GREMLIN Database
SYL - Leucine--tRNA ligase
UniProt: Q9HN72 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 885 (774)
Sequences: 3625 (1911)
Seq/√Len: 68.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_E146_D5.2991.00
769_N772_G4.8351.00
240_H315_E4.4101.00
770_P774_D4.2091.00
21_D114_E4.0061.00
203_D207_D3.9841.00
314_A355_R3.8031.00
18_R22_D3.7871.00
434_S476_A3.6321.00
236_P249_V3.6141.00
234_E249_V3.5451.00
302_E306_T3.4731.00
19_E23_A3.2661.00
760_D780_E3.2151.00
702_T725_G3.2071.00
389_D392_T3.1371.00
510_T514_N3.0971.00
500_S503_F3.0671.00
747_A763_D3.0651.00
388_L396_E2.9591.00
24_D123_E2.8721.00
178_L185_P2.7651.00
8_D11_A2.7281.00
210_D224_R2.6281.00
145_R429_I2.6181.00
203_D229_R2.6141.00
236_P247_D2.5951.00
67_R72_E2.5691.00
211_E552_R2.5571.00
664_F711_I2.5201.00
154_A190_D2.5141.00
27_R123_E2.5061.00
309_N312_T2.5001.00
24_D27_R2.4871.00
208_G541_K2.4771.00
246_E275_A2.4661.00
248_V266_L2.4191.00
271_P326_S2.3791.00
100_E104_R2.3671.00
82_S129_C2.3571.00
514_N550_E2.3381.00
506_A509_D2.3371.00
143_E442_D2.3211.00
108_Q111_D2.3041.00
470_T477_P2.2981.00
73_D515_D2.2901.00
775_V779_P2.2571.00
259_H384_D2.2561.00
179_C182_C2.2121.00
306_T315_E2.2091.00
80_W110_R2.2021.00
764_T773_V2.1861.00
107_D110_R2.1831.00
261_A316_I2.1791.00
503_F506_A2.1781.00
201_Y545_D2.1771.00
207_D229_R2.1711.00
110_R125_E2.1521.00
142_T439_S2.1411.00
569_G577_D2.1411.00
80_W125_E2.1401.00
402_D405_A2.1271.00
655_A744_H2.1211.00
509_D512_R2.0981.00
749_S763_D2.0901.00
468_Q479_V2.0901.00
162_S184_T2.0861.00
307_A318_V2.0831.00
276_A305_F2.0801.00
289_E299_Q2.0791.00
356_Q380_V2.0741.00
34_D72_E2.0701.00
341_D345_E2.0511.00
440_V444_D2.0241.00
69_M706_K2.0231.00
441_P444_D2.0201.00
160_C182_C2.0161.00
471_C474_C2.0101.00
396_E399_A2.0091.00
650_A699_R2.0071.00
234_E405_A2.0021.00
771_T774_D1.9871.00
705_V729_V1.9861.00
653_T700_G1.9531.00
430_V469_T1.9451.00
384_D400_D1.9441.00
774_D778_A1.9401.00
274_E287_V1.9401.00
499_A517_L1.9391.00
429_I437_P1.9331.00
339_H357_V1.9331.00
432_C435_C1.9321.00
659_A675_A1.9311.00
760_D782_M1.9301.00
652_E656_T1.9191.00
435_C474_C1.9181.00
238_T247_D1.9161.00
348_Q354_V1.9141.00
658_Q737_P1.9001.00
395_E406_S1.8961.00
768_E773_V1.8961.00
372_A375_A1.8941.00
772_G775_V1.8881.00
70_D661_T1.8851.00
17_Q714_H1.8701.00
622_L712_A1.8611.00
154_A192_D1.8561.00
204_E544_A1.8541.00
160_C179_C1.8451.00
390_S394_R1.8271.00
266_L273_A1.8201.00
235_V258_I1.8101.00
432_C474_C1.8091.00
155_A195_F1.8081.00
540_T551_H1.8081.00
417_V485_M1.7971.00
787_A792_A1.7931.00
137_N425_T1.7831.00
359_A378_V1.7701.00
782_M785_V1.7701.00
231_D406_S1.7691.00
702_T706_K1.7681.00
658_Q662_T1.7621.00
196_F489_L1.7541.00
544_A552_R1.7471.00
622_L715_V1.7391.00
383_G386_T1.7341.00
66_Y70_D1.7151.00
749_S761_I1.7141.00
432_C471_C1.7001.00
758_V761_I1.6971.00
661_T734_W1.6931.00
229_R408_V1.6871.00
235_V401_I1.6871.00
258_I401_I1.6810.99
750_L773_V1.6800.99
452_F463_A1.6740.99
385_Y400_D1.6720.99
297_E349_A1.6690.99
658_Q739_R1.6640.99
536_S555_F1.6640.99
280_D284_A1.6560.99
402_D406_S1.6520.99
162_S182_C1.6460.99
29_P512_R1.6460.99
219_V560_T1.6370.99
650_A741_V1.6360.99
584_R587_D1.6350.99
435_C471_C1.6220.99
60_T523_V1.6200.99
208_G211_E1.6170.99
248_V264_F1.6150.99
740_D743_D1.6140.99
283_V320_V1.6120.99
233_V398_T1.6070.99
157_V166_V1.6060.99
464_E468_Q1.5980.99
283_V301_V1.5920.99
759_R786_L1.5900.99
440_V447_V1.5900.99
286_F299_Q1.5870.99
288_E291_A1.5840.99
261_A333_L1.5780.99
147_A546_L1.5670.99
311_A400_D1.5630.99
152_R192_D1.5610.99
160_C184_T1.5570.99
314_A353_P1.5530.99
467_K479_V1.5460.99
507_P548_M1.5440.99
137_N490_D1.5440.99
146_D442_D1.5410.99
398_T406_S1.5410.99
751_I761_I1.5380.99
703_A707_L1.5350.99
495_F540_T1.5330.99
542_A546_L1.5330.99
344_H354_V1.5300.99
432_C436_G1.5220.99
657_V707_L1.5130.99
568_D577_D1.5090.99
381_N386_T1.5090.99
197_E200_A1.5030.99
162_S179_C1.4980.99
231_D408_V1.4940.99
436_G474_C1.4690.99
698_A702_T1.4690.99
203_D410_Y1.4630.99
179_C184_T1.4610.99
285_H289_E1.4600.99
308_T315_E1.4580.99
508_F513_A1.4580.99
652_E655_A1.4580.99
706_K732_A1.4530.99
628_M680_V1.4430.98
657_V703_A1.4410.98
705_V719_C1.4320.98
468_Q477_P1.4310.98
14_Q18_R1.4310.98
103_E130_D1.4290.98
234_E407_A1.4190.98
235_V250_A1.4180.98
433_E477_P1.4130.98
651_R744_H1.4100.98
15_H718_E1.4080.98
264_F316_I1.3990.98
356_Q359_A1.3920.98
204_E208_G1.3890.98
126_I498_F1.3820.98
448_E451_E1.3800.98
653_T703_A1.3780.98
152_R431_H1.3770.98
344_H348_Q1.3750.98
432_C438_V1.3690.98
429_I439_S1.3680.98
767_I772_G1.3640.98
282_D285_H1.3560.98
385_Y397_L1.3450.98
104_R107_D1.3450.98
359_A380_V1.3380.97
19_E721_T1.3340.97
66_Y661_T1.3340.97
207_D210_D1.3280.97
469_T478_A1.3270.97
303_T320_V1.3230.97
596_L712_A1.3230.97
567_E577_D1.3220.97
751_I758_V1.3130.97
110_R114_E1.3110.97
783_Y786_L1.3110.97
737_P742_S1.3090.97
705_V723_L1.3050.97
782_M786_L1.3040.97
600_R677_D1.3040.97
255_V398_T1.3030.97
391_E394_R1.3010.97
652_E682_L1.2980.97
754_T786_L1.2940.97
674_Q678_E1.2930.97
570_T576_K1.2900.97
585_I594_A1.2700.96
506_A510_T1.2670.96
727_G732_A1.2570.96
203_D231_D1.2520.96
142_T442_D1.2480.96
647_E746_R1.2470.96
432_C472_P1.2450.96
26_F730_A1.2390.96
703_A706_K1.2380.96
709_A716_A1.2360.96
433_E479_V1.2350.96
399_A406_S1.2340.96
395_E399_A1.2320.96
626_L715_V1.2280.96
656_T660_A1.2270.96
30_D33_D1.2260.96
280_D301_V1.2260.96
54_V116_L1.2190.96
625_L708_L1.2140.95
40_A76_H1.2110.95
259_H400_D1.2110.95
683_L700_G1.2030.95
136_W139_W1.2000.95
779_P784_D1.1980.95
425_T490_D1.1940.95
593_T615_V1.1940.95
463_A467_K1.1900.95
238_T403_G1.1900.95
99_R103_E1.1890.95
675_A678_E1.1890.95
302_E305_F1.1850.95
258_I311_A1.1850.95
150_V196_F1.1830.95
143_E546_L1.1820.95
436_G471_C1.1790.95
288_E292_D1.1790.95
241_T244_G1.1730.95
100_E451_E1.1700.94
432_C478_A1.1680.94
9_H619_H1.1650.94
341_D372_A1.1650.94
200_A203_D1.1640.94
146_D473_D1.1620.94
764_T768_E1.1620.94
570_T577_D1.1580.94
10_H587_D1.1490.94
435_C438_V1.1490.94
510_T550_E1.1440.94
289_E292_D1.1440.94
628_M701_V1.1420.94
161_P187_T1.1420.94
653_T657_V1.1390.94
567_E570_T1.1360.94
145_R437_P1.1350.93
629_A701_V1.1340.93
15_H721_T1.1330.93
99_R451_E1.1330.93
619_H623_E1.1320.93
36_E67_R1.1310.93
511_Q514_N1.1300.93
785_V788_R1.1260.93
496_L517_L1.1230.93
373_Y377_G1.1210.93
396_E400_D1.1200.93
625_L704_A1.1160.93
163_C182_C1.1150.93
435_C472_P1.1150.93
35_P515_D1.1140.93
241_T245_D1.1140.93
185_P292_D1.1120.93
752_E762_V1.1100.93
273_A277_A1.1070.93
771_T775_V1.1070.93
219_V526_D1.1050.93
709_A729_V1.1030.92
273_A320_V1.1010.92
203_D408_V1.1010.92
142_T429_I1.1000.92
360_P363_D1.0980.92
67_R70_D1.0970.92
789_A794_G1.0960.92
16_W718_E1.0960.92
376_D391_E1.0950.92
163_C179_C1.0930.92
115_A587_D1.0930.92
588_E616_R1.0930.92
341_D344_H1.0930.92
161_P184_T1.0900.92
768_E776_V1.0880.92
68_R119_G1.0870.92
433_E476_A1.0850.92
218_N526_D1.0840.92
452_F465_D1.0830.92
708_L716_A1.0830.92
63_F521_E1.0820.92
649_V686_Y1.0810.92
220_R224_R1.0800.92
472_P478_A1.0800.92
649_V683_L1.0750.92
233_V401_I1.0710.91
279_R282_D1.0670.91
144_F539_V1.0630.91
394_R397_L1.0590.91
262_T355_R1.0580.91
778_A792_A1.0570.91
680_V684_V1.0570.91
467_K482_T1.0560.91
235_V255_V1.0560.91
360_P373_Y1.0510.91
143_E548_M1.0510.91
139_W442_D1.0500.91
163_C184_T1.0480.90
717_E728_F1.0450.90
762_V773_V1.0440.90
659_A663_H1.0430.90
790_K794_G1.0430.90
430_V478_A1.0420.90
602_A608_F1.0420.90
277_A305_F1.0390.90
438_V474_C1.0380.90
764_T776_V1.0370.90
676_V704_A1.0350.90
173_E176_D1.0340.90
375_A390_S1.0310.90
680_V704_A1.0310.90
373_Y376_D1.0270.90
311_A397_L1.0260.89
683_L704_A1.0260.89
787_A790_K1.0260.89
368_V371_A1.0240.89
284_A288_E1.0240.89
440_V443_D1.0220.89
255_V394_R1.0210.89
64_A119_G1.0190.89
132_D504_D1.0180.89
663_H671_R1.0180.89
720_W724_G1.0160.89
255_V397_L1.0160.89
265_A321_A1.0080.89
378_V389_D1.0070.89
463_A466_W1.0060.89
358_V379_L1.0050.89
559_T605_S1.0050.89
513_A550_E1.0050.89
630_R722_A1.0040.88
380_V386_T1.0030.88
160_C183_D1.0030.88
474_C478_A1.0020.88
131_P448_E1.0010.88
204_E541_K0.9990.88
344_H363_D0.9980.88
87_A101_W0.9950.88
236_P405_A0.9910.88
781_W784_D0.9900.88
358_V373_Y0.9900.88
738_D741_V0.9850.87
770_P775_V0.9840.87
70_D736_T0.9830.87
19_E25_V0.9820.87
438_V478_A0.9800.87
768_E772_G0.9790.87
762_V780_E0.9780.87
569_G579_G0.9770.87
743_D766_G0.9760.87
597_F601_A0.9740.87
312_T315_E0.9740.87
139_W143_E0.9730.87
358_V390_S0.9720.87
19_E728_F0.9700.87
259_H311_A0.9700.87
565_L577_D0.9670.87
284_A287_V0.9670.87
285_H288_E0.9640.86
583_E587_D0.9610.86
321_A350_H0.9610.86
144_F542_A0.9600.86
656_T707_L0.9580.86
147_A542_A0.9580.86
239_V244_G0.9540.86
379_L390_S0.9530.86
173_E180_W0.9510.86
653_T696_V0.9500.86
274_E284_A0.9500.86
132_D502_A0.9480.85
629_A705_V0.9470.85
160_C167_L0.9460.85
754_T777_T0.9460.85
708_L712_A0.9460.85
58_A599_L0.9450.85
281_D285_H0.9440.85
276_A303_T0.9430.85
40_A60_T0.9420.85
372_A377_G0.9410.85
127_T130_D0.9400.85
239_V245_D0.9390.85
365_D368_V0.9380.85
500_S509_D0.9380.85
392_T396_E0.9380.85
266_L276_A0.9370.85
765_A768_E0.9370.85
182_C185_P0.9340.85
33_D36_E0.9340.85
660_A672_A0.9320.84
251_F409_Q0.9300.84
500_S512_R0.9300.84
772_G776_V0.9270.84
16_W717_E0.9250.84
188_E294_D0.9190.84
299_Q322_D0.9180.84
48_Q108_Q0.9130.83
366_A369_E0.9100.83
93_E577_D0.9100.83
565_L568_D0.9070.83
435_C478_A0.9070.83
283_V287_V0.9050.83
156_T188_E0.9040.83
438_V471_C0.9040.83
311_A401_I0.9030.83
379_L385_Y0.9020.82
103_E107_D0.9020.82
55_R608_F0.8990.82
367_D370_A0.8980.82
152_R437_P0.8980.82
25_V730_A0.8970.82
208_G552_R0.8970.82
240_H308_T0.8970.82
216_P219_V0.8970.82
139_W548_M0.8930.82
388_L393_A0.8930.82
173_E178_L0.8920.82
286_F322_D0.8920.82
286_F290_V0.8910.82
69_M733_A0.8890.82
248_V332_A0.8890.82
502_A512_R0.8880.81
63_F667_M0.8880.81
305_F318_V0.8880.81
90_A101_W0.8880.81
499_A512_R0.8870.81
672_A676_V0.8870.81
559_T608_F0.8870.81
760_D777_T0.8860.81
435_C473_D0.8840.81
38_V64_A0.8840.81
287_V291_A0.8830.81
629_A719_C0.8830.81
649_V682_L0.8820.81
395_E398_T0.8800.81
60_T76_H0.8800.81
751_I762_V0.8800.81
593_T619_H0.8790.81
727_G731_E0.8770.81
279_R283_V0.8760.81
500_S508_F0.8760.81
705_V716_A0.8750.80
314_A383_G0.8730.80
97_N451_E0.8720.80
265_A335_A0.8710.80
495_F549_L0.8710.80
398_T402_D0.8690.80
217_S221_D0.8690.80
469_T472_P0.8690.80
432_C476_A0.8680.80
338_A356_Q0.8640.80
559_T667_M0.8630.80
565_L569_G0.8620.79
540_T549_L0.8610.79
391_E395_E0.8610.79
111_D115_A0.8590.79
235_V252_T0.8570.79
650_A654_A0.8570.79
35_P520_D0.8560.79
748_T766_G0.8560.79
264_F333_L0.8540.79
379_L393_A0.8510.79
654_A657_V0.8510.79
774_D793_D0.8500.79
566_G577_D0.8500.79
517_L551_H0.8500.79
492_S495_F0.8500.79
273_A287_V0.8440.78
239_V318_V0.8440.78
776_V780_E0.8440.78
142_T145_R0.8420.78
584_R588_E0.8410.78
784_D787_A0.8400.78
272_L275_A0.8390.78
160_C185_P0.8390.78
463_A468_Q0.8370.77
239_V246_E0.8360.77
770_P773_V0.8340.77
589_Y616_R0.8330.77
754_T787_A0.8330.77
458_N461_D0.8320.77
25_V728_F0.8320.77
42_F555_F0.8310.77
80_W127_T0.8310.77
62_A664_F0.8300.77
321_A333_L0.8290.77
213_D220_R0.8280.77
471_C476_A0.8270.77
436_G472_P0.8260.77
156_T190_D0.8260.77
145_R439_S0.8220.76
144_F546_L0.8220.76
746_R766_G0.8200.76
179_C183_D0.8200.76
579_G583_E0.8180.76
702_T724_G0.8170.76
399_A402_D0.8160.76
625_L628_M0.8160.76
716_A729_V0.8150.76
160_C163_C0.8150.76
557_G667_M0.8140.75
126_I130_D0.8140.75
471_C478_A0.8130.75
163_C183_D0.8130.75
69_M709_A0.8120.75
249_V405_A0.8110.75
353_P356_Q0.8060.75
656_T675_A0.8040.75
625_L712_A0.8040.75
790_K793_D0.8040.75
42_F531_M0.8020.74
96_T100_E0.8000.74
778_A784_D0.8000.74
221_D224_R0.7990.74
485_M489_L0.7990.74
338_A354_V0.7980.74
80_W114_E0.7970.74
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351_D726_D0.5040.41
526_D530_V0.5030.41
558_L561_Q0.5030.41
371_A374_T0.5030.41
9_H615_V0.5020.41
122_W125_E0.5020.41
190_D409_Q0.5020.41
344_H357_V0.5020.41
117_G591_A0.5020.41
253_T331_G0.5020.41
647_E651_R0.5010.41
89_N179_C0.5000.40
622_L625_L0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2v0cA 1 0.8249 100 0.267 Contact Map
4arcA 1 0.8554 100 0.272 Contact Map
1gaxA 1 0.8678 100 0.439 Contact Map
3ziuA 1 0.6814 100 0.458 Contact Map
1ffyA 1 0.8927 100 0.48 Contact Map
1ileA 1 0.7966 100 0.482 Contact Map
1wz2A 1 0.8881 100 0.495 Contact Map
1wkbA 1 0.7186 100 0.54 Contact Map
4qreA 1 0.5424 100 0.701 Contact Map
1rqgA 2 0.5627 100 0.704 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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