GREMLIN Database
SAHH - Adenosylhomocysteinase
UniProt: Q9HN50 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 427 (414)
Sequences: 1933 (689)
Seq/√Len: 33.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_E396_E4.5571.00
309_L339_V4.4051.00
220_A263_M3.9601.00
308_N311_H3.7771.00
229_V276_T3.4671.00
217_V233_A3.3811.00
54_G121_V3.3721.00
169_D385_G3.2261.00
46_Q49_A3.1901.00
271_D292_D3.1731.00
25_I64_A3.1601.00
239_N259_D3.1511.00
270_G273_F3.1511.00
141_H175_E3.0741.00
268_E290_R3.0441.00
273_F283_I2.9171.00
341_A350_S2.8441.00
41_E45_N2.6611.00
378_N381_E2.6441.00
241_I261_M2.6141.00
414_D418_E2.5851.00
218_V270_G2.5321.00
123_A144_H2.5321.00
168_M173_A2.5251.00
313_S319_E2.4751.00
373_R377_A2.4281.00
319_E329_Y2.4171.00
110_E113_A2.4030.99
280_K415_D2.4020.99
298_A346_V2.3940.99
321_E327_R2.3830.99
43_D72_D2.3670.99
218_V243_T2.3190.99
285_R289_E2.3160.99
265_E408_E2.2950.99
371_C389_V2.2820.99
222_Y256_E2.2790.99
119_D143_D2.2520.99
11_L14_P2.2140.99
273_F295_V2.2090.99
51_E376_V2.1710.99
263_M266_A2.1610.99
243_T410_D2.1560.99
41_E373_R2.1520.99
52_T76_E2.1480.99
13_D16_S2.1330.99
320_R328_E2.0950.99
51_E127_T2.0810.98
289_E333_D2.0740.98
267_A273_F2.0560.98
281_N415_D2.0340.98
273_F291_M2.0030.98
374_E382_Y1.9860.98
116_D120_A1.9730.98
389_V393_L1.9630.98
128_V372_V1.9600.98
284_T287_H1.8920.97
202_A206_M1.8760.97
85_L342_E1.8380.97
328_E336_R1.8250.96
281_N308_N1.8210.96
148_I175_E1.7830.96
125_E150_T1.7710.96
154_G178_V1.7650.96
118_I139_R1.7630.96
201_L233_A1.7360.95
10_R116_D1.7350.95
24_K90_G1.7000.95
119_D144_H1.6880.95
11_L96_D1.6760.94
80_T121_V1.6660.94
220_A243_T1.6500.94
311_H315_L1.6460.94
22_R68_E1.6230.93
42_F73_A1.6160.93
140_V151_I1.5780.92
9_S14_P1.5750.92
28_A65_A1.5730.92
204_I346_V1.5630.92
154_G176_Y1.5560.92
201_L236_Q1.5360.91
38_L366_G1.5330.91
42_F72_D1.5180.91
184_T389_V1.5110.90
341_A346_V1.4960.90
417_A421_D1.4900.90
210_L296_V1.4820.90
73_A369_A1.4810.90
52_T127_T1.4770.89
145_P175_E1.4750.89
331_L335_R1.4680.89
46_Q72_D1.4670.89
263_M267_A1.4560.89
106_E117_A1.4550.89
10_R106_E1.4550.89
40_E44_A1.4480.88
293_D336_R1.4450.88
285_R311_H1.4330.88
120_A123_A1.4260.88
29_F68_E1.4240.88
216_D239_N1.4130.87
270_G295_V1.4050.87
313_S329_Y1.4030.87
383_A387_H1.3990.87
127_T150_T1.3870.86
193_V256_E1.3830.86
212_W236_Q1.3790.86
201_L212_W1.3700.86
262_P265_E1.3580.85
267_A270_G1.3520.85
264_A286_A1.3510.85
246_E249_R1.3490.85
71_A101_I1.3430.84
20_T24_K1.3430.84
265_E268_E1.3400.84
391_D395_I1.3360.84
222_Y258_Y1.3350.84
119_D139_R1.3320.84
203_N207_T1.3240.83
201_L217_V1.3210.83
241_I269_V1.3200.83
284_T308_N1.3170.83
216_D241_I1.3100.83
285_R315_L1.3040.83
399_E411_A1.2990.82
78_A124_H1.2970.82
285_R314_E1.2950.82
128_V155_T1.2950.82
10_R117_A1.2920.82
297_L337_L1.2890.82
73_A373_R1.2870.82
231_K256_E1.2850.82
328_E338_N1.2840.82
243_T263_M1.2830.81
137_V178_V1.2740.81
119_D123_A1.2710.81
262_P266_A1.2700.81
186_M367_V1.2540.80
200_A300_A1.2500.80
42_F369_A1.2490.80
218_V263_M1.2430.79
318_S330_E1.2410.79
30_E293_D1.2400.79
274_L346_V1.2390.79
45_N377_A1.2380.79
68_E99_E1.2270.78
55_M79_I1.2230.78
212_W238_A1.2200.78
414_D424_Q1.2120.78
274_L298_A1.2100.77
164_R167_A1.2070.77
142_E145_P1.2030.77
288_F337_L1.2010.77
408_E411_A1.1980.77
207_T350_S1.1960.77
19_E98_H1.1930.76
20_T90_G1.1860.76
288_F297_L1.1740.75
289_E331_L1.1690.75
310_D339_V1.1680.75
24_K61_A1.1670.75
128_V375_L1.1580.74
210_L215_K1.1550.74
48_L73_A1.1530.74
56_A118_I1.1510.74
212_W272_V1.1480.74
261_M266_A1.1470.74
37_A40_E1.1470.74
53_I70_M1.1450.73
29_F39_R1.1420.73
10_R120_A1.1380.73
264_A290_R1.1320.73
280_K305_V1.1300.72
279_N420_M1.1270.72
316_A332_A1.1190.72
48_L372_V1.1050.71
414_D417_A1.0990.70
371_C393_L1.0980.70
185_P248_R1.0970.70
198_E202_A1.0910.70
396_E399_E1.0910.70
281_N284_T1.0880.69
80_T118_I1.0820.69
127_T130_V1.0770.69
283_I291_M1.0770.69
263_M273_F1.0710.68
320_R330_E1.0710.68
37_A403_A1.0520.67
264_A287_H1.0470.66
411_A417_A1.0460.66
106_E110_E1.0450.66
107_R325_G1.0450.66
92_S103_S1.0430.66
263_M287_H1.0400.66
134_G178_V1.0350.66
367_V397_I1.0240.65
216_D259_D1.0220.65
179_F371_C1.0190.64
198_E205_A1.0160.64
384_A387_H1.0140.64
217_V274_L1.0100.64
262_P408_E1.0060.63
22_R98_H1.0050.63
39_R69_T1.0030.63
116_D119_D1.0010.63
309_L313_S0.9940.62
259_D269_V0.9940.62
270_G283_I0.9840.62
12_D106_E0.9840.62
62_K358_V0.9840.62
294_G328_E0.9830.62
129_T140_V0.9820.61
263_M270_G0.9820.61
115_Y426_G0.9820.61
31_H359_G0.9810.61
93_A96_D0.9750.61
129_T176_Y0.9740.61
193_V252_E0.9700.60
184_T371_C0.9660.60
121_V136_L0.9660.60
283_I288_F0.9630.60
152_I379_R0.9610.60
319_E327_R0.9600.60
219_V229_V0.9530.59
418_E424_Q0.9500.59
206_M354_L0.9480.59
20_T324_E0.9440.58
205_A236_Q0.9410.58
67_V79_I0.9410.58
52_T150_T0.9390.58
329_Y339_V0.9390.58
114_Y135_D0.9340.58
185_P188_R0.9340.58
80_T136_L0.9300.57
78_A104_Y0.9250.57
215_K272_V0.9250.57
309_L329_Y0.9220.57
196_T300_A0.9170.56
231_K234_A0.9170.56
160_T345_L0.9160.56
94_A98_H0.9150.56
39_R72_D0.9070.55
169_D384_A0.8950.54
289_E335_R0.8920.54
106_E116_D0.8910.54
403_A408_E0.8900.54
25_I94_A0.8890.54
144_H148_I0.8880.54
254_H407_V0.8860.54
130_V155_T0.8850.53
162_V179_F0.8770.53
219_V233_A0.8760.53
186_M251_L0.8750.53
395_I399_E0.8740.53
308_N314_E0.8730.52
137_V154_G0.8680.52
319_E342_E0.8630.52
263_M283_I0.8630.52
155_T376_V0.8600.51
77_I101_I0.8590.51
24_K62_K0.8570.51
217_V272_V0.8570.51
65_A68_E0.8540.51
152_I375_L0.8520.51
114_Y364_S0.8460.50
218_V241_I0.8460.50
159_T182_N0.8440.50
413_T420_M0.8330.49
29_F36_S0.8250.48
362_D401_K0.8240.48
30_E294_G0.8230.48
224_D252_E0.8200.48
198_E232_K0.8170.48
56_A80_T0.8170.48
333_D336_R0.8170.48
285_R288_F0.8100.47
411_A425_H0.8080.47
369_A373_R0.8080.47
106_E113_A0.8050.47
266_A270_G0.8010.46
55_M67_V0.7970.46
216_D269_V0.7970.46
25_I65_A0.7950.46
47_P73_A0.7950.46
61_A90_G0.7930.46
14_P96_D0.7910.46
22_R99_E0.7890.45
148_I176_Y0.7880.45
218_V273_F0.7870.45
144_H147_L0.7860.45
286_A289_E0.7850.45
130_V162_V0.7820.45
261_M408_E0.7790.45
59_V67_V0.7780.44
185_P246_E0.7740.44
241_I266_A0.7740.44
360_V367_V0.7730.44
270_G291_M0.7720.44
203_N206_M0.7690.44
229_V300_A0.7690.44
83_N135_D0.7620.43
35_L66_L0.7600.43
284_T289_E0.7590.43
262_P410_D0.7590.43
254_H405_E0.7590.43
122_L144_H0.7590.43
374_E377_A0.7580.43
330_E336_R0.7580.43
37_A400_I0.7580.43
109_A117_A0.7570.43
256_E341_A0.7560.43
122_L140_V0.7520.42
288_F291_M0.7510.42
315_L332_A0.7500.42
51_E128_V0.7480.42
104_Y124_H0.7470.42
29_F65_A0.7460.42
58_H83_N0.7440.42
140_V147_L0.7400.41
156_E161_G0.7390.41
41_E399_E0.7330.41
193_V231_K0.7300.40
204_I298_A0.7260.40
60_E358_V0.7220.40
412_L420_M0.7200.40
123_A147_L0.7200.40
39_R68_E0.7170.39
361_M368_Q0.7170.39
262_P411_A0.7170.39
289_E315_L0.7160.39
345_L356_H0.7160.39
241_I259_D0.7150.39
18_R98_H0.7150.39
135_D302_H0.7150.39
229_V232_K0.7140.39
311_H339_V0.7120.39
53_I376_V0.7110.39
111_G136_L0.7110.39
304_D309_L0.7100.39
11_L264_A0.7090.39
60_E354_L0.7090.39
310_D313_S0.7080.39
140_V148_I0.7070.39
179_F374_E0.7070.39
52_T124_H0.7060.39
134_G154_G0.7060.39
22_R39_R0.7060.39
61_A323_R0.7050.38
401_K405_E0.7040.38
315_L331_L0.7040.38
8_S319_E0.7010.38
67_V95_L0.7000.38
58_H86_S0.6960.38
58_H302_H0.6950.38
207_T341_A0.6950.38
11_L16_S0.6940.38
179_F263_M0.6920.37
262_P268_E0.6920.37
59_V79_I0.6900.37
18_R96_D0.6900.37
96_D104_Y0.6890.37
403_A421_D0.6880.37
152_I376_V0.6870.37
45_N373_R0.6860.37
289_E332_A0.6860.37
39_R43_D0.6860.37
220_A281_N0.6840.37
61_A354_L0.6840.37
54_G124_H0.6830.37
162_V386_V0.6830.37
316_A331_L0.6830.37
170_D418_E0.6820.37
179_F245_V0.6820.37
402_L407_V0.6810.37
205_A294_G0.6810.37
141_H148_I0.6780.36
157_E361_M0.6780.36
160_T302_H0.6760.36
310_D314_E0.6760.36
213_A346_V0.6740.36
201_L205_A0.6730.36
62_K354_L0.6720.36
55_M60_E0.6720.36
361_M365_F0.6710.36
180_A386_V0.6700.36
38_L369_A0.6700.36
287_H291_M0.6690.36
220_A282_V0.6690.36
54_G119_D0.6600.35
417_A422_S0.6600.35
41_E378_N0.6600.35
418_E422_S0.6570.35
12_D110_E0.6560.35
198_E213_A0.6560.35
245_V410_D0.6550.35
62_K351_P0.6510.34
417_A420_M0.6510.34
205_A298_A0.6500.34
198_E236_Q0.6500.34
217_V229_V0.6480.34
128_V376_V0.6460.34
345_L348_L0.6450.34
149_D383_A0.6440.34
227_R304_D0.6440.34
289_E314_E0.6430.34
36_S65_A0.6410.33
123_A146_E0.6410.33
201_L232_K0.6380.33
169_D222_Y0.6380.33
265_E290_R0.6370.33
271_D294_G0.6370.33
10_R104_Y0.6370.33
363_Q366_G0.6340.33
129_T136_L0.6340.33
59_V62_K0.6330.33
225_C276_T0.6330.33
105_A360_V0.6330.33
166_R183_D0.6320.33
58_H345_L0.6310.33
19_E23_A0.6290.33
332_A335_R0.6280.33
28_A358_V0.6230.32
20_T23_A0.6220.32
60_E359_G0.6210.32
59_V207_T0.6200.32
184_T224_D0.6200.32
166_R399_E0.6170.32
188_R224_D0.6160.32
38_L373_R0.6140.31
302_H345_L0.6140.31
135_D164_R0.6140.31
321_E342_E0.6120.31
168_M175_E0.6120.31
219_V274_L0.6120.31
34_I362_D0.6110.31
355_G361_M0.6110.31
41_E370_V0.6100.31
184_T397_I0.6100.31
208_T275_T0.6080.31
195_G304_D0.6080.31
105_A162_V0.6070.31
28_A59_V0.6050.31
114_Y303_F0.6050.31
23_A320_R0.6040.31
71_A77_I0.6040.31
36_S39_R0.6030.31
356_H361_M0.6020.31
16_S112_E0.6010.31
198_E346_V0.6000.30
66_L369_A0.6000.30
121_V145_P0.5990.30
113_A359_G0.5980.30
157_E368_Q0.5960.30
227_R276_T0.5960.30
55_M82_C0.5950.30
344_R348_L0.5950.30
138_F175_E0.5940.30
155_T162_V0.5930.30
45_N73_A0.5920.30
112_E116_D0.5910.30
137_V225_C0.5910.30
169_D387_H0.5890.30
205_A212_W0.5890.30
370_V396_E0.5870.30
36_S40_E0.5870.30
272_V337_L0.5860.29
44_A149_D0.5850.29
67_V130_V0.5850.29
414_D425_H0.5850.29
81_G359_G0.5840.29
111_G138_F0.5840.29
71_A99_E0.5840.29
371_C391_D0.5840.29
56_A138_F0.5830.29
60_E367_V0.5820.29
83_N114_Y0.5810.29
222_Y231_K0.5810.29
76_E333_D0.5800.29
282_V420_M0.5790.29
138_F142_E0.5790.29
411_A424_Q0.5780.29
265_E269_V0.5770.29
218_V267_A0.5770.29
83_N86_S0.5770.29
162_V326_V0.5760.29
39_R170_D0.5760.29
35_L69_T0.5760.29
414_D423_W0.5750.29
374_E390_P0.5750.29
302_H348_L0.5740.29
155_T372_V0.5740.29
130_V372_V0.5720.29
117_A120_A0.5720.29
229_V274_L0.5710.28
310_D399_E0.5690.28
285_R308_N0.5680.28
125_E149_D0.5680.28
296_V389_V0.5680.28
251_L401_K0.5670.28
220_A266_A0.5670.28
132_D191_D0.5670.28
40_E146_E0.5670.28
118_I136_L0.5670.28
135_D157_E0.5660.28
91_V95_L0.5640.28
33_P247_P0.5640.28
159_T356_H0.5630.28
57_M130_V0.5630.28
384_A396_E0.5620.28
207_T326_V0.5620.28
180_A350_S0.5610.28
184_T388_N0.5610.28
285_R332_A0.5610.28
83_N87_T0.5600.28
355_G365_F0.5590.28
218_V261_M0.5590.28
396_E400_I0.5580.28
34_I401_K0.5570.28
204_I340_L0.5560.27
111_G176_Y0.5560.27
65_A69_T0.5560.27
298_A350_S0.5550.27
210_L272_V0.5550.27
326_V340_L0.5550.27
299_N302_H0.5530.27
275_T299_N0.5520.27
185_P391_D0.5510.27
107_R326_V0.5510.27
249_R271_D0.5500.27
193_V224_D0.5490.27
206_M351_P0.5490.27
30_E336_R0.5480.27
282_V337_L0.5480.27
375_L393_L0.5480.27
356_H365_F0.5470.27
184_T198_E0.5470.27
193_V341_A0.5470.27
149_D314_E0.5460.27
403_A414_D0.5450.27
245_V279_N0.5430.27
143_D403_A0.5420.27
162_V364_S0.5420.27
111_G118_I0.5420.27
244_E250_A0.5410.26
65_A186_M0.5410.26
158_T195_G0.5400.26
159_T355_G0.5400.26
228_G302_H0.5390.26
142_E168_M0.5390.26
16_S418_E0.5390.26
45_N72_D0.5390.26
65_A109_A0.5380.26
49_A76_E0.5380.26
395_I417_A0.5370.26
163_H420_M0.5360.26
418_E423_W0.5360.26
160_T356_H0.5360.26
129_T178_V0.5350.26
14_P98_H0.5340.26
136_L147_L0.5340.26
249_R252_E0.5340.26
139_R145_P0.5340.26
149_D391_D0.5330.26
105_A190_F0.5330.26
320_R336_R0.5310.26
152_I265_E0.5310.26
66_L157_E0.5300.26
186_M351_P0.5290.26
11_L176_Y0.5290.26
53_I123_A0.5280.26
83_N302_H0.5270.26
147_L151_I0.5270.26
380_E418_E0.5260.25
266_A269_V0.5260.25
86_S165_L0.5250.25
48_L373_R0.5250.25
70_M364_S0.5240.25
91_V323_R0.5240.25
204_I274_L0.5220.25
61_A367_V0.5210.25
154_G169_D0.5210.25
141_H176_Y0.5210.25
288_F331_L0.5210.25
157_E364_S0.5200.25
135_D364_S0.5200.25
182_N190_F0.5190.25
68_E79_I0.5190.25
37_A381_E0.5180.25
156_E159_T0.5170.25
109_A114_Y0.5170.25
58_H299_N0.5160.25
53_I212_W0.5160.25
200_A229_V0.5150.25
282_V305_V0.5150.25
32_M135_D0.5140.25
380_E411_A0.5120.25
22_R26_D0.5120.25
220_A290_R0.5110.25
151_I176_Y0.5100.24
155_T389_V0.5100.24
49_A125_E0.5090.24
87_T92_S0.5090.24
145_P148_I0.5080.24
69_T72_D0.5080.24
110_E139_R0.5080.24
316_A319_E0.5070.24
110_E176_Y0.5070.24
31_H215_K0.5070.24
41_E413_T0.5060.24
267_A305_V0.5060.24
229_V382_Y0.5050.24
304_D356_H0.5050.24
274_L395_I0.5040.24
415_D418_E0.5040.24
294_G336_R0.5040.24
363_Q401_K0.5040.24
60_E360_V0.5040.24
142_E424_Q0.5030.24
132_D190_F0.5010.24
143_D147_L0.5000.24
65_A79_I0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ce6A 4 0.993 100 0.334 Contact Map
3d64A 4 0.9719 100 0.335 Contact Map
4lvcA 4 0.9719 100 0.339 Contact Map
1v8bA 4 0.9766 100 0.34 Contact Map
3gvpA 4 0.9883 100 0.344 Contact Map
3h9uA 5 0.9742 100 0.374 Contact Map
3ondA 4 0.9906 100 0.377 Contact Map
3x2fA 4 0.9532 100 0.394 Contact Map
1ygyA 4 0.7705 99.8 0.874 Contact Map
3fr7A 2 0.5714 99.8 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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