GREMLIN Database
TBPE - TATA-box-binding protein E
UniProt: Q9HN56 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 186 (174)
Sequences: 546 (348)
Seq/√Len: 26.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_L28_V5.2211.00
54_S69_A4.3561.00
59_F67_T3.0331.00
135_F152_F3.0301.00
142_L145_P2.9961.00
35_A45_L2.9241.00
42_F59_F2.7320.99
15_A75_V2.5390.99
54_S78_S2.5260.99
42_F57_L2.3800.99
147_V171_A2.3550.98
44_G154_S2.3360.98
67_T160_T2.2610.98
150_L158_V2.2180.98
12_N103_N2.2060.98
84_D87_R2.2030.98
36_D48_R2.0480.96
46_V59_F2.0380.96
54_S82_V2.0100.96
105_V158_V1.9640.95
142_L175_I1.9390.95
159_I168_A1.9190.95
135_F150_L1.8910.94
80_R84_D1.8460.93
18_G98_E1.8330.93
33_E40_E1.8250.93
149_A175_I1.8050.92
142_L174_K1.7720.92
46_V57_L1.7110.90
13_V75_V1.6720.89
13_V71_S1.6650.89
26_Q30_M1.6580.89
19_I86_L1.6540.89
132_P155_G1.6420.88
102_Q105_V1.5160.84
120_A138_L1.4490.81
42_F103_N1.4310.80
57_L65_V1.4270.80
136_P152_F1.4170.79
47_Y58_I1.3640.77
17_T64_I1.3560.76
47_Y85_K1.3490.76
119_I149_A1.3330.75
110_L159_I1.3320.75
61_S131_E1.3290.75
65_V107_S1.2950.73
45_L168_A1.2750.72
68_G132_P1.2680.71
22_E60_R1.2470.70
149_A157_L1.2390.69
137_G154_S1.2380.69
45_L126_E1.2070.67
15_A66_C1.2020.67
54_S75_V1.1930.66
66_C175_I1.1850.66
105_V150_L1.1790.66
10_I49_T1.1780.65
144_D170_H1.1680.65
50_Q178_R1.1620.64
21_Q91_I1.1580.64
139_V150_L1.1300.62
56_A82_V1.1280.62
109_D156_K1.1270.62
35_A181_E1.1200.61
44_G59_F1.1110.61
42_F46_V1.1040.60
8_I172_V1.0800.59
103_N160_T1.0790.59
154_S179_L1.0740.58
10_I20_G1.0730.58
93_V151_L1.0600.57
34_G48_R1.0550.57
101_V151_L1.0540.57
58_I136_P1.0460.56
68_G161_G1.0380.56
8_I108_A1.0370.55
57_L150_L1.0320.55
19_I83_F1.0270.55
12_N160_T1.0250.55
162_G171_A1.0230.54
41_Q45_L1.0220.54
44_G57_L1.0130.54
114_L151_L1.0050.53
40_E159_I1.0020.53
55_A59_F1.0020.53
159_I172_V1.0000.53
20_G71_S0.9940.52
59_F65_V0.9870.52
24_D27_S0.9870.52
71_S78_S0.9850.52
84_D178_R0.9810.51
117_N121_I0.9710.51
45_L106_T0.9690.50
49_T107_S0.9620.50
89_L182_L0.9520.49
127_N140_Y0.9370.48
104_I161_G0.9340.48
46_V55_A0.9280.47
66_C75_V0.9200.47
11_E107_S0.9180.47
13_V144_D0.9090.46
115_N153_G0.9060.46
27_S180_E0.9060.46
17_T111_G0.9040.46
27_S31_D0.9030.46
15_A43_P0.9010.45
173_D181_E0.9000.45
28_V36_D0.8920.45
14_V42_F0.8910.45
53_K154_S0.8870.44
55_A79_L0.8860.44
131_E141_R0.8820.44
128_I182_L0.8780.44
41_Q146_E0.8750.43
150_L156_K0.8750.43
66_C69_A0.8740.43
29_A35_A0.8640.43
123_L140_Y0.8510.42
49_T78_S0.8490.42
43_P115_N0.8450.41
121_I126_E0.8440.41
10_I107_S0.8390.41
16_S46_V0.8330.40
77_E81_I0.8330.40
20_G179_L0.8320.40
21_Q95_D0.8290.40
120_A126_E0.8270.40
29_A86_L0.8260.40
157_L177_S0.8210.40
9_N70_K0.8180.39
31_D89_L0.8130.39
38_D113_Q0.8060.38
28_V107_S0.8010.38
24_D113_Q0.7940.38
122_G182_L0.7940.38
95_D177_S0.7870.37
108_A168_A0.7850.37
104_I147_V0.7830.37
71_S111_G0.7820.37
61_S74_D0.7720.36
57_L135_F0.7640.36
7_T169_E0.7620.35
81_I177_S0.7600.35
144_D174_K0.7580.35
156_K163_K0.7580.35
22_E118_A0.7560.35
52_P145_P0.7550.35
63_K103_N0.7490.35
43_P110_L0.7460.34
148_V160_T0.7460.34
48_R102_Q0.7430.34
62_G68_G0.7360.34
147_V162_G0.7310.33
81_I85_K0.7310.33
9_N140_Y0.7300.33
137_G152_F0.7300.33
126_E143_D0.7270.33
40_E115_N0.7240.33
169_E173_D0.7210.33
13_V91_I0.7190.33
131_E161_G0.7170.32
123_L129_E0.7080.32
170_H173_D0.7070.32
31_D38_D0.7070.32
75_V78_S0.7050.32
51_D92_K0.7040.32
131_E137_G0.6960.31
19_I176_T0.6930.31
78_S158_V0.6880.31
141_R154_S0.6840.30
67_T102_Q0.6820.30
39_P119_I0.6770.30
178_R182_L0.6750.30
53_K145_P0.6750.30
137_G162_G0.6700.29
119_I138_L0.6670.29
106_T110_L0.6630.29
77_E95_D0.6600.29
123_L128_I0.6600.29
33_E127_N0.6590.29
111_G177_S0.6570.29
21_Q28_V0.6550.29
13_V157_L0.6490.28
132_P161_G0.6490.28
82_V107_S0.6490.28
79_L108_A0.6480.28
11_E119_I0.6450.28
29_A60_R0.6440.28
27_S181_E0.6430.28
102_Q136_P0.6400.28
35_A172_V0.6340.27
48_R52_P0.6330.27
105_V135_F0.6330.27
21_Q89_L0.6290.27
53_K146_E0.6260.27
74_D164_E0.6250.27
63_K81_I0.6220.27
47_Y55_A0.6180.26
129_E134_Q0.6140.26
47_Y65_V0.6130.26
169_E181_E0.6130.26
70_K163_K0.6110.26
35_A122_G0.6040.26
125_L129_E0.6030.25
32_L118_A0.5940.25
38_D107_S0.5930.25
23_L37_Y0.5920.25
8_I118_A0.5900.25
135_F156_K0.5890.25
60_R107_S0.5870.25
61_S147_V0.5850.24
62_G155_G0.5840.24
88_E95_D0.5810.24
71_S159_I0.5810.24
30_M88_E0.5790.24
136_P140_Y0.5780.24
118_A121_I0.5640.23
106_T168_A0.5620.23
141_R148_V0.5570.23
83_F87_R0.5550.23
84_D94_E0.5550.23
24_D114_L0.5550.23
147_V175_I0.5540.23
133_E155_G0.5530.23
156_K161_G0.5490.23
59_F103_N0.5490.23
157_L176_T0.5470.22
148_V153_G0.5470.22
97_P106_T0.5430.22
91_I95_D0.5380.22
14_V133_E0.5360.22
92_K119_I0.5350.22
74_D173_D0.5340.22
31_D151_L0.5340.22
42_F55_A0.5320.22
23_L119_I0.5310.22
120_A171_A0.5310.22
28_V82_V0.5290.22
120_A125_L0.5280.21
104_I120_A0.5270.21
16_S55_A0.5220.21
8_I75_V0.5210.21
65_V78_S0.5190.21
9_N175_I0.5190.21
49_T59_F0.5180.21
19_I169_E0.5180.21
100_V148_V0.5160.21
17_T128_I0.5160.21
89_L93_V0.5150.21
21_Q82_V0.5150.21
18_G21_Q0.5120.21
105_V139_V0.5070.20
30_M82_V0.5070.20
12_N130_Y0.5030.20
16_S105_V0.5030.20
10_I147_V0.5030.20
123_L127_N0.5020.20
58_I106_T0.5020.20
16_S19_I0.5020.20
13_V101_V0.5000.20
136_P158_V0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rm1A 1 0.9677 100 0.063 Contact Map
4b0aA 1 0.9624 100 0.07 Contact Map
1ytbA 1 0.9677 100 0.074 Contact Map
3eikA 2 0.957 100 0.078 Contact Map
1aisA 1 0.9677 100 0.114 Contact Map
2z8uA 2 0.9462 100 0.115 Contact Map
1mp9A 2 0.9892 100 0.116 Contact Map
2d0bA 1 0.4247 88 0.921 Contact Map
3vn5A 1 0.3763 76.8 0.93 Contact Map
4py5A 1 0.3978 75.5 0.931 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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