GREMLIN Database
Q9HN76 - Pyruvate dehydrogenase beta subunit
UniProt: Q9HN76 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (263)
Sequences: 13755 (8051)
Seq/√Len: 496.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_D292_E4.8901.00
197_N288_A3.3471.00
283_E286_R2.9031.00
179_V291_I2.8761.00
41_A53_P2.8741.00
170_A218_T2.7211.00
174_T195_A2.3931.00
192_V205_V2.3851.00
120_A131_M2.2141.00
195_A205_V2.1671.00
197_N284_P2.1611.00
193_E284_P2.1441.00
174_T196_E2.1251.00
216_F248_T2.0831.00
284_P288_A2.0751.00
177_E202_D2.0381.00
262_E293_E2.0081.00
44_M49_L2.0021.00
50_K84_T1.9931.00
179_V203_V1.9811.00
180_S226_T1.9711.00
278_D283_E1.9451.00
251_E263_R1.9201.00
262_E290_G1.9121.00
190_P284_P1.8871.00
42_V72_M1.8031.00
72_M87_M1.8021.00
178_D202_D1.7951.00
220_I248_T1.7561.00
38_I72_M1.7501.00
243_A247_A1.7481.00
204_E225_K1.7261.00
204_E222_S1.7171.00
178_D227_G1.7061.00
220_I252_E1.6841.00
183_T191_T1.6641.00
197_N285_A1.6631.00
204_E226_T1.6591.00
109_A235_A1.6581.00
191_T232_V1.6511.00
288_A292_E1.6431.00
172_V204_E1.6421.00
237_N265_T1.6311.00
118_K138_D1.6291.00
117_L143_V1.6261.00
275_A278_D1.6231.00
118_K140_D1.6221.00
52_V136_I1.5931.00
175_E204_E1.5891.00
112_A244_E1.5871.00
82_R116_G1.5871.00
86_P135_S1.5811.00
181_V191_T1.5801.00
289_A293_E1.5531.00
135_S142_V1.5321.00
246_T261_V1.5311.00
193_E196_E1.5251.00
216_F252_E1.4951.00
38_I87_M1.4911.00
190_P193_E1.4871.00
290_G293_E1.4551.00
189_Q193_E1.4491.00
112_A247_A1.4421.00
182_F208_L1.4391.00
183_T188_T1.4251.00
170_A208_L1.4251.00
166_E169_D1.4231.00
38_I53_P1.4211.00
133_I137_R1.4161.00
286_R290_G1.3991.00
50_K86_P1.3951.00
111_Y143_V1.3881.00
181_V291_I1.3611.00
84_T140_D1.3561.00
190_P287_I1.3421.00
206_V218_T1.3401.00
165_V168_G1.3401.00
194_A288_A1.3381.00
220_I224_K1.3231.00
171_A207_D1.3191.00
38_I64_G1.3151.00
118_K210_S1.3111.00
278_D285_A1.3011.00
221_E225_K1.2861.00
68_V117_L1.2671.00
127_D207_D1.2631.00
215_D248_T1.2621.00
249_I261_V1.2591.00
180_S222_S1.2521.00
230_A294_A1.2501.00
123_S188_T1.2411.00
120_A210_S1.2371.00
127_D209_R1.2211.00
254_L259_A1.2191.00
172_V175_E1.2141.00
206_V222_S1.2071.00
84_T139_P1.2061.00
17_G20_E1.2001.00
246_T250_Q1.1951.00
214_I219_I1.1951.00
208_L241_L1.1911.00
120_A142_V1.1761.00
221_E226_T1.1751.00
233_H242_G1.1741.00
134_A167_L1.1741.00
68_V89_L1.1671.00
123_S207_D1.1591.00
90_R146_E1.1381.00
220_I253_A1.1241.00
89_L143_V1.1231.00
65_F110_F1.1211.00
217_D221_E1.1181.00
109_A113_H1.1121.00
173_R188_T1.1111.00
231_I234_E1.1091.00
262_E294_A1.1011.00
230_A291_I1.0941.00
45_A51_P1.0931.00
59_G107_K1.0891.00
246_T263_R1.0881.00
286_R289_A1.0771.00
170_A206_V1.0751.00
125_P153_A1.0741.00
272_P279_Y1.0661.00
216_F220_I1.0651.00
72_M85_L1.0651.00
241_L245_I1.0611.00
172_V218_T1.0571.00
232_V287_I1.0531.00
17_G21_E1.0501.00
181_V203_V1.0471.00
229_A249_I1.0471.00
182_F229_A1.0471.00
187_M190_P1.0451.00
203_V291_I1.0391.00
35_S67_Q1.0391.00
108_E184_W1.0381.00
212_S268_D1.0371.00
223_F249_I1.0341.00
230_A233_H1.0281.00
169_D217_D1.0241.00
247_A263_R1.0201.00
172_V206_V1.0191.00
108_E145_L1.0071.00
218_T222_S1.0071.00
41_A85_L1.0071.00
266_G280_Y1.0021.00
58_S145_L1.0021.00
180_S206_V0.9961.00
242_G263_R0.9931.00
180_S204_E0.9911.00
194_A287_I0.9891.00
30_T40_S0.9891.00
37_I53_P0.9871.00
118_K142_V0.9841.00
248_T252_E0.9791.00
184_W211_L0.9621.00
118_K213_P0.9611.00
275_A279_Y0.9601.00
82_R140_D0.9551.00
231_I242_G0.9471.00
228_R294_A0.9421.00
269_V279_Y0.9381.00
250_Q261_V0.9371.00
123_S171_A0.9371.00
285_A289_A0.9341.00
105_E266_G0.9331.00
230_A264_I0.9321.00
242_G265_T0.9301.00
50_K139_P0.9291.00
174_T202_D0.9271.00
281_L286_R0.9111.00
191_T205_V0.9091.00
238_T268_D0.9071.00
74_R100_P0.9061.00
120_A167_L0.9051.00
134_A166_E0.9001.00
132_L144_F0.8991.00
178_D201_I0.8971.00
133_I162_P0.8871.00
137_R162_P0.8871.00
198_L291_I0.8871.00
152_R189_Q0.8861.00
73_S114_E0.8851.00
201_I292_E0.8841.00
208_L211_L0.8811.00
22_F26_R0.8721.00
36_G40_S0.8671.00
18_L27_V0.8661.00
228_R260_P0.8631.00
254_L293_E0.8611.00
176_G202_D0.8601.00
291_I294_A0.8591.00
109_A239_G0.8591.00
222_S225_K0.8581.00
61_M111_Y0.8561.00
221_E224_K0.8551.00
58_S111_Y0.8511.00
128_A146_E0.8501.00
68_V111_Y0.8481.00
61_M91_A0.8381.00
86_P142_V0.8361.00
198_L288_A0.8351.00
95_G277_E0.8341.00
130_G133_I0.8291.00
41_A54_E0.8281.00
117_L141_P0.8271.00
190_P277_E0.8251.00
121_M184_W0.8241.00
190_P283_E0.8221.00
214_I248_T0.8181.00
134_A137_R0.8181.00
118_K212_S0.8161.00
72_M141_P0.8161.00
230_A234_E0.8081.00
40_S44_M0.8071.00
147_P151_Y0.8071.00
108_E235_A0.8071.00
45_A85_L0.8041.00
38_I89_L0.8001.00
199_D288_A0.7991.00
276_L280_Y0.7991.00
112_A211_L0.7991.00
19_Y27_V0.7871.00
158_V161_D0.7861.00
229_A233_H0.7791.00
222_S226_T0.7771.00
227_G230_A0.7721.00
290_G294_A0.7701.00
118_K167_L0.7671.00
289_A292_E0.7671.00
107_K145_L0.7661.00
219_I223_F0.7631.00
193_E197_N0.7631.00
183_T187_M0.7561.00
126_Y159_P0.7541.00
94_G276_L0.7531.00
179_V230_A0.7511.00
112_A239_G0.7501.00
174_T192_V0.7501.00
68_V87_M0.7461.00
110_F114_E0.7461.00
219_I248_T0.7451.00
182_F206_V0.7441.00
254_L290_G0.7441.00
219_I249_I0.7421.00
211_L215_D0.7401.00
273_L277_E0.7391.00
278_D286_R0.7391.00
73_S117_L0.7391.00
39_G67_Q0.7351.00
244_E247_A0.7291.00
215_D247_A0.7271.00
19_Y22_F0.7201.00
50_K136_I0.7181.00
18_L22_F0.7171.00
220_I254_L0.7151.00
134_A164_E0.7141.00
219_I224_K0.7111.00
61_M89_L0.6991.00
233_H240_G0.6981.00
238_T263_R0.6951.00
45_A83_F0.6911.00
124_T173_R0.6881.00
130_G164_E0.6871.00
53_P87_M0.6831.00
46_A83_F0.6831.00
173_R192_V0.6811.00
131_M209_R0.6801.00
52_V132_L0.6781.00
250_Q253_A0.6761.00
237_N251_E0.6761.00
230_A262_E0.6711.00
62_Y65_F0.6701.00
237_N263_R0.6691.00
120_A135_S0.6651.00
73_S270_P0.6651.00
28_I40_S0.6651.00
126_Y130_G0.6641.00
119_V143_V0.6621.00
65_F113_H0.6611.00
108_E119_V0.6591.00
184_W208_L0.6571.00
194_A232_V0.6561.00
223_F229_A0.6541.00
172_V221_E0.6521.00
66_D70_S0.6451.00
228_R231_I0.6431.00
120_A134_A0.6431.00
267_F280_Y0.6421.00
100_P103_H0.6391.00
269_V280_Y0.6391.00
129_K133_I0.6391.00
69_V114_E0.6381.00
58_S107_K0.6381.00
232_V261_V0.6351.00
133_I164_E0.6331.00
33_A36_G0.6301.00
44_M51_P0.6291.00
126_Y153_A0.6271.00
264_I290_G0.6261.00
118_K168_G0.6261.00
244_E248_T0.6261.00
130_G134_A0.6241.00
62_Y107_K0.6241.00
178_D203_V0.6211.00
194_A291_I0.6191.00
220_I223_F0.6171.00
114_E117_L0.6161.00
165_V169_D0.6141.00
277_E282_P0.6141.00
135_S144_F0.6130.99
75_L83_F0.6110.99
267_F286_R0.6100.99
138_D142_V0.6100.99
130_G162_P0.6080.99
86_P132_L0.6060.99
264_I282_P0.6050.99
175_E225_K0.6010.99
105_E236_P0.6000.99
210_S213_P0.5960.99
194_A284_P0.5940.99
231_I261_V0.5940.99
18_L23_G0.5940.99
186_A190_P0.5910.99
239_G243_A0.5910.99
86_P144_F0.5900.99
188_T205_V0.5880.99
169_D215_D0.5860.99
163_Y166_E0.5840.99
187_M232_V0.5830.99
46_A75_L0.5810.99
147_P186_A0.5810.99
152_R193_E0.5810.99
231_I245_I0.5770.99
271_F280_Y0.5750.99
180_S229_A0.5730.99
175_E221_E0.5730.99
82_R139_P0.5720.99
191_T233_H0.5690.99
57_F91_A0.5680.99
121_M185_G0.5670.99
30_T37_I0.5670.99
198_L203_V0.5660.99
219_I222_S0.5660.99
282_P286_R0.5640.99
123_S127_D0.5630.99
88_V135_S0.5610.99
168_G210_S0.5610.99
64_G68_V0.5590.99
195_A203_V0.5570.99
112_A241_L0.5560.99
91_A98_R0.5540.99
112_A119_V0.5530.99
244_E263_R0.5520.99
57_F90_R0.5510.99
183_T208_L0.5500.99
137_R164_E0.5500.99
69_V106_S0.5460.99
162_P165_V0.5460.99
126_Y163_Y0.5450.99
285_A288_A0.5450.99
94_G277_E0.5450.99
62_Y110_F0.5450.99
164_E167_L0.5420.99
55_I91_A0.5390.99
138_D167_L0.5350.99
38_I55_I0.5330.99
118_K216_F0.5320.99
211_L241_L0.5320.99
55_I89_L0.5310.99
216_F251_E0.5300.99
121_M186_A0.5290.99
41_A51_P0.5290.99
59_G105_E0.5270.98
243_A263_R0.5270.98
131_M165_V0.5260.98
242_G246_T0.5260.98
35_S66_D0.5230.98
281_L290_G0.5210.98
94_G266_G0.5210.98
170_A215_D0.5110.98
175_E202_D0.5100.98
157_D160_D0.5090.98
125_P151_Y0.5050.98
130_G165_V0.5050.98
95_G281_L0.5050.98
130_G163_Y0.5040.98
179_V228_R0.5040.98
95_G149_K0.5040.98
35_S63_P0.5040.98
184_W241_L0.5030.98
140_D216_F0.5010.98
172_V222_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ik6A 3 0.8485 100 0.23 Contact Map
1w85B 2 0.9899 100 0.237 Contact Map
1umdB 2 0.9865 100 0.245 Contact Map
1qs0B 2 0.9899 100 0.257 Contact Map
2o1xA 2 0.9327 100 0.27 Contact Map
2ozlB 2 0.9933 100 0.275 Contact Map
2bfdB 2 0.9865 100 0.277 Contact Map
2o1sA 2 0.9293 100 0.293 Contact Map
4kxvA 2 0.9259 100 0.299 Contact Map
1r9jA 2 0.9024 100 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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