GREMLIN Database
Q9HN73 - Prephenate dehydratase
UniProt: Q9HN73 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 270 (259)
Sequences: 3568 (2438)
Seq/√Len: 151.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_P156_S3.5101.00
4_V43_A3.2851.00
97_S124_T2.9301.00
129_E133_N2.8811.00
34_I46_G2.7041.00
93_D136_T2.6521.00
86_L141_A2.6131.00
140_I158_I2.5721.00
92_F138_A2.5661.00
12_Y83_H2.5131.00
94_A117_D2.4701.00
146_A153_V2.4681.00
86_L128_V2.4161.00
233_I242_T2.2021.00
208_R244_N2.1391.00
82_R157_G2.1341.00
128_V151_L2.1001.00
28_M37_A2.0811.00
126_R129_E2.0731.00
63_D218_R2.0571.00
108_Y155_G2.0211.00
199_L203_E2.0171.00
101_A124_T2.0001.00
94_A119_R1.9891.00
4_V28_M1.9841.00
247_A250_A1.9441.00
203_E207_D1.9381.00
183_K186_I1.9031.00
189_Y231_V1.8901.00
17_A25_V1.8801.00
5_T27_F1.8621.00
207_D248_D1.8571.00
106_R160_D1.8561.00
73_V169_F1.8391.00
89_D152_D1.8301.00
186_I233_I1.7941.00
74_V172_G1.7931.00
201_L249_V1.7921.00
205_F212_L1.7831.00
87_A152_D1.7821.00
193_N211_N1.7711.00
82_R159_Q1.7631.00
211_N234_A1.7481.00
14_H144_D1.7261.00
194_H200_E1.7151.00
2_D24_D1.7131.00
184_S263_S1.7101.00
95_V116_V1.6861.00
6_L123_S1.6831.00
105_C140_I1.6611.00
50_I169_F1.6591.00
83_H100_Q1.6351.00
5_T9_A1.6281.00
97_S102_L1.6251.00
96_A137_T1.5931.00
38_V71_L1.5581.00
41_G173_P1.5361.00
232_D264_Y1.5361.00
208_R248_D1.5311.00
87_A154_H1.5241.00
11_T125_A1.5231.00
14_H18_S1.4791.00
15_R144_D1.4771.00
235_S242_T1.4721.00
86_L146_A1.4721.00
91_G135_E1.4541.00
102_L118_R1.4361.00
6_L13_S1.4221.00
38_V46_G1.4071.00
48_V61_T1.4001.00
15_R19_A1.3891.00
96_A119_R1.3821.00
72_A175_S1.3751.00
179_P182_G1.3661.00
21_S170_V1.3601.00
9_A148_G1.3601.00
107_E160_D1.3561.00
143_P147_D1.3521.00
80_P159_Q1.3461.00
185_S232_D1.3371.00
219_P227_Y1.3081.00
200_E206_A1.3011.00
39_A68_T1.2961.00
102_L120_A1.2771.00
122_A126_R1.2721.00
9_A14_H1.2711.00
8_P123_S1.2681.00
35_V48_V1.2561.00
35_V171_V1.2511.00
223_R226_D1.2501.00
84_A143_P1.2291.00
212_L233_I1.2221.00
108_Y158_I1.2211.00
204_P248_D1.2131.00
55_Q103_A1.2121.00
12_Y142_H1.2081.00
94_A137_T1.2071.00
240_E244_N1.2031.00
36_D40_V1.2021.00
19_A77_V1.1971.00
220_S228_V1.1941.00
31_V61_T1.1881.00
235_S239_E1.1841.00
47_V170_V1.1701.00
6_L11_T1.1661.00
2_D26_S1.1661.00
26_S43_A1.1631.00
95_V109_L1.1611.00
83_H101_A1.1311.00
46_G171_V1.1301.00
17_A47_V1.1281.00
110_D118_R1.1281.00
121_V127_G1.1230.99
73_V264_Y1.1190.99
18_S144_D1.1120.99
96_A121_V1.1080.99
134_D137_T1.1010.99
37_A43_A1.0980.99
84_A153_V1.0980.99
85_L158_I1.0910.99
131_A134_D1.0900.99
131_A139_A1.0820.99
37_A42_D1.0750.99
20_V170_V1.0730.99
93_D117_D1.0680.99
3_T21_S1.0650.99
92_F116_V1.0620.99
130_V134_D1.0470.99
182_G236_G1.0400.99
78_V165_E1.0380.99
84_A157_G1.0290.99
44_D173_P1.0270.99
86_L151_L1.0250.99
83_H105_C1.0190.99
108_Y114_P1.0160.99
20_V75_R1.0150.99
38_V43_A1.0130.99
86_L153_V1.0060.99
205_F245_A1.0050.99
193_N226_D0.9970.99
123_S126_R0.9960.99
190_P257_W0.9950.99
109_L116_V0.9950.99
21_S45_R0.9900.99
126_R130_V0.9900.99
185_S264_Y0.9890.99
196_G211_N0.9860.99
28_M42_D0.9860.99
58_V100_Q0.9820.99
205_F249_V0.9810.99
45_R74_V0.9790.99
76_E183_K0.9730.99
39_A70_G0.9600.98
84_A156_S0.9590.98
55_Q58_V0.9530.98
57_S216_E0.9500.98
14_H25_V0.9480.98
204_P208_R0.9430.98
85_L138_A0.9400.98
2_D44_D0.9380.98
234_A266_T0.9330.98
62_L214_R0.9220.98
26_S37_A0.9210.98
89_D150_E0.9080.98
144_D147_D0.9060.98
127_G139_A0.9020.98
13_S49_P0.9010.98
38_V171_V0.9000.98
75_R170_V0.8980.98
200_E252_I0.8960.98
11_T123_S0.8950.98
253_A258_V0.8950.98
5_T25_V0.8940.97
32_R110_D0.8920.97
57_S214_R0.8870.97
8_P11_T0.8870.97
121_V130_V0.8740.97
30_S33_D0.8660.97
200_E203_E0.8600.97
4_V34_I0.8590.97
188_V228_V0.8570.97
88_Q135_E0.8570.97
87_A136_T0.8490.97
208_R245_A0.8450.96
141_A145_S0.8430.96
128_V141_A0.8430.96
236_G263_S0.8390.96
32_R67_D0.8370.96
182_G186_I0.8320.96
33_D110_D0.8310.96
107_E111_A0.8260.96
196_G229_F0.8240.96
71_L171_V0.8200.96
35_V46_G0.8160.96
65_L169_F0.8150.96
12_Y84_A0.8150.96
216_E232_D0.8130.96
35_V71_L0.8130.96
88_Q134_D0.8110.96
191_N201_L0.8080.95
129_E149_T0.8060.95
143_P153_V0.8050.95
109_L118_R0.7990.95
175_S237_C0.7940.95
49_P124_T0.7890.95
107_E110_D0.7880.95
72_A174_A0.7860.95
184_S260_R0.7840.95
83_H164_N0.7730.94
87_A138_A0.7700.94
32_R36_D0.7650.94
66_A188_V0.7640.94
83_H140_I0.7610.94
222_E226_D0.7550.93
204_P252_I0.7520.93
4_V37_A0.7480.93
210_I233_I0.7480.93
191_N197_L0.7450.93
214_R232_D0.7400.93
83_H142_H0.7390.93
179_P236_G0.7390.93
235_S263_S0.7380.93
32_R60_E0.7350.93
55_Q100_Q0.7330.92
31_V64_A0.7320.92
196_G217_S0.7310.92
242_T246_V0.7230.92
57_S232_D0.7200.92
28_M43_A0.7190.92
12_Y100_Q0.7180.92
128_V132_R0.7130.91
67_D107_E0.7130.91
111_A155_G0.7090.91
45_R170_V0.7070.91
99_A120_A0.7060.91
76_E167_R0.7050.91
95_V102_L0.7030.91
96_A130_V0.7020.91
182_G263_S0.6980.91
94_A136_T0.6980.91
70_G259_R0.6960.90
91_G136_T0.6920.90
73_V261_L0.6920.90
180_A236_G0.6910.90
36_D39_A0.6900.90
198_L211_N0.6880.90
9_A27_F0.6860.90
6_L125_A0.6860.90
66_A228_V0.6780.89
159_Q162_A0.6770.89
190_P256_G0.6740.89
35_V68_T0.6740.89
33_D36_D0.6690.89
51_E227_Y0.6580.88
248_D252_I0.6580.88
58_V103_A0.6560.88
241_R244_N0.6550.88
144_D148_G0.6550.88
13_S123_S0.6540.87
20_V77_V0.6520.87
237_C246_V0.6510.87
172_G175_S0.6500.87
132_R150_E0.6460.87
68_T71_L0.6440.87
178_T238_Y0.6440.87
63_D219_P0.6440.87
125_A128_V0.6400.86
236_G242_T0.6390.86
10_G148_G0.6390.86
2_D42_D0.6380.86
212_L231_V0.6370.86
108_Y116_V0.6350.86
243_R247_A0.6340.86
94_A134_D0.6340.86
180_A184_S0.6330.86
52_N104_Q0.6310.86
122_A129_E0.6280.85
238_Y243_R0.6270.85
8_P129_E0.6250.85
182_G185_S0.6240.85
6_L31_V0.6230.85
212_L215_V0.6180.84
219_P225_G0.6180.84
184_S235_S0.6160.84
21_S75_R0.6160.84
91_G94_A0.6150.84
177_R238_Y0.6140.84
239_E263_S0.6140.84
31_V48_V0.6130.84
82_R143_P0.6130.84
109_L140_I0.6130.84
29_E33_D0.6120.84
242_T263_S0.6120.84
233_I245_A0.6110.84
237_C260_R0.6060.83
49_P100_Q0.6050.83
80_P165_E0.6050.83
130_V133_N0.6030.83
124_T142_H0.6030.83
202_L212_L0.6020.83
83_H104_Q0.6010.83
237_C263_S0.5980.82
238_Y241_R0.5970.82
121_V126_R0.5930.82
28_M33_D0.5930.82
185_S230_H0.5930.82
81_I142_H0.5910.82
211_N229_F0.5910.82
15_R18_S0.5880.81
190_P197_L0.5860.81
31_V60_E0.5850.81
54_I161_R0.5840.81
19_A79_T0.5830.81
95_V118_R0.5820.81
73_V185_S0.5820.81
15_R79_T0.5780.80
217_S227_Y0.5780.80
6_L126_R0.5750.80
53_S100_Q0.5750.80
60_E106_R0.5740.80
109_L114_P0.5730.80
250_A258_V0.5700.79
182_G265_D0.5700.79
190_P225_G0.5690.79
196_G212_L0.5680.79
13_S60_E0.5670.79
155_G158_I0.5670.79
189_Y201_L0.5660.79
9_A129_E0.5650.79
99_A121_V0.5640.79
181_G266_T0.5630.79
16_A77_V0.5620.78
21_S225_G0.5610.78
146_A150_E0.5600.78
212_L229_F0.5580.78
78_V224_L0.5560.78
76_E232_D0.5550.78
27_F123_S0.5530.77
86_L149_T0.5520.77
87_A131_A0.5520.77
201_L253_A0.5510.77
104_Q168_F0.5500.77
67_D188_V0.5470.77
132_R151_L0.5470.77
86_L142_H0.5450.76
13_S61_T0.5430.76
8_P126_R0.5420.76
18_S25_V0.5410.76
89_D154_H0.5400.76
217_S229_F0.5390.75
145_S149_T0.5380.75
98_H202_L0.5360.75
71_L173_P0.5360.75
35_V230_H0.5350.75
97_S101_A0.5350.75
203_E206_A0.5340.75
193_N212_L0.5300.74
197_L200_E0.5300.74
12_Y81_I0.5290.74
188_V191_N0.5280.74
88_Q136_T0.5270.74
58_V101_A0.5270.74
65_L188_V0.5260.74
200_E251_E0.5260.74
212_L217_S0.5240.73
11_T31_V0.5240.73
161_R222_E0.5220.73
201_L204_P0.5210.73
200_E209_N0.5200.73
14_H60_E0.5170.72
211_N217_S0.5170.72
199_L206_A0.5150.72
111_A244_N0.5150.72
54_I61_T0.5140.72
185_S188_V0.5130.72
178_T181_G0.5130.72
236_G265_D0.5130.72
215_V231_V0.5120.72
195_P211_N0.5110.72
215_V222_E0.5110.72
181_G184_S0.5100.71
198_L229_F0.5080.71
49_P61_T0.5070.71
15_R83_H0.5070.71
84_A100_Q0.5060.71
118_R121_V0.5030.70
100_Q103_A0.5020.70
200_E248_D0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lubA 2 0.6852 100 0.044 Contact Map
2qmxA 3 0.9704 100 0.045 Contact Map
3mwbA 3 0.9889 100 0.053 Contact Map
3luyA 2 0.9741 100 0.079 Contact Map
2qmwA 2 0.9519 100 0.083 Contact Map
1phzA 2 0.3667 99.9 0.727 Contact Map
2mdaA 2 0.337 99.9 0.765 Contact Map
2ko1A 2 0.3222 97.4 0.915 Contact Map
1y7pA 5 0.3111 96.3 0.926 Contact Map
2lvwA 2 0.3407 96.2 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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