GREMLIN Database
Q9HN71 - Alanine dehydrogenase
UniProt: Q9HN71 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 291 (265)
Sequences: 3933 (2825)
Seq/√Len: 173.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_T121_E4.4591.00
103_A127_D3.6781.00
108_Y139_H3.4661.00
97_S124_V3.3101.00
89_H241_V3.1991.00
181_H255_T3.0001.00
204_T253_G2.8631.00
176_V199_I2.7271.00
97_S122_E2.4461.00
99_G157_C2.3121.00
100_V111_L2.2821.00
239_E244_N2.2721.00
271_H275_E2.2461.00
111_L123_V2.2181.00
150_S153_E2.2121.00
130_D134_Q2.1651.00
111_L140_F2.1401.00
235_A245_A2.1071.00
66_L274_Y2.0901.00
195_L256_V2.0651.00
133_V137_V2.0421.00
151_I155_G1.9921.00
129_S132_A1.9801.00
173_A196_A1.9591.00
122_E147_R1.9451.00
172_T175_D1.9411.00
87_T114_I1.9371.00
173_A202_A1.9271.00
32_G267_V1.9001.00
179_H253_G1.8621.00
57_Y274_Y1.8571.00
177_G180_T1.8451.00
149_G152_S1.8221.00
112_E143_R1.7891.00
249_T253_G1.7721.00
41_D44_A1.7701.00
98_F120_I1.7601.00
127_D132_A1.7581.00
172_T196_A1.7091.00
151_I175_D1.7071.00
99_G153_E1.7051.00
124_V156_H1.6801.00
55_M270_A1.6491.00
239_E245_A1.6261.00
59_D66_L1.6111.00
103_A125_V1.6091.00
55_M74_L1.6021.00
87_T183_N1.6001.00
134_Q138_D1.5591.00
200_L256_V1.5451.00
274_Y278_S1.5441.00
188_D192_K1.5401.00
98_F114_I1.5361.00
193_H197_D1.5321.00
197_D225_E1.5201.00
198_D201_L1.5201.00
131_D134_Q1.5181.00
67_A274_Y1.5111.00
178_D252_D1.5041.00
55_M71_G1.5021.00
150_S154_A1.4881.00
148_G151_I1.4831.00
156_H177_G1.4771.00
125_V136_Y1.4461.00
13_N41_D1.4461.00
88_D118_R1.4391.00
46_H61_E1.4361.00
82_A265_Q1.4331.00
120_I159_I1.4311.00
184_A195_L1.4241.00
204_T249_T1.3991.00
83_A110_Q1.3711.00
92_V158_D1.3681.00
59_D62_T1.3551.00
210_H239_E1.3261.00
96_T158_D1.3121.00
127_D133_V1.3031.00
87_T181_H1.2901.00
137_V141_S1.2881.00
101_V126_S1.2781.00
85_V89_H1.2771.00
98_F123_V1.2701.00
57_Y270_A1.2631.00
209_D212_Q1.2621.00
93_A251_S1.2581.00
92_V95_A1.2531.00
205_L228_L1.2521.00
84_A117_I1.2461.00
99_G124_V1.2351.00
95_A118_R1.2311.00
248_R253_G1.2191.00
59_D64_F1.2141.00
276_H279_E1.2131.00
101_V171_V1.2111.00
272_V276_H1.2101.00
154_A175_D1.2011.00
210_H236_E1.1961.00
206_V240_I1.1951.00
203_G256_V1.1871.00
90_L206_V1.1831.00
48_L62_T1.1831.00
42_N48_L1.1771.00
151_I154_A1.1691.00
122_E156_H1.1671.00
30_A275_E1.1641.00
250_D253_G1.1581.00
32_G57_Y1.1541.00
229_A232_D1.1511.00
158_D177_G1.1511.00
91_A95_A1.1491.00
149_G153_E1.1441.00
135_Q139_H1.1311.00
95_A159_I1.1271.00
138_D142_D1.1261.00
87_T159_I1.1251.00
138_D141_S1.1241.00
136_Y140_F1.1241.00
210_H230_D1.1211.00
35_W58_S1.1171.00
147_R153_E1.0981.00
29_D61_E1.0941.00
202_A254_V1.0921.00
48_L64_F1.0901.00
36_V53_G1.0891.00
80_G110_Q1.0891.00
106_Q110_Q1.0891.00
161_S183_N1.0871.00
162_T184_A1.0841.00
97_S156_H1.0841.00
148_G154_A1.0841.00
95_A158_D1.0661.00
111_L136_Y1.0621.00
36_V51_V1.0621.00
196_A199_I1.0601.00
130_D148_G1.0450.99
35_W56_V1.0410.99
88_D117_I1.0320.99
53_G71_G1.0300.99
132_A135_Q1.0270.99
110_Q163_V1.0260.99
218_E258_D1.0220.99
115_S144_F1.0150.99
103_A107_A1.0130.99
84_A114_I1.0110.99
109_T112_E1.0100.99
56_V65_P0.9960.99
135_Q138_D0.9880.99
122_E145_D0.9860.99
69_M273_V0.9850.99
103_A136_Y0.9840.99
176_V180_T0.9820.99
52_M64_F0.9800.99
56_V68_L0.9750.99
155_G175_D0.9740.99
179_H254_V0.9730.99
134_Q137_V0.9710.99
74_L273_V0.9690.99
107_A136_Y0.9690.99
53_G72_T0.9680.99
30_A66_L0.9640.99
247_G253_G0.9590.99
103_A132_A0.9550.99
193_H221_V0.9550.99
99_G150_S0.9520.99
39_H63_A0.9490.99
186_G194_E0.9480.99
174_E198_D0.9410.99
228_L232_D0.9360.99
76_M105_V0.9280.99
87_T118_R0.9270.99
107_A127_D0.9260.99
114_I161_S0.9240.99
246_D249_T0.9220.99
167_E191_G0.9200.99
160_L176_V0.9190.99
148_G153_E0.9190.99
98_F161_S0.9140.99
207_I213_T0.9120.99
21_A263_A0.9120.99
82_A257_F0.9100.99
110_Q185_M0.9030.99
91_A118_R0.9010.98
30_A271_H0.8980.98
201_L227_T0.8930.98
99_G160_L0.8910.98
115_S120_I0.8910.98
73_E77_K0.8850.98
87_T161_S0.8800.98
84_A118_R0.8730.98
230_D233_I0.8660.98
19_M36_V0.8610.98
275_E279_E0.8500.98
209_D236_E0.8490.98
83_A183_N0.8470.98
86_A259_S0.8450.98
183_N255_T0.8390.98
32_G55_M0.8370.98
206_V235_A0.8370.98
17_R36_V0.8350.98
235_A239_E0.8340.97
124_V147_R0.8330.97
189_A192_K0.8290.97
86_A183_N0.8240.97
221_V225_E0.8220.97
107_A163_V0.8130.97
101_V170_I0.8100.97
97_S158_D0.8090.97
38_V51_V0.8050.97
76_M109_T0.8040.97
41_D46_H0.8000.97
197_D222_P0.7950.97
236_E239_E0.7890.96
207_I219_I0.7860.96
58_S65_P0.7860.96
69_M270_A0.7820.96
89_H240_I0.7820.96
171_V182_I0.7800.96
80_G109_T0.7790.96
212_Q260_T0.7770.96
83_A185_M0.7730.96
99_G126_S0.7700.96
92_V251_S0.7690.96
84_A116_K0.7670.96
153_E156_H0.7630.96
149_G154_A0.7620.96
248_R251_S0.7610.96
66_L278_S0.7570.96
188_D212_Q0.7560.96
182_I199_I0.7560.96
152_S175_D0.7540.95
197_D201_L0.7520.95
180_T254_V0.7480.95
108_Y140_F0.7430.95
130_D133_V0.7400.95
128_V132_A0.7390.95
126_S171_V0.7370.95
205_L232_D0.7350.95
204_T255_T0.7330.95
243_G247_G0.7320.95
173_A199_I0.7320.95
87_T91_A0.7190.94
91_A159_I0.7180.94
31_A39_H0.7160.94
17_R51_V0.7120.94
192_K258_D0.7100.94
205_L219_I0.7040.93
162_T171_V0.6990.93
112_E144_F0.6980.93
208_D213_T0.6930.93
17_R188_D0.6910.93
57_Y267_V0.6900.93
87_T255_T0.6880.93
17_R192_K0.6830.92
34_K266_D0.6830.92
42_N49_P0.6820.92
171_V196_A0.6810.92
50_T75_T0.6800.92
101_V150_S0.6790.92
42_N47_D0.6780.92
176_V254_V0.6760.92
54_T65_P0.6730.92
204_T245_A0.6710.92
84_A98_F0.6690.92
188_D258_D0.6660.91
99_G149_G0.6630.91
185_M259_S0.6630.91
54_T68_L0.6610.91
53_G75_T0.6590.91
106_Q161_S0.6590.91
212_Q258_D0.6570.91
51_V75_T0.6530.91
18_S35_W0.6520.91
118_R159_I0.6510.91
93_A118_R0.6500.90
65_P68_L0.6490.90
206_V247_G0.6470.90
120_I123_V0.6470.90
19_M215_H0.6450.90
216_S220_N0.6430.90
216_S258_D0.6410.90
38_V53_G0.6400.90
152_S155_G0.6370.90
16_F37_N0.6370.90
209_D262_L0.6350.89
188_D260_T0.6300.89
80_G113_A0.6300.89
125_V137_V0.6290.89
141_S145_D0.6290.89
155_G177_G0.6290.89
155_G174_E0.6240.89
112_E140_F0.6200.88
219_I228_L0.6200.88
179_H248_R0.6200.88
243_G246_D0.6190.88
94_D251_S0.6180.88
216_S260_T0.6140.88
97_S157_C0.6140.88
164_T194_E0.6130.88
86_A257_F0.6110.88
212_Q262_L0.6110.88
82_A262_L0.6040.87
173_A198_D0.5990.87
83_A114_I0.5960.86
272_V275_E0.5960.86
29_D271_H0.5930.86
21_A267_V0.5900.86
31_A60_P0.5900.86
126_S150_S0.5880.86
97_S177_G0.5850.85
147_R150_S0.5840.85
97_S121_E0.5830.85
14_G39_H0.5810.85
30_A274_Y0.5780.85
275_E278_S0.5770.84
134_Q141_S0.5760.84
213_T260_T0.5750.84
96_T119_D0.5740.84
239_E243_G0.5740.84
216_S222_P0.5730.84
182_I195_L0.5730.84
17_R38_V0.5720.84
163_V185_M0.5710.84
200_L205_L0.5710.84
215_H220_N0.5700.84
32_G270_A0.5690.84
222_P227_T0.5680.84
160_L180_T0.5670.83
46_H62_T0.5660.83
78_R260_T0.5650.83
23_M28_W0.5640.83
190_E220_N0.5630.83
151_I172_T0.5630.83
15_D192_K0.5630.83
204_T247_G0.5620.83
139_H142_D0.5610.83
98_F111_L0.5590.83
219_I233_I0.5580.82
85_V88_D0.5570.82
127_D259_S0.5530.82
166_V169_P0.5520.82
85_V237_I0.5500.82
124_V157_C0.5500.82
238_G241_V0.5490.81
39_H59_D0.5470.81
83_A161_S0.5460.81
148_G152_S0.5450.81
178_D254_V0.5450.81
20_P36_V0.5430.81
218_E221_V0.5420.81
86_A237_I0.5410.81
80_G106_Q0.5400.80
23_M268_A0.5390.80
176_V182_I0.5380.80
207_I233_I0.5370.80
16_F31_A0.5370.80
153_E157_C0.5370.80
44_A47_D0.5360.80
142_D145_D0.5350.80
114_I183_N0.5350.80
207_I210_H0.5330.80
103_A133_V0.5330.80
30_A267_V0.5310.79
111_L144_F0.5310.79
243_G248_R0.5290.79
199_I256_V0.5280.79
70_D75_T0.5270.79
187_A194_E0.5260.79
71_G74_L0.5240.78
136_Y139_H0.5240.78
166_V194_E0.5230.78
184_A187_A0.5210.78
170_I184_A0.5210.78
17_R212_Q0.5200.78
43_P46_H0.5200.78
54_T58_S0.5190.78
15_D189_A0.5190.78
215_H218_E0.5180.78
201_L222_P0.5150.77
124_V148_G0.5140.77
38_V188_D0.5140.77
22_Y31_A0.5120.77
15_D188_D0.5120.77
72_T105_V0.5110.77
147_R151_I0.5110.77
83_A87_T0.5100.77
33_I56_V0.5080.76
195_L199_I0.5070.76
125_V140_F0.5070.76
31_A35_W0.5070.76
37_N58_S0.5060.76
171_V199_I0.5060.76
138_D251_S0.5040.76
74_L269_A0.5030.76
96_T122_E0.5020.75
126_S170_I0.5020.75
215_H219_I0.5010.75
19_M38_V0.5010.75
80_G126_S0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1omoA 2 0.9656 100 0.265 Contact Map
4mp8A 2 0.9725 100 0.284 Contact Map
4bvaA 2 0.8969 100 0.304 Contact Map
3hdjA 2 0.9278 100 0.322 Contact Map
1x7dA 2 0.9553 100 0.363 Contact Map
3oj0A 1 0.4742 99.4 0.823 Contact Map
4ppmA 2 0 99.2 0.839 Contact Map
3pwzA 1 0.7766 99 0.85 Contact Map
4k28A 2 0.7388 98.7 0.865 Contact Map
3phhA 1 0.6976 98.7 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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