GREMLIN Database
Q9HN69 - Uncharacterized protein
UniProt: Q9HN69 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (170)
Sequences: 387 (242)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_I33_I4.6781.00
112_T160_Y4.3341.00
23_R27_A4.1061.00
120_T124_V3.0680.99
6_I64_G2.9020.99
116_M143_A2.8360.98
14_L60_V2.7260.98
106_I126_I2.5880.97
82_M111_R2.4630.96
16_G19_G2.3130.95
6_I14_L2.2660.94
22_L35_V2.1590.92
155_P158_S2.0840.91
88_I105_L1.9970.89
105_L126_I1.9510.88
65_R128_G1.8440.85
141_D145_S1.8140.84
50_P163_L1.7670.82
89_G105_L1.7630.82
117_E150_L1.7610.82
75_L160_Y1.7540.81
15_I19_G1.7360.81
97_D100_R1.7310.81
29_A56_A1.7300.81
84_D144_R1.7040.79
65_R130_T1.6030.75
112_T115_L1.5910.75
105_L150_L1.5400.72
166_K170_E1.5380.72
15_I113_R1.5370.72
105_L131_F1.5160.71
60_V111_R1.5030.70
25_I56_A1.4550.68
68_K71_E1.4540.67
71_E74_T1.4310.66
11_I40_G1.4040.65
85_T147_A1.3770.63
68_K126_I1.3660.62
85_T132_G1.3650.62
38_Q42_V1.3600.62
17_D63_I1.3550.62
105_L147_A1.3490.61
37_S40_G1.3230.60
149_M162_F1.3130.59
73_L111_R1.2990.59
46_R73_L1.2810.57
137_P167_R1.2750.57
115_L119_L1.2740.57
6_I11_I1.2710.57
89_G129_S1.2630.56
59_I76_L1.2570.56
7_P64_G1.2550.56
10_R13_V1.2540.56
25_I94_N1.2500.56
5_K138_S1.2360.55
15_I22_L1.2340.55
42_V75_L1.2340.55
60_V133_V1.2280.54
70_D111_R1.2130.53
114_E126_I1.1880.52
20_E140_V1.1860.52
121_G139_E1.1830.51
60_V105_L1.1710.51
34_D42_V1.1550.50
15_I121_G1.1460.49
133_V143_A1.1310.48
120_T171_L1.1250.48
19_G22_L1.1130.47
12_G146_A1.1040.46
71_E123_S1.0990.46
119_L167_R1.0820.45
6_I9_D1.0800.45
31_V119_L1.0780.45
13_V63_I1.0730.44
34_D143_A1.0670.44
84_D145_S1.0650.44
41_A171_L1.0580.44
29_A76_L1.0520.43
30_E48_G1.0400.42
102_K127_Y1.0310.42
89_G131_F1.0300.42
4_V19_G1.0290.42
145_S162_F1.0250.42
104_R110_G1.0130.41
48_G83_F0.9910.40
155_P161_S0.9880.39
115_L146_A0.9880.39
25_I59_I0.9860.39
15_I37_S0.9820.39
10_R14_L0.9790.39
53_G59_I0.9790.39
133_V140_V0.9680.38
35_V157_G0.9660.38
9_D127_Y0.9640.38
12_G16_G0.9620.38
53_G167_R0.9620.38
110_G153_G0.9570.37
92_A101_K0.9450.37
18_G31_V0.9450.37
4_V15_I0.9440.37
50_P136_Q0.9430.37
20_E23_R0.9430.37
30_E47_T0.9310.36
27_A76_L0.9280.36
11_I163_L0.9200.35
14_L72_A0.9180.35
35_V145_S0.9100.35
47_T52_R0.9050.35
71_E125_V0.8950.34
20_E70_D0.8920.34
103_G108_E0.8920.34
20_E171_L0.8890.34
35_V82_M0.8810.33
21_T147_A0.8760.33
137_P141_D0.8740.33
109_N160_Y0.8740.33
50_P126_I0.8680.32
115_L160_Y0.8590.32
69_P106_I0.8550.32
113_R154_A0.8520.32
34_D90_R0.8510.32
4_V149_M0.8500.31
80_M102_K0.8470.31
13_V127_Y0.8460.31
39_D124_V0.8350.31
12_G19_G0.8340.31
9_D13_V0.8320.31
15_I126_I0.8300.30
49_D113_R0.8230.30
92_A97_D0.8180.30
19_G37_S0.8130.30
54_M158_S0.8110.29
122_A133_V0.8050.29
69_P113_R0.8000.29
8_T11_I0.8000.29
128_G139_E0.7910.28
44_I144_R0.7890.28
89_G94_N0.7870.28
77_D132_G0.7830.28
24_R34_D0.7810.28
50_P83_F0.7770.28
127_Y132_G0.7680.27
58_E88_I0.7660.27
34_D131_F0.7650.27
25_I168_S0.7630.27
19_G162_F0.7620.27
131_F147_A0.7620.27
30_E120_T0.7610.27
46_R52_R0.7610.27
105_L146_A0.7610.27
44_I131_F0.7570.27
87_D156_H0.7510.26
44_I57_P0.7500.26
3_H39_D0.7460.26
106_I114_E0.7450.26
71_E113_R0.7380.26
76_L144_R0.7360.26
50_P133_V0.7320.25
62_A67_F0.7310.25
55_Q136_Q0.7260.25
45_E49_D0.7190.25
22_L168_S0.7180.25
15_I40_G0.7040.24
88_I102_K0.7010.24
129_S147_A0.7000.24
40_G69_P0.6990.24
163_L172_K0.6960.24
107_G110_G0.6950.24
76_L100_R0.6940.24
97_D151_L0.6900.24
91_A147_A0.6890.24
86_I111_R0.6860.23
43_A118_E0.6840.23
101_K151_L0.6810.23
11_I35_V0.6800.23
154_A157_G0.6720.23
72_A113_R0.6720.23
53_G159_V0.6700.23
79_D108_E0.6690.23
55_Q81_R0.6630.22
98_L139_E0.6610.22
45_E52_R0.6580.22
105_L142_V0.6580.22
58_E101_K0.6520.22
31_V56_A0.6500.22
104_R107_G0.6480.22
25_I89_G0.6450.22
84_D141_D0.6440.22
81_R172_K0.6410.21
153_G159_V0.6400.21
68_K113_R0.6360.21
164_E173_Q0.6340.21
21_T103_G0.6310.21
104_R153_G0.6240.21
49_D70_D0.6220.21
156_H161_S0.6210.21
56_A70_D0.6200.21
89_G93_R0.6170.20
87_D129_S0.6170.20
25_I50_P0.6120.20
144_R154_A0.6070.20
21_T85_T0.6070.20
79_D95_D0.6010.20
34_D53_G0.5930.19
100_R110_G0.5920.19
19_G69_P0.5900.19
55_Q59_I0.5900.19
37_S64_G0.5890.19
39_D47_T0.5820.19
83_F113_R0.5800.19
143_A147_A0.5770.19
82_M140_V0.5740.19
125_V132_G0.5680.19
106_I119_L0.5680.19
9_D87_D0.5670.18
43_A77_D0.5670.18
77_D140_V0.5660.18
16_G69_P0.5640.18
65_R141_D0.5620.18
141_D147_A0.5610.18
42_V53_G0.5590.18
114_E137_P0.5540.18
21_T131_F0.5540.18
47_T158_S0.5540.18
164_E168_S0.5530.18
154_A166_K0.5520.18
157_G161_S0.5490.18
98_L142_V0.5490.18
58_E74_T0.5490.18
111_R167_R0.5450.18
30_E124_V0.5430.18
28_A165_R0.5400.17
157_G160_Y0.5380.17
83_F131_F0.5350.17
97_D129_S0.5330.17
134_I158_S0.5320.17
99_R123_S0.5290.17
22_L108_E0.5290.17
59_I91_A0.5270.17
4_V103_G0.5250.17
47_T101_K0.5180.17
22_L83_F0.5180.17
28_A32_D0.5180.17
65_R127_Y0.5170.17
83_F126_I0.5140.17
8_T143_A0.5120.16
12_G60_V0.5080.16
35_V119_L0.5070.16
16_G63_I0.5060.16
22_L73_L0.5060.16
71_E95_D0.5030.16
48_G109_N0.5020.16
10_R118_E0.5010.16
22_L26_E0.5000.16
81_R139_E0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qmfD 1 0.929 100 0.341 Contact Map
2e3uA 1 0.8743 100 0.421 Contact Map
1tuaA 1 0.9836 100 0.466 Contact Map
1j4wA 1 0.6831 99.5 0.774 Contact Map
2jvzA 1 0.7814 99.5 0.774 Contact Map
3krmA 3 0.7541 99.5 0.778 Contact Map
2anrA 1 0.7377 99.4 0.786 Contact Map
2jzxA 1 0.7705 99.3 0.792 Contact Map
2qndA 2 0.6776 99.2 0.806 Contact Map
3n89A 2 0.918 98.7 0.841 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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