GREMLIN Database
LIPA - Probable lipoyl synthase
UniProt: Q9HN78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (279)
Sequences: 2194 (909)
Seq/√Len: 54.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_M83_L5.3221.00
220_L231_V4.3581.00
141_I162_I3.8171.00
171_R215_E3.7171.00
248_D254_K3.6611.00
183_Y222_D3.6121.00
221_G266_F3.5601.00
194_T229_D3.4581.00
259_Q263_E3.4081.00
207_L233_L3.2991.00
256_E259_Q3.2591.00
170_A184_E3.0051.00
102_Y136_L2.9781.00
213_D257_T2.7591.00
91_V124_T2.6121.00
127_E130_E2.6101.00
217_Y261_V2.5821.00
203_T223_L2.4561.00
61_L105_L2.3581.00
274_G277_V2.3131.00
86_D89_A2.2921.00
132_D135_I2.2661.00
125_I139_V2.2541.00
119_G123_R2.2331.00
220_L262_A2.2321.00
213_D254_K2.2231.00
176_V244_L2.1961.00
107_S142_P2.1891.00
96_A131_R2.0811.00
28_R37_E2.0791.00
261_V265_E2.0401.00
213_D258_W1.9951.00
116_Q150_L1.9891.00
102_Y161_V1.9451.00
188_S191_E1.9341.00
223_L228_V1.9261.00
72_F181_A1.9061.00
40_S74_D1.8610.99
64_D76_K1.8600.99
35_V39_A1.8350.99
250_V258_W1.8210.99
162_I193_V1.8000.99
125_I157_A1.7970.99
89_A127_E1.7860.99
105_L128_I1.7840.99
190_L228_V1.7650.99
261_V266_F1.7560.99
170_A173_Q1.7490.99
152_Q156_D1.7430.99
144_F154_I1.7110.99
19_R22_D1.7010.99
155_I193_V1.6780.99
170_A218_Q1.6760.99
262_A271_C1.6570.99
170_A219_T1.6440.99
129_K137_V1.6260.98
46_E281_Y1.6000.98
89_A93_E1.5940.98
60_M75_V1.5810.98
224_R268_F1.5560.98
90_N93_E1.5460.98
54_P284_G1.5260.98
20_F44_M1.5190.98
254_K258_W1.5070.97
147_E150_L1.5060.97
257_T261_V1.4950.97
191_E195_R1.4860.97
152_Q192_Y1.4510.97
192_Y195_R1.4410.97
123_R126_R1.4070.96
122_A126_R1.4040.96
26_T97_E1.3660.95
118_A153_K1.3630.95
30_N94_S1.3580.95
184_E188_S1.3500.95
12_M276_M1.3460.95
128_I135_I1.3350.95
29_D97_E1.3330.95
71_N244_L1.3280.95
224_R266_F1.3250.95
62_M120_H1.3240.95
207_L258_W1.3220.95
127_E131_R1.3110.94
224_R227_G1.2870.94
84_D90_N1.2830.94
95_V132_D1.2690.93
30_N97_E1.2570.93
173_Q178_D1.2200.92
65_R78_G1.2170.92
148_K192_Y1.1990.91
12_M45_G1.1950.91
260_R265_E1.1950.91
188_S192_Y1.1950.91
253_Q256_E1.1850.91
194_T201_T1.1780.90
86_D90_N1.1690.90
38_E64_D1.1660.90
93_E97_E1.1640.90
217_Y266_F1.1530.89
256_E260_R1.1360.89
206_M209_V1.1310.88
173_Q182_G1.1270.88
155_I196_E1.1200.88
193_V199_I1.1170.88
205_I219_T1.1090.87
89_A131_R1.1000.87
223_L231_V1.0860.86
31_D90_N1.0830.86
158_G196_E1.0770.86
93_E131_R1.0750.86
109_D185_Q1.0670.85
148_K188_S1.0640.85
207_L216_V1.0630.85
107_S121_F1.0610.85
67_S80_M1.0600.85
65_R81_E1.0410.84
240_S243_H1.0370.84
164_H186_S1.0340.83
217_Y221_G1.0340.83
216_V248_D1.0300.83
216_V250_V1.0290.83
48_W77_T1.0270.83
163_A204_S1.0230.83
4_R249_Y1.0210.83
55_G98_I1.0190.83
33_H64_D1.0090.82
259_Q273_S1.0080.82
213_D217_Y1.0070.82
250_V254_K1.0040.82
96_A132_D0.9980.81
129_K159_P0.9960.81
151_V192_Y0.9930.81
218_Q222_D0.9900.81
65_R76_K0.9850.80
61_L124_T0.9840.80
155_I162_I0.9820.80
72_F173_Q0.9770.80
128_I132_D0.9700.79
6_K40_S0.9700.79
175_P247_A0.9670.79
24_K37_E0.9600.79
123_R127_E0.9540.78
20_F48_W0.9480.78
221_G225_E0.9460.78
149_S152_Q0.9310.76
122_A154_I0.9300.76
154_I158_G0.9270.76
59_F91_V0.9250.76
155_I199_I0.9210.76
177_R181_A0.9200.76
100_L103_V0.9150.75
74_D240_S0.8990.74
139_V163_A0.8860.73
95_V135_I0.8830.73
8_E12_M0.8820.72
22_D55_G0.8800.72
173_Q180_R0.8800.72
254_K257_T0.8790.72
139_V159_P0.8780.72
146_G185_Q0.8730.72
272_A282_K0.8730.72
119_G153_K0.8700.71
23_I49_S0.8670.71
19_R55_G0.8600.71
141_I154_I0.8590.70
238_Q249_Y0.8560.70
55_G99_G0.8540.70
95_V103_V0.8520.70
191_E226_A0.8500.70
229_D269_L0.8500.70
142_P154_I0.8490.70
92_A131_R0.8440.69
14_P45_G0.8440.69
166_I219_T0.8420.69
5_R8_E0.8410.69
217_Y257_T0.8330.68
203_T233_L0.8320.68
220_L261_V0.8320.68
221_G261_V0.8310.68
173_Q181_A0.8300.68
23_I98_I0.8230.67
77_T109_D0.8210.67
178_D204_S0.8190.67
85_P120_H0.8150.66
89_A130_E0.8140.66
124_T128_I0.8100.66
148_K151_V0.8040.65
224_R229_D0.8000.65
109_D173_Q0.7990.65
103_V135_I0.7970.65
83_L120_H0.7930.64
15_P45_G0.7910.64
38_E74_D0.7910.64
263_E271_C0.7910.64
201_T229_D0.7840.63
60_M272_A0.7800.63
191_E227_G0.7790.63
122_A153_K0.7750.62
26_T30_N0.7730.62
220_L266_F0.7720.62
232_T277_V0.7720.62
58_T283_A0.7670.62
44_M48_W0.7600.61
126_R156_D0.7590.61
116_Q145_Q0.7540.60
251_H254_K0.7530.60
74_D109_D0.7530.60
28_R38_E0.7510.60
223_L226_A0.7470.60
220_L224_R0.7470.60
101_D284_G0.7450.59
125_I137_V0.7450.59
27_L48_W0.7410.59
33_H81_E0.7370.59
109_D144_F0.7330.58
214_H217_Y0.7300.58
191_E225_E0.7260.57
95_V128_I0.7240.57
9_W252_P0.7220.57
173_Q219_T0.7200.57
141_I144_F0.7190.57
170_A174_V0.7170.56
139_V162_I0.7160.56
141_I193_V0.7150.56
136_L160_D0.7110.56
270_Y282_K0.7080.55
173_Q184_E0.7030.55
145_Q150_L0.7020.55
151_V189_V0.7020.55
244_L247_A0.7000.55
213_D250_V0.6970.54
251_H256_E0.6960.54
272_A286_L0.6950.54
105_L139_V0.6930.54
173_Q204_S0.6900.54
200_Y230_V0.6890.53
257_T260_R0.6890.53
154_I193_V0.6880.53
48_W173_Q0.6870.53
155_I194_T0.6860.53
145_Q180_R0.6860.53
187_L226_A0.6860.53
148_K152_Q0.6850.53
217_Y265_E0.6850.53
126_R157_A0.6840.53
6_K237_L0.6840.53
166_I186_S0.6820.53
205_I216_V0.6810.53
183_Y218_Q0.6800.53
209_V244_L0.6790.52
154_I157_A0.6780.52
218_Q221_G0.6780.52
212_Y247_A0.6760.52
17_G20_F0.6750.52
220_L268_F0.6740.52
230_V286_L0.6730.52
107_S144_F0.6670.51
233_L258_W0.6660.51
69_G180_R0.6630.51
37_E44_M0.6580.50
193_V196_E0.6570.50
207_L250_V0.6540.50
92_A128_I0.6540.50
139_V157_A0.6480.49
69_G77_T0.6480.49
203_T226_A0.6460.49
168_T207_L0.6430.49
10_L276_M0.6430.49
25_E29_D0.6420.48
33_H37_E0.6410.48
248_D258_W0.6400.48
262_A272_A0.6380.48
270_Y286_L0.6380.48
18_E22_D0.6380.48
259_Q262_A0.6360.48
166_I203_T0.6360.48
163_A282_K0.6350.48
162_I189_V0.6350.48
18_E21_T0.6330.47
216_V233_L0.6250.47
38_E121_F0.6240.47
151_V162_I0.6240.47
187_L222_D0.6220.46
129_K162_I0.6220.46
37_E109_D0.6210.46
139_V204_S0.6190.46
69_G109_D0.6170.46
93_E96_A0.6170.46
120_H272_A0.6160.46
163_A178_D0.6150.46
231_V262_A0.6140.45
109_D228_V0.6140.45
129_K160_D0.6140.45
75_V282_K0.6090.45
256_E263_E0.6080.45
6_K13_R0.6070.45
152_Q262_A0.6070.45
141_I189_V0.6050.45
104_V234_G0.6050.45
13_R16_S0.6050.45
121_F163_A0.6040.44
162_I201_T0.6040.44
19_R49_S0.6030.44
6_K12_M0.6020.44
13_R19_R0.6020.44
221_G265_E0.6020.44
12_M15_P0.6000.44
48_W182_G0.5960.44
11_K274_G0.5960.44
14_P40_S0.5950.43
60_M109_D0.5950.43
59_F103_V0.5940.43
129_K158_G0.5940.43
181_A206_M0.5910.43
251_H273_S0.5900.43
262_A286_L0.5890.43
243_H279_S0.5880.43
117_G142_P0.5870.43
168_T176_V0.5860.43
212_Y215_E0.5850.42
237_L249_Y0.5830.42
105_L199_I0.5830.42
166_I183_Y0.5800.42
178_D182_G0.5790.42
224_R231_V0.5780.42
158_G193_V0.5740.41
59_F98_I0.5730.41
255_F273_S0.5730.41
74_D77_T0.5710.41
171_R237_L0.5700.41
20_F23_I0.5690.41
204_S282_K0.5660.40
60_M105_L0.5660.40
209_V247_A0.5650.40
193_V200_Y0.5630.40
177_R206_M0.5630.40
260_R263_E0.5610.40
171_R218_Q0.5610.40
71_N74_D0.5610.40
153_K158_G0.5610.40
123_R128_I0.5600.40
11_K258_W0.5580.40
35_V178_D0.5580.40
173_Q189_V0.5570.40
23_I27_L0.5560.39
31_D86_D0.5550.39
20_F228_V0.5550.39
163_A232_T0.5540.39
26_T90_N0.5530.39
215_E218_Q0.5530.39
101_D128_I0.5530.39
35_V60_M0.5510.39
8_E253_Q0.5500.39
195_R198_D0.5500.39
60_M120_H0.5490.39
170_A182_G0.5480.39
78_G81_E0.5470.39
189_V192_Y0.5460.38
94_S97_E0.5460.38
214_H253_Q0.5450.38
204_S219_T0.5440.38
30_N90_N0.5440.38
71_N180_R0.5430.38
12_M44_M0.5410.38
214_H224_R0.5410.38
170_A178_D0.5410.38
65_R79_G0.5400.38
252_P275_P0.5390.38
64_D81_E0.5390.38
218_Q260_R0.5390.38
176_V206_M0.5380.38
159_P163_A0.5360.37
139_V144_F0.5350.37
91_V103_V0.5330.37
62_M107_S0.5300.37
213_D261_V0.5300.37
166_I205_I0.5290.37
82_P120_H0.5280.37
72_F166_I0.5260.36
238_Q244_L0.5260.36
216_V220_L0.5260.36
168_T172_R0.5260.36
6_K37_E0.5260.36
230_V238_Q0.5250.36
85_P119_G0.5250.36
74_D98_I0.5230.36
24_K44_M0.5220.36
180_R204_S0.5190.36
216_V258_W0.5170.36
30_N98_I0.5150.35
101_D130_E0.5150.35
148_K185_Q0.5150.35
230_V272_A0.5140.35
119_G122_A0.5130.35
107_S173_Q0.5120.35
105_L124_T0.5120.35
40_S242_S0.5120.35
168_T181_A0.5120.35
270_Y287_F0.5120.35
89_A123_R0.5120.35
35_V75_V0.5120.35
221_G224_R0.5110.35
30_N93_E0.5110.35
213_D216_V0.5110.35
139_V193_V0.5100.35
40_S69_G0.5090.35
284_G287_F0.5080.35
8_E21_T0.5070.35
4_R238_Q0.5070.35
168_T183_Y0.5070.35
19_R156_D0.5070.35
82_P85_P0.5060.34
150_L153_K0.5050.34
29_D260_R0.5030.34
102_Y137_V0.5030.34
54_P228_V0.5020.34
161_V178_D0.5000.34
206_M279_S0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u0oB 1 0.8521 100 0.648 Contact Map
4r33A 2 0.955 99.7 0.876 Contact Map
3t7vA 1 0.9293 99.7 0.884 Contact Map
4wcxA 1 0.9389 99.6 0.885 Contact Map
3iixA 1 0.9325 99.6 0.886 Contact Map
4rtbA 2 0.9293 99.6 0.886 Contact Map
1r30A 2 0.9068 99.6 0.888 Contact Map
1oltA 1 0.91 99.4 0.901 Contact Map
2qgqA 1 0.7203 99.4 0.902 Contact Map
4jc0A 1 0.9068 99.3 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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