GREMLIN Database
IF1A1 - Translation initiation factor 1A 1
UniProt: Q9HN64 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 95 (89)
Sequences: 332 (175)
Seq/√Len: 18.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A74_A4.8841.00
23_V56_I3.4581.00
34_V44_A3.2670.99
21_A34_V2.7060.98
34_V62_V2.6800.98
32_V76_V2.4510.96
56_I73_K2.3540.95
34_V64_V2.2320.94
44_A64_V2.0630.90
23_V62_V2.0590.90
50_M62_V1.7720.82
82_K94_I1.5550.73
20_F67_W1.5150.71
20_F79_R1.4570.68
9_K12_R1.4430.67
43_T63_L1.4380.66
25_D33_Q1.4300.66
43_T70_Q1.3740.63
34_V74_A1.3730.63
8_R11_L1.3640.62
26_M75_D1.3370.61
19_V41_E1.2810.57
22_E94_I1.2810.57
86_D93_H1.2300.54
62_V76_V1.1990.52
55_W60_D1.1840.51
54_I78_W1.1800.51
34_V76_V1.1690.50
36_C42_R1.1610.50
21_A44_A1.1600.50
33_Q41_E1.1560.50
23_V74_A1.1460.49
50_M54_I1.1410.49
13_M91_E1.1260.48
63_L84_D1.1150.47
61_I85_A1.1000.46
63_L90_E1.0910.46
19_V37_A1.0640.44
23_V73_K1.0580.43
44_A51_Q1.0390.42
45_R67_W1.0280.42
12_R18_E1.0150.41
31_R58_E0.9990.40
38_D42_R0.9770.39
76_V94_I0.9760.39
74_A85_A0.9720.38
49_R69_W0.9680.38
66_P79_R0.9670.38
30_N51_Q0.9590.38
20_F93_H0.9580.37
30_N71_D0.9570.37
23_V32_V0.9560.37
9_K63_L0.9480.37
31_R68_D0.9450.37
38_D80_Y0.9200.35
21_A74_A0.8930.34
14_P73_K0.8900.34
27_L37_A0.8900.34
24_T35_R0.8850.33
21_A40_E0.8680.32
28_G80_Y0.8580.32
13_M17_D0.8560.32
84_D88_L0.8540.32
50_M69_W0.8530.32
11_L20_F0.8500.31
48_G55_W0.8370.31
57_R79_R0.8350.31
47_P67_W0.8300.30
34_V49_R0.8190.30
30_N86_D0.8160.30
20_F86_D0.8090.29
50_M63_L0.7680.27
70_Q75_D0.7620.27
61_I79_R0.7610.27
8_R12_R0.7540.26
58_E76_V0.7480.26
56_I62_V0.7420.26
43_T76_V0.7180.25
29_A52_K0.7170.25
26_M54_I0.7160.25
87_Q90_E0.7050.24
39_G47_P0.7020.24
56_I74_A0.7020.24
50_M77_T0.7020.24
53_R79_R0.7000.24
32_V46_I0.6880.23
40_E71_D0.6860.23
16_D85_A0.6860.23
27_L43_T0.6840.23
18_E83_S0.6810.23
10_N87_Q0.6730.23
37_A79_R0.6730.23
63_L83_S0.6700.23
58_E78_W0.6670.22
53_R82_K0.6670.22
7_G90_E0.6650.22
30_N35_R0.6610.22
73_K79_R0.6590.22
23_V48_G0.6580.22
51_Q82_K0.6560.22
36_C53_R0.6540.22
29_A47_P0.6490.22
7_G12_R0.6460.22
7_G44_A0.6300.21
64_V74_A0.6260.21
13_M16_D0.6250.21
87_Q91_E0.6230.21
8_R84_D0.6150.20
43_T51_Q0.6100.20
54_I84_D0.6070.20
89_R94_I0.6030.20
13_M19_V0.6010.20
35_R56_I0.5910.19
14_P64_V0.5890.19
52_K55_W0.5830.19
33_Q76_V0.5810.19
25_D40_E0.5750.19
42_R70_Q0.5520.18
41_E79_R0.5520.18
14_P26_M0.5490.18
15_E65_E0.5490.18
30_N33_Q0.5470.18
26_M31_R0.5450.18
66_P78_W0.5430.18
65_E79_R0.5410.17
46_I70_Q0.5400.17
31_R78_W0.5360.17
47_P65_E0.5290.17
19_V67_W0.5270.17
65_E68_D0.5160.17
46_I55_W0.5100.16
45_R68_D0.5030.16
46_I76_V0.5000.16
27_L31_R0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bpe0 1 0.9684 100 0.319 Contact Map
3j80i 1 0.9368 100 0.319 Contact Map
4kzyn 1 0.8316 100 0.32 Contact Map
3wbkC 1 0.0105 100 0.339 Contact Map
1jt8A 1 1 100 0.352 Contact Map
2oqkA 1 0.9368 99.9 0.357 Contact Map
4mnoA 1 0.9263 99.9 0.367 Contact Map
2dgyA 1 0.9789 99.9 0.383 Contact Map
4ql5A 4 0.7053 99.6 0.601 Contact Map
1ah9A 1 0.7368 99.6 0.601 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0051 seconds.