GREMLIN Database
Q9HN77 - Pyruvate dehydrogenase alpha subunit
UniProt: Q9HN77 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (340)
Sequences: 3074 (1695)
Seq/√Len: 91.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_R362_D5.0061.00
221_H265_Y4.0791.00
352_D355_A3.9551.00
126_S209_Y3.6421.00
235_V291_A3.5601.00
205_A288_I3.4341.00
289_E293_D3.3871.00
288_I292_K3.3461.00
137_V192_M3.0911.00
65_D69_E3.0681.00
262_A269_G3.0511.00
94_A144_G2.9971.00
353_D357_E2.9821.00
80_T83_E2.9601.00
342_E346_V2.9371.00
210_F238_C2.9341.00
154_K373_A2.7741.00
294_P300_R2.6801.00
290_K302_T2.6481.00
351_L356_I2.5891.00
196_S206_F2.5691.00
290_K299_M2.4901.00
342_E356_I2.4701.00
231_D254_A2.4011.00
131_A203_D2.2531.00
346_V353_D2.2501.00
293_D299_M2.2221.00
186_I223_G2.1731.00
86_E90_Y2.1691.00
210_F214_A2.1301.00
270_V286_D2.1221.00
93_L366_A2.1001.00
84_L345_L2.0711.00
387_E401_L2.0511.00
384_S387_E2.0171.00
193_G234_N1.9991.00
220_F224_L1.9811.00
238_C258_L1.9671.00
81_D350_R1.9521.00
268_E300_R1.9471.00
237_F306_A1.9041.00
81_D348_T1.8811.00
196_S204_T1.8571.00
369_D373_A1.8491.00
365_D369_D1.8441.00
109_R375_E1.8151.00
268_E290_K1.7631.00
165_R388_N1.7471.00
61_Y283_V1.7411.00
181_P184_S1.7251.00
275_M311_F1.7171.00
372_E376_E1.6991.00
358_S362_D1.6881.00
92_K363_I1.6791.00
362_D366_A1.6731.00
196_S201_E1.6711.00
81_D355_A1.6391.00
186_I220_F1.5841.00
126_S284_A1.5751.00
190_T223_G1.5741.00
200_D203_D1.5671.00
126_S237_F1.5641.00
283_V304_I1.5491.00
85_V355_A1.5441.00
354_A357_E1.5431.00
87_M128_M1.5391.00
179_A184_S1.5261.00
90_Y128_M1.5201.00
270_V283_V1.5191.00
125_A277_P1.5181.00
271_Q307_V1.5071.00
146_S175_I1.5011.00
87_M277_P1.5011.00
218_G222_E1.4861.00
126_S207_M1.4801.00
262_A267_F1.4781.00
133_D204_T1.4741.00
152_P155_D1.4711.00
330_E334_D1.4701.00
275_M308_Q1.4631.00
194_W198_L1.4541.00
272_V283_V1.4541.00
207_M284_A1.4511.00
291_A302_T1.4330.99
326_E330_E1.4310.99
355_A358_S1.4140.99
125_A280_V1.4080.99
276_D279_A1.3990.99
243_W328_E1.3780.99
327_S330_E1.3620.99
330_E333_K1.3570.99
205_A235_V1.3560.99
193_G233_P1.3330.99
207_M235_V1.3290.99
237_F284_A1.3270.99
81_D85_V1.3100.99
105_Q316_T1.3080.99
343_T347_E1.2950.99
370_A374_A1.2820.99
272_V279_A1.2710.99
205_A292_K1.2680.99
207_M237_F1.2620.99
122_A237_F1.2590.99
201_E204_T1.2580.99
346_V356_I1.2560.99
278_L341_L1.2560.99
394_P397_L1.2550.99
357_E361_A1.2500.99
85_V351_L1.2410.98
155_D172_E1.2400.98
313_A320_P1.2320.98
231_D300_R1.2310.98
92_K338_I1.2190.98
269_G303_L1.2190.98
366_A370_A1.2180.98
398_E402_E1.2100.98
96_R367_V1.2050.98
351_L359_I1.1880.98
242_Q307_V1.1850.98
332_W335_K1.1820.98
130_L136_I1.1810.98
361_A365_D1.1800.98
190_T236_F1.1760.98
183_A220_F1.1730.98
299_M302_T1.1730.98
396_R399_Q1.1680.98
286_D289_E1.1620.98
116_L143_H1.1450.97
281_Y285_H1.1440.97
294_P299_M1.1300.97
326_E329_V1.1270.97
284_A304_I1.1240.97
62_R71_V1.1220.97
135_W196_S1.1180.97
79_L281_Y1.1180.97
83_E86_E1.1150.97
168_A177_T1.1130.97
136_I145_A1.1070.97
287_A291_A1.0940.97
309_Y328_E1.0850.96
344_F348_T1.0830.96
84_L341_L1.0810.96
381_D384_S1.0770.96
69_E347_E1.0770.96
215_T258_L1.0760.96
366_A369_D1.0760.96
216_S252_Q1.0700.96
112_T315_T1.0690.96
341_L344_F1.0560.96
62_R65_D1.0520.96
351_L355_A1.0460.95
154_K370_A1.0460.95
342_E360_E1.0450.95
183_A214_A1.0430.95
88_Y92_K1.0430.95
86_E128_M1.0410.95
205_A291_A1.0390.95
287_A302_T1.0380.95
397_L400_Q1.0360.95
133_D203_D1.0360.95
345_L350_R1.0360.95
270_V302_T1.0340.95
189_A234_N1.0290.95
84_L278_L1.0280.95
339_P343_T1.0220.95
356_I360_E1.0210.95
154_K369_D1.0140.95
129_A281_Y1.0090.95
159_Y180_V1.0030.94
260_Q263_A1.0030.94
213_G244_A1.0010.94
62_R66_E0.9940.94
96_R364_E0.9920.94
87_M281_Y0.9880.94
372_E375_E0.9870.94
209_Y237_F0.9840.94
224_L303_L0.9830.94
253_T261_K0.9810.94
235_V288_I0.9750.93
203_D293_D0.9740.93
128_M281_Y0.9690.93
99_E117_S0.9690.93
257_T260_Q0.9670.93
112_T168_A0.9640.93
89_R93_L0.9630.93
240_N305_E0.9600.93
137_V176_F0.9570.93
393_M401_L0.9470.92
133_D201_E0.9470.92
193_G232_T0.9470.92
147_L156_T0.9460.92
324_R328_E0.9460.92
231_D299_M0.9440.92
92_K360_E0.9410.92
253_T258_L0.9410.92
122_A306_A0.9400.92
285_H289_E0.9380.92
346_V351_L0.9270.92
354_A358_S0.9270.92
280_V306_A0.9240.91
341_L345_L0.9140.91
331_A334_D0.9120.91
214_A238_C0.9070.91
215_T220_F0.9010.90
309_Y332_W0.8990.90
114_P315_T0.8980.90
238_C303_L0.8920.90
174_N204_T0.8900.90
359_I363_I0.8840.90
224_L267_F0.8810.89
182_I217_E0.8780.89
392_E398_E0.8760.89
104_L371_I0.8760.89
131_A288_I0.8750.89
91_M341_L0.8710.89
83_E281_Y0.8710.89
363_I366_A0.8680.89
342_E351_L0.8680.89
130_L235_V0.8670.89
186_I210_F0.8650.89
135_W176_F0.8650.89
132_D173_E0.8610.88
82_D86_E0.8610.88
83_E285_H0.8560.88
155_D158_L0.8540.88
216_S261_K0.8520.88
197_Q231_D0.8450.87
273_D279_A0.8430.87
131_A204_T0.8360.87
255_T264_A0.8360.87
383_A387_E0.8350.87
192_M206_F0.8300.86
91_M338_I0.8290.86
88_Y342_E0.8280.86
290_K294_P0.8260.86
154_K158_L0.8260.86
60_T63_V0.8230.86
127_A149_R0.8220.86
84_L350_R0.8200.86
228_G266_G0.8180.86
159_Y167_N0.8160.85
282_Q286_D0.8150.85
343_T346_V0.8090.85
260_Q264_A0.8060.85
124_I144_G0.8040.85
190_T232_T0.8040.85
130_L288_I0.8020.84
90_Y148_V0.8010.84
183_A186_I0.7970.84
119_Q139_S0.7960.84
228_G267_F0.7950.84
210_F215_T0.7860.83
92_K359_I0.7850.83
85_V345_L0.7830.83
368_A372_E0.7810.83
125_A129_A0.7800.83
290_K300_R0.7790.83
383_A401_L0.7780.83
93_L147_L0.7660.82
369_D372_E0.7650.82
158_L377_T0.7580.81
255_T260_Q0.7570.81
153_L366_A0.7560.81
140_Y315_T0.7510.80
331_A335_K0.7490.80
61_Y270_V0.7470.80
130_L207_M0.7460.80
63_V70_L0.7440.80
101_A157_L0.7430.80
167_N180_V0.7430.80
139_S142_E0.7420.80
175_I178_V0.7410.79
157_L371_I0.7370.79
261_K264_A0.7340.79
114_P180_V0.7330.79
97_F156_T0.7320.79
64_L70_L0.7320.79
95_R336_D0.7300.78
158_L163_D0.7270.78
255_T258_L0.7220.78
189_A208_C0.7210.78
228_G254_A0.7210.78
393_M402_E0.7210.78
268_E286_D0.7180.77
145_A209_Y0.7180.77
393_M398_E0.7150.77
186_I206_F0.7150.77
79_L83_E0.7110.77
311_F333_K0.7110.77
341_L350_R0.7090.76
395_Q399_Q0.7060.76
183_A317_A0.7030.76
152_P373_A0.7000.76
216_S219_D0.6980.75
356_I359_I0.6940.75
98_D105_Q0.6940.75
311_F336_D0.6940.75
190_T208_C0.6930.75
229_V251_Q0.6910.75
161_M375_E0.6880.74
161_M374_A0.6860.74
355_A359_I0.6850.74
101_A160_W0.6790.73
142_E239_N0.6790.73
189_A206_F0.6780.73
151_L173_E0.6760.73
89_R359_I0.6760.73
327_S331_A0.6760.73
209_Y284_A0.6750.73
74_A77_P0.6750.73
312_G320_P0.6750.73
88_Y359_I0.6730.73
179_A188_H0.6720.73
374_A377_T0.6720.73
93_L367_V0.6710.72
64_L278_L0.6710.72
244_A252_Q0.6710.72
115_P313_A0.6700.72
159_Y182_I0.6690.72
117_S312_G0.6680.72
267_F301_P0.6670.72
73_G77_P0.6650.72
245_I316_T0.6620.71
128_M148_V0.6620.71
112_T180_V0.6590.71
235_V302_T0.6590.71
357_E360_E0.6590.71
239_N308_Q0.6580.71
398_E401_L0.6570.71
286_D290_K0.6570.71
399_Q403_Y0.6560.71
87_M278_L0.6530.70
164_E378_P0.6520.70
93_L363_I0.6510.70
86_E89_R0.6500.70
93_L153_L0.6500.70
210_F236_F0.6470.70
362_D365_D0.6470.70
125_A284_A0.6460.70
105_Q317_A0.6460.70
117_S243_W0.6460.70
237_F280_V0.6430.69
319_D322_V0.6430.69
85_V350_R0.6430.69
153_L367_V0.6430.69
370_A373_A0.6390.69
140_Y178_V0.6390.69
329_V333_K0.6380.69
112_T170_P0.6380.69
190_T234_N0.6380.69
119_Q239_N0.6360.68
136_I175_I0.6360.68
115_P312_G0.6360.68
96_R360_E0.6340.68
248_P252_Q0.6320.68
64_L344_F0.6310.68
115_P159_Y0.6290.68
63_V278_L0.6290.68
138_P175_I0.6280.67
65_D71_V0.6270.67
133_D149_R0.6270.67
89_R366_A0.6220.67
195_A234_N0.6220.67
228_G265_Y0.6210.67
85_V89_R0.6190.66
182_I264_A0.6170.66
126_S145_A0.6170.66
273_D340_R0.6170.66
184_S188_H0.6140.66
223_G236_F0.6130.66
84_L344_F0.6130.66
396_R400_Q0.6120.65
259_A271_Q0.6120.65
135_W204_T0.6110.65
160_W167_N0.6110.65
142_E209_Y0.6110.65
195_A264_A0.6090.65
221_H264_A0.6080.65
123_Q144_G0.6080.65
255_T261_K0.6080.65
363_I367_V0.6080.65
321_S326_E0.6070.65
220_F303_L0.6050.65
119_Q222_E0.6030.64
100_R371_I0.6020.64
117_S311_F0.6010.64
131_A285_H0.6010.64
243_W311_F0.6010.64
287_A290_K0.5990.64
104_L161_M0.5990.64
70_L348_T0.5970.64
147_L153_L0.5970.64
257_T271_Q0.5960.63
97_F143_H0.5950.63
145_A207_M0.5940.63
102_V316_T0.5930.63
97_F101_A0.5930.63
373_A376_E0.5930.63
358_S361_A0.5920.63
139_S210_F0.5910.63
112_T167_N0.5880.62
344_F350_R0.5860.62
365_D368_A0.5850.62
165_R180_V0.5820.62
127_A145_A0.5820.62
159_Y315_T0.5810.61
258_L303_L0.5800.61
249_R253_T0.5790.61
308_Q332_W0.5770.61
122_A125_A0.5760.61
129_A288_I0.5730.60
70_L76_V0.5710.60
215_T249_R0.5690.60
66_E69_E0.5680.60
67_N73_G0.5680.60
192_M195_A0.5670.60
154_K377_T0.5670.60
131_A292_K0.5670.60
165_R168_A0.5650.59
112_T159_Y0.5630.59
275_M340_R0.5630.59
276_D340_R0.5620.59
270_V304_I0.5610.59
187_P219_D0.5610.59
127_A144_G0.5610.59
116_L144_G0.5600.59
194_W232_T0.5600.59
206_F234_N0.5580.58
160_W180_V0.5570.58
242_Q250_E0.5560.58
121_G308_Q0.5560.58
212_D291_A0.5560.58
181_P217_E0.5550.58
249_R258_L0.5540.58
112_T177_T0.5520.58
116_L167_N0.5510.57
320_P329_V0.5490.57
182_I215_T0.5450.57
183_A217_E0.5450.57
68_G71_V0.5440.56
290_K293_D0.5440.56
138_P178_V0.5440.56
79_L84_L0.5430.56
159_Y176_F0.5420.56
94_A124_I0.5420.56
87_M125_A0.5400.56
226_F230_Y0.5390.56
310_R318_D0.5370.55
215_T229_V0.5370.55
77_P282_Q0.5370.55
166_G177_T0.5360.55
78_D285_H0.5360.55
235_V304_I0.5340.55
216_S253_T0.5340.55
309_Y329_V0.5330.55
82_D358_S0.5320.55
212_D261_K0.5310.55
102_V117_S0.5310.55
60_T271_Q0.5310.55
121_G125_A0.5310.55
208_C236_F0.5280.54
102_V313_A0.5270.54
272_V304_I0.5270.54
137_V236_F0.5270.54
253_T266_G0.5250.54
133_D174_N0.5240.54
242_Q249_R0.5230.54
167_N181_P0.5220.53
168_A180_V0.5220.53
364_E368_A0.5210.53
105_Q112_T0.5210.53
221_H225_N0.5200.53
136_I209_Y0.5200.53
193_G206_F0.5190.53
342_E353_D0.5190.53
124_I277_P0.5180.53
126_S136_I0.5170.53
229_V252_Q0.5170.53
259_A269_G0.5170.53
143_H178_V0.5160.53
75_E78_D0.5160.53
346_V352_D0.5150.52
365_D372_E0.5140.52
221_H267_F0.5120.52
293_D347_E0.5120.52
140_Y185_Q0.5120.52
62_R335_K0.5110.52
393_M397_L0.5090.52
268_E294_P0.5090.52
160_W178_V0.5090.52
65_D338_I0.5080.51
176_F180_V0.5080.51
272_V280_V0.5070.51
114_P247_V0.5070.51
367_V371_I0.5060.51
215_T247_V0.5050.51
373_A377_T0.5050.51
104_L294_P0.5050.51
279_A283_V0.5050.51
122_A308_Q0.5040.51
69_E343_T0.5040.51
225_N229_V0.5030.51
112_T316_T0.5030.51
88_Y355_A0.5030.51
157_L374_A0.5030.51
212_D249_R0.5020.51
63_V375_E0.5020.51
173_E303_L0.5020.51
83_E277_P0.5010.51
380_P388_N0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bfdA 2 0.8568 100 0.328 Contact Map
1qs0A 2 0.9308 100 0.37 Contact Map
1umdA 2 0.8401 100 0.378 Contact Map
1w85A 2 0.8687 100 0.381 Contact Map
2ozlA 2 0.8425 100 0.443 Contact Map
2xt6A 2 0.9356 100 0.533 Contact Map
2yicA 2 0.9141 100 0.536 Contact Map
2jgdA 2 0.9045 100 0.549 Contact Map
5c4iC 2 0.5871 100 0.716 Contact Map
3m49A 2 0.7279 100 0.74 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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