Q9HN68 - HALSA - GREMLIN Contacts

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Q9HN68 - Uncharacterized protein

UniProt:	Q9HN68	Sequences: MTDDAEAAFSAVADELRVRILRELWDADDPLSFSELRECVDVQDSGRFNYHLGELRGLFVEQTEDGYDLRFAGRKLVGSLHSGVYTETGGMVGPQSVDGTCVLCGSDLEAVYEDQVGKVDCTDCEVTIIQTGVPPAFVDGREDDLAAAIDGYVRTTSRSLLDGFCPTCSGPTAGHLAENDYGPQAVVNCERCGISFSGLAAWVAVDHPAVLSFYDDHDRSVRDTALWHLDWLADAEWVDGAAGDRATVEVRLDDERLRVTVTDDLAVTAVDRAQTD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	276 (267)
Sequences:	173 (156)
Seq/√Len:	9.6

HALSA - Q9HN68 Q9HRF4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
133_V	137_F	3.729	0.98
137_F	148_A	3.408	0.96
24_L	60_V	3.392	0.96
14_D	47_R	3.157	0.94
14_D	54_E	2.634	0.85
154_R	227_W	2.548	0.83
214_Y	221_V	2.461	0.81
49_N	260_T	2.346	0.78
33_F	164_F	2.272	0.75
57_G	61_E	2.255	0.75
108_L	248_V	2.239	0.74
178_E	181_Y	2.220	0.74
157_S	160_L	2.164	0.72
219_R	240_G	2.141	0.71
133_V	149_I	2.023	0.66
4_D	224_T	2.005	0.65
44_D	49_N	1.981	0.64
85_Y	207_H	1.978	0.64
175_H	237_W	1.972	0.64
45_S	112_Y	1.958	0.63
4_D	253_D	1.957	0.63
240_G	243_G	1.952	0.63
37_R	41_D	1.938	0.63
73_G	213_F	1.914	0.62
9_F	22_R	1.907	0.61
65_D	143_D	1.904	0.61
8_A	35_E	1.898	0.61
213_F	257_L	1.885	0.60
99_G	228_H	1.872	0.60
101_C	121_C	1.862	0.59
69_L	73_G	1.857	0.59
133_V	148_A	1.832	0.58
99_G	108_L	1.826	0.58
35_E	263_D	1.784	0.56
5_A	9_F	1.768	0.55
47_R	145_L	1.755	0.55
33_F	63_T	1.732	0.54
36_L	48_F	1.729	0.54
44_D	112_Y	1.699	0.52
119_V	197_S	1.690	0.52
163_G	210_V	1.686	0.52
15_E	171_P	1.657	0.50
101_C	104_C	1.653	0.50
201_A	227_W	1.626	0.49
33_F	85_Y	1.602	0.48
19_R	142_E	1.589	0.47
150_D	154_R	1.583	0.47
141_R	146_A	1.572	0.47
98_D	242_A	1.568	0.46
24_L	59_F	1.563	0.46
137_F	141_R	1.552	0.46
114_D	200_A	1.551	0.46
31_L	39_C	1.549	0.45
138_V	158_R	1.534	0.45
175_H	241_A	1.530	0.45
65_D	253_D	1.514	0.44
57_G	267_V	1.504	0.43
216_D	223_D	1.486	0.43
136_A	191_R	1.470	0.42
106_S	123_D	1.464	0.42
112_Y	201_A	1.463	0.42
114_D	205_V	1.461	0.42
46_G	112_Y	1.458	0.41
162_D	202_W	1.457	0.41
43_Q	229_L	1.441	0.41
63_T	219_R	1.439	0.41
39_C	259_V	1.437	0.41
18_V	230_D	1.416	0.40
78_G	137_F	1.415	0.40
15_E	18_V	1.413	0.40
144_D	255_E	1.401	0.39
104_C	121_C	1.398	0.39
76_L	123_D	1.392	0.39
5_A	13_A	1.372	0.38
18_V	80_L	1.372	0.38
133_V	238_V	1.371	0.38
80_L	200_A	1.367	0.38
190_E	212_S	1.365	0.37
62_Q	86_T	1.362	0.37
21_L	170_G	1.358	0.37
98_D	217_H	1.357	0.37
33_F	64_E	1.351	0.37
133_V	159_S	1.338	0.36
132_G	269_A	1.335	0.36
24_L	48_F	1.333	0.36
21_L	108_L	1.325	0.36
200_A	247_T	1.308	0.35
46_G	137_F	1.303	0.35
112_Y	210_V	1.270	0.34
108_L	149_I	1.267	0.33
33_F	110_A	1.252	0.33
17_R	51_H	1.244	0.33
17_R	50_Y	1.244	0.33
203_V	216_D	1.238	0.32
152_Y	199_L	1.237	0.32
14_D	34_S	1.229	0.32
39_C	88_T	1.222	0.32
106_S	122_T	1.220	0.32
61_E	97_V	1.215	0.31
125_E	253_D	1.209	0.31
76_L	79_S	1.207	0.31
20_I	48_F	1.205	0.31
14_D	62_Q	1.203	0.31
7_A	10_S	1.203	0.31
8_A	78_G	1.202	0.31
79_S	253_D	1.199	0.31
144_D	254_D	1.185	0.30
70_R	261_V	1.181	0.30
46_G	148_A	1.170	0.30
149_I	233_A	1.163	0.29
179_N	223_D	1.154	0.29
109_E	188_N	1.148	0.29
25_W	137_F	1.142	0.29
78_G	167_T	1.138	0.29
150_D	211_L	1.134	0.28
217_H	254_D	1.125	0.28
166_P	238_V	1.125	0.28
100_T	209_A	1.124	0.28
15_E	85_Y	1.116	0.28
46_G	49_N	1.112	0.28
24_L	53_G	1.112	0.28
62_Q	119_V	1.109	0.27
118_K	176_L	1.105	0.27
7_A	242_A	1.103	0.27
160_L	254_D	1.100	0.27
72_A	135_P	1.093	0.27
84_V	162_D	1.092	0.27
77_V	195_S	1.091	0.27
175_H	239_D	1.084	0.27
82_S	128_I	1.084	0.27
111_V	254_D	1.080	0.26
207_H	236_E	1.078	0.26
75_K	167_T	1.075	0.26
76_L	260_T	1.075	0.26
59_F	136_A	1.074	0.26
69_L	75_K	1.074	0.26
145_L	255_E	1.071	0.26
10_S	64_E	1.066	0.26
146_A	228_H	1.056	0.26
78_G	124_C	1.049	0.25
170_G	219_R	1.037	0.25
98_D	239_D	1.031	0.25
13_A	216_D	1.029	0.25
24_L	36_L	1.023	0.25
255_E	269_A	1.022	0.24
108_L	141_R	1.019	0.24
83_G	114_D	1.018	0.24
12_V	70_R	1.016	0.24
70_R	136_A	1.013	0.24
13_A	247_T	0.997	0.24
17_R	48_F	0.993	0.24
94_P	97_V	0.990	0.23
149_I	225_A	0.990	0.23
45_S	49_N	0.988	0.23
81_H	212_S	0.984	0.23
97_V	123_D	0.984	0.23
207_H	223_D	0.979	0.23
80_L	103_L	0.968	0.23
89_G	145_L	0.962	0.23
170_G	210_V	0.958	0.22
19_R	147_A	0.957	0.22
128_I	208_P	0.953	0.22
112_Y	245_R	0.951	0.22
84_V	88_T	0.949	0.22
217_H	257_L	0.947	0.22
77_V	199_L	0.942	0.22
65_D	261_V	0.939	0.22
56_R	153_V	0.935	0.22
173_A	207_H	0.928	0.22
238_V	249_E	0.924	0.21
124_C	148_A	0.924	0.21
173_A	190_E	0.918	0.21
86_T	134_P	0.915	0.21
204_A	259_V	0.912	0.21
33_F	47_R	0.910	0.21
25_W	161_L	0.908	0.21
25_W	31_L	0.899	0.21
141_R	148_A	0.893	0.20
66_G	73_G	0.893	0.20
208_P	215_D	0.892	0.20
48_F	79_S	0.888	0.20
200_A	269_A	0.886	0.20
32_S	97_V	0.885	0.20
176_L	200_A	0.884	0.20
91_M	239_D	0.881	0.20
63_T	249_E	0.877	0.20
54_E	151_G	0.876	0.20
214_Y	217_H	0.875	0.20
78_G	164_F	0.875	0.20
45_S	70_R	0.872	0.20
23_E	237_W	0.870	0.20
122_T	177_A	0.870	0.20
34_S	214_Y	0.863	0.20
33_F	213_F	0.863	0.20
21_L	131_T	0.856	0.19
78_G	265_L	0.854	0.19
51_H	55_L	0.854	0.19
50_Y	55_L	0.854	0.19
119_V	254_D	0.853	0.19
220_S	223_D	0.852	0.19
21_L	82_S	0.846	0.19
6_E	31_L	0.844	0.19
44_D	137_F	0.841	0.19
26_D	173_A	0.839	0.19
21_L	77_V	0.836	0.19
154_R	225_A	0.836	0.19
49_N	85_Y	0.816	0.18
198_G	254_D	0.816	0.18
106_S	256_R	0.811	0.18
5_A	22_R	0.807	0.18
54_E	218_D	0.805	0.18
22_R	152_Y	0.804	0.18
182_G	197_S	0.800	0.18
32_S	35_E	0.800	0.18
35_E	111_V	0.797	0.18
16_L	35_E	0.796	0.18
155_T	164_F	0.794	0.18
58_L	259_V	0.793	0.18
107_D	222_R	0.791	0.18
47_R	144_D	0.780	0.17
97_V	222_R	0.778	0.17
26_D	266_A	0.775	0.17
27_A	96_S	0.772	0.17
129_I	145_L	0.767	0.17
33_F	45_S	0.767	0.17
19_R	97_V	0.766	0.17
147_A	263_D	0.763	0.17
33_F	46_G	0.761	0.17
221_V	231_W	0.759	0.17
123_D	180_D	0.756	0.17
169_S	214_Y	0.756	0.17
72_A	113_E	0.756	0.17
97_V	207_H	0.753	0.17
131_T	156_T	0.752	0.17
48_F	210_V	0.750	0.17
68_D	147_A	0.748	0.17
28_D	49_N	0.747	0.17
157_S	263_D	0.746	0.17
52_L	55_L	0.745	0.16
27_A	105_G	0.744	0.16
126_V	193_G	0.743	0.16
12_V	102_V	0.741	0.16
72_A	114_D	0.738	0.16
5_A	251_R	0.735	0.16
65_D	213_F	0.731	0.16
26_D	105_G	0.729	0.16
124_C	158_R	0.728	0.16
117_G	142_E	0.728	0.16
154_R	200_A	0.726	0.16
16_L	240_G	0.724	0.16
124_C	133_V	0.723	0.16
149_I	173_A	0.723	0.16
64_E	253_D	0.722	0.16
69_L	213_F	0.722	0.16
113_E	254_D	0.721	0.16
9_F	150_D	0.718	0.16
64_E	79_S	0.715	0.16
11_A	268_T	0.715	0.16
49_N	60_V	0.712	0.16
23_E	47_R	0.706	0.16
38_E	100_T	0.706	0.16
216_D	256_R	0.704	0.15
159_S	238_V	0.693	0.15
13_A	110_A	0.691	0.15
98_D	255_E	0.690	0.15
49_N	112_Y	0.687	0.15
48_F	51_H	0.680	0.15
47_R	156_T	0.679	0.15
209_A	270_V	0.679	0.15
59_F	250_V	0.676	0.15
20_I	43_Q	0.674	0.15
46_G	153_V	0.673	0.15
211_L	264_D	0.672	0.15
209_A	213_F	0.668	0.15
253_D	264_D	0.667	0.15
30_P	232_L	0.665	0.15
165_C	192_C	0.660	0.14
168_C	189_C	0.660	0.14
165_C	189_C	0.660	0.14
168_C	192_C	0.660	0.14
189_C	192_C	0.660	0.14
165_C	168_C	0.660	0.14
116_V	181_Y	0.656	0.14
66_G	138_V	0.656	0.14
53_G	172_T	0.653	0.14
207_H	267_V	0.652	0.14
98_D	186_V	0.651	0.14
12_V	147_A	0.648	0.14
85_Y	137_F	0.647	0.14
99_G	227_W	0.646	0.14
15_E	254_D	0.643	0.14
35_E	125_E	0.642	0.14
113_E	217_H	0.641	0.14
21_L	234_D	0.638	0.14
41_D	217_H	0.636	0.14
137_F	166_P	0.635	0.14
20_I	49_N	0.633	0.14
237_W	262_T	0.630	0.14
14_D	145_L	0.630	0.14
159_S	218_D	0.629	0.14
124_C	137_F	0.628	0.14
81_H	98_D	0.628	0.14
249_E	264_D	0.626	0.14
60_V	261_V	0.624	0.14
45_S	48_F	0.624	0.14
160_L	209_A	0.624	0.14
119_V	219_R	0.623	0.14
87_E	141_R	0.621	0.14
37_R	49_N	0.621	0.14
129_I	226_L	0.619	0.14
75_K	124_C	0.617	0.14
12_V	157_S	0.615	0.14
96_S	181_Y	0.614	0.13
13_A	185_A	0.610	0.13
148_A	166_P	0.610	0.13
144_D	242_A	0.610	0.13
78_G	169_S	0.610	0.13
16_L	78_G	0.609	0.13
137_F	164_F	0.609	0.13
215_D	222_R	0.606	0.13
152_Y	191_R	0.605	0.13
46_G	74_R	0.603	0.13
101_C	134_P	0.600	0.13
13_A	80_L	0.599	0.13
79_S	86_T	0.599	0.13
130_Q	255_E	0.598	0.13
145_L	176_L	0.596	0.13
126_V	178_E	0.591	0.13
150_D	227_W	0.590	0.13
174_G	242_A	0.590	0.13
177_A	255_E	0.589	0.13
48_F	134_P	0.587	0.13
46_G	233_A	0.586	0.13
63_T	66_G	0.585	0.13
34_S	264_D	0.584	0.13
127_T	145_L	0.583	0.13
6_E	259_V	0.580	0.13
39_C	42_V	0.579	0.13
86_T	152_Y	0.579	0.13
142_E	155_T	0.575	0.13
125_E	250_V	0.575	0.13
185_A	217_H	0.572	0.13
89_G	102_V	0.570	0.13
237_W	268_T	0.569	0.13
20_I	250_V	0.565	0.13
97_V	265_L	0.564	0.12
39_C	224_T	0.564	0.12
96_S	237_W	0.562	0.12
47_R	223_D	0.561	0.12
146_A	154_R	0.561	0.12
45_S	227_W	0.560	0.12
104_C	134_P	0.559	0.12
113_E	142_E	0.558	0.12
175_H	265_L	0.558	0.12
16_L	163_G	0.558	0.12
146_A	164_F	0.557	0.12
149_I	152_Y	0.552	0.12
213_F	217_H	0.550	0.12
131_T	152_Y	0.548	0.12
58_L	146_A	0.546	0.12
209_A	214_Y	0.544	0.12
56_R	114_D	0.543	0.12
224_T	246_A	0.540	0.12
119_V	201_A	0.538	0.12
220_S	266_A	0.538	0.12
99_G	218_D	0.538	0.12
59_F	266_A	0.537	0.12
88_T	102_V	0.536	0.12
117_G	261_V	0.535	0.12
91_M	241_A	0.535	0.12
37_R	47_R	0.534	0.12
214_Y	219_R	0.533	0.12
123_D	179_N	0.533	0.12
12_V	151_G	0.532	0.12
47_R	83_G	0.532	0.12
263_D	266_A	0.531	0.12
212_S	217_H	0.530	0.12
27_A	136_A	0.529	0.12
72_A	85_Y	0.528	0.12
97_V	179_N	0.528	0.12
54_E	248_V	0.528	0.12
20_I	267_V	0.527	0.12
220_S	262_T	0.524	0.12
193_G	222_R	0.524	0.12
202_W	225_A	0.523	0.12
66_G	213_F	0.523	0.12
143_D	176_L	0.522	0.12
124_C	138_V	0.521	0.12
175_H	220_S	0.518	0.12
83_G	205_V	0.516	0.12
64_E	170_G	0.513	0.12
115_Q	150_D	0.511	0.11
40_V	44_D	0.507	0.11
80_L	87_E	0.506	0.11
63_T	213_F	0.505	0.11
39_C	54_E	0.504	0.11
73_G	257_L	0.503	0.11
195_S	235_A	0.502	0.11
14_D	242_A	0.500	0.11
9_F	17_R	0.500	0.11

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4gcvA	3	0.4964	98.4	0.899	Contact Map
2f2eA	4	0.4565	98.4	0.9	Contact Map
1y0uA	2	0.2609	98.4	0.9	Contact Map
3f6vA	2	0.3116	98.3	0.904	Contact Map
2zkzA	2	0.2971	98.1	0.909	Contact Map
2kkoA	2	0.337	98	0.91	Contact Map
2fswA	2	0.3152	98	0.91	Contact Map
3cuoA	2	0.3043	98	0.911	Contact Map
4k2eA	2	0.3043	98	0.911	Contact Map
3pqkA	2	0.3225	97.9	0.912	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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