GREMLIN Database
RNZ - Ribonuclease Z
UniProt: Q9HN60 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 308 (295)
Sequences: 2365 (1709)
Seq/√Len: 99.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
87_T116_T4.5901.00
175_T180_Q3.8181.00
95_R99_E3.5261.00
206_V224_A3.5121.00
133_R149_V3.1741.00
96_G103_F3.1151.00
126_S151_D2.9411.00
225_D262_K2.8091.00
138_A212_R2.5911.00
223_D260_G2.5791.00
31_D55_S2.5761.00
181_P192_P2.5131.00
235_N250_G2.5041.00
85_P112_P2.4561.00
204_T224_A2.4071.00
150_E203_R2.3981.00
87_T114_R2.3721.00
147_A204_T2.2871.00
233_F244_T2.2661.00
97_D101_L2.2221.00
263_A292_F2.1701.00
254_D258_E2.1401.00
93_G117_E2.1241.00
35_F148_L2.0541.00
131_E149_V2.0511.00
74_V86_L2.0511.00
165_L195_V2.0451.00
149_V204_T2.0301.00
265_A294_A2.0261.00
174_S178_D2.0091.00
40_A43_R1.9881.00
58_F132_V1.9831.00
265_A300_H1.9621.00
250_G286_G1.9611.00
219_S222_E1.9461.00
23_S34_L1.9341.00
25_F34_L1.8951.00
123_V133_R1.8861.00
190_V195_V1.8841.00
89_H116_T1.8811.00
158_D161_R1.8601.00
71_P101_L1.8601.00
295_H298_L1.8481.00
229_H247_S1.8461.00
161_R164_E1.8351.00
44_Q47_R1.8281.00
5_V228_I1.8181.00
191_S194_Q1.7871.00
4_E27_R1.7731.00
24_V267_T1.7681.00
181_P191_S1.7581.00
85_P114_R1.7561.00
126_S131_E1.7501.00
184_L188_T1.7501.00
292_F298_L1.7241.00
284_A288_D1.6951.00
25_F32_A1.6901.00
4_E299_T1.6841.00
48_Y297_G1.6671.00
294_A298_L1.6641.00
56_D89_H1.6631.00
183_E189_V1.6351.00
11_S16_T1.6321.00
263_A290_E1.6201.00
235_N238_S1.6191.00
231_A266_L1.6171.00
23_S41_T1.6171.00
218_V258_E1.5991.00
78_D110_G1.5951.00
212_R251_E1.5931.00
5_V26_V1.5911.00
206_V221_A1.5481.00
218_V255_V1.5461.00
222_E260_G1.5271.00
238_S251_E1.5231.00
4_E301_E1.5131.00
7_F10_T1.5091.00
25_F50_T1.5021.00
288_D291_A1.4581.00
135_F220_A1.4531.00
216_P219_S1.4491.00
253_A287_F1.4391.00
285_S291_A1.3780.99
284_A287_F1.3590.99
179_G192_P1.3560.99
64_G68_F1.3460.99
157_F162_A1.3350.99
6_T299_T1.3350.99
44_Q297_G1.3300.99
221_A259_A1.3250.99
215_D258_E1.3230.99
54_V73_L1.3160.99
145_G208_T1.2890.99
20_N43_R1.2880.99
137_T145_G1.2870.99
56_D87_T1.2700.99
137_T208_T1.2530.99
183_E187_G1.2380.99
60_T146_Y1.2330.99
140_S245_G1.2310.99
249_A253_A1.2230.99
218_V259_A1.2170.99
88_I98_I1.2040.99
254_D257_T1.1990.98
239_E243_E1.1990.98
147_A224_A1.1990.98
26_V148_L1.1970.98
221_A224_A1.1910.98
35_F58_F1.1820.98
7_F294_A1.1800.98
159_R163_E1.1770.98
137_T143_S1.1710.98
57_V73_L1.1630.98
192_P195_V1.1530.98
176_L195_V1.1520.98
227_L261_A1.1400.98
286_G289_G1.1390.98
57_V70_L1.1390.98
158_D197_G1.1380.98
248_T252_A1.1380.98
147_A206_V1.1340.98
138_A245_G1.1310.98
136_E142_A1.1210.98
280_I291_A1.1170.98
284_A291_A1.1090.97
292_F300_H1.1030.97
95_R115_I1.1000.97
33_F130_Y1.0970.97
22_S267_T1.0960.97
250_G254_D1.0950.97
95_R117_E1.0880.97
10_T19_R1.0840.97
192_P196_V1.0790.97
167_V173_F1.0590.97
22_S207_Y1.0590.97
256_A264_L1.0520.97
242_A251_E1.0510.97
131_E151_D1.0510.97
42_Q72_G1.0440.96
212_R245_G1.0420.96
250_G287_F1.0410.96
75_H107_G1.0370.96
124_V146_Y1.0330.96
162_A195_V1.0290.96
59_I94_L1.0200.96
285_S288_D1.0170.96
213_P251_E1.0140.96
287_F291_A1.0140.96
5_V226_L0.9950.95
90_V94_L0.9800.95
33_F148_L0.9660.94
64_G232_T0.9590.94
20_N41_T0.9520.94
181_P193_E0.9480.94
26_V35_F0.9440.94
226_L265_A0.9390.94
136_E144_V0.9340.93
224_A261_A0.9320.93
223_D262_K0.9320.93
171_P175_T0.9270.93
216_P220_A0.9270.93
61_H66_H0.9240.93
98_I115_I0.9240.93
90_V117_E0.9210.93
98_I102_V0.9190.93
280_I285_S0.9180.93
7_F24_V0.9180.93
99_E103_F0.9120.93
231_A249_A0.8970.92
63_H66_H0.8970.92
90_V93_G0.8950.92
167_V176_L0.8830.91
213_P255_V0.8810.91
180_Q192_P0.8810.91
32_A54_V0.8810.91
152_D202_G0.8790.91
217_V255_V0.8760.91
11_S19_R0.8750.91
269_V293_V0.8740.91
172_K175_T0.8720.91
280_I284_A0.8640.90
240_R244_T0.8620.90
208_T217_V0.8590.90
241_A248_T0.8560.90
175_T179_G0.8560.90
58_F89_H0.8550.90
88_I94_L0.8540.90
161_R194_Q0.8510.90
191_S195_V0.8490.90
176_L182_V0.8410.89
152_D201_P0.8410.89
222_E258_E0.8370.89
68_F75_H0.8350.89
70_L74_V0.8220.88
251_E254_D0.8220.88
34_L54_V0.8210.88
183_E186_D0.8190.88
165_L190_V0.8150.88
18_E274_A0.8130.87
228_I267_T0.8130.87
17_T47_R0.8120.87
145_G217_V0.8080.87
257_T287_F0.8060.87
101_L105_A0.8040.87
106_G142_A0.8020.87
20_N44_Q0.8000.87
285_S289_G0.7990.87
285_S290_E0.7990.87
39_E42_Q0.7960.86
161_R165_L0.7940.86
253_A256_A0.7940.86
226_L263_A0.7930.86
267_T294_A0.7910.86
168_P172_K0.7900.86
92_R117_E0.7890.86
82_R111_Y0.7870.86
159_R173_F0.7830.85
6_T48_Y0.7810.85
172_K182_V0.7800.85
223_D261_A0.7740.85
276_D293_V0.7730.85
60_T209_G0.7720.85
67_V105_A0.7710.85
61_H65_D0.7640.84
118_A144_V0.7640.84
34_L45_M0.7630.84
197_G202_G0.7630.84
119_T222_E0.7610.84
55_S84_D0.7600.84
176_L192_P0.7600.84
5_V265_A0.7590.84
252_A261_A0.7590.84
143_S209_G0.7580.84
207_Y228_I0.7580.84
13_A21_P0.7570.83
253_A288_D0.7560.83
67_V71_P0.7530.83
217_V221_A0.7500.83
234_A249_A0.7500.83
263_A300_H0.7480.83
265_A292_F0.7420.82
176_L179_G0.7390.82
123_V126_S0.7360.82
135_F145_G0.7350.82
129_D151_D0.7330.81
235_N249_A0.7320.81
102_V107_G0.7290.81
118_A146_Y0.7260.81
45_M48_Y0.7260.81
295_H300_H0.7240.81
165_L194_Q0.7230.81
68_F105_A0.7220.81
204_T225_D0.7220.81
143_S146_Y0.7170.80
27_R32_A0.7130.80
82_R86_L0.7100.79
123_V131_E0.7090.79
218_V222_E0.7080.79
12_G22_S0.7080.79
215_D218_V0.7080.79
139_H146_Y0.7070.79
74_V88_I0.7050.79
214_H220_A0.7030.79
155_G197_G0.7030.79
27_R205_L0.7020.79
179_G182_V0.6990.78
52_F73_L0.6990.78
235_N282_A0.6990.78
135_F219_S0.6980.78
39_E72_G0.6940.78
66_H210_D0.6930.78
121_G135_F0.6910.78
29_N55_S0.6890.77
94_L98_I0.6880.77
215_D219_S0.6850.77
34_L41_T0.6830.77
60_T208_T0.6820.77
209_G229_H0.6800.76
45_M50_T0.6800.76
29_N127_H0.6780.76
231_A269_V0.6750.76
184_L190_V0.6750.76
181_P189_V0.6740.76
11_S271_S0.6710.75
45_M54_V0.6680.75
124_V133_R0.6670.75
197_G200_R0.6670.75
209_G247_S0.6650.75
240_R243_E0.6650.75
68_F107_G0.6600.74
31_D127_H0.6600.74
234_A237_A0.6600.74
137_T217_V0.6600.74
210_D246_H0.6590.74
166_G170_G0.6590.74
281_S285_S0.6580.74
155_G193_E0.6570.74
160_A163_E0.6530.73
134_A144_V0.6500.73
280_I293_V0.6490.73
37_A41_T0.6480.73
62_G94_L0.6440.72
176_L191_S0.6430.72
175_T178_D0.6430.72
276_D279_E0.6380.72
94_L117_E0.6380.72
157_F177_H0.6370.72
66_H230_D0.6360.72
214_H221_A0.6350.71
211_T252_A0.6340.71
100_D104_S0.6310.71
210_D268_H0.6300.71
54_V57_V0.6290.71
253_A259_A0.6280.71
277_A295_H0.6270.70
10_T296_D0.6240.70
170_G174_S0.6240.70
6_T50_T0.6240.70
12_G269_V0.6190.69
282_A285_S0.6160.69
36_D65_D0.6160.69
13_A232_T0.6150.69
73_L76_T0.6140.69
218_V254_D0.6130.69
137_T209_G0.6110.68
217_V220_A0.6110.68
97_D105_A0.6110.68
59_I88_I0.6070.68
229_H252_A0.6070.68
284_A289_G0.6070.68
149_V152_D0.6060.68
31_D130_Y0.6030.67
13_A271_S0.6030.67
238_S249_A0.6020.67
23_S37_A0.6020.67
62_G97_D0.6020.67
203_R302_I0.5990.67
269_V294_A0.5980.67
248_T256_A0.5950.66
90_V101_L0.5950.66
231_A279_E0.5920.66
63_H230_D0.5900.66
77_W111_Y0.5890.66
135_F147_A0.5880.66
214_H217_V0.5870.65
205_L228_I0.5860.65
66_H246_H0.5830.65
74_V111_Y0.5820.65
160_A164_E0.5820.65
36_D66_H0.5810.65
184_L187_G0.5800.64
163_E168_P0.5790.64
36_D61_H0.5780.64
123_V127_H0.5760.64
168_P173_F0.5730.64
229_H255_V0.5730.64
37_A59_I0.5730.64
99_E115_I0.5710.63
19_R296_D0.5710.63
59_I70_L0.5710.63
63_H210_D0.5680.63
26_V205_L0.5680.63
292_F295_H0.5680.63
24_V228_I0.5650.62
61_H246_H0.5640.62
137_T230_D0.5630.62
250_G282_A0.5620.62
246_H268_H0.5620.62
20_N296_D0.5620.62
43_R47_R0.5610.62
135_F217_V0.5600.62
98_I113_V0.5590.62
138_A214_H0.5560.61
24_V207_Y0.5550.61
5_V207_Y0.5550.61
155_G198_D0.5540.61
11_S17_T0.5540.61
127_H151_D0.5520.61
91_P146_Y0.5520.61
74_V107_G0.5520.61
277_A281_S0.5510.61
163_E166_G0.5500.60
198_D215_D0.5490.60
133_R220_A0.5490.60
66_H268_H0.5470.60
155_G199_P0.5460.60
156_R200_R0.5440.60
227_L255_V0.5440.60
266_L291_A0.5410.59
27_R30_G0.5400.59
239_E242_A0.5390.59
94_L101_L0.5370.59
43_R46_M0.5360.58
209_G213_P0.5360.58
213_P258_E0.5360.58
10_T294_A0.5350.58
155_G202_G0.5350.58
175_T182_V0.5340.58
212_R255_V0.5340.58
33_F58_F0.5340.58
147_A220_A0.5340.58
256_A288_D0.5330.58
155_G196_V0.5330.58
178_D201_P0.5330.58
125_R130_Y0.5320.58
209_G232_T0.5290.57
143_S208_T0.5260.57
211_T214_H0.5260.57
213_P259_A0.5260.57
17_T48_Y0.5230.57
12_G21_P0.5230.57
101_L104_S0.5210.56
253_A264_L0.5210.56
135_F216_P0.5190.56
36_D63_H0.5180.56
42_Q76_T0.5180.56
208_T229_H0.5170.56
184_L189_V0.5160.56
57_V88_I0.5160.56
183_E260_G0.5150.56
287_F290_E0.5140.55
281_S286_G0.5130.55
237_A273_Y0.5130.55
121_G260_G0.5120.55
143_S207_Y0.5110.55
61_H210_D0.5090.55
44_Q48_Y0.5080.54
157_F167_V0.5080.54
209_G269_V0.5080.54
282_A293_V0.5060.54
127_H130_Y0.5050.54
64_G75_H0.5050.54
55_S127_H0.5050.54
139_H145_G0.5050.54
129_D153_R0.5040.54
52_F76_T0.5040.54
171_P174_S0.5030.54
167_V172_K0.5020.54
89_H124_V0.5020.54
249_A273_Y0.5000.53
119_T123_V0.5000.53
147_A221_A0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.7695 100 0.306 Contact Map
1y44A 2 0.9805 100 0.367 Contact Map
2cbnA 2 0.9708 100 0.368 Contact Map
2e7yA 2 0.8474 100 0.53 Contact Map
3jxpA 2 0.8377 100 0.58 Contact Map
1zkpA 2 0.7857 100 0.585 Contact Map
3g1pA 2 0.7338 100 0.6 Contact Map
4ojvA 2 0.8084 100 0.604 Contact Map
3md7A 2 0.763 100 0.614 Contact Map
4jo0A 2 0.7468 100 0.693 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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