GREMLIN Database
SYY - Tyrosine--tRNA ligase
UniProt: Q9HN62 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (275)
Sequences: 7144 (3349)
Seq/√Len: 202.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_S229_D4.5521.00
31_R62_E3.6381.00
64_V105_E3.0051.00
315_E319_Q2.9821.00
231_E235_T2.7581.00
289_A293_E2.6551.00
312_E315_E2.6371.00
292_L305_A2.5941.00
33_Y66_L2.5921.00
85_A89_Q2.5891.00
286_E289_A2.5631.00
128_E152_V2.4621.00
286_E290_D2.3101.00
79_S82_E2.2931.00
62_E105_E2.2711.00
287_D291_D2.2531.00
54_M58_D2.2371.00
132_K152_V2.1391.00
229_D232_E2.0601.00
283_E291_D2.0601.00
283_E287_D2.0571.00
227_T311_D2.0511.00
235_T304_G1.9971.00
284_S287_D1.9461.00
59_A103_Q1.9251.00
82_E85_A1.9131.00
225_D233_K1.9091.00
38_P72_A1.9031.00
295_G301_D1.8731.00
87_A108_L1.8521.00
233_K236_G1.8431.00
149_V153_V1.8291.00
117_D120_L1.8291.00
97_Y317_G1.8001.00
33_Y68_A1.7711.00
163_E187_L1.7501.00
290_D293_E1.7371.00
231_E307_A1.7271.00
205_D219_V1.7151.00
187_L195_R1.7121.00
64_V167_L1.6991.00
318_R322_R1.6811.00
93_Q321_L1.6791.00
255_E258_Q1.6671.00
36_Y94_F1.6651.00
300_A304_G1.6471.00
227_T315_E1.6391.00
234_V310_L1.6241.00
31_R64_V1.6181.00
247_G251_N1.6091.00
163_E190_V1.6001.00
30_K168_D1.5991.00
287_D290_D1.5971.00
38_P67_L1.5801.00
230_I311_D1.5681.00
301_D304_G1.5561.00
67_L91_K1.5541.00
285_Y289_A1.5531.00
168_D199_H1.5441.00
131_L149_V1.5431.00
258_Q288_L1.5081.00
53_L56_L1.4821.00
225_D229_D1.4701.00
180_H197_V1.4501.00
284_S305_A1.4451.00
198_L202_I1.4391.00
99_L104_T1.4381.00
290_D294_S1.4361.00
107_V165_L1.4311.00
211_G217_E1.4181.00
307_A311_D1.4021.00
247_G250_V1.4001.00
288_L292_L1.3931.00
70_V113_Q1.3821.00
227_T318_R1.3741.00
222_S225_D1.3671.00
261_V306_L1.3621.00
107_V111_S1.3571.00
50_A94_F1.3551.00
159_A183_A1.3431.00
196_P202_I1.3401.00
231_E308_A1.3281.00
123_H153_V1.3201.00
193_E198_L1.3171.00
247_G255_E1.3171.00
52_K56_L1.3141.00
166_D199_H1.3051.00
198_L201_P1.2961.00
205_D217_E1.2831.00
291_D305_A1.2731.00
128_E132_K1.2701.00
194_K197_V1.2441.00
232_E236_G1.2431.00
69_D110_S1.2421.00
84_R88_D1.2361.00
115_D165_L1.2251.00
308_A312_E1.2241.00
193_E196_P1.2241.00
305_A309_A1.2161.00
33_Y167_L1.2151.00
91_K95_L1.2121.00
33_Y64_V1.2001.00
82_E86_T1.1981.00
34_V49_T1.1841.00
70_V116_E1.1781.00
264_R309_A1.1611.00
119_E123_H1.1591.00
230_I314_I1.1471.00
235_T239_C1.1391.00
35_G66_L1.1381.00
108_L111_S1.1351.00
69_D111_S1.1341.00
195_R198_L1.1291.00
205_D211_G1.1191.00
194_K198_L1.1161.00
306_L309_A1.1151.00
262_F288_L1.1101.00
100_D103_Q1.1021.00
149_V156_L1.1011.00
113_Q117_D1.0911.00
248_E255_E1.0901.00
32_V53_L1.0861.00
42_L90_M1.0741.00
298_H301_D1.0581.00
235_T238_F1.0521.00
36_Y49_T1.0511.00
231_E311_D1.0491.00
252_P255_E1.0461.00
34_V171_I1.0341.00
49_T200_T1.0341.00
256_L260_H1.0311.00
292_L302_A1.0291.00
36_Y42_L1.0271.00
110_S114_L1.0221.00
30_K61_M1.0201.00
260_H263_P1.0081.00
98_G101_E1.0061.00
196_P199_H1.0021.00
32_V56_L1.0021.00
166_D191_G1.0011.00
309_A312_E0.9941.00
36_Y50_A0.9931.00
93_Q224_E0.9881.00
42_L94_F0.9871.00
81_E85_A0.9821.00
311_D315_E0.9811.00
52_K313_L0.9751.00
163_E191_G0.9650.99
251_N254_L0.9550.99
319_Q322_R0.9510.99
234_V238_F0.9500.99
66_L107_V0.9470.99
238_F242_T0.9470.99
234_V239_C0.9460.99
223_M314_I0.9450.99
78_G86_T0.9440.99
197_V200_T0.9420.99
207_G211_G0.9390.99
46_H50_A0.9360.99
56_L60_G0.9350.99
311_D318_R0.9310.99
128_E137_A0.9210.99
185_E188_P0.9200.99
31_R167_L0.9170.99
226_S322_R0.9170.99
233_K238_F0.9160.99
265_F269_V0.9130.99
316_P320_R0.9120.99
207_G217_E0.9090.99
35_G68_A0.9090.99
292_L299_P0.9050.99
113_Q116_E0.9040.99
85_A88_D0.9030.99
92_A95_L0.9010.99
199_H202_I0.9000.99
188_P192_Y0.9000.99
258_Q262_F0.8980.99
94_F106_F0.8950.99
29_G62_E0.8950.99
75_N78_G0.8950.99
95_L106_F0.8920.99
187_L191_G0.8890.99
69_D87_A0.8870.99
120_L124_A0.8850.99
228_A231_E0.8810.99
30_K169_L0.8710.99
256_L259_Y0.8690.99
233_K239_C0.8670.99
88_D92_A0.8670.99
301_D305_A0.8650.99
62_E103_Q0.8640.99
127_V130_S0.8640.99
36_Y51_N0.8640.99
264_R313_L0.8640.99
91_K106_F0.8560.99
258_Q285_Y0.8510.99
311_D314_I0.8500.99
41_V222_S0.8400.99
224_E321_L0.8380.99
81_E84_R0.8370.99
252_P258_Q0.8360.99
235_T307_A0.8360.99
162_I183_A0.8350.98
55_D58_D0.8340.98
249_T255_E0.8300.98
309_A313_L0.8300.98
248_E252_P0.8220.98
291_D294_S0.8210.98
36_Y54_M0.8190.98
88_D91_K0.8190.98
122_L156_L0.8190.98
252_P256_L0.8140.98
135_Q139_A0.8140.98
129_T133_R0.8130.98
131_L156_L0.8130.98
262_F285_Y0.8110.98
257_F260_H0.8020.98
124_A150_S0.8020.98
113_Q160_L0.7970.98
289_A292_L0.7900.98
126_Q186_E0.7890.98
242_T251_N0.7880.98
236_G239_C0.7870.98
65_V94_F0.7800.98
193_E197_V0.7790.98
258_Q289_A0.7780.98
30_K60_G0.7760.98
285_Y288_L0.7740.98
54_M94_F0.7730.98
315_E318_R0.7730.98
242_T255_E0.7690.97
54_M65_V0.7680.97
64_V107_V0.7680.97
245_P248_E0.7660.97
257_F289_A0.7640.97
257_F262_F0.7610.97
51_N97_Y0.7590.97
153_V156_L0.7550.97
260_H264_R0.7540.97
235_T300_A0.7540.97
129_T182_L0.7490.97
118_Y160_L0.7470.97
41_V224_E0.7450.97
47_L52_K0.7450.97
34_V54_M0.7440.97
217_E220_T0.7430.97
130_S189_S0.7430.97
44_L264_R0.7410.97
118_Y157_M0.7400.97
159_A182_L0.7390.97
316_P319_Q0.7360.97
46_H49_T0.7350.97
196_P200_T0.7350.97
193_E200_T0.7350.97
55_D59_A0.7350.97
255_E259_Y0.7340.97
195_R200_T0.7310.97
231_E234_V0.7310.97
58_D104_T0.7260.96
283_E286_E0.7250.96
231_E304_G0.7180.96
133_R185_E0.7150.96
299_P302_A0.7130.96
105_E108_L0.7120.96
308_A311_D0.7100.96
48_L203_I0.7090.96
89_Q321_L0.7080.96
125_M186_E0.7080.96
304_G308_A0.7040.96
243_R298_H0.7020.96
235_T241_Q0.7000.96
247_G256_L0.6970.95
252_P257_F0.6960.95
257_F261_V0.6950.95
261_V264_R0.6840.95
253_V306_L0.6830.95
223_M317_G0.6830.95
238_F253_V0.6800.95
37_E75_N0.6780.95
83_I87_A0.6760.95
228_A232_E0.6740.95
235_T242_T0.6720.94
123_H148_K0.6710.94
101_E104_T0.6660.94
227_T231_E0.6660.94
221_I234_V0.6660.94
122_L157_M0.6630.94
222_S233_K0.6630.94
143_S146_T0.6580.94
78_G82_E0.6580.94
238_F241_Q0.6550.94
195_R199_H0.6550.94
34_V46_H0.6540.94
95_L101_E0.6530.94
119_E153_V0.6530.94
249_T252_P0.6520.94
206_L233_K0.6500.93
240_P244_D0.6490.93
73_Y78_G0.6460.93
262_F289_A0.6450.93
73_Y80_F0.6450.93
130_S133_R0.6430.93
261_V302_A0.6410.93
245_P254_L0.6400.93
292_L295_G0.6370.93
57_Q104_T0.6350.93
67_L90_M0.6340.93
137_A181_M0.6320.92
80_F84_R0.6320.92
251_N256_L0.6310.92
239_C243_R0.6310.92
286_E293_E0.6300.92
99_L102_D0.6300.92
130_S185_E0.6270.92
90_M94_F0.6270.92
42_L46_H0.6260.92
239_C242_T0.6250.92
261_V265_F0.6230.92
156_L186_E0.6220.92
237_A240_P0.6210.92
181_M184_R0.6190.92
304_G307_A0.6180.92
252_P262_F0.6170.92
305_A308_A0.6140.91
254_L257_F0.6130.91
144_G147_P0.6130.91
261_V305_A0.6120.91
314_I318_R0.6110.91
250_V254_L0.6100.91
57_Q63_V0.6070.91
166_D193_E0.6060.91
61_M169_L0.6060.91
51_N55_D0.6040.91
259_Y262_F0.6040.91
84_R87_A0.6030.91
159_A163_E0.6020.91
283_E288_L0.6010.90
99_L106_F0.6000.90
284_S309_A0.5990.90
229_D233_K0.5980.90
37_E90_M0.5980.90
69_D108_L0.5970.90
227_T314_I0.5960.90
261_V309_A0.5950.90
260_H265_F0.5950.90
118_Y121_D0.5920.90
248_E251_N0.5920.90
36_Y46_H0.5910.90
238_F243_R0.5910.90
92_A321_L0.5890.90
263_P266_D0.5880.90
70_V121_D0.5870.89
291_D302_A0.5860.89
255_E261_V0.5850.89
234_V306_L0.5840.89
255_E285_Y0.5820.89
310_L313_L0.5810.89
163_E186_E0.5800.89
123_H156_L0.5800.89
295_G298_H0.5790.89
123_H149_V0.5770.89
80_F83_I0.5760.89
313_L317_G0.5730.88
63_V104_T0.5730.88
41_V86_T0.5730.88
50_A54_M0.5680.88
258_Q261_V0.5660.88
188_P200_T0.5650.88
53_L65_V0.5650.88
251_N255_E0.5560.87
49_T171_I0.5560.87
119_E149_V0.5540.87
248_E254_L0.5530.87
205_D218_G0.5520.86
223_M313_L0.5510.86
249_T253_V0.5500.86
31_R168_D0.5500.86
34_V65_V0.5460.86
194_K202_I0.5440.86
39_S43_H0.5440.86
130_S146_T0.5430.86
204_G263_P0.5420.85
318_R321_L0.5400.85
262_F266_D0.5400.85
234_V240_P0.5400.85
31_R166_D0.5390.85
250_V256_L0.5380.85
225_D230_I0.5380.85
93_Q318_R0.5300.84
133_R137_A0.5260.84
197_V202_I0.5260.84
158_Q183_A0.5260.84
83_I86_T0.5250.84
228_A300_A0.5210.83
44_L310_L0.5210.83
259_Y292_L0.5210.83
137_A141_I0.5200.83
56_L169_L0.5190.83
47_L313_L0.5130.82
170_A180_H0.5130.82
128_E189_S0.5100.82
142_Q146_T0.5080.82
98_G102_D0.5080.82
235_T243_R0.5080.82
41_V89_Q0.5060.81
50_A99_L0.5050.81
115_D164_Y0.5050.81
163_E195_R0.5040.81
182_L186_E0.5030.81
127_V148_K0.5000.81
251_N258_Q0.5000.81
107_V112_F0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vgjA 2 0.9878 100 0.158 Contact Map
2cycA 2 0.9878 100 0.168 Contact Map
2dlcX 2 0.9541 100 0.175 Contact Map
2cyaA 2 0.945 100 0.179 Contact Map
1n3lA 2 0.9511 100 0.181 Contact Map
3p0jA 1 0.9817 100 0.19 Contact Map
2zp1A 2 0.9388 100 0.192 Contact Map
3jxeA 2 0.896 100 0.208 Contact Map
3i05A 2 0.844 100 0.227 Contact Map
3prhA 2 0.8196 100 0.229 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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