.00
48_R277_A1.1981.00
360_E366_A1.1971.00
240_D243_R1.1961.00
395_T399_V1.1951.00
170_I220_G1.1951.00
181_L208_I1.1941.00
40_V287_R1.1921.00
83_V91_A1.1891.00
40_V51_V1.1861.00
414_A418_Y1.1831.00
49_N276_S1.1701.00
110_A114_L1.1661.00
15_P329_A1.1621.00
288_I348_I1.1591.00
121_V134_G1.1541.00
97_H242_V1.1521.00
182_D205_A1.1421.00
185_L208_I1.1411.00
79_V160_G1.1361.00
53_A130_V1.1251.00
237_V242_V1.1221.00
97_H237_V1.1211.00
81_Q392_G1.1181.00
45_R187_V1.1171.00
363_Y366_A1.1101.00
173_V216_V1.1071.00
428_A432_A1.1071.00
54_V199_I1.1041.00
250_V254_G1.1041.00
411_P415_L1.1021.00
349_V359_I1.1011.00
307_V319_A1.0951.00
183_P186_V1.0951.00
278_G426_V1.0941.00
424_V431_W1.0941.00
178_N206_T1.0931.00
46_V50_A1.0901.00
13_S16_R1.0861.00
95_G157_G1.0861.00
400_A444_V1.0721.00
177_T209_G1.0711.00
300_G386_G1.0671.00
285_G367_Y1.0661.00
39_D182_D1.0661.00
163_D167_S1.0661.00
183_P188_G1.0631.00
101_L242_V1.0541.00
359_I364_T1.0521.00
416_G424_V1.0521.00
102_V149_G1.0491.00
185_L188_G1.0421.00
419_V424_V1.0381.00
162_G309_Q1.0371.00
103_G150_M1.0361.00
92_R234_D1.0361.00
231_G234_D1.0341.00
115_W119_D1.0251.00
277_A363_Y1.0221.00
399_V403_L1.0201.00
49_N133_L1.0201.00
18_L326_A1.0201.00
332_A336_V1.0181.00
166_M220_G1.0131.00
325_L329_A1.0091.00
188_G197_Y1.0071.00
98_A245_L1.0001.00
381_I437_N0.9931.00
93_S241_T0.9901.00
84_G313_A0.9881.00
310_N322_A0.9791.00
19_L23_A0.9791.00
110_A143_V0.9711.00
139_T143_V0.9691.00
204_L207_A0.9661.00
94_T241_T0.9661.00
407_G411_P0.9641.00
189_W197_Y0.9621.00
442_V446_A0.9531.00
367_Y426_V0.9531.00
370_I427_H0.9471.00
269_I413_A0.9411.00
154_I214_F0.9351.00
83_V161_W0.9291.00
17_A20_V0.9261.00
335_A339_V0.9251.00
353_A358_G0.9251.00
244_S247_S0.9251.00
447_Y450_A0.9241.00
117_A138_L0.9201.00
207_A211_V0.9191.00
172_V176_L0.9151.00
360_E365_V0.9151.00
396_V447_Y0.9131.00
288_I341_Q0.9131.00
342_Y346_A0.9091.00
56_L126_S0.9091.00
115_W139_T0.9081.00
75_C79_V0.9071.00
271_A279_L0.9031.00
307_V390_G0.9031.00
298_A302_A0.9021.00
182_D206_T0.9001.00
45_R354_P0.9001.00
427_H431_W0.9001.00
96_F235_L0.8991.00
136_T139_T0.8991.00
212_A216_V0.8991.00
83_V88_A0.8991.00
346_A360_E0.8951.00
41_F44_G0.8941.00
68_T149_G0.8901.00
133_L199_I0.8891.00
81_Q311_V0.8861.00
181_L185_L0.8861.00
143_V207_A0.8851.00
211_V215_T0.8851.00
436_S440_C0.8851.00
377_A441_A0.8841.00
319_A323_T0.8841.00
408_V411_P0.8831.00
336_V340_A0.8791.00
25_L301_S0.8781.00
412_V435_A0.8771.00
432_A436_S0.8701.00
163_D220_G0.8671.00
114_L118_P0.8661.00
327_A380_L0.8651.00
281_A364_T0.8641.00
158_F221_L0.8641.00
36_Q58_A0.8631.00
247_S395_T0.8621.00
284_I352_F0.8551.00
319_A391_A0.8551.00
61_I141_T0.8551.00
336_V339_V0.8541.00
345_P368_L0.8531.00
38_V178_N0.8501.00
21_L164_S0.8491.00
310_N313_A0.8471.00
258_G402_L0.8451.00
254_G398_M0.8441.00
307_V387_G0.8431.00
81_Q244_S0.8401.00
278_G363_Y0.8401.00
204_L208_I0.8391.00
104_A108_L0.8381.00
178_N182_D0.8351.00
284_I364_T0.8291.00
296_A334_M0.8281.00
216_V219_A0.8261.00
349_V365_V0.8261.00
343_S347_T0.8241.00
321_R328_G0.8241.00
52_S130_V0.8231.00
108_L112_V0.8181.00
169_L172_V0.8171.00
282_Y430_F0.8161.00
38_V175_V0.8161.00
257_A261_I0.8151.00
111_V115_W0.8141.00
42_W187_V0.8141.00
380_L441_A0.8141.00
132_Q135_A0.8121.00
226_T229_T0.8081.00
80_A160_G0.8071.00
49_N130_V0.8061.00
78_L248_V0.8061.00
154_I221_L0.8051.00
168_M172_V0.8041.00
128_E131_I0.8031.00
98_A153_T0.8021.00
151_S213_G0.8021.00
404_Q440_C0.8021.00
388_F447_Y0.8011.00
359_I365_V0.7991.00
15_P328_G0.7981.00
31_V175_V0.7981.00
412_V416_G0.7891.00
310_N319_A0.7891.00
325_L328_G0.7861.00
331_T335_A0.7851.00
269_I417_A0.7851.00
112_V116_L0.7841.00
117_A142_T0.7841.00
357_S363_Y0.7841.00
218_V222_G0.7831.00
281_A358_G0.7831.00
100_V104_A0.7801.00
268_A271_A0.7801.00
140_V143_V0.7781.00
18_L325_L0.7771.00
356_F359_I0.7771.00
287_R352_F0.7751.00
384_I444_V0.7741.00
318_R321_R0.7741.00
413_A417_A0.7711.00
78_L82_H0.7701.00
158_F166_M0.7691.00
342_Y345_P0.7691.00
299_V326_A0.7671.00
428_A431_W0.7661.00
46_V196_G0.7651.00
370_I434_T0.7641.00
130_V279_L0.7641.00
173_V177_T0.7621.00
163_D224_D0.7621.00
241_T244_S0.7591.00
89_A92_R0.7581.00
332_A335_A0.7581.00
89_A234_D0.7571.00
274_A278_G0.7561.00
92_R231_G0.7541.00
17_A306_I0.7541.00
93_S96_F0.7541.00
48_R358_G0.7531.00
159_V167_S0.7511.00
328_G331_T0.7511.00
158_F217_A0.7501.00
100_V237_V0.7501.00
44_G51_V0.7491.00
281_A367_Y0.7491.00
121_V138_L0.7481.00
219_A222_G0.7481.00
79_V157_G0.7391.00
85_A312_G0.7381.00
182_D186_V0.7381.00
17_A309_Q0.7371.00
136_T199_I0.7351.00
323_T448_F0.7331.00
28_Q171_N0.7331.00
265_L410_L0.7291.00
100_V235_L0.7281.00
317_D324_W0.7281.00
438_V442_V0.7271.00
53_A199_I0.7271.00
274_A417_A0.7231.00
43_L186_V0.7211.00
326_A383_P0.7181.00
331_T379_G0.7161.00
355_T359_I0.7161.00
178_N209_G0.7151.00
67_A253_A0.7121.00
373_V376_W0.7121.00
77_V81_Q0.7121.00
244_S392_G0.7111.00
166_M216_V0.7091.00
35_Q206_T0.7091.00
138_L142_T0.7091.00
196_G200_F0.7081.00
307_V323_T0.7071.00
353_A356_F0.7061.00
15_P19_L0.7061.00
409_R413_A0.7051.00
37_I291_V0.7051.00
79_V91_A0.7041.00
96_F234_D0.7031.00
335_A376_W0.7021.00
386_G390_G0.7001.00
417_A428_A0.7001.00
431_W434_T0.7001.00
173_V212_A0.6981.00
344_S348_I0.6961.00
416_G428_A0.6951.00
108_L111_V0.6951.00
90_A94_T0.6941.00
396_V400_A0.6921.00
142_T145_R0.6921.00
129_A133_L0.6911.00
118_P139_T0.6911.00
41_F351_V0.6881.00
31_V34_V0.6881.00
289_A375_Y0.6861.00
317_D320_T0.6861.00
34_V38_V0.6831.00
137_Y182_D0.6821.00
249_G253_A0.6821.00
38_V42_W0.6821.00
275_G278_G0.6811.00
18_L302_A0.6811.00
343_S346_A0.6761.00
369_Q373_V0.6711.00
334_M379_G0.6711.00
251_P398_M0.6701.00
316_P319_A0.6681.00
227_S230_I0.6661.00
426_V430_F0.6611.00
53_A134_G0.6601.00
246_L250_V0.6581.00
410_L414_A0.6561.00
51_V353_A0.6551.00
144_G147_F0.6531.00
144_G210_Y0.6521.00
43_L199_I0.6511.00
270_V282_Y0.6501.00
116_L120_L0.6501.00
295_P333_G0.6491.00
360_E363_Y0.6491.00
408_V412_V0.6481.00
203_A207_A0.6481.00
281_A430_F0.6471.00
154_I218_V0.6451.00
299_V333_G0.6451.00
41_F45_R0.6431.00
311_V316_P0.6421.00
303_V307_V0.6411.00
139_T200_F0.6411.00
293_F378_F0.6391.00
143_V147_F0.6381.00
114_L143_V0.6381.00
345_P349_V0.6371.00
22_T298_A0.6351.00
333_G337_L0.6351.00
277_A280_A0.6321.00
208_I211_V0.6311.00
30_Y34_V0.6311.00
111_V114_L0.6281.00
130_V133_L0.6281.00
85_A314_G0.6271.00
103_G107_L0.6251.00
151_S214_F0.6251.00
248_V394_T0.6241.00
185_L202_A0.6211.00
197_Y200_F0.6191.00
35_Q174_A0.6181.00
292_A337_L0.6181.00
77_V308_G0.6141.00
131_I134_G0.6121.00
431_W435_A0.6101.00
299_V330_T0.6091.00
266_V413_A0.6081.00
209_G212_A0.6081.00
13_S17_A0.6081.00
240_D244_S0.6061.00
142_T146_V0.6041.00
17_A318_R0.6031.00
387_G391_A0.6031.00
197_Y201_G0.6021.00
267_V271_A0.6001.00
70_V253_A0.5991.00
309_Q313_A0.5981.00
304_S389_N0.5981.00
93_S97_H0.5971.00
77_V248_V0.5971.00
222_G229_T0.5971.00
270_V426_V0.5961.00
52_S55_G0.5961.00
198_G201_G0.5961.00
177_T208_I0.5951.00
35_Q210_Y0.5921.00
76_R156_S0.5921.00
187_V197_Y0.5921.00
331_T376_W0.5921.00
58_A62_G0.5911.00
106_N142_T0.5901.00
340_A344_S0.5901.00
34_V175_V0.5891.00
74_G249_G0.5891.00
14_L321_R0.5891.00
155_E159_V0.5881.00
278_G281_A0.5861.00
106_N146_V0.5851.00
87_D93_S0.5851.00
411_P414_A0.5851.00
124_L264_L0.5841.00
223_V226_T0.5831.00
51_V284_I0.5821.00
266_V429_A0.5821.00
269_I272_G0.5821.00
146_V211_V0.5811.00
400_A443_G0.5811.00
409_R436_S0.5781.00
225_S228_F0.5761.00
172_V175_V0.5761.00
107_L111_V0.5751.00
329_A332_A0.5751.00
49_N52_S0.5731.00
214_F218_V0.5731.00
331_T380_L0.5721.00
353_A359_I0.5701.00
50_A53_A0.5691.00
443_G446_A0.5681.00
232_R235_L0.5671.00
250_V253_A0.5671.00
173_V176_L0.5661.00
404_Q443_G0.5651.00
394_T398_M0.5651.00
71_A253_A0.5631.00
178_N205_A0.5631.00
269_I414_A0.5631.00
46_V199_I0.5621.00
43_L50_A0.5611.00
289_A371_L0.5611.00
338_G376_W0.5601.00
177_T180_V0.5601.00
147_F207_A0.5591.00
412_V415_L0.5581.00
366_A369_Q0.5571.00
327_A331_T0.5561.00
107_L110_A0.5561.00
136_T140_V0.5551.00
216_V220_G0.5551.00
151_S155_E0.5551.00
106_N110_A0.5521.00
401_T404_Q0.5521.00
86_D313_A0.5511.00
416_G419_V0.5511.00
272_G418_Y0.5501.00
18_L22_T0.5491.00
323_T327_A0.5491.00
156_S159_V0.5481.00
372_A376_W0.5481.00
110_A115_W0.5481.00
415_L418_Y0.5471.00
70_V304_S0.5461.00
358_G364_T0.5461.00
304_S386_G0.5461.00
201_G205_A0.5461.00
102_V106_N0.5451.00
96_F100_V0.5441.00
50_A198_G0.5431.00
228_F231_G0.5431.00
413_A429_A0.5431.00
185_L204_L0.5421.00
179_V183_P0.5391.00
388_F393_K0.5391.00
79_V94_T0.5391.00
327_A384_I0.5381.00
41_F352_F0.5381.00
354_P359_I0.5361.00
137_Y202_A0.5351.00
242_V246_L0.5351.00
384_I441_A0.5351.00
205_A209_G0.5341.00
97_H241_T0.5331.00
73_I301_S0.5311.00
56_L134_G0.5311.00
130_V276_S0.5301.00
324_W327_A0.5301.00
43_L46_V0.5291.00
232_R236_G0.5281.00
14_L325_L0.5271.00
439_A443_G0.5271.00
130_V134_G0.5251.00
36_Q141_T0.5251.00
355_T360_E0.5251.00
303_V383_P0.5241.00
159_V164_S0.5241.00
38_V41_F0.5221.00
114_L142_T0.5221.00
121_V135_A0.5211.00
290_T293_F0.5211.00
411_P418_Y0.5211.00
115_W118_P0.5211.00
14_L322_A0.5201.00
412_V432_A0.5190.99
409_R412_V0.5190.99
121_V126_S0.5190.99
425_P432_A0.5190.99
64_L145_R0.5180.99
346_A359_I0.5170.99
42_W205_A0.5170.99
306_I310_N0.5160.99
52_S279_L0.5150.99
381_I440_C0.5150.99
276_S280_A0.5140.99
341_Q348_I0.5120.99
54_V137_Y0.5120.99
79_V95_G0.5100.99
14_L318_R0.5100.99
71_A105_A0.5100.99
91_A95_G0.5090.99
95_G154_I0.5080.99
222_G225_S0.5060.99
170_I213_G0.5050.99
113_V117_A0.5050.99
45_R353_A0.5040.99
430_F433_I0.5040.99
85_A90_A0.5040.99
345_P372_A0.5030.99
262_A405_Y0.5010.99
46_V186_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.9488 100 0.278 Contact Map
3mktA 1 0.9701 100 0.281 Contact Map
4humA 1 0.9723 100 0.281 Contact Map
3w4tA 1 0.9382 100 0.327 Contact Map
4ikvA 1 0.8678 86.2 0.936 Contact Map
4w6vA 1 0.8422 82.9 0.938 Contact Map
1pw4A 1 0.8593 81.5 0.939 Contact Map
3wdoA 1 0.8529 81.1 0.939 Contact Map
4tphA 2 0.806 78.1 0.941 Contact Map
4xnjA 1 0.8358 67.4 0.946 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0127 seconds.