Q9HN49 - HALSA - GREMLIN Contacts

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Q9HN49 - Holliday junction resolvase

UniProt:	Q9HN49	Sequences: MANSNAKGNRRERELVNALDETGFAVMRAPASGAATKRDLPDVLAGNGEEFYAIEAKSSAGDPIYLDGEEVESLVYFARNFGAKPRIGARFDREDWYFFHPADLHTTDAGSYRVKKQTALADGTELETLAGGPERTGLDDY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	141 (127)
Sequences:	123 (85)
Seq/√Len:	7.5

HALSA - Q9HN49
SULSO - HJC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
85_P	101_P	3.504	0.93
47_N	51_F	3.481	0.93
5_N	9_N	2.888	0.83
27_M	44_L	2.764	0.80
53_A	83_A	2.612	0.76
33_G	41_P	2.548	0.74
68_G	89_A	2.488	0.73
7_K	60_A	2.439	0.71
46_G	81_F	2.265	0.65
5_N	30_P	2.054	0.57
16_V	43_V	1.981	0.54
19_L	45_A	1.972	0.54
15_L	96_W	1.948	0.53
50_E	84_K	1.897	0.51
126_L	130_A	1.869	0.50
66_L	70_E	1.861	0.49
5_N	31_A	1.783	0.46
24_F	77_F	1.765	0.46
30_P	41_P	1.751	0.45
14_E	20_D	1.658	0.41
25_A	82_G	1.646	0.41
21_E	99_F	1.644	0.41
98_F	111_S	1.617	0.40
128_T	131_G	1.613	0.40
41_P	70_E	1.609	0.40
91_F	114_V	1.577	0.38
30_P	70_E	1.573	0.38
26_V	39_D	1.522	0.36
50_E	87_I	1.427	0.33
26_V	29_A	1.418	0.33
22_T	114_V	1.386	0.31
59_S	97_Y	1.377	0.31
44_L	85_P	1.351	0.30
19_L	126_L	1.330	0.30
43_V	122_D	1.310	0.29
125_E	128_T	1.295	0.28
68_G	130_A	1.284	0.28
84_K	114_V	1.279	0.28
74_L	101_P	1.274	0.28
65_Y	82_G	1.270	0.28
52_Y	129_L	1.268	0.28
71_V	74_L	1.254	0.27
22_T	126_L	1.250	0.27
33_G	70_E	1.242	0.27
27_M	72_E	1.225	0.26
59_S	92_D	1.217	0.26
7_K	80_N	1.208	0.26
44_L	75_V	1.207	0.26
31_A	37_K	1.207	0.26
61_G	66_L	1.206	0.26
87_I	126_L	1.201	0.25
41_P	108_D	1.198	0.25
56_A	122_D	1.180	0.25
45_A	89_A	1.170	0.25
105_H	113_R	1.163	0.24
71_V	129_L	1.131	0.23
5_N	41_P	1.124	0.23
47_N	54_I	1.108	0.23
84_K	102_A	1.098	0.23
18_A	22_T	1.055	0.21
65_Y	113_R	1.020	0.20
14_E	96_W	1.004	0.20
31_A	65_Y	1.000	0.20
52_Y	83_A	0.996	0.20
19_L	26_V	0.991	0.20
37_K	54_I	0.981	0.19
26_V	69_E	0.973	0.19
71_V	101_P	0.958	0.19
99_F	123_G	0.953	0.19
24_F	82_G	0.947	0.19
54_I	127_E	0.942	0.18
86_R	115_K	0.937	0.18
126_L	134_E	0.934	0.18
54_I	117_Q	0.927	0.18
29_A	36_T	0.924	0.18
25_A	65_Y	0.895	0.17
54_I	62_D	0.883	0.17
30_P	109_A	0.881	0.17
44_L	94_E	0.873	0.17
7_K	97_Y	0.864	0.17
29_A	33_G	0.857	0.17
20_D	70_E	0.855	0.16
26_V	83_A	0.851	0.16
9_N	95_D	0.849	0.16
36_T	40_L	0.846	0.16
25_A	77_F	0.840	0.16
48_G	96_W	0.835	0.16
15_L	74_L	0.835	0.16
7_K	128_T	0.832	0.16
75_V	101_P	0.828	0.16
41_P	107_T	0.828	0.16
9_N	34_A	0.827	0.16
131_G	134_E	0.823	0.16
21_E	72_E	0.820	0.16
96_W	113_R	0.819	0.16
121_A	130_A	0.815	0.16
20_D	101_P	0.808	0.15
61_G	100_H	0.803	0.15
8_G	59_S	0.802	0.15
10_R	83_A	0.793	0.15
48_G	91_F	0.790	0.15
100_H	129_L	0.788	0.15
68_G	109_A	0.785	0.15
19_L	24_F	0.770	0.15
53_A	96_W	0.770	0.15
33_G	107_T	0.762	0.15
17_N	63_P	0.747	0.14
36_T	88_G	0.746	0.14
75_V	116_K	0.745	0.14
9_N	13_R	0.741	0.14
30_P	45_A	0.738	0.14
74_L	85_P	0.733	0.14
124_T	128_T	0.728	0.14
52_Y	87_I	0.723	0.14
51_F	54_I	0.712	0.14
10_R	87_I	0.710	0.14
83_A	87_I	0.706	0.13
25_A	31_A	0.704	0.13
120_L	125_E	0.700	0.13
7_K	23_G	0.681	0.13
103_D	122_D	0.677	0.13
25_A	96_W	0.676	0.13
5_N	73_S	0.676	0.13
19_L	58_S	0.675	0.13
89_A	102_A	0.670	0.13
8_G	12_E	0.668	0.13
69_E	97_Y	0.665	0.13
23_G	27_M	0.663	0.13
47_N	131_G	0.662	0.13
104_L	112_Y	0.661	0.13
46_G	131_G	0.660	0.13
76_Y	129_L	0.659	0.13
10_R	14_E	0.659	0.13
58_S	62_D	0.658	0.13
58_S	83_A	0.657	0.13
84_K	93_R	0.641	0.12
29_A	41_P	0.640	0.12
60_A	92_D	0.634	0.12
64_I	113_R	0.631	0.12
48_G	114_V	0.629	0.12
34_A	133_P	0.627	0.12
27_M	128_T	0.626	0.12
64_I	126_L	0.620	0.12
44_L	71_V	0.617	0.12
21_E	66_L	0.616	0.12
25_A	104_L	0.611	0.12
29_A	88_G	0.609	0.12
74_L	81_F	0.606	0.12
54_I	98_F	0.604	0.12
65_Y	98_F	0.603	0.12
36_T	101_P	0.599	0.12
81_F	131_G	0.595	0.12
63_P	113_R	0.591	0.11
34_A	103_D	0.589	0.11
28_R	57_K	0.588	0.11
28_R	55_E	0.588	0.11
28_R	42_D	0.588	0.11
28_R	32_S	0.588	0.11
42_D	57_K	0.588	0.11
42_D	55_E	0.588	0.11
32_S	42_D	0.588	0.11
32_S	55_E	0.588	0.11
32_S	57_K	0.588	0.11
50_E	64_I	0.583	0.11
43_V	115_K	0.582	0.11
86_R	129_L	0.580	0.11
30_P	64_I	0.580	0.11
64_I	88_G	0.578	0.11
78_A	83_A	0.574	0.11
30_P	37_K	0.574	0.11
20_D	81_F	0.570	0.11
48_G	51_F	0.568	0.11
67_D	91_F	0.564	0.11
6_A	66_L	0.559	0.11
71_V	134_E	0.559	0.11
6_A	90_R	0.556	0.11
68_G	85_P	0.554	0.11
66_L	115_K	0.552	0.11
67_D	129_L	0.543	0.11
103_D	124_T	0.541	0.11
38_R	85_P	0.532	0.11
5_N	70_E	0.528	0.11
74_L	96_W	0.524	0.10
31_A	41_P	0.521	0.10
20_D	33_G	0.515	0.10
22_T	44_L	0.511	0.10
22_T	104_L	0.506	0.10
93_R	116_K	0.504	0.10
30_P	107_T	0.503	0.10
59_S	81_F	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2wcwA	2	0.9007	100	0.495	Contact Map
2eo0A	2	0.8865	100	0.502	Contact Map
1hh1A	2	0.8511	100	0.512	Contact Map
1ob8A	1	0.8511	99.9	0.593	Contact Map
1gefA	2	0.8511	99.9	0.599	Contact Map
1y88A	5	0.8865	96.8	0.871	Contact Map
2ostA	4	0.9078	96.8	0.872	Contact Map
2fcoA	2	0.8582	94.8	0.891	Contact Map
3fovA	2	0.6596	94.7	0.892	Contact Map
1zp7A	2	0.8369	94.3	0.894	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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