GREMLIN Database
Q9HN57 - Uncharacterized protein
UniProt: Q9HN57 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 161 (150)
Sequences: 2900 (1886)
Seq/√Len: 154.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_L44_G4.6621.00
59_L68_T4.3881.00
59_L64_D3.3511.00
84_D120_G3.0821.00
26_C44_G2.7711.00
52_A68_T2.7331.00
144_R156_H2.6881.00
49_A70_R2.5181.00
32_L42_P2.4561.00
52_A70_R2.4351.00
72_D75_A2.3241.00
11_N38_L2.2441.00
45_T71_A2.2231.00
9_A31_V2.1631.00
22_L76_L2.0791.00
9_A157_V2.0641.00
114_L122_C1.9371.00
21_V87_V1.9171.00
10_C13_A1.9091.00
110_A114_L1.8941.00
22_L45_T1.8041.00
98_I102_D1.7041.00
21_V42_P1.6591.00
13_A85_A1.6101.00
53_A56_R1.6061.00
59_L66_A1.6041.00
41_H67_T1.6031.00
74_T109_G1.5971.00
55_A68_T1.5661.00
37_L64_D1.5381.00
51_M54_G1.5281.00
25_M88_L1.5261.00
44_G55_A1.4951.00
113_E117_V1.4611.00
29_G55_A1.4441.00
45_T76_L1.4101.00
15_V21_V1.4061.00
16_T19_D1.4031.00
52_A55_A1.3871.00
70_R98_I1.3631.00
57_R60_T1.3511.00
114_L118_T1.3461.00
73_A113_E1.3461.00
122_C137_A1.3061.00
20_R119_A1.2961.00
13_A123_V1.2931.00
131_R154_V1.2931.00
24_P88_L1.2911.00
88_L124_L1.2571.00
21_V32_L1.2211.00
109_G112_D1.2201.00
83_I119_A1.2061.00
32_L59_L1.1951.00
73_A110_A1.1831.00
29_G44_G1.1611.00
31_V87_V1.1461.00
103_L107_V1.1441.00
42_P66_A1.1391.00
107_V126_A1.1391.00
26_C29_G1.1301.00
15_V125_V1.1201.00
113_E116_R1.1070.99
32_L66_A1.1060.99
115_A139_W1.0690.99
32_L68_T1.0690.99
112_D116_R1.0490.99
150_H153_L1.0320.99
99_A104_A1.0200.99
21_V35_A1.0150.99
19_D85_A1.0100.99
104_A136_A1.0060.99
132_A136_A1.0050.99
92_Y150_H1.0040.99
141_V144_R1.0040.99
134_A137_A1.0010.99
71_A75_A0.9980.99
45_T69_G0.9950.99
9_A87_V0.9940.99
92_Y95_Q0.9670.99
92_Y130_W0.9670.99
12_L145_F0.9490.98
10_C31_V0.9470.98
29_G68_T0.9460.98
21_V31_V0.9410.98
78_L82_S0.9400.98
22_L118_T0.9390.98
20_R41_H0.9340.98
72_D109_G0.9210.98
150_H155_R0.9180.98
19_D121_R0.9150.98
36_G42_P0.9130.98
46_D51_M0.8850.97
64_D68_T0.8830.97
36_G64_D0.8820.97
43_I69_G0.8800.97
7_R89_D0.8680.97
133_E137_A0.8560.97
34_E37_L0.8530.97
88_L110_A0.8520.97
9_A125_V0.8440.97
57_R61_H0.8420.97
47_A72_D0.8410.97
97_K133_E0.8330.96
41_H81_D0.8190.96
53_A57_R0.8130.96
23_D91_P0.8030.96
132_A135_T0.8030.96
13_A34_E0.8020.95
33_I64_D0.7990.95
10_C21_V0.7800.95
78_L81_D0.7790.95
118_T139_W0.7730.94
20_R84_D0.7650.94
146_Q156_H0.7650.94
111_L138_G0.7560.94
56_R68_T0.7560.94
29_G59_L0.7510.94
79_P82_S0.7500.94
93_G97_K0.7470.93
82_S119_A0.7470.93
16_T85_A0.7450.93
86_A114_L0.7450.93
143_A146_Q0.7440.93
113_E118_T0.7400.93
15_V35_A0.7360.93
76_L113_E0.7330.93
123_V145_F0.7320.93
46_D52_A0.7290.93
22_L43_I0.7280.93
105_D109_G0.7260.92
127_D153_L0.7250.92
33_I66_A0.7210.92
131_R144_R0.7170.92
48_Q51_M0.7120.92
114_L137_A0.7070.91
53_A67_T0.7050.91
10_C87_V0.6990.91
25_M106_L0.6850.90
4_L7_R0.6830.90
10_C85_A0.6820.90
102_D105_D0.6800.90
125_V136_A0.6760.90
19_D83_I0.6720.89
135_T139_W0.6690.89
56_R69_G0.6680.89
5_L94_R0.6650.89
10_C35_A0.6640.89
89_D95_Q0.6620.89
9_A147_R0.6600.88
5_L8_A0.6550.88
12_L147_R0.6550.88
5_L150_H0.6540.88
20_R82_S0.6520.88
144_R154_V0.6420.87
43_I67_T0.6410.87
23_D44_G0.6320.86
28_T89_D0.6320.86
34_E87_V0.6280.86
114_L124_L0.6220.85
52_A56_R0.6220.85
10_C32_L0.6160.85
30_G125_V0.6130.84
114_L117_V0.6120.84
105_D108_G0.6110.84
36_G62_Y0.6100.84
44_G66_A0.6090.84
151_R154_V0.6060.84
122_C153_L0.6040.84
134_A141_V0.6020.83
89_D96_S0.6010.83
123_V157_V0.6000.83
30_G89_D0.5960.83
103_L133_E0.5930.82
134_A138_G0.5890.82
45_T67_T0.5870.82
25_M73_A0.5860.82
90_A95_Q0.5850.82
57_R115_A0.5850.82
99_A102_D0.5840.81
111_L115_A0.5840.81
147_R150_H0.5830.81
140_T144_R0.5820.81
9_A25_M0.5770.81
104_A130_W0.5760.81
92_Y153_L0.5750.80
4_L8_A0.5750.80
9_A127_D0.5740.80
71_A76_L0.5630.79
146_Q154_V0.5580.78
46_D71_A0.5570.78
58_N155_R0.5500.77
72_D78_L0.5460.77
43_I83_I0.5460.77
20_R43_I0.5430.77
108_G112_D0.5430.77
76_L118_T0.5430.77
10_C15_V0.5390.76
17_P39_G0.5370.76
26_C34_E0.5370.76
22_L25_M0.5330.75
67_T70_R0.5330.75
73_A109_G0.5330.75
131_R156_H0.5310.75
10_C39_G0.5260.74
107_V130_W0.5250.74
98_I101_H0.5240.74
12_L143_A0.5230.74
130_W133_E0.5220.74
54_G58_N0.5190.73
9_A23_D0.5180.73
23_D106_L0.5170.73
108_G138_G0.5170.73
79_P119_A0.5160.73
101_H104_A0.5160.73
13_A38_L0.5160.73
42_P59_L0.5150.73
26_C150_H0.5130.73
25_M118_T0.5100.72
104_A108_G0.5090.72
144_R147_R0.5060.71
125_V155_R0.5060.71
131_R141_V0.5050.71
94_R127_D0.5050.71
88_L114_L0.5040.71
31_V34_E0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ldgA 1 0.9689 100 0.259 Contact Map
3lduA 1 0.9689 100 0.269 Contact Map
3k0bA 1 0.9441 100 0.281 Contact Map
3v97A 1 0.9565 100 0.288 Contact Map
3tm4A 1 0.9441 100 0.364 Contact Map
3tmaA 2 0.9503 100 0.374 Contact Map
3s1sA 1 0.9814 99.8 0.593 Contact Map
3ufbA 1 0.9876 99.8 0.6 Contact Map
3khkA 1 0.9689 99.8 0.607 Contact Map
2ar0A 1 0.9752 99.8 0.608 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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