Q9HN69 - HALSA - GREMLIN Contacts

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Q9HN69 - Uncharacterized protein

UniProt:	Q9HN69	Sequences: MKHVKIPTDRIGVLIGDGGETLRRIEAAAEVDIDVDSQDGAVAIERTGDPVRGMQAPEIVQAIGRGFKPDEALTLLDDDMRMFDTIDIGRAARNDNDLRRKKGRLIGENGRTRELMEELTGASVVIYGSTFGVIGQPSEVDVARSAAEMLLDGAPHGSVYSFLERKRSEELKQQGMEYHEFPG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	183 (170)
Sequences:	387 (242)
Seq/√Len:	18.5

HALSA - Q9HN69
SULSO - Q97W64

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_I	33_I	4.678	1.00
112_T	160_Y	4.334	1.00
23_R	27_A	4.106	1.00
120_T	124_V	3.068	0.99
6_I	64_G	2.902	0.99
116_M	143_A	2.836	0.98
14_L	60_V	2.726	0.98
106_I	126_I	2.588	0.97
82_M	111_R	2.463	0.96
16_G	19_G	2.313	0.95
6_I	14_L	2.266	0.94
22_L	35_V	2.159	0.92
155_P	158_S	2.084	0.91
88_I	105_L	1.997	0.89
105_L	126_I	1.951	0.88
65_R	128_G	1.844	0.85
141_D	145_S	1.814	0.84
50_P	163_L	1.767	0.82
89_G	105_L	1.763	0.82
117_E	150_L	1.761	0.82
75_L	160_Y	1.754	0.81
15_I	19_G	1.736	0.81
97_D	100_R	1.731	0.81
29_A	56_A	1.730	0.81
84_D	144_R	1.704	0.79
65_R	130_T	1.603	0.75
112_T	115_L	1.591	0.75
105_L	150_L	1.540	0.72
166_K	170_E	1.538	0.72
15_I	113_R	1.537	0.72
105_L	131_F	1.516	0.71
60_V	111_R	1.503	0.70
25_I	56_A	1.455	0.68
68_K	71_E	1.454	0.67
71_E	74_T	1.431	0.66
11_I	40_G	1.404	0.65
85_T	147_A	1.377	0.63
68_K	126_I	1.366	0.62
85_T	132_G	1.365	0.62
38_Q	42_V	1.360	0.62
17_D	63_I	1.355	0.62
105_L	147_A	1.349	0.61
37_S	40_G	1.323	0.60
149_M	162_F	1.313	0.59
73_L	111_R	1.299	0.59
46_R	73_L	1.281	0.57
137_P	167_R	1.275	0.57
115_L	119_L	1.274	0.57
6_I	11_I	1.271	0.57
89_G	129_S	1.263	0.56
59_I	76_L	1.257	0.56
7_P	64_G	1.255	0.56
10_R	13_V	1.254	0.56
25_I	94_N	1.250	0.56
5_K	138_S	1.236	0.55
15_I	22_L	1.234	0.55
42_V	75_L	1.234	0.55
60_V	133_V	1.228	0.54
70_D	111_R	1.213	0.53
114_E	126_I	1.188	0.52
20_E	140_V	1.186	0.52
121_G	139_E	1.183	0.51
60_V	105_L	1.171	0.51
34_D	42_V	1.155	0.50
15_I	121_G	1.146	0.49
133_V	143_A	1.131	0.48
120_T	171_L	1.125	0.48
19_G	22_L	1.113	0.47
12_G	146_A	1.104	0.46
71_E	123_S	1.099	0.46
119_L	167_R	1.082	0.45
6_I	9_D	1.080	0.45
31_V	119_L	1.078	0.45
13_V	63_I	1.073	0.44
34_D	143_A	1.067	0.44
84_D	145_S	1.065	0.44
41_A	171_L	1.058	0.44
29_A	76_L	1.052	0.43
30_E	48_G	1.040	0.42
102_K	127_Y	1.031	0.42
89_G	131_F	1.030	0.42
4_V	19_G	1.029	0.42
145_S	162_F	1.025	0.42
104_R	110_G	1.013	0.41
48_G	83_F	0.991	0.40
155_P	161_S	0.988	0.39
115_L	146_A	0.988	0.39
25_I	59_I	0.986	0.39
15_I	37_S	0.982	0.39
10_R	14_L	0.979	0.39
53_G	59_I	0.979	0.39
133_V	140_V	0.968	0.38
35_V	157_G	0.966	0.38
9_D	127_Y	0.964	0.38
12_G	16_G	0.962	0.38
53_G	167_R	0.962	0.38
110_G	153_G	0.957	0.37
92_A	101_K	0.945	0.37
18_G	31_V	0.945	0.37
4_V	15_I	0.944	0.37
50_P	136_Q	0.943	0.37
20_E	23_R	0.943	0.37
30_E	47_T	0.931	0.36
27_A	76_L	0.928	0.36
11_I	163_L	0.920	0.35
14_L	72_A	0.918	0.35
35_V	145_S	0.910	0.35
47_T	52_R	0.905	0.35
71_E	125_V	0.895	0.34
20_E	70_D	0.892	0.34
103_G	108_E	0.892	0.34
20_E	171_L	0.889	0.34
35_V	82_M	0.881	0.33
21_T	147_A	0.876	0.33
137_P	141_D	0.874	0.33
109_N	160_Y	0.874	0.33
50_P	126_I	0.868	0.32
115_L	160_Y	0.859	0.32
69_P	106_I	0.855	0.32
113_R	154_A	0.852	0.32
34_D	90_R	0.851	0.32
4_V	149_M	0.850	0.31
80_M	102_K	0.847	0.31
13_V	127_Y	0.846	0.31
39_D	124_V	0.835	0.31
12_G	19_G	0.834	0.31
9_D	13_V	0.832	0.31
15_I	126_I	0.830	0.30
49_D	113_R	0.823	0.30
92_A	97_D	0.818	0.30
19_G	37_S	0.813	0.30
54_M	158_S	0.811	0.29
122_A	133_V	0.805	0.29
69_P	113_R	0.800	0.29
8_T	11_I	0.800	0.29
128_G	139_E	0.791	0.28
44_I	144_R	0.789	0.28
89_G	94_N	0.787	0.28
77_D	132_G	0.783	0.28
24_R	34_D	0.781	0.28
50_P	83_F	0.777	0.28
127_Y	132_G	0.768	0.27
58_E	88_I	0.766	0.27
34_D	131_F	0.765	0.27
25_I	168_S	0.763	0.27
19_G	162_F	0.762	0.27
131_F	147_A	0.762	0.27
30_E	120_T	0.761	0.27
46_R	52_R	0.761	0.27
105_L	146_A	0.761	0.27
44_I	131_F	0.757	0.27
87_D	156_H	0.751	0.26
44_I	57_P	0.750	0.26
3_H	39_D	0.746	0.26
106_I	114_E	0.745	0.26
71_E	113_R	0.738	0.26
76_L	144_R	0.736	0.26
50_P	133_V	0.732	0.25
62_A	67_F	0.731	0.25
55_Q	136_Q	0.726	0.25
45_E	49_D	0.719	0.25
22_L	168_S	0.718	0.25
15_I	40_G	0.704	0.24
88_I	102_K	0.701	0.24
129_S	147_A	0.700	0.24
40_G	69_P	0.699	0.24
163_L	172_K	0.696	0.24
107_G	110_G	0.695	0.24
76_L	100_R	0.694	0.24
97_D	151_L	0.690	0.24
91_A	147_A	0.689	0.24
86_I	111_R	0.686	0.23
43_A	118_E	0.684	0.23
101_K	151_L	0.681	0.23
11_I	35_V	0.680	0.23
154_A	157_G	0.672	0.23
72_A	113_R	0.672	0.23
53_G	159_V	0.670	0.23
79_D	108_E	0.669	0.23
55_Q	81_R	0.663	0.22
98_L	139_E	0.661	0.22
45_E	52_R	0.658	0.22
105_L	142_V	0.658	0.22
58_E	101_K	0.652	0.22
31_V	56_A	0.650	0.22
104_R	107_G	0.648	0.22
25_I	89_G	0.645	0.22
84_D	141_D	0.644	0.22
81_R	172_K	0.641	0.21
153_G	159_V	0.640	0.21
68_K	113_R	0.636	0.21
164_E	173_Q	0.634	0.21
21_T	103_G	0.631	0.21
104_R	153_G	0.624	0.21
49_D	70_D	0.622	0.21
156_H	161_S	0.621	0.21
56_A	70_D	0.620	0.21
89_G	93_R	0.617	0.20
87_D	129_S	0.617	0.20
25_I	50_P	0.612	0.20
144_R	154_A	0.607	0.20
21_T	85_T	0.607	0.20
79_D	95_D	0.601	0.20
34_D	53_G	0.593	0.19
100_R	110_G	0.592	0.19
19_G	69_P	0.590	0.19
55_Q	59_I	0.590	0.19
37_S	64_G	0.589	0.19
39_D	47_T	0.582	0.19
83_F	113_R	0.580	0.19
143_A	147_A	0.577	0.19
82_M	140_V	0.574	0.19
125_V	132_G	0.568	0.19
106_I	119_L	0.568	0.19
9_D	87_D	0.567	0.18
43_A	77_D	0.567	0.18
77_D	140_V	0.566	0.18
16_G	69_P	0.564	0.18
65_R	141_D	0.562	0.18
141_D	147_A	0.561	0.18
42_V	53_G	0.559	0.18
114_E	137_P	0.554	0.18
21_T	131_F	0.554	0.18
47_T	158_S	0.554	0.18
164_E	168_S	0.553	0.18
154_A	166_K	0.552	0.18
157_G	161_S	0.549	0.18
98_L	142_V	0.549	0.18
58_E	74_T	0.549	0.18
111_R	167_R	0.545	0.18
30_E	124_V	0.543	0.18
28_A	165_R	0.540	0.17
157_G	160_Y	0.538	0.17
83_F	131_F	0.535	0.17
97_D	129_S	0.533	0.17
134_I	158_S	0.532	0.17
99_R	123_S	0.529	0.17
22_L	108_E	0.529	0.17
59_I	91_A	0.527	0.17
4_V	103_G	0.525	0.17
47_T	101_K	0.518	0.17
22_L	83_F	0.518	0.17
28_A	32_D	0.518	0.17
65_R	127_Y	0.517	0.17
83_F	126_I	0.514	0.17
8_T	143_A	0.512	0.16
12_G	60_V	0.508	0.16
35_V	119_L	0.507	0.16
16_G	63_I	0.506	0.16
22_L	73_L	0.506	0.16
71_E	95_D	0.503	0.16
48_G	109_N	0.502	0.16
10_R	118_E	0.501	0.16
22_L	26_E	0.500	0.16
81_R	139_E	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qmfD	1	0.929	100	0.341	Contact Map
2e3uA	1	0.8743	100	0.421	Contact Map
1tuaA	1	0.9836	100	0.466	Contact Map
1j4wA	1	0.6831	99.5	0.774	Contact Map
2jvzA	1	0.7814	99.5	0.774	Contact Map
3krmA	3	0.7541	99.5	0.778	Contact Map
2anrA	1	0.7377	99.4	0.786	Contact Map
2jzxA	1	0.7705	99.3	0.792	Contact Map
2qndA	2	0.6776	99.2	0.806	Contact Map
3n89A	2	0.918	98.7	0.841	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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