GREMLIN Database
Q9HN68 - Uncharacterized protein
UniProt: Q9HN68 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (267)
Sequences: 173 (156)
Seq/√Len: 9.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_V137_F3.7290.98
137_F148_A3.4080.96
24_L60_V3.3920.96
14_D47_R3.1570.94
14_D54_E2.6340.85
154_R227_W2.5480.83
214_Y221_V2.4610.81
49_N260_T2.3460.78
33_F164_F2.2720.75
57_G61_E2.2550.75
108_L248_V2.2390.74
178_E181_Y2.2200.74
157_S160_L2.1640.72
219_R240_G2.1410.71
133_V149_I2.0230.66
4_D224_T2.0050.65
44_D49_N1.9810.64
85_Y207_H1.9780.64
175_H237_W1.9720.64
45_S112_Y1.9580.63
4_D253_D1.9570.63
240_G243_G1.9520.63
37_R41_D1.9380.63
73_G213_F1.9140.62
9_F22_R1.9070.61
65_D143_D1.9040.61
8_A35_E1.8980.61
213_F257_L1.8850.60
99_G228_H1.8720.60
101_C121_C1.8620.59
69_L73_G1.8570.59
133_V148_A1.8320.58
99_G108_L1.8260.58
35_E263_D1.7840.56
5_A9_F1.7680.55
47_R145_L1.7550.55
33_F63_T1.7320.54
36_L48_F1.7290.54
44_D112_Y1.6990.52
119_V197_S1.6900.52
163_G210_V1.6860.52
15_E171_P1.6570.50
101_C104_C1.6530.50
201_A227_W1.6260.49
33_F85_Y1.6020.48
19_R142_E1.5890.47
150_D154_R1.5830.47
141_R146_A1.5720.47
98_D242_A1.5680.46
24_L59_F1.5630.46
137_F141_R1.5520.46
114_D200_A1.5510.46
31_L39_C1.5490.45
138_V158_R1.5340.45
175_H241_A1.5300.45
65_D253_D1.5140.44
57_G267_V1.5040.43
216_D223_D1.4860.43
136_A191_R1.4700.42
106_S123_D1.4640.42
112_Y201_A1.4630.42
114_D205_V1.4610.42
46_G112_Y1.4580.41
162_D202_W1.4570.41
43_Q229_L1.4410.41
63_T219_R1.4390.41
39_C259_V1.4370.41
18_V230_D1.4160.40
78_G137_F1.4150.40
15_E18_V1.4130.40
144_D255_E1.4010.39
104_C121_C1.3980.39
76_L123_D1.3920.39
5_A13_A1.3720.38
18_V80_L1.3720.38
133_V238_V1.3710.38
80_L200_A1.3670.38
190_E212_S1.3650.37
62_Q86_T1.3620.37
21_L170_G1.3580.37
98_D217_H1.3570.37
33_F64_E1.3510.37
133_V159_S1.3380.36
132_G269_A1.3350.36
24_L48_F1.3330.36
21_L108_L1.3250.36
200_A247_T1.3080.35
46_G137_F1.3030.35
112_Y210_V1.2700.34
108_L149_I1.2670.33
33_F110_A1.2520.33
17_R51_H1.2440.33
17_R50_Y1.2440.33
203_V216_D1.2380.32
152_Y199_L1.2370.32
14_D34_S1.2290.32
39_C88_T1.2220.32
106_S122_T1.2200.32
61_E97_V1.2150.31
125_E253_D1.2090.31
76_L79_S1.2070.31
20_I48_F1.2050.31
14_D62_Q1.2030.31
7_A10_S1.2030.31
8_A78_G1.2020.31
79_S253_D1.1990.31
144_D254_D1.1850.30
70_R261_V1.1810.30
46_G148_A1.1700.30
149_I233_A1.1630.29
179_N223_D1.1540.29
109_E188_N1.1480.29
25_W137_F1.1420.29
78_G167_T1.1380.29
150_D211_L1.1340.28
217_H254_D1.1250.28
166_P238_V1.1250.28
100_T209_A1.1240.28
15_E85_Y1.1160.28
46_G49_N1.1120.28
24_L53_G1.1120.28
62_Q119_V1.1090.27
118_K176_L1.1050.27
7_A242_A1.1030.27
160_L254_D1.1000.27
72_A135_P1.0930.27
84_V162_D1.0920.27
77_V195_S1.0910.27
175_H239_D1.0840.27
82_S128_I1.0840.27
111_V254_D1.0800.26
207_H236_E1.0780.26
75_K167_T1.0750.26
76_L260_T1.0750.26
59_F136_A1.0740.26
69_L75_K1.0740.26
145_L255_E1.0710.26
10_S64_E1.0660.26
146_A228_H1.0560.26
78_G124_C1.0490.25
170_G219_R1.0370.25
98_D239_D1.0310.25
13_A216_D1.0290.25
24_L36_L1.0230.25
255_E269_A1.0220.24
108_L141_R1.0190.24
83_G114_D1.0180.24
12_V70_R1.0160.24
70_R136_A1.0130.24
13_A247_T0.9970.24
17_R48_F0.9930.24
94_P97_V0.9900.23
149_I225_A0.9900.23
45_S49_N0.9880.23
81_H212_S0.9840.23
97_V123_D0.9840.23
207_H223_D0.9790.23
80_L103_L0.9680.23
89_G145_L0.9620.23
170_G210_V0.9580.22
19_R147_A0.9570.22
128_I208_P0.9530.22
112_Y245_R0.9510.22
84_V88_T0.9490.22
217_H257_L0.9470.22
77_V199_L0.9420.22
65_D261_V0.9390.22
56_R153_V0.9350.22
173_A207_H0.9280.22
238_V249_E0.9240.21
124_C148_A0.9240.21
173_A190_E0.9180.21
86_T134_P0.9150.21
204_A259_V0.9120.21
33_F47_R0.9100.21
25_W161_L0.9080.21
25_W31_L0.8990.21
141_R148_A0.8930.20
66_G73_G0.8930.20
208_P215_D0.8920.20
48_F79_S0.8880.20
200_A269_A0.8860.20
32_S97_V0.8850.20
176_L200_A0.8840.20
91_M239_D0.8810.20
63_T249_E0.8770.20
54_E151_G0.8760.20
214_Y217_H0.8750.20
78_G164_F0.8750.20
45_S70_R0.8720.20
23_E237_W0.8700.20
122_T177_A0.8700.20
34_S214_Y0.8630.20
33_F213_F0.8630.20
21_L131_T0.8560.19
78_G265_L0.8540.19
51_H55_L0.8540.19
50_Y55_L0.8540.19
119_V254_D0.8530.19
220_S223_D0.8520.19
21_L82_S0.8460.19
6_E31_L0.8440.19
44_D137_F0.8410.19
26_D173_A0.8390.19
21_L77_V0.8360.19
154_R225_A0.8360.19
49_N85_Y0.8160.18
198_G254_D0.8160.18
106_S256_R0.8110.18
5_A22_R0.8070.18
54_E218_D0.8050.18
22_R152_Y0.8040.18
182_G197_S0.8000.18
32_S35_E0.8000.18
35_E111_V0.7970.18
16_L35_E0.7960.18
155_T164_F0.7940.18
58_L259_V0.7930.18
107_D222_R0.7910.18
47_R144_D0.7800.17
97_V222_R0.7780.17
26_D266_A0.7750.17
27_A96_S0.7720.17
129_I145_L0.7670.17
33_F45_S0.7670.17
19_R97_V0.7660.17
147_A263_D0.7630.17
33_F46_G0.7610.17
221_V231_W0.7590.17
123_D180_D0.7560.17
169_S214_Y0.7560.17
72_A113_E0.7560.17
97_V207_H0.7530.17
131_T156_T0.7520.17
48_F210_V0.7500.17
68_D147_A0.7480.17
28_D49_N0.7470.17
157_S263_D0.7460.17
52_L55_L0.7450.16
27_A105_G0.7440.16
126_V193_G0.7430.16
12_V102_V0.7410.16
72_A114_D0.7380.16
5_A251_R0.7350.16
65_D213_F0.7310.16
26_D105_G0.7290.16
124_C158_R0.7280.16
117_G142_E0.7280.16
154_R200_A0.7260.16
16_L240_G0.7240.16
124_C133_V0.7230.16
149_I173_A0.7230.16
64_E253_D0.7220.16
69_L213_F0.7220.16
113_E254_D0.7210.16
9_F150_D0.7180.16
64_E79_S0.7150.16
11_A268_T0.7150.16
49_N60_V0.7120.16
23_E47_R0.7060.16
38_E100_T0.7060.16
216_D256_R0.7040.15
159_S238_V0.6930.15
13_A110_A0.6910.15
98_D255_E0.6900.15
49_N112_Y0.6870.15
48_F51_H0.6800.15
47_R156_T0.6790.15
209_A270_V0.6790.15
59_F250_V0.6760.15
20_I43_Q0.6740.15
46_G153_V0.6730.15
211_L264_D0.6720.15
209_A213_F0.6680.15
253_D264_D0.6670.15
30_P232_L0.6650.15
165_C192_C0.6600.14
168_C189_C0.6600.14
165_C189_C0.6600.14
168_C192_C0.6600.14
189_C192_C0.6600.14
165_C168_C0.6600.14
116_V181_Y0.6560.14
66_G138_V0.6560.14
53_G172_T0.6530.14
207_H267_V0.6520.14
98_D186_V0.6510.14
12_V147_A0.6480.14
85_Y137_F0.6470.14
99_G227_W0.6460.14
15_E254_D0.6430.14
35_E125_E0.6420.14
113_E217_H0.6410.14
21_L234_D0.6380.14
41_D217_H0.6360.14
137_F166_P0.6350.14
20_I49_N0.6330.14
237_W262_T0.6300.14
14_D145_L0.6300.14
159_S218_D0.6290.14
124_C137_F0.6280.14
81_H98_D0.6280.14
249_E264_D0.6260.14
60_V261_V0.6240.14
45_S48_F0.6240.14
160_L209_A0.6240.14
119_V219_R0.6230.14
87_E141_R0.6210.14
37_R49_N0.6210.14
129_I226_L0.6190.14
75_K124_C0.6170.14
12_V157_S0.6150.14
96_S181_Y0.6140.13
13_A185_A0.6100.13
148_A166_P0.6100.13
144_D242_A0.6100.13
78_G169_S0.6100.13
16_L78_G0.6090.13
137_F164_F0.6090.13
215_D222_R0.6060.13
152_Y191_R0.6050.13
46_G74_R0.6030.13
101_C134_P0.6000.13
13_A80_L0.5990.13
79_S86_T0.5990.13
130_Q255_E0.5980.13
145_L176_L0.5960.13
126_V178_E0.5910.13
150_D227_W0.5900.13
174_G242_A0.5900.13
177_A255_E0.5890.13
48_F134_P0.5870.13
46_G233_A0.5860.13
63_T66_G0.5850.13
34_S264_D0.5840.13
127_T145_L0.5830.13
6_E259_V0.5800.13
39_C42_V0.5790.13
86_T152_Y0.5790.13
142_E155_T0.5750.13
125_E250_V0.5750.13
185_A217_H0.5720.13
89_G102_V0.5700.13
237_W268_T0.5690.13
20_I250_V0.5650.13
97_V265_L0.5640.12
39_C224_T0.5640.12
96_S237_W0.5620.12
47_R223_D0.5610.12
146_A154_R0.5610.12
45_S227_W0.5600.12
104_C134_P0.5590.12
113_E142_E0.5580.12
175_H265_L0.5580.12
16_L163_G0.5580.12
146_A164_F0.5570.12
149_I152_Y0.5520.12
213_F217_H0.5500.12
131_T152_Y0.5480.12
58_L146_A0.5460.12
209_A214_Y0.5440.12
56_R114_D0.5430.12
224_T246_A0.5400.12
119_V201_A0.5380.12
220_S266_A0.5380.12
99_G218_D0.5380.12
59_F266_A0.5370.12
88_T102_V0.5360.12
117_G261_V0.5350.12
91_M241_A0.5350.12
37_R47_R0.5340.12
214_Y219_R0.5330.12
123_D179_N0.5330.12
12_V151_G0.5320.12
47_R83_G0.5320.12
263_D266_A0.5310.12
212_S217_H0.5300.12
27_A136_A0.5290.12
72_A85_Y0.5280.12
97_V179_N0.5280.12
54_E248_V0.5280.12
20_I267_V0.5270.12
220_S262_T0.5240.12
193_G222_R0.5240.12
202_W225_A0.5230.12
66_G213_F0.5230.12
143_D176_L0.5220.12
124_C138_V0.5210.12
175_H220_S0.5180.12
83_G205_V0.5160.12
64_E170_G0.5130.12
115_Q150_D0.5110.11
40_V44_D0.5070.11
80_L87_E0.5060.11
63_T213_F0.5050.11
39_C54_E0.5040.11
73_G257_L0.5030.11
195_S235_A0.5020.11
14_D242_A0.5000.11
9_F17_R0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gcvA 3 0.4964 98.4 0.899 Contact Map
2f2eA 4 0.4565 98.4 0.9 Contact Map
1y0uA 2 0.2609 98.4 0.9 Contact Map
3f6vA 2 0.3116 98.3 0.904 Contact Map
2zkzA 2 0.2971 98.1 0.909 Contact Map
2kkoA 2 0.337 98 0.91 Contact Map
2fswA 2 0.3152 98 0.91 Contact Map
3cuoA 2 0.3043 98 0.911 Contact Map
4k2eA 2 0.3043 98 0.911 Contact Map
3pqkA 2 0.3225 97.9 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0087 seconds.