GREMLIN Database
Q9HN59 - Replication factor C small subunit
UniProt: Q9HN59 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (285)
Sequences: 21197 (13328)
Seq/√Len: 789.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_V206_E4.1201.00
8_D12_P3.9421.00
20_A184_E3.4391.00
186_V190_R3.1421.00
181_T184_E3.1251.00
190_R205_L2.5791.00
190_R202_P2.4711.00
182_D210_G2.4141.00
185_V209_A2.3251.00
262_A265_D2.2801.00
313_F317_R2.2381.00
182_D209_A2.2051.00
302_A306_A2.1971.00
49_A177_V2.1891.00
310_D314_D2.1311.00
186_V205_L2.1251.00
267_R270_L2.0871.00
305_Y309_G1.9911.00
239_Y242_L1.9831.00
268_S272_D1.9631.00
191_E195_A1.9321.00
201_E204_G1.9011.00
234_T237_A1.8971.00
312_E316_T1.8751.00
278_G282_G1.8591.00
187_D190_R1.8301.00
291_V294_S1.7931.00
318_G321_D1.7741.00
278_G281_G1.7691.00
68_V71_A1.7591.00
67_E74_F1.7571.00
64_D67_E1.7411.00
199_D232_E1.7241.00
309_G313_F1.7191.00
133_I136_D1.7031.00
309_G312_E1.6511.00
65_L74_F1.6311.00
38_V177_V1.6191.00
252_E256_D1.6121.00
69_N74_F1.6001.00
206_E210_G1.5881.00
15_A27_R1.5841.00
248_D252_E1.5821.00
301_V305_Y1.5531.00
179_A216_L1.5491.00
193_V205_L1.5421.00
39_Y174_P1.5211.00
297_S300_D1.5211.00
189_L219_A1.4941.00
250_A254_M1.4861.00
182_D206_E1.4821.00
37_V130_A1.4791.00
102_A106_N1.4721.00
256_D260_A1.4681.00
289_L293_R1.4671.00
275_V278_G1.4671.00
212_A219_A1.4641.00
261_G265_D1.4611.00
73_V76_M1.4541.00
269_T273_L1.4501.00
188_V216_L1.4431.00
253_S257_D1.4421.00
303_E307_L1.4221.00
259_E262_A1.4181.00
240_E244_D1.4121.00
308_A312_E1.4091.00
65_L70_V1.4081.00
65_L69_N1.4051.00
288_L292_A1.3951.00
114_S118_V1.3941.00
290_E294_S1.3931.00
306_A310_D1.3821.00
186_V209_A1.3711.00
20_A187_D1.3601.00
249_A253_S1.3591.00
302_A305_Y1.3511.00
272_D276_D1.3491.00
258_A291_V1.3371.00
277_E281_G1.3281.00
66_V69_N1.3241.00
126_L157_A1.3211.00
184_E187_D1.3211.00
22_V175_V1.3201.00
287_D291_V1.3101.00
289_L292_A1.3031.00
188_V191_E1.3011.00
115_Y119_S1.2981.00
281_G284_V1.2961.00
72_D76_M1.2961.00
101_K104_L1.2921.00
207_F210_G1.2911.00
269_T272_D1.2881.00
70_V75_G1.2861.00
182_D186_V1.2851.00
180_P216_L1.2791.00
189_L205_L1.2731.00
72_D75_G1.2721.00
192_I220_V1.2691.00
239_Y244_D1.2681.00
133_I137_F1.2681.00
246_G249_A1.2641.00
23_R27_R1.2611.00
69_N72_D1.2591.00
241_A244_D1.2321.00
70_V73_V1.2321.00
298_G302_A1.2271.00
8_D11_A1.2131.00
27_R31_D1.2131.00
39_Y176_S1.2021.00
187_D191_E1.2011.00
235_M239_Y1.1981.00
248_D251_V1.1891.00
183_N186_V1.1851.00
286_D290_E1.1661.00
275_V279_M1.1571.00
70_V74_F1.1571.00
132_A135_E1.1351.00
182_D213_E1.1321.00
230_E234_T1.1281.00
247_S258_A1.1271.00
231_G235_M1.1261.00
232_E235_M1.1251.00
246_G250_A1.1231.00
200_Y205_L1.1191.00
300_D303_E1.1121.00
280_S283_E1.1071.00
288_L291_V1.1061.00
279_M282_G1.1041.00
267_R271_D1.1011.00
261_G264_T1.0981.00
247_S250_A1.0961.00
305_Y308_A1.0961.00
37_V172_C1.0961.00
288_L293_R1.0821.00
252_E255_L1.0791.00
272_D277_E1.0781.00
253_S256_D1.0691.00
69_N73_V1.0641.00
114_S117_P1.0561.00
112_T116_S1.0531.00
250_A253_S1.0521.00
193_V200_Y1.0511.00
71_A74_F1.0481.00
247_S254_M1.0451.00
263_F266_A1.0391.00
230_E237_A1.0321.00
19_Q22_V1.0301.00
276_D280_S1.0221.00
185_V219_A1.0211.00
65_L72_D1.0161.00
192_I195_A1.0161.00
183_N187_D1.0151.00
139_Q142_R1.0141.00
67_E70_V1.0141.00
134_R137_F1.0131.00
281_G285_L1.0101.00
255_L258_A1.0091.00
113_A117_P1.0071.00
205_L209_A1.0071.00
236_N239_Y0.9931.00
239_Y243_Q0.9911.00
189_L220_V0.9891.00
311_V314_D0.9881.00
307_L311_V0.9771.00
291_V295_R0.9771.00
266_A270_L0.9741.00
235_M238_A0.9671.00
267_R273_L0.9611.00
102_A136_D0.9591.00
251_V255_L0.9571.00
297_S301_V0.9561.00
62_E65_L0.9551.00
9_E196_E0.9551.00
207_F235_M0.9541.00
279_M283_E0.9511.00
117_P149_H0.9511.00
201_E232_E0.9451.00
266_A269_T0.9421.00
26_L53_L0.9421.00
265_D269_T0.9331.00
310_D313_F0.9321.00
231_G239_Y0.9251.00
21_S178_R0.9251.00
228_E237_A0.9241.00
275_V282_G0.9221.00
313_F316_T0.9221.00
13_S55_A0.9221.00
50_V155_I0.9211.00
307_L310_D0.9191.00
66_V70_V0.9171.00
299_D303_E0.9161.00
306_A309_G0.9161.00
169_H174_P0.9141.00
233_V238_A0.9131.00
132_A136_D0.9111.00
14_L55_A0.9081.00
47_T128_D0.9081.00
103_D107_H0.9071.00
248_D255_L0.9021.00
112_T115_Y0.9011.00
231_G237_A0.9001.00
140_A144_V0.9001.00
278_G285_L0.8991.00
257_D265_D0.8981.00
254_M258_A0.8961.00
228_E232_E0.8931.00
107_H110_K0.8931.00
183_N206_E0.8921.00
298_G301_V0.8921.00
39_Y161_P0.8851.00
190_R194_A0.8771.00
280_S284_V0.8741.00
54_A124_T0.8731.00
231_G234_T0.8701.00
101_K105_V0.8681.00
282_G285_L0.8651.00
275_V281_G0.8591.00
103_D106_N0.8571.00
179_A213_E0.8561.00
67_E71_A0.8541.00
202_P206_E0.8521.00
232_E237_A0.8521.00
204_G207_F0.8521.00
303_E306_A0.8521.00
208_V223_A0.8511.00
254_M257_D0.8511.00
200_Y227_A0.8441.00
270_L273_L0.8441.00
162_S165_I0.8421.00
249_A252_E0.8401.00
234_T238_A0.8331.00
66_V73_V0.8331.00
198_V227_A0.8301.00
29_A36_L0.8281.00
193_V223_A0.8271.00
300_D304_L0.8251.00
33_P36_L0.8251.00
251_V254_M0.8241.00
13_S16_D0.8231.00
264_T268_S0.8171.00
105_V109_L0.8151.00
283_E287_D0.8121.00
155_I158_T0.8111.00
67_E72_D0.8071.00
185_V216_L0.8011.00
122_Y153_Q0.7991.00
286_D289_L0.7951.00
130_A164_L0.7911.00
247_S252_E0.7911.00
219_A223_A0.7901.00
263_F267_R0.7891.00
271_D275_V0.7881.00
248_D258_A0.7861.00
275_V285_L0.7861.00
25_R28_D0.7841.00
154_F157_A0.7821.00
278_G284_V0.7791.00
236_N240_E0.7771.00
70_V76_M0.7751.00
208_V219_A0.7631.00
154_F158_T0.7621.00
278_G283_E0.7601.00
277_E280_S0.7591.00
279_M284_V0.7541.00
66_V71_A0.7511.00
229_Q235_M0.7501.00
304_L307_L0.7481.00
252_E257_D0.7471.00
209_A219_A0.7471.00
116_S119_S0.7461.00
57_A153_Q0.7461.00
71_A75_G0.7451.00
240_E243_Q0.7451.00
203_D235_M0.7451.00
71_A140_A0.7441.00
10_H196_E0.7431.00
212_A215_D0.7401.00
67_E75_G0.7391.00
63_T66_V0.7361.00
66_V74_F0.7321.00
316_T319_T0.7271.00
140_A146_E0.7211.00
250_A255_L0.7171.00
229_Q232_E0.7141.00
24_D27_R0.7131.00
247_S251_V0.7121.00
64_D73_V0.7081.00
142_R146_E0.7061.00
65_L68_V0.7041.00
233_V237_A0.7021.00
69_N75_G0.7021.00
189_L208_V0.7021.00
304_L308_A0.7001.00
248_D253_S0.6991.00
167_P171_R0.6991.00
282_G286_D0.6971.00
101_K134_R0.6941.00
311_V315_L0.6941.00
9_E12_P0.6931.00
185_V189_L0.6931.00
247_S256_D0.6921.00
104_L108_V0.6901.00
68_V73_V0.6891.00
268_S271_D0.6881.00
255_L259_E0.6881.00
246_G255_L0.6841.00
301_V304_L0.6821.00
277_E284_V0.6811.00
130_A156_I0.6811.00
130_A154_F0.6791.00
53_L155_I0.6781.00
115_Y118_V0.6711.00
247_S253_S0.6701.00
152_T158_T0.6691.00
314_D319_T0.6671.00
228_E231_G0.6671.00
64_D69_N0.6651.00
22_V25_R0.6631.00
65_L126_L0.6631.00
207_F211_Y0.6561.00
219_A222_G0.6531.00
186_V202_P0.6501.00
298_G305_Y0.6501.00
243_Q247_S0.6491.00
292_A295_R0.6491.00
68_V127_L0.6481.00
44_A177_V0.6471.00
102_A105_V0.6461.00
232_E236_N0.6441.00
20_A24_D0.6431.00
112_T117_P0.6401.00
25_R175_V0.6371.00
199_D202_P0.6371.00
277_E285_L0.6311.00
263_F269_T0.6291.00
161_P174_P0.6281.00
71_A76_M0.6261.00
65_L71_A0.6261.00
65_L73_V0.6241.00
284_V288_L0.6211.00
26_L175_V0.6211.00
113_A116_S0.6201.00
109_L113_A0.6171.00
64_D70_V0.6161.00
250_A257_D0.6161.00
105_V108_V0.6161.00
216_L219_A0.6151.00
314_D317_R0.6141.00
247_S255_L0.6101.00
36_L175_V0.6081.00
50_V126_L0.6071.00
212_A222_G0.6061.00
57_A63_T0.6051.00
286_D293_R0.6041.00
66_V75_G0.6031.00
296_Y301_V0.6021.00
298_G306_A0.6011.00
130_A138_Q0.5981.00
62_E66_V0.5981.00
64_D74_F0.5931.00
11_A64_D0.5921.00
275_V284_V0.5911.00
25_R225_T0.5911.00
262_A267_R0.5891.00
239_Y247_S0.5831.00
23_R49_A0.5761.00
188_V192_I0.5751.00
312_E315_L0.5741.00
295_R298_G0.5741.00
290_E293_R0.5731.00
248_D256_D0.5721.00
63_T67_E0.5711.00
40_G46_K0.5701.00
142_R145_M0.5681.00
265_D268_S0.5681.00
311_V316_T0.5671.00
101_K106_N0.5671.00
255_L290_E0.5631.00
68_V75_G0.5621.00
102_A140_A0.5611.00
246_G258_A0.5601.00
65_L76_M0.5591.00
30_V53_L0.5541.00
237_A241_A0.5521.00
258_A261_G0.5511.00
52_A55_A0.5511.00
191_E194_A0.5501.00
180_P184_E0.5491.00
276_D279_M0.5471.00
27_R56_A0.5451.00
247_S257_D0.5451.00
180_P185_V0.5431.00
232_E239_Y0.5431.00
192_I196_E0.5431.00
38_V49_A0.5421.00
224_Q227_A0.5411.00
143_R146_E0.5411.00
10_H195_A0.5351.00
41_P44_A0.5321.00
257_D262_A0.5311.00
10_H192_I0.5311.00
64_D68_V0.5291.00
189_L223_A0.5281.00
36_L177_V0.5271.00
215_D223_A0.5261.00
67_E73_V0.5261.00
233_V236_N0.5251.00
143_R147_R0.5251.00
68_V72_D0.5231.00
231_G238_A0.5211.00
299_D302_A0.5191.00
251_V257_D0.5181.00
259_E263_F0.5181.00
237_A240_E0.5181.00
132_A137_F0.5181.00
106_N110_K0.5171.00
297_S303_E0.5151.00
196_E233_V0.5101.00
243_Q258_A0.5091.00
65_L75_G0.5081.00
208_V222_G0.5071.00
68_V74_F0.5061.00
28_D31_D0.5051.00
113_A125_I0.5051.00
103_D110_K0.5031.00
67_E76_M0.5031.00
300_D307_L0.5011.00
286_D292_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1sxjD 1 0.9042 100 0.381 Contact Map
1iqpA 5 0.9192 100 0.383 Contact Map
2chqA 3 0.9072 100 0.389 Contact Map
1sxjC 1 0.9132 100 0.409 Contact Map
1sxjE 1 0.9012 100 0.434 Contact Map
1jr3A 3 0.9671 100 0.449 Contact Map
3u61B 3 0.8832 100 0.457 Contact Map
1sxjB 1 0.9042 100 0.476 Contact Map
3pvsA 4 0.8862 100 0.509 Contact Map
1a5tA 2 0.9012 100 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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