GREMLIN Database
Q9HN49 - Holliday junction resolvase
UniProt: Q9HN49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 141 (127)
Sequences: 123 (85)
Seq/√Len: 7.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
85_P101_P3.5040.93
47_N51_F3.4810.93
5_N9_N2.8880.83
27_M44_L2.7640.80
53_A83_A2.6120.76
33_G41_P2.5480.74
68_G89_A2.4880.73
7_K60_A2.4390.71
46_G81_F2.2650.65
5_N30_P2.0540.57
16_V43_V1.9810.54
19_L45_A1.9720.54
15_L96_W1.9480.53
50_E84_K1.8970.51
126_L130_A1.8690.50
66_L70_E1.8610.49
5_N31_A1.7830.46
24_F77_F1.7650.46
30_P41_P1.7510.45
14_E20_D1.6580.41
25_A82_G1.6460.41
21_E99_F1.6440.41
98_F111_S1.6170.40
128_T131_G1.6130.40
41_P70_E1.6090.40
91_F114_V1.5770.38
30_P70_E1.5730.38
26_V39_D1.5220.36
50_E87_I1.4270.33
26_V29_A1.4180.33
22_T114_V1.3860.31
59_S97_Y1.3770.31
44_L85_P1.3510.30
19_L126_L1.3300.30
43_V122_D1.3100.29
125_E128_T1.2950.28
68_G130_A1.2840.28
84_K114_V1.2790.28
74_L101_P1.2740.28
65_Y82_G1.2700.28
52_Y129_L1.2680.28
71_V74_L1.2540.27
22_T126_L1.2500.27
33_G70_E1.2420.27
27_M72_E1.2250.26
59_S92_D1.2170.26
7_K80_N1.2080.26
44_L75_V1.2070.26
31_A37_K1.2070.26
61_G66_L1.2060.26
87_I126_L1.2010.25
41_P108_D1.1980.25
56_A122_D1.1800.25
45_A89_A1.1700.25
105_H113_R1.1630.24
71_V129_L1.1310.23
5_N41_P1.1240.23
47_N54_I1.1080.23
84_K102_A1.0980.23
18_A22_T1.0550.21
65_Y113_R1.0200.20
14_E96_W1.0040.20
31_A65_Y1.0000.20
52_Y83_A0.9960.20
19_L26_V0.9910.20
37_K54_I0.9810.19
26_V69_E0.9730.19
71_V101_P0.9580.19
99_F123_G0.9530.19
24_F82_G0.9470.19
54_I127_E0.9420.18
86_R115_K0.9370.18
126_L134_E0.9340.18
54_I117_Q0.9270.18
29_A36_T0.9240.18
25_A65_Y0.8950.17
54_I62_D0.8830.17
30_P109_A0.8810.17
44_L94_E0.8730.17
7_K97_Y0.8640.17
29_A33_G0.8570.17
20_D70_E0.8550.16
26_V83_A0.8510.16
9_N95_D0.8490.16
36_T40_L0.8460.16
25_A77_F0.8400.16
48_G96_W0.8350.16
15_L74_L0.8350.16
7_K128_T0.8320.16
75_V101_P0.8280.16
41_P107_T0.8280.16
9_N34_A0.8270.16
131_G134_E0.8230.16
21_E72_E0.8200.16
96_W113_R0.8190.16
121_A130_A0.8150.16
20_D101_P0.8080.15
61_G100_H0.8030.15
8_G59_S0.8020.15
10_R83_A0.7930.15
48_G91_F0.7900.15
100_H129_L0.7880.15
68_G109_A0.7850.15
19_L24_F0.7700.15
53_A96_W0.7700.15
33_G107_T0.7620.15
17_N63_P0.7470.14
36_T88_G0.7460.14
75_V116_K0.7450.14
9_N13_R0.7410.14
30_P45_A0.7380.14
74_L85_P0.7330.14
124_T128_T0.7280.14
52_Y87_I0.7230.14
51_F54_I0.7120.14
10_R87_I0.7100.14
83_A87_I0.7060.13
25_A31_A0.7040.13
120_L125_E0.7000.13
7_K23_G0.6810.13
103_D122_D0.6770.13
25_A96_W0.6760.13
5_N73_S0.6760.13
19_L58_S0.6750.13
89_A102_A0.6700.13
8_G12_E0.6680.13
69_E97_Y0.6650.13
23_G27_M0.6630.13
47_N131_G0.6620.13
104_L112_Y0.6610.13
46_G131_G0.6600.13
76_Y129_L0.6590.13
10_R14_E0.6590.13
58_S62_D0.6580.13
58_S83_A0.6570.13
84_K93_R0.6410.12
29_A41_P0.6400.12
60_A92_D0.6340.12
64_I113_R0.6310.12
48_G114_V0.6290.12
34_A133_P0.6270.12
27_M128_T0.6260.12
64_I126_L0.6200.12
44_L71_V0.6170.12
21_E66_L0.6160.12
25_A104_L0.6110.12
29_A88_G0.6090.12
74_L81_F0.6060.12
54_I98_F0.6040.12
65_Y98_F0.6030.12
36_T101_P0.5990.12
81_F131_G0.5950.12
63_P113_R0.5910.11
34_A103_D0.5890.11
28_R57_K0.5880.11
28_R55_E0.5880.11
28_R42_D0.5880.11
28_R32_S0.5880.11
42_D57_K0.5880.11
42_D55_E0.5880.11
32_S42_D0.5880.11
32_S55_E0.5880.11
32_S57_K0.5880.11
50_E64_I0.5830.11
43_V115_K0.5820.11
86_R129_L0.5800.11
30_P64_I0.5800.11
64_I88_G0.5780.11
78_A83_A0.5740.11
30_P37_K0.5740.11
20_D81_F0.5700.11
48_G51_F0.5680.11
67_D91_F0.5640.11
6_A66_L0.5590.11
71_V134_E0.5590.11
6_A90_R0.5560.11
68_G85_P0.5540.11
66_L115_K0.5520.11
67_D129_L0.5430.11
103_D124_T0.5410.11
38_R85_P0.5320.11
5_N70_E0.5280.11
74_L96_W0.5240.10
31_A41_P0.5210.10
20_D33_G0.5150.10
22_T44_L0.5110.10
22_T104_L0.5060.10
93_R116_K0.5040.10
30_P107_T0.5030.10
59_S81_F0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wcwA 2 0.9007 100 0.495 Contact Map
2eo0A 2 0.8865 100 0.502 Contact Map
1hh1A 2 0.8511 100 0.512 Contact Map
1ob8A 1 0.8511 99.9 0.593 Contact Map
1gefA 2 0.8511 99.9 0.599 Contact Map
1y88A 5 0.8865 96.8 0.871 Contact Map
2ostA 4 0.9078 96.8 0.872 Contact Map
2fcoA 2 0.8582 94.8 0.891 Contact Map
3fovA 2 0.6596 94.7 0.892 Contact Map
1zp7A 2 0.8369 94.3 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0063 seconds.