GREMLIN Database
Q9HN65 - Uncharacterized protein
UniProt: Q9HN65 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (200)
Sequences: 1425 (834)
Seq/√Len: 59.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_V153_V4.3631.00
97_I104_A3.7421.00
125_Y153_V3.5091.00
122_V151_L3.1761.00
18_D22_G2.9921.00
121_V150_E2.9851.00
97_I152_V2.8151.00
144_V151_L2.7851.00
123_R194_L2.7661.00
80_R150_E2.7231.00
75_K83_A2.6331.00
83_A95_E2.6051.00
104_A107_L2.5381.00
129_L153_V2.4861.00
80_R125_Y2.4181.00
74_A129_L2.3321.00
26_L93_V2.3211.00
126_V139_L2.2461.00
144_V178_V2.2231.00
18_D24_V2.1041.00
118_A146_V2.0971.00
38_Q41_A2.0961.00
38_Q42_Y2.0291.00
126_V175_C2.0081.00
118_A151_L1.9781.00
28_V91_V1.9581.00
74_A156_V1.9471.00
126_V178_V1.9391.00
5_I25_A1.9191.00
168_A172_E1.9131.00
75_K84_P1.9041.00
74_A79_V1.8080.99
126_V198_V1.7590.99
7_T12_N1.7420.99
119_Y179_A1.6940.99
24_V85_L1.6930.99
129_L156_V1.6400.99
140_S177_N1.6170.99
176_R180_N1.6080.99
4_P12_N1.5740.99
145_V154_I1.5600.98
122_V144_V1.5440.98
16_A93_V1.5390.98
64_T87_V1.4760.98
85_L95_E1.4490.97
66_K70_N1.4290.97
195_L199_H1.4120.97
16_A24_V1.4030.97
15_E23_D1.3930.97
55_D58_A1.3890.97
65_R87_V1.3750.97
124_E128_R1.3680.96
13_V25_A1.3640.96
127_R197_Y1.3610.96
127_R131_D1.3540.96
118_A122_V1.3390.96
147_Y152_V1.3290.96
42_Y63_W1.3090.95
22_G83_A1.3070.95
176_R191_P1.2970.95
72_R76_A1.2910.95
122_V178_V1.2870.95
193_D196_S1.2760.95
70_N159_A1.2730.95
29_Y92_L1.2420.94
125_Y128_R1.2350.94
172_E195_L1.2220.93
175_C194_L1.1970.93
58_A61_L1.1920.92
117_M121_V1.1850.92
57_K88_Q1.1830.92
121_V151_L1.1760.92
127_R198_V1.1590.91
190_D193_D1.1500.91
4_P14_Y1.1480.91
40_R44_E1.1450.91
99_R148_E1.1380.91
30_R129_L1.1370.91
183_A190_D1.1310.90
16_A26_L1.1180.90
146_V149_G1.1030.89
135_V186_G1.0970.89
87_V90_N1.0840.88
68_F84_P1.0780.88
181_F185_Q1.0620.87
172_E176_R1.0530.87
137_G170_F1.0530.87
52_L55_D1.0520.87
112_I118_A1.0510.87
15_E96_L1.0500.87
98_G147_Y1.0410.86
12_N30_R1.0360.86
51_G99_R1.0220.85
61_L90_N1.0170.85
112_I115_P1.0140.85
65_R73_R1.0030.84
96_L101_G1.0000.84
123_R126_V0.9970.84
79_V125_Y0.9830.83
103_A106_T0.9820.83
122_V153_V0.9780.83
70_N156_V0.9640.82
80_R121_V0.9500.81
113_E116_Q0.9480.81
81_V95_E0.9450.80
29_Y63_W0.9450.80
121_V125_Y0.9440.80
42_Y46_D0.9430.80
101_G107_L0.9280.79
110_V125_Y0.9170.78
156_V159_A0.9160.78
19_A129_L0.9110.78
154_I158_Q0.9050.77
104_A147_Y0.9010.77
6_S156_V0.8960.77
12_N33_A0.8930.76
117_M149_G0.8810.75
97_I147_Y0.8800.75
116_Q149_G0.8740.75
29_Y45_G0.8710.75
97_I194_L0.8700.74
133_G157_G0.8690.74
7_T90_N0.8630.74
191_P194_L0.8560.73
137_G173_R0.8360.72
60_V90_N0.8350.71
125_Y139_L0.8330.71
10_E36_F0.8290.71
19_A117_M0.8270.71
116_Q187_A0.8240.70
74_A157_G0.8210.70
32_N56_K0.8190.70
75_K95_E0.8150.70
196_S201_H0.8120.69
173_R177_N0.8100.69
24_V93_V0.8090.69
196_S200_E0.8050.69
42_Y45_G0.8040.69
48_R70_N0.8020.68
15_E137_G0.8010.68
15_E30_R0.7910.67
139_L177_N0.7900.67
118_A182_F0.7870.67
137_G162_I0.7850.67
31_I57_K0.7760.66
115_P121_V0.7740.66
46_D70_N0.7710.65
70_N140_S0.7630.64
66_K141_E0.7620.64
61_L65_R0.7560.64
130_Y171_L0.7550.64
29_Y157_G0.7550.64
43_L59_V0.7550.64
32_N35_N0.7460.63
151_L178_V0.7410.62
119_Y123_R0.7400.62
47_P92_L0.7400.62
78_G81_V0.7390.62
14_Y38_Q0.7360.62
33_A90_N0.7360.62
134_L159_A0.7310.61
2_G15_E0.7310.61
47_P74_A0.7290.61
57_K92_L0.7240.60
45_G63_W0.7240.60
116_Q142_Y0.7220.60
123_R188_D0.7170.60
138_D143_N0.7140.59
166_N169_T0.7120.59
190_D200_E0.7100.59
6_S142_Y0.7100.59
26_L157_G0.7090.59
62_S118_A0.7090.59
99_R184_R0.7070.59
103_A145_V0.7050.58
36_F157_G0.7020.58
191_P197_Y0.7000.58
144_V166_N0.6950.57
113_E117_M0.6950.57
168_A180_N0.6950.57
179_A191_P0.6940.57
6_S32_N0.6940.57
85_L142_Y0.6910.57
66_K164_H0.6910.57
103_A109_D0.6900.57
31_I35_N0.6890.57
194_L198_V0.6890.57
172_E196_S0.6880.57
14_Y41_A0.6870.56
130_Y198_V0.6840.56
57_K61_L0.6800.56
38_Q163_H0.6800.56
30_R56_K0.6780.55
12_N49_F0.6760.55
31_I39_M0.6750.55
35_N135_V0.6710.55
60_V63_W0.6670.54
139_L194_L0.6660.54
68_F72_R0.6650.54
11_A73_R0.6650.54
126_V176_R0.6620.54
103_A156_V0.6620.54
128_R183_A0.6610.54
113_E148_E0.6570.53
66_K134_L0.6560.53
175_C179_A0.6550.53
111_D149_G0.6540.53
35_N50_E0.6490.52
191_P201_H0.6460.52
141_E178_V0.6360.51
46_D162_I0.6350.51
89_R173_R0.6330.50
106_T137_G0.6290.50
71_L91_V0.6290.50
139_L153_V0.6280.50
59_V87_V0.6250.50
112_I153_V0.6240.49
133_G162_I0.6240.49
99_R117_M0.6240.49
35_N41_A0.6130.48
100_E111_D0.6120.48
191_P200_E0.6100.48
49_F134_L0.6070.48
176_R198_V0.6070.48
79_V139_L0.6060.47
189_A196_S0.5990.47
45_G66_K0.5980.47
6_S159_A0.5980.47
65_R90_N0.5950.46
138_D154_I0.5910.46
79_V129_L0.5910.46
42_Y140_S0.5880.45
9_K138_D0.5860.45
179_A194_L0.5820.45
160_V164_H0.5810.45
40_R172_E0.5790.44
122_V125_Y0.5780.44
168_A199_H0.5750.44
63_W98_G0.5740.44
88_Q92_L0.5720.44
56_K59_V0.5710.44
73_R134_L0.5690.43
63_W70_N0.5680.43
24_V95_E0.5640.43
16_A71_L0.5620.43
136_H143_N0.5610.42
7_T73_R0.5610.42
98_G151_L0.5600.42
126_V191_P0.5580.42
39_M43_L0.5560.42
49_F164_H0.5540.42
63_W104_A0.5510.41
121_V191_P0.5500.41
122_V176_R0.5500.41
194_L199_H0.5490.41
100_E149_G0.5490.41
35_N43_L0.5470.41
74_A158_Q0.5470.41
9_K27_K0.5460.41
74_A81_V0.5450.41
37_Q182_F0.5450.41
30_R38_Q0.5440.41
109_D168_A0.5420.40
19_A148_E0.5420.40
140_S171_L0.5410.40
116_Q120_E0.5380.40
55_D106_T0.5360.40
24_V89_R0.5350.40
60_V157_G0.5340.40
120_E149_G0.5330.39
131_D199_H0.5320.39
143_N155_D0.5310.39
131_D201_H0.5310.39
68_F188_D0.5290.39
134_L156_V0.5280.39
180_N184_R0.5270.39
79_V132_A0.5270.39
30_R158_Q0.5270.39
177_N180_N0.5250.39
6_S12_N0.5250.39
10_E27_K0.5240.38
96_L102_D0.5230.38
183_A188_D0.5200.38
123_R175_C0.5190.38
75_K81_V0.5190.38
118_A147_Y0.5160.38
128_R150_E0.5140.37
135_V169_T0.5140.37
5_I13_V0.5130.37
26_L86_A0.5130.37
56_K64_T0.5120.37
13_V169_T0.5110.37
73_R161_T0.5110.37
156_V161_T0.5110.37
30_R90_N0.5100.37
123_R179_A0.5080.37
3_G170_F0.5060.37
40_R53_R0.5040.36
148_E200_E0.5030.36
37_Q41_A0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gyiA 1 0.8528 100 0.553 Contact Map
1zarA 1 0.7532 100 0.56 Contact Map
1zthA 1 0.8182 100 0.591 Contact Map
4otpA 1 0.8658 100 0.657 Contact Map
4pedA 1 0.974 99.7 0.776 Contact Map
2zmdA 2 0.8182 99.5 0.801 Contact Map
4bvuA 1 0.684 99.5 0.805 Contact Map
3en9A 1 0.8268 99.5 0.809 Contact Map
4h05A 1 0.7619 99.4 0.811 Contact Map
2y7jA 3 0.9048 99.4 0.814 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.008 seconds.