GREMLIN Database
HIS1 - ATP phosphoribosyltransferase
UniProt: Q9HN53 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (277)
Sequences: 1486 (790)
Seq/√Len: 47.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
110_D132_T5.7621.00
85_D179_S5.2191.00
126_F133_P4.7531.00
109_L153_A4.1231.00
221_R224_D4.1211.00
219_A246_V4.0261.00
78_D186_E3.6801.00
222_L248_V3.5161.00
124_A128_D3.4251.00
217_A225_V3.2621.00
69_H82_E3.0361.00
218_P221_R3.0001.00
114_V126_F2.9471.00
95_L125_Y2.9371.00
104_T108_D2.8881.00
122_T155_V2.8481.00
220_D244_G2.7341.00
57_V183_F2.7201.00
214_M249_H2.6941.00
120_T123_R2.6931.00
106_P125_Y2.6821.00
87_N179_S2.4641.00
72_L80_V2.3901.00
24_I38_T2.3801.00
219_A244_G2.3291.00
123_R127_A2.3041.00
82_E181_R2.2751.00
13_D17_A2.2751.00
105_A108_D2.2621.00
92_R171_V2.2591.00
107_A129_T2.2531.00
99_E168_R2.2381.00
174_E177_S2.1911.00
94_V171_V2.1731.00
69_H85_D2.1361.00
229_L250_A1.9890.99
102_D170_Q1.9850.99
224_D227_A1.9810.99
76_D124_A1.9730.99
97_A101_G1.9370.99
94_V158_T1.9370.99
256_D259_E1.8720.99
53_I156_D1.8400.99
97_A170_Q1.8370.99
64_A182_L1.8330.99
233_G270_S1.7620.99
81_E186_E1.7390.98
83_R184_A1.7350.98
91_C178_S1.7330.98
84_L202_R1.6990.98
225_V267_V1.6800.98
259_E263_E1.6620.98
210_K253_P1.6490.98
106_P131_A1.6170.97
251_V277_I1.6020.97
7_N141_A1.5790.97
216_N233_G1.5320.96
33_Q166_V1.5230.96
93_L157_I1.5020.96
96_A164_L1.4980.96
101_G108_D1.4970.96
149_E163_T1.4100.94
73_R124_A1.4000.94
232_L271_G1.3940.94
90_S159_S1.3650.93
97_A103_V1.3580.93
125_Y173_D1.3400.93
234_G240_V1.3060.92
18_L201_L1.2970.91
142_T158_T1.2880.91
253_P256_D1.2630.90
80_V183_F1.2600.90
50_A67_T1.2590.90
274_V278_E1.2560.90
26_V36_A1.2410.89
126_F155_V1.2350.89
73_R176_L1.2190.89
217_A267_V1.2180.89
123_R132_T1.2010.88
162_T166_V1.1870.87
109_L114_V1.1830.87
219_A239_D1.1760.87
95_L122_T1.1670.86
95_L109_L1.1630.86
211_R278_E1.1590.86
84_L198_E1.1510.86
97_A102_D1.1450.85
117_E142_T1.1370.85
221_R267_V1.1300.85
223_D226_K1.1220.84
126_F129_T1.1190.84
107_A131_A1.1030.83
38_T43_L1.0980.83
110_D131_A1.0930.82
123_R135_I1.0930.82
217_A248_V1.0810.82
118_F121_I1.0750.81
192_P266_A1.0520.80
227_A266_A1.0490.80
224_D267_V1.0480.80
263_E266_A1.0470.80
45_V53_I1.0450.80
51_A71_Q1.0430.79
11_L180_V1.0430.79
6_P70_D1.0360.79
85_D181_R1.0160.78
106_P173_D1.0080.77
257_V274_V1.0050.77
270_S277_I0.9960.76
203_S261_I0.9950.76
92_R177_S0.9900.76
234_G242_E0.9880.76
219_A243_P0.9870.75
212_Y249_H0.9780.75
95_L155_V0.9780.75
219_A242_E0.9750.75
224_D228_V0.9680.74
67_T70_D0.9660.74
231_G235_P0.9640.74
42_A193_K0.9620.74
141_A193_K0.9590.73
96_A115_A0.9570.73
26_V45_V0.9570.73
158_T200_A0.9550.73
129_T173_D0.9480.72
215_L250_A0.9470.72
97_A172_V0.9440.72
223_D227_A0.9430.72
189_H237_V0.9430.72
123_R190_D0.9380.72
217_A221_R0.9310.71
10_R159_S0.9270.71
236_T247_A0.9270.71
6_P50_A0.9260.71
73_R76_D0.9190.70
146_P167_N0.9100.69
28_D33_Q0.9080.69
162_T203_S0.9000.68
22_A206_D0.8990.68
71_Q155_V0.8980.68
221_R237_V0.8920.68
215_L229_L0.8920.68
73_R121_I0.8830.67
236_T240_V0.8810.67
195_Q198_E0.8800.67
238_L249_H0.8790.67
202_R206_D0.8780.67
273_L277_I0.8670.66
191_D195_Q0.8670.66
69_H181_R0.8640.65
64_A198_E0.8620.65
83_R194_V0.8610.65
52_D138_V0.8600.65
225_V229_L0.8540.64
15_T88_Y0.8490.64
54_P93_L0.8480.64
100_D170_Q0.8450.64
73_R82_E0.8390.63
117_E158_T0.8380.63
158_T171_V0.8320.62
69_H73_R0.8300.62
198_E202_R0.8260.62
114_V153_A0.8240.62
112_A153_A0.8230.62
5_V16_L0.8220.61
114_V175_V0.8180.61
58_A80_V0.8150.61
142_T200_A0.8130.61
35_Y194_V0.8110.60
99_E170_Q0.8070.60
6_P67_T0.8070.60
230_P273_L0.8060.60
40_D193_K0.8040.60
97_A109_L0.8030.60
34_L138_V0.8010.59
166_V203_S0.8000.59
160_T171_V0.7990.59
99_E124_A0.7990.59
23_G115_A0.7970.59
8_K210_K0.7970.59
78_D81_E0.7960.59
233_G271_G0.7960.59
12_H15_T0.7960.59
84_L205_L0.7960.59
50_A93_L0.7920.59
254_E279_R0.7890.58
112_A152_D0.7850.58
32_R65_G0.7820.58
81_E187_D0.7820.58
2_R131_A0.7810.57
17_A21_R0.7800.57
66_I180_V0.7800.57
31_D125_Y0.7780.57
115_A151_A0.7750.57
32_R166_V0.7740.57
4_A62_A0.7710.56
155_V175_V0.7700.56
187_D255_R0.7660.56
12_H138_V0.7640.56
216_N240_V0.7630.56
82_E85_D0.7590.55
10_R146_P0.7540.55
160_T168_R0.7510.55
78_D243_P0.7500.54
76_D120_T0.7450.54
159_S171_V0.7430.54
1_M162_T0.7430.54
59_D276_E0.7420.54
55_E136_V0.7380.53
144_L159_S0.7360.53
21_R204_V0.7340.53
88_Y180_V0.7340.53
26_V167_N0.7330.53
115_A136_V0.7330.53
54_P77_V0.7320.53
54_P75_S0.7310.53
4_A274_V0.7280.52
34_L38_T0.7250.52
43_L54_P0.7230.52
101_G170_Q0.7210.52
83_R189_H0.7170.51
106_P263_E0.7140.51
185_H188_V0.7140.51
80_V83_R0.7130.51
225_V251_V0.7130.51
37_D208_H0.7120.51
136_V160_T0.7100.50
7_N56_Y0.7090.50
35_Y274_V0.7090.50
124_A187_D0.7080.50
16_L20_D0.7070.50
33_Q159_S0.7070.50
138_V142_T0.7060.50
120_T124_A0.7030.50
32_R183_F0.7020.50
103_V108_D0.7010.50
139_T271_G0.7010.50
235_P240_V0.7000.49
119_P166_V0.6990.49
146_P154_I0.6970.49
196_Q266_A0.6960.49
48_A240_V0.6960.49
232_L242_E0.6920.49
146_P151_A0.6920.49
19_L90_S0.6900.48
58_A77_V0.6890.48
53_I113_T0.6880.48
115_A138_V0.6870.48
130_T266_A0.6860.48
104_T170_Q0.6850.48
218_P244_G0.6840.48
184_A194_V0.6820.48
5_V19_L0.6820.48
93_L118_F0.6810.48
65_G121_I0.6810.48
69_H176_L0.6780.47
49_R133_P0.6780.47
104_T123_R0.6760.47
196_Q262_S0.6710.47
37_D64_A0.6700.46
39_V112_A0.6650.46
134_E223_D0.6620.46
94_V142_T0.6580.45
224_D263_E0.6550.45
147_H160_T0.6540.45
50_A65_G0.6530.45
44_T162_T0.6510.45
123_R221_R0.6500.44
19_L45_V0.6490.44
47_Y166_V0.6490.44
102_D127_A0.6480.44
76_D186_E0.6460.44
94_V174_E0.6460.44
101_G112_A0.6450.44
3_I45_V0.6430.44
239_D246_V0.6420.44
187_D237_V0.6310.43
222_L226_K0.6300.42
216_N270_S0.6300.42
219_A241_D0.6290.42
96_A146_P0.6280.42
91_C149_E0.6240.42
192_P196_Q0.6240.42
254_E276_E0.6230.42
69_H178_S0.6220.42
116_T145_T0.6210.42
25_G205_L0.6210.42
164_L178_S0.6180.41
110_D224_D0.6170.41
24_I45_V0.6150.41
43_L85_D0.6150.41
159_S163_T0.6120.41
71_Q91_C0.6120.41
120_T128_D0.6080.40
65_G183_F0.6070.40
93_L139_T0.6040.40
64_A194_V0.6020.40
18_L190_D0.5990.40
13_D179_S0.5990.40
215_L231_G0.5990.40
126_F131_A0.5970.39
63_D190_D0.5960.39
192_P195_Q0.5950.39
50_A71_Q0.5950.39
39_V42_A0.5940.39
240_V245_T0.5930.39
123_R202_R0.5900.39
61_A64_A0.5890.39
187_D220_D0.5880.38
130_T195_Q0.5870.38
22_A155_V0.5870.38
146_P214_M0.5860.38
34_L52_D0.5850.38
16_L26_V0.5850.38
73_R90_S0.5830.38
8_K70_D0.5830.38
8_K22_A0.5800.38
220_D224_D0.5800.38
124_A267_V0.5800.38
188_V191_D0.5790.38
134_E220_D0.5780.38
164_L167_N0.5780.38
51_A74_E0.5770.37
91_C163_T0.5770.37
256_D263_E0.5760.37
26_V97_A0.5760.37
211_R274_V0.5750.37
77_V186_E0.5750.37
111_G230_P0.5720.37
188_V194_V0.5690.37
36_A167_N0.5680.37
212_Y251_V0.5670.36
19_L201_L0.5670.36
217_A222_L0.5660.36
93_L231_G0.5660.36
185_H260_A0.5650.36
70_D258_F0.5640.36
10_R14_P0.5640.36
85_D90_S0.5630.36
138_V145_T0.5620.36
90_S177_S0.5620.36
216_N235_P0.5600.36
36_A45_V0.5600.36
49_R164_L0.5580.36
109_L248_V0.5570.36
57_V65_G0.5570.36
90_S123_R0.5560.35
10_R24_I0.5550.35
22_A210_K0.5540.35
212_Y273_L0.5530.35
10_R122_T0.5520.35
83_R222_L0.5510.35
2_R14_P0.5500.35
120_T227_A0.5490.35
47_Y186_E0.5490.35
40_D162_T0.5480.35
124_A188_V0.5470.35
50_A166_V0.5470.35
227_A243_P0.5470.35
252_V260_A0.5460.35
49_R96_A0.5450.34
114_V186_E0.5440.34
212_Y275_T0.5430.34
48_A53_I0.5430.34
209_G237_V0.5430.34
95_L173_D0.5410.34
47_Y231_G0.5400.34
96_A154_I0.5390.34
251_V273_L0.5390.34
10_R74_E0.5390.34
171_V174_E0.5390.34
6_P258_F0.5370.34
218_P234_G0.5360.34
70_D118_F0.5350.34
106_P129_T0.5340.33
132_T220_D0.5340.33
119_P169_L0.5320.33
205_L209_G0.5320.33
195_Q266_A0.5310.33
111_G132_T0.5300.33
39_V177_S0.5280.33
24_I119_P0.5280.33
99_E247_A0.5260.33
4_A53_I0.5260.33
77_V80_V0.5260.33
124_A226_K0.5260.33
135_I166_V0.5260.33
5_V37_D0.5250.33
13_D256_D0.5240.33
25_G84_L0.5240.33
46_L146_P0.5230.33
8_K32_R0.5220.32
105_A127_A0.5190.32
214_M275_T0.5180.32
50_A70_D0.5170.32
102_D220_D0.5160.32
27_E121_I0.5160.32
238_L247_A0.5150.32
1_M35_Y0.5150.32
47_Y260_A0.5110.31
113_T160_T0.5100.31
20_D132_T0.5090.31
2_R276_E0.5090.31
117_E200_A0.5080.31
69_H179_S0.5080.31
65_G93_L0.5060.31
131_A201_L0.5060.31
38_T45_V0.5060.31
205_L237_V0.5050.31
200_A203_S0.5050.31
57_V185_H0.5040.31
26_V32_R0.5040.31
230_P250_A0.5030.31
77_V126_F0.5010.31
53_I118_F0.5010.31
192_P227_A0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vd3A 5 0.9965 100 0.074 Contact Map
1h3dA 4 0.9752 100 0.076 Contact Map
1nh8A 5 0.9716 100 0.082 Contact Map
2vd2A 2 0.7199 100 0.338 Contact Map
1z7mE 2 0.7057 100 0.352 Contact Map
1o63A 2 0.7128 100 0.353 Contact Map
1ve4A 1 0.6879 100 0.356 Contact Map
3qslA 1 0.9326 99.1 0.878 Contact Map
3ix1A 2 0.9184 98.9 0.887 Contact Map
4nmyA 1 0.9149 98.7 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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