LIPA - HALSA - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

LIPA - Probable lipoyl synthase

UniProt:	Q9HN78	Sequences: MSSRRKPEWLKMRPPSGERFTDIKETLRDNDLHTVCEEASCPNMGECWSGRDGPGTATFMLMGDRCSRGCNFCDVKTGGMEPLDPDEPANVAESVAEIGLDYVVLTSVDRDDLDDQGAGHFARTIREIKERDPSILVEVLIPDFQGEKSLVQKIIDAGPDVIAHNIETVARRQVPVRDRRAGYEQSLSVLEYVTRESDIYTKTSIMLGVGEYDHEVYQTLGDLREAGVDVVTLGQYLQPSRSHLDVADYVHPQKFETWQRVAESEFGFLYCASGPMVRSSYKAGELFVDAVLREGKSVQEARRNARRAASE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (279)
Sequences:	2194 (909)
Seq/√Len:	54.4

ECOLI - LIPA
BACSU - LIPA
HALSA - LIPA
SULSO - LIPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
62_M	83_L	5.322	1.00
220_L	231_V	4.358	1.00
141_I	162_I	3.817	1.00
171_R	215_E	3.717	1.00
248_D	254_K	3.661	1.00
183_Y	222_D	3.612	1.00
221_G	266_F	3.560	1.00
194_T	229_D	3.458	1.00
259_Q	263_E	3.408	1.00
207_L	233_L	3.299	1.00
256_E	259_Q	3.259	1.00
170_A	184_E	3.005	1.00
102_Y	136_L	2.978	1.00
213_D	257_T	2.759	1.00
91_V	124_T	2.612	1.00
127_E	130_E	2.610	1.00
217_Y	261_V	2.582	1.00
203_T	223_L	2.456	1.00
61_L	105_L	2.358	1.00
274_G	277_V	2.313	1.00
86_D	89_A	2.292	1.00
132_D	135_I	2.266	1.00
125_I	139_V	2.254	1.00
119_G	123_R	2.233	1.00
220_L	262_A	2.232	1.00
213_D	254_K	2.223	1.00
176_V	244_L	2.196	1.00
107_S	142_P	2.189	1.00
96_A	131_R	2.081	1.00
28_R	37_E	2.079	1.00
261_V	265_E	2.040	1.00
213_D	258_W	1.995	1.00
116_Q	150_L	1.989	1.00
102_Y	161_V	1.945	1.00
188_S	191_E	1.934	1.00
223_L	228_V	1.926	1.00
72_F	181_A	1.906	1.00
40_S	74_D	1.861	0.99
64_D	76_K	1.860	0.99
35_V	39_A	1.835	0.99
250_V	258_W	1.821	0.99
162_I	193_V	1.800	0.99
125_I	157_A	1.797	0.99
89_A	127_E	1.786	0.99
105_L	128_I	1.784	0.99
190_L	228_V	1.765	0.99
261_V	266_F	1.756	0.99
170_A	173_Q	1.749	0.99
152_Q	156_D	1.743	0.99
144_F	154_I	1.711	0.99
19_R	22_D	1.701	0.99
155_I	193_V	1.678	0.99
170_A	218_Q	1.676	0.99
262_A	271_C	1.657	0.99
170_A	219_T	1.644	0.99
129_K	137_V	1.626	0.98
46_E	281_Y	1.600	0.98
89_A	93_E	1.594	0.98
60_M	75_V	1.581	0.98
224_R	268_F	1.556	0.98
90_N	93_E	1.546	0.98
54_P	284_G	1.526	0.98
20_F	44_M	1.519	0.98
254_K	258_W	1.507	0.97
147_E	150_L	1.506	0.97
257_T	261_V	1.495	0.97
191_E	195_R	1.486	0.97
152_Q	192_Y	1.451	0.97
192_Y	195_R	1.441	0.97
123_R	126_R	1.407	0.96
122_A	126_R	1.404	0.96
26_T	97_E	1.366	0.95
118_A	153_K	1.363	0.95
30_N	94_S	1.358	0.95
184_E	188_S	1.350	0.95
12_M	276_M	1.346	0.95
128_I	135_I	1.335	0.95
29_D	97_E	1.333	0.95
71_N	244_L	1.328	0.95
224_R	266_F	1.325	0.95
62_M	120_H	1.324	0.95
207_L	258_W	1.322	0.95
127_E	131_R	1.311	0.94
224_R	227_G	1.287	0.94
84_D	90_N	1.283	0.94
95_V	132_D	1.269	0.93
30_N	97_E	1.257	0.93
173_Q	178_D	1.220	0.92
65_R	78_G	1.217	0.92
148_K	192_Y	1.199	0.91
12_M	45_G	1.195	0.91
260_R	265_E	1.195	0.91
188_S	192_Y	1.195	0.91
253_Q	256_E	1.185	0.91
194_T	201_T	1.178	0.90
86_D	90_N	1.169	0.90
38_E	64_D	1.166	0.90
93_E	97_E	1.164	0.90
217_Y	266_F	1.153	0.89
256_E	260_R	1.136	0.89
206_M	209_V	1.131	0.88
173_Q	182_G	1.127	0.88
155_I	196_E	1.120	0.88
193_V	199_I	1.117	0.88
205_I	219_T	1.109	0.87
89_A	131_R	1.100	0.87
223_L	231_V	1.086	0.86
31_D	90_N	1.083	0.86
158_G	196_E	1.077	0.86
93_E	131_R	1.075	0.86
109_D	185_Q	1.067	0.85
148_K	188_S	1.064	0.85
207_L	216_V	1.063	0.85
107_S	121_F	1.061	0.85
67_S	80_M	1.060	0.85
65_R	81_E	1.041	0.84
240_S	243_H	1.037	0.84
164_H	186_S	1.034	0.83
217_Y	221_G	1.034	0.83
216_V	248_D	1.030	0.83
216_V	250_V	1.029	0.83
48_W	77_T	1.027	0.83
163_A	204_S	1.023	0.83
4_R	249_Y	1.021	0.83
55_G	98_I	1.019	0.83
33_H	64_D	1.009	0.82
259_Q	273_S	1.008	0.82
213_D	217_Y	1.007	0.82
250_V	254_K	1.004	0.82
96_A	132_D	0.998	0.81
129_K	159_P	0.996	0.81
151_V	192_Y	0.993	0.81
218_Q	222_D	0.990	0.81
65_R	76_K	0.985	0.80
61_L	124_T	0.984	0.80
155_I	162_I	0.982	0.80
72_F	173_Q	0.977	0.80
128_I	132_D	0.970	0.79
6_K	40_S	0.970	0.79
175_P	247_A	0.967	0.79
24_K	37_E	0.960	0.79
123_R	127_E	0.954	0.78
20_F	48_W	0.948	0.78
221_G	225_E	0.946	0.78
149_S	152_Q	0.931	0.76
122_A	154_I	0.930	0.76
154_I	158_G	0.927	0.76
59_F	91_V	0.925	0.76
155_I	199_I	0.921	0.76
177_R	181_A	0.920	0.76
100_L	103_V	0.915	0.75
74_D	240_S	0.899	0.74
139_V	163_A	0.886	0.73
95_V	135_I	0.883	0.73
8_E	12_M	0.882	0.72
22_D	55_G	0.880	0.72
173_Q	180_R	0.880	0.72
254_K	257_T	0.879	0.72
139_V	159_P	0.878	0.72
146_G	185_Q	0.873	0.72
272_A	282_K	0.873	0.72
119_G	153_K	0.870	0.71
23_I	49_S	0.867	0.71
19_R	55_G	0.860	0.71
141_I	154_I	0.859	0.70
238_Q	249_Y	0.856	0.70
55_G	99_G	0.854	0.70
95_V	103_V	0.852	0.70
191_E	226_A	0.850	0.70
229_D	269_L	0.850	0.70
142_P	154_I	0.849	0.70
92_A	131_R	0.844	0.69
14_P	45_G	0.844	0.69
166_I	219_T	0.842	0.69
5_R	8_E	0.841	0.69
217_Y	257_T	0.833	0.68
203_T	233_L	0.832	0.68
220_L	261_V	0.832	0.68
221_G	261_V	0.831	0.68
173_Q	181_A	0.830	0.68
23_I	98_I	0.823	0.67
77_T	109_D	0.821	0.67
178_D	204_S	0.819	0.67
85_P	120_H	0.815	0.66
89_A	130_E	0.814	0.66
124_T	128_I	0.810	0.66
148_K	151_V	0.804	0.65
224_R	229_D	0.800	0.65
109_D	173_Q	0.799	0.65
103_V	135_I	0.797	0.65
83_L	120_H	0.793	0.64
15_P	45_G	0.791	0.64
38_E	74_D	0.791	0.64
263_E	271_C	0.791	0.64
201_T	229_D	0.784	0.63
60_M	272_A	0.780	0.63
191_E	227_G	0.779	0.63
122_A	153_K	0.775	0.62
26_T	30_N	0.773	0.62
220_L	266_F	0.772	0.62
232_T	277_V	0.772	0.62
58_T	283_A	0.767	0.62
44_M	48_W	0.760	0.61
126_R	156_D	0.759	0.61
116_Q	145_Q	0.754	0.60
251_H	254_K	0.753	0.60
74_D	109_D	0.753	0.60
28_R	38_E	0.751	0.60
223_L	226_A	0.747	0.60
220_L	224_R	0.747	0.60
101_D	284_G	0.745	0.59
125_I	137_V	0.745	0.59
27_L	48_W	0.741	0.59
33_H	81_E	0.737	0.59
109_D	144_F	0.733	0.58
214_H	217_Y	0.730	0.58
191_E	225_E	0.726	0.57
95_V	128_I	0.724	0.57
9_W	252_P	0.722	0.57
173_Q	219_T	0.720	0.57
141_I	144_F	0.719	0.57
170_A	174_V	0.717	0.56
139_V	162_I	0.716	0.56
141_I	193_V	0.715	0.56
136_L	160_D	0.711	0.56
270_Y	282_K	0.708	0.55
173_Q	184_E	0.703	0.55
145_Q	150_L	0.702	0.55
151_V	189_V	0.702	0.55
244_L	247_A	0.700	0.55
213_D	250_V	0.697	0.54
251_H	256_E	0.696	0.54
272_A	286_L	0.695	0.54
105_L	139_V	0.693	0.54
173_Q	204_S	0.690	0.54
200_Y	230_V	0.689	0.53
257_T	260_R	0.689	0.53
154_I	193_V	0.688	0.53
48_W	173_Q	0.687	0.53
155_I	194_T	0.686	0.53
145_Q	180_R	0.686	0.53
187_L	226_A	0.686	0.53
148_K	152_Q	0.685	0.53
217_Y	265_E	0.685	0.53
126_R	157_A	0.684	0.53
6_K	237_L	0.684	0.53
166_I	186_S	0.682	0.53
205_I	216_V	0.681	0.53
183_Y	218_Q	0.680	0.53
209_V	244_L	0.679	0.52
154_I	157_A	0.678	0.52
218_Q	221_G	0.678	0.52
212_Y	247_A	0.676	0.52
17_G	20_F	0.675	0.52
220_L	268_F	0.674	0.52
230_V	286_L	0.673	0.52
107_S	144_F	0.667	0.51
233_L	258_W	0.666	0.51
69_G	180_R	0.663	0.51
37_E	44_M	0.658	0.50
193_V	196_E	0.657	0.50
207_L	250_V	0.654	0.50
92_A	128_I	0.654	0.50
139_V	157_A	0.648	0.49
69_G	77_T	0.648	0.49
203_T	226_A	0.646	0.49
168_T	207_L	0.643	0.49
10_L	276_M	0.643	0.49
25_E	29_D	0.642	0.48
33_H	37_E	0.641	0.48
248_D	258_W	0.640	0.48
262_A	272_A	0.638	0.48
270_Y	286_L	0.638	0.48
18_E	22_D	0.638	0.48
259_Q	262_A	0.636	0.48
166_I	203_T	0.636	0.48
163_A	282_K	0.635	0.48
162_I	189_V	0.635	0.48
18_E	21_T	0.633	0.47
216_V	233_L	0.625	0.47
38_E	121_F	0.624	0.47
151_V	162_I	0.624	0.47
187_L	222_D	0.622	0.46
129_K	162_I	0.622	0.46
37_E	109_D	0.621	0.46
139_V	204_S	0.619	0.46
69_G	109_D	0.617	0.46
93_E	96_A	0.617	0.46
120_H	272_A	0.616	0.46
163_A	178_D	0.615	0.46
231_V	262_A	0.614	0.45
109_D	228_V	0.614	0.45
129_K	160_D	0.614	0.45
75_V	282_K	0.609	0.45
256_E	263_E	0.608	0.45
6_K	13_R	0.607	0.45
152_Q	262_A	0.607	0.45
141_I	189_V	0.605	0.45
104_V	234_G	0.605	0.45
13_R	16_S	0.605	0.45
121_F	163_A	0.604	0.44
162_I	201_T	0.604	0.44
19_R	49_S	0.603	0.44
6_K	12_M	0.602	0.44
13_R	19_R	0.602	0.44
221_G	265_E	0.602	0.44
12_M	15_P	0.600	0.44
48_W	182_G	0.596	0.44
11_K	274_G	0.596	0.44
14_P	40_S	0.595	0.43
60_M	109_D	0.595	0.43
59_F	103_V	0.594	0.43
129_K	158_G	0.594	0.43
181_A	206_M	0.591	0.43
251_H	273_S	0.590	0.43
262_A	286_L	0.589	0.43
243_H	279_S	0.588	0.43
117_G	142_P	0.587	0.43
168_T	176_V	0.586	0.43
212_Y	215_E	0.585	0.42
237_L	249_Y	0.583	0.42
105_L	199_I	0.583	0.42
166_I	183_Y	0.580	0.42
178_D	182_G	0.579	0.42
224_R	231_V	0.578	0.42
158_G	193_V	0.574	0.41
59_F	98_I	0.573	0.41
255_F	273_S	0.573	0.41
74_D	77_T	0.571	0.41
171_R	237_L	0.570	0.41
20_F	23_I	0.569	0.41
204_S	282_K	0.566	0.40
60_M	105_L	0.566	0.40
209_V	247_A	0.565	0.40
193_V	200_Y	0.563	0.40
177_R	206_M	0.563	0.40
260_R	263_E	0.561	0.40
171_R	218_Q	0.561	0.40
71_N	74_D	0.561	0.40
153_K	158_G	0.561	0.40
123_R	128_I	0.560	0.40
11_K	258_W	0.558	0.40
35_V	178_D	0.558	0.40
173_Q	189_V	0.557	0.40
23_I	27_L	0.556	0.39
31_D	86_D	0.555	0.39
20_F	228_V	0.555	0.39
163_A	232_T	0.554	0.39
26_T	90_N	0.553	0.39
215_E	218_Q	0.553	0.39
101_D	128_I	0.553	0.39
35_V	60_M	0.551	0.39
8_E	253_Q	0.550	0.39
195_R	198_D	0.550	0.39
60_M	120_H	0.549	0.39
170_A	182_G	0.548	0.39
78_G	81_E	0.547	0.39
189_V	192_Y	0.546	0.38
94_S	97_E	0.546	0.38
214_H	253_Q	0.545	0.38
204_S	219_T	0.544	0.38
30_N	90_N	0.544	0.38
71_N	180_R	0.543	0.38
12_M	44_M	0.541	0.38
214_H	224_R	0.541	0.38
170_A	178_D	0.541	0.38
65_R	79_G	0.540	0.38
252_P	275_P	0.539	0.38
64_D	81_E	0.539	0.38
218_Q	260_R	0.539	0.38
176_V	206_M	0.538	0.38
159_P	163_A	0.536	0.37
139_V	144_F	0.535	0.37
91_V	103_V	0.533	0.37
62_M	107_S	0.530	0.37
213_D	261_V	0.530	0.37
166_I	205_I	0.529	0.37
82_P	120_H	0.528	0.37
72_F	166_I	0.526	0.36
238_Q	244_L	0.526	0.36
216_V	220_L	0.526	0.36
168_T	172_R	0.526	0.36
6_K	37_E	0.526	0.36
230_V	238_Q	0.525	0.36
85_P	119_G	0.525	0.36
74_D	98_I	0.523	0.36
24_K	44_M	0.522	0.36
180_R	204_S	0.519	0.36
216_V	258_W	0.517	0.36
30_N	98_I	0.515	0.35
101_D	130_E	0.515	0.35
148_K	185_Q	0.515	0.35
230_V	272_A	0.514	0.35
119_G	122_A	0.513	0.35
107_S	173_Q	0.512	0.35
105_L	124_T	0.512	0.35
40_S	242_S	0.512	0.35
168_T	181_A	0.512	0.35
270_Y	287_F	0.512	0.35
89_A	123_R	0.512	0.35
35_V	75_V	0.512	0.35
221_G	224_R	0.511	0.35
30_N	93_E	0.511	0.35
213_D	216_V	0.511	0.35
139_V	193_V	0.510	0.35
40_S	69_G	0.509	0.35
284_G	287_F	0.508	0.35
8_E	21_T	0.507	0.35
4_R	238_Q	0.507	0.35
168_T	183_Y	0.507	0.35
19_R	156_D	0.507	0.35
82_P	85_P	0.506	0.34
150_L	153_K	0.505	0.34
29_D	260_R	0.503	0.34
102_Y	137_V	0.503	0.34
54_P	228_V	0.502	0.34
161_V	178_D	0.500	0.34
206_M	279_S	0.500	0.34

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4u0oB	1	0.8521	100	0.648	Contact Map
4r33A	2	0.955	99.7	0.876	Contact Map
3t7vA	1	0.9293	99.7	0.884	Contact Map
4wcxA	1	0.9389	99.6	0.885	Contact Map
3iixA	1	0.9325	99.6	0.886	Contact Map
4rtbA	2	0.9293	99.6	0.886	Contact Map
1r30A	2	0.9068	99.6	0.888	Contact Map
1oltA	1	0.91	99.4	0.901	Contact Map
2qgqA	1	0.7203	99.4	0.902	Contact Map
4jc0A	1	0.9068	99.3	0.908	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0094 seconds.