GREMLIN Database
SYW2 - Tryptophan--tRNA ligase 2
UniProt: Q9HN66 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 380 (282)
Sequences: 7049 (3362)
Seq/√Len: 200.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_S266_T4.2831.00
125_R360_D3.7251.00
348_R351_A3.0961.00
343_A347_R2.5911.00
358_A361_A2.5891.00
166_H182_A2.5871.00
101_Y142_R2.5831.00
314_A317_E2.4981.00
139_E365_T2.4871.00
320_Y333_L2.3741.00
69_V103_P2.2951.00
315_R319_E2.2901.00
122_D126_A2.2471.00
268_R272_R2.2251.00
116_T119_E2.2191.00
280_R292_V2.1541.00
312_E315_R2.1411.00
170_Q182_A2.1291.00
358_A362_F2.1211.00
340_E343_A2.0751.00
317_E321_R2.0601.00
67_S99_R2.0491.00
318_R321_R2.0361.00
233_P237_L2.0201.00
311_A315_R1.9361.00
314_A318_R1.9321.00
347_R351_A1.9221.00
99_R142_R1.9071.00
230_V233_P1.8991.00
272_R332_D1.8561.00
311_A319_E1.8541.00
129_R359_L1.8521.00
129_R353_G1.8501.00
96_F140_L1.8411.00
262_D270_K1.8381.00
230_V236_L1.8311.00
230_V234_G1.7951.00
264_P339_T1.7861.00
230_V235_A1.7611.00
345_H349_R1.7591.00
210_V240_F1.7571.00
234_G237_L1.7211.00
128_L363_R1.7191.00
69_V105_S1.7171.00
74_P109_K1.6631.00
119_E122_D1.6571.00
179_V183_F1.6371.00
302_L334_A1.6331.00
231_G237_L1.6061.00
318_R322_A1.6061.00
299_F317_E1.6031.00
346_Q350_A1.5861.00
268_R335_A1.5691.00
136_F141_T1.5661.00
116_T120_T1.5601.00
315_R318_R1.5401.00
271_V338_I1.5381.00
166_H170_Q1.5301.00
193_L223_A1.5231.00
223_A233_P1.5101.00
361_A365_T1.5101.00
134_V345_H1.5081.00
312_E333_L1.4981.00
292_V295_E1.4791.00
264_P343_A1.4611.00
351_A355_V1.4561.00
132_L352_L1.4541.00
262_D266_T1.4511.00
243_S256_V1.4451.00
74_P104_L1.4381.00
267_V339_T1.4361.00
161_A183_F1.4331.00
231_G236_L1.4291.00
169_L179_V1.4261.00
303_S317_E1.4181.00
333_L337_R1.4161.00
336_D340_E1.3981.00
355_V358_A1.3911.00
72_V131_L1.3901.00
144_V195_P1.3781.00
148_R367_D1.3771.00
329_E332_D1.3761.00
193_L226_A1.3731.00
357_E361_A1.3701.00
276_Y292_V1.3561.00
313_L317_E1.3501.00
231_G234_G1.3471.00
107_D154_Y1.3191.00
347_R350_A1.3141.00
130_D349_R1.3131.00
288_A291_G1.3131.00
117_P120_T1.2971.00
196_Q229_P1.2941.00
328_G332_D1.2801.00
335_A339_T1.2791.00
88_F91_R1.2731.00
189_T219_S1.2731.00
248_G254_A1.2701.00
90_R95_E1.2551.00
299_F313_L1.2541.00
231_G235_A1.2491.00
128_L359_L1.2421.00
153_L195_P1.2281.00
305_F337_R1.2191.00
319_E333_L1.2041.00
309_D312_E1.2011.00
104_L128_L1.2001.00
118_A122_D1.1911.00
168_T221_D1.1891.00
306_F337_R1.1891.00
165_R168_T1.1811.00
230_V237_L1.1791.00
349_R353_G1.1781.00
66_Q204_T1.1771.00
310_D314_A1.1771.00
135_G138_P1.1771.00
255_G273_T1.1701.00
268_R336_D1.1631.00
119_E123_Y1.1561.00
197_L227_R1.1491.00
316_I320_Y1.1471.00
128_L132_L1.1441.00
259_R262_D1.1411.00
91_R95_E1.1381.00
350_A353_G1.1291.00
157_A161_A1.1281.00
216_V235_A1.1281.00
69_V101_Y1.1241.00
126_A353_G1.0941.00
224_A230_V1.0831.00
152_V155_P1.0821.00
344_A347_R1.0811.00
85_V238_M1.0801.00
355_V361_A1.0801.00
299_F303_S1.0801.00
340_E345_H1.0781.00
123_Y126_A1.0781.00
78_M127_N1.0751.00
299_F316_I1.0731.00
145_V148_R1.0721.00
116_T121_G1.0601.00
265_D268_R1.0441.00
84_M304_A1.0441.00
264_P346_Q1.0391.00
337_R340_E1.0251.00
118_A121_G1.0231.00
71_G103_P1.0221.00
325_L329_E1.0201.00
233_P236_L1.0171.00
128_L131_L1.0071.00
69_V197_L1.0051.00
124_L145_V1.0011.00
72_V85_V0.9981.00
125_R356_T0.9971.00
120_T123_Y0.9911.00
268_R339_T0.9911.00
196_Q231_G0.9811.00
125_R129_R0.9771.00
70_T207_P0.9740.99
70_T85_V0.9730.99
334_A337_R0.9720.99
213_D233_P0.9700.99
125_R128_L0.9670.99
310_D319_E0.9620.99
123_Y131_L0.9560.99
106_D148_R0.9540.99
262_D267_V0.9510.99
88_F341_F0.9480.99
151_D155_P0.9400.99
269_E273_T0.9370.99
360_D364_L0.9360.99
162_G180_G0.9280.99
267_V342_L0.9240.99
319_E325_L0.9230.99
144_V148_R0.9230.99
160_F186_A0.9200.99
72_V86_F0.9190.99
179_V186_A0.9190.99
320_Y327_S0.9140.99
93_Q141_T0.9110.99
106_D147_T0.9110.99
156_L190_A0.9060.99
224_A228_Y0.9000.99
164_V222_V0.8990.99
161_A179_V0.8940.99
84_M305_F0.8880.99
137_D140_L0.8870.99
221_D224_A0.8870.99
266_T269_E0.8850.99
127_N131_L0.8840.99
294_A297_V0.8840.99
117_P121_G0.8820.99
194_L197_L0.8800.99
260_L342_L0.8780.99
288_A296_D0.8760.99
82_H86_F0.8680.99
243_S248_G0.8670.99
245_A248_G0.8660.99
165_R178_N0.8630.99
232_K235_A0.8600.99
242_P300_Q0.8550.99
272_R328_G0.8530.99
136_F139_E0.8520.99
112_F115_Q0.8520.99
303_S313_L0.8510.99
305_F341_F0.8480.99
350_A354_D0.8410.99
132_L138_P0.8360.98
169_L186_A0.8360.98
135_G139_E0.8340.98
83_A88_F0.8320.98
132_L362_F0.8280.98
80_L305_F0.8260.98
352_L355_V0.8260.98
193_L227_R0.8260.98
72_V87_Y0.8230.98
68_I89_A0.8220.98
339_T343_A0.8190.98
272_R335_A0.8190.98
333_L336_D0.8160.98
299_F320_Y0.8130.98
320_Y330_L0.8130.98
302_L330_L0.8130.98
71_G105_S0.8120.98
78_M131_L0.8110.98
311_A314_A0.8100.98
131_L134_V0.8080.98
361_A364_L0.8060.98
160_F193_L0.8060.98
124_L128_L0.8050.98
326_L329_E0.8010.98
122_D125_R0.8010.98
270_K338_I0.7940.98
276_Y294_A0.7850.98
223_A227_R0.7810.98
72_V78_M0.7780.98
319_E322_A0.7770.98
145_V363_R0.7720.97
329_E333_L0.7710.97
103_P144_V0.7670.97
297_V300_Q0.7650.97
332_D336_D0.7650.97
229_P236_L0.7600.97
290_G296_D0.7580.97
204_T229_P0.7540.97
77_P259_R0.7530.97
229_P233_P0.7520.97
167_A171_N0.7510.97
92_L205_L0.7490.97
70_T90_R0.7480.97
72_V90_R0.7480.97
336_D352_L0.7480.97
87_Y134_V0.7410.97
356_T359_L0.7390.97
192_L219_S0.7360.97
161_A178_N0.7330.96
126_A130_D0.7320.96
165_R176_P0.7300.96
99_R140_L0.7290.96
193_L197_L0.7270.96
336_D348_R0.7250.96
268_R332_D0.7250.96
126_A349_R0.7200.96
340_E348_R0.7160.96
229_P234_G0.7160.96
186_A222_V0.7140.96
293_P296_D0.7140.96
120_T124_L0.7140.96
337_R341_F0.7130.96
196_Q204_T0.7110.96
189_T218_V0.7090.96
303_S310_D0.7070.96
301_Y305_F0.6970.95
229_P235_A0.6930.95
296_D320_Y0.6890.95
91_R96_F0.6840.95
157_A183_F0.6820.95
183_F186_A0.6790.95
77_P261_T0.6790.95
160_F190_A0.6760.95
244_L270_K0.6740.94
106_D124_L0.6720.94
351_A358_A0.6660.94
161_A186_A0.6630.94
298_P330_L0.6630.94
70_T82_H0.6630.94
265_D328_G0.6610.94
213_D235_A0.6600.94
289_K296_D0.6590.94
125_R359_L0.6580.94
344_A348_R0.6570.94
320_Y325_L0.6560.94
300_Q303_S0.6520.93
339_T342_L0.6460.93
73_G112_F0.6460.93
348_R352_L0.6460.93
86_F131_L0.6460.93
121_G125_R0.6450.93
294_A317_E0.6450.93
265_D269_E0.6450.93
297_V301_Y0.6440.93
302_L306_F0.6440.93
101_Y144_V0.6410.93
90_R102_V0.6370.93
339_T346_Q0.6350.92
306_F316_I0.6350.92
116_T123_Y0.6340.92
123_Y127_N0.6310.92
270_K339_T0.6310.92
80_L338_I0.6300.92
68_I92_L0.6300.92
86_F90_R0.6280.92
150_A153_L0.6260.92
88_F238_M0.6260.92
142_R145_V0.6230.92
258_I271_V0.6230.92
277_T298_P0.6220.92
229_P237_L0.6210.92
130_D134_V0.6190.92
82_H85_V0.6170.91
352_L356_T0.6160.91
351_A354_D0.6150.91
353_G356_T0.6150.91
255_G269_E0.6140.91
353_G359_L0.6130.91
133_A139_E0.6100.91
259_R270_K0.6090.91
352_L358_A0.6090.91
172_V218_V0.6070.91
310_D313_L0.6050.91
163_D222_V0.6040.91
78_M82_H0.6040.91
72_V82_H0.6030.90
164_V218_V0.6030.90
73_G127_N0.6000.90
189_T193_L0.5990.90
319_E329_E0.5980.90
317_E320_Y0.5970.90
153_L156_L0.5970.90
196_Q227_R0.5950.90
357_E360_D0.5930.90
133_A137_D0.5910.90
98_A205_L0.5900.89
161_A176_P0.5890.89
313_L316_I0.5880.89
291_G296_D0.5870.89
136_F143_I0.5860.89
295_E299_F0.5750.88
77_P126_A0.5730.88
158_T162_G0.5720.88
157_A179_V0.5720.88
235_A238_M0.5720.88
133_A138_P0.5710.88
311_A316_I0.5700.88
302_L337_R0.5700.88
260_L345_H0.5690.88
264_P268_R0.5690.88
217_R220_R0.5680.88
133_A136_F0.5670.88
131_L143_I0.5670.88
168_T171_N0.5670.88
121_G124_L0.5650.87
163_D226_A0.5650.87
292_V296_D0.5640.87
261_T349_R0.5640.87
90_R131_L0.5640.87
130_D261_T0.5640.87
316_I330_L0.5620.87
144_V153_L0.5610.87
168_T225_K0.5590.87
271_V334_A0.5570.87
160_F189_T0.5570.87
295_E298_P0.5560.87
268_R271_V0.5550.86
163_D225_K0.5540.86
325_L333_L0.5520.86
363_R367_D0.5510.86
346_Q349_R0.5500.86
260_L341_F0.5490.86
92_L234_G0.5470.86
267_V343_A0.5460.86
303_S316_I0.5460.86
264_P342_L0.5450.85
236_L239_Q0.5440.85
127_N130_D0.5420.85
183_F187_V0.5400.85
295_E303_S0.5400.85
250_M331_K0.5380.85
227_R231_G0.5370.85
296_D313_L0.5370.85
65_E99_R0.5350.84
77_P123_Y0.5330.84
206_V216_V0.5330.84
356_T360_D0.5310.84
169_L185_P0.5310.84
83_A341_F0.5290.84
134_V137_D0.5290.84
292_V303_S0.5290.84
325_L330_L0.5270.84
107_D159_A0.5270.84
293_P321_R0.5270.84
316_I325_L0.5260.83
298_P302_L0.5240.83
170_Q175_E0.5240.83
241_L304_A0.5220.83
312_E337_R0.5210.83
179_V182_A0.5200.83
84_M88_F0.5200.83
296_D327_S0.5180.82
126_A132_L0.5180.82
316_I333_L0.5170.82
280_R291_G0.5150.82
362_F366_D0.5150.82
298_P303_S0.5130.82
263_S350_A0.5110.82
153_L194_L0.5100.82
168_T172_V0.5060.81
332_D335_A0.5060.81
91_R97_G0.5040.81
110_Y159_A0.5040.81
85_V207_P0.5040.81
280_R289_K0.5020.81
67_S101_Y0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3jxeA 2 0.9079 100 0.164 Contact Map
3i05A 2 0.8237 100 0.185 Contact Map
3tzeA 2 0.8921 100 0.207 Contact Map
2ip1A 1 0.9026 100 0.209 Contact Map
1r6uA 2 0.95 100 0.213 Contact Map
1r6tA 2 0.9447 100 0.218 Contact Map
3a04A 2 0.9237 100 0.218 Contact Map
3hv0A 2 0.8737 100 0.221 Contact Map
3focA 4 0.9395 100 0.231 Contact Map
3hzrA 2 0.9342 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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