GREMLIN Database
PSD - Phosphatidylserine decarboxylase proenzyme
UniProt: Q9HN46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (189)
Sequences: 1392 (927)
Seq/√Len: 67.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_E124_E4.4681.00
85_N186_T3.6291.00
69_T73_G3.6261.00
46_D156_R3.5791.00
19_G37_A3.4101.00
58_V79_V3.2601.00
182_E185_Q3.0011.00
59_P79_V2.8741.00
75_V179_V2.6471.00
124_E127_E2.6451.00
91_V151_L2.4471.00
67_I183_S2.3611.00
98_E127_E2.2261.00
96_R150_D2.1791.00
146_E149_E2.1611.00
168_V194_L2.1121.00
12_A41_V2.1111.00
59_P168_V2.0991.00
106_G117_H2.0841.00
44_H162_F2.0801.00
145_V151_L2.0361.00
81_M166_A2.0021.00
94_A152_A1.9131.00
56_V93_V1.8931.00
60_A89_N1.8711.00
58_V187_V1.8521.00
15_P40_V1.8021.00
56_V195_A1.7721.00
81_M189_A1.7331.00
16_A37_A1.6840.99
131_V169_V1.6700.99
123_I130_V1.6520.99
4_R12_A1.6410.99
83_V136_A1.6070.99
188_R191_E1.5930.99
76_R169_V1.5890.99
48_D156_R1.5610.99
93_V128_W1.5410.99
141_I163_G1.5320.99
23_L33_G1.5260.99
23_L30_G1.5200.99
11_Y161_S1.5150.99
96_R124_E1.5110.99
91_V157_L1.5020.99
57_V153_R1.4950.99
152_A155_D1.4900.99
90_R190_G1.4860.99
80_F110_A1.4600.98
89_N157_L1.4460.98
120_R131_V1.4180.98
69_T172_P1.4170.98
77_V179_V1.4030.98
95_G123_I1.3870.98
86_V166_A1.3750.98
144_Y159_H1.3660.98
91_V145_V1.3640.98
142_H161_S1.3350.97
49_R61_D1.3200.97
110_A138_A1.3160.97
130_V157_L1.3150.97
99_S147_A1.3020.97
99_S122_R1.2980.97
13_L17_V1.2600.96
122_R127_E1.2050.95
81_M89_N1.1810.94
46_D90_R1.1790.94
174_Y195_A1.1760.94
188_R192_T1.1750.94
93_V125_T1.1690.94
5_G144_Y1.1490.94
72_D129_T1.1400.93
75_V173_A1.1310.93
69_T75_V1.1300.93
121_V145_V1.1260.93
173_A179_V1.1260.93
19_G23_L1.1190.93
100_V146_E1.1090.92
11_Y15_P1.0790.91
103_E120_R1.0740.91
92_P130_V1.0700.91
187_V192_T1.0640.91
180_V193_V1.0510.90
15_P37_A1.0410.90
87_H160_I1.0380.90
10_K14_P1.0310.89
100_V147_A1.0130.88
43_F87_H1.0110.88
43_F164_S1.0070.88
100_V143_P1.0040.88
6_P9_W1.0030.88
121_V151_L1.0010.88
121_V157_L0.9990.88
77_V194_L0.9980.88
75_V172_P0.9950.88
113_K134_A0.9940.87
77_V170_L0.9900.87
89_N132_L0.9830.87
78_G165_R0.9800.87
119_E134_A0.9500.85
37_A41_V0.9440.85
109_P112_S0.9210.83
125_T174_Y0.9210.83
39_F84_H0.9160.83
80_F138_A0.9150.83
81_M160_I0.9150.83
126_A173_A0.9120.83
12_A15_P0.9100.82
123_I128_W0.9070.82
102_H119_E0.9050.82
21_A25_A0.9010.82
66_V76_R0.8980.82
36_L40_V0.8960.81
110_A135_G0.8830.80
105_G139_R0.8820.80
47_P86_V0.8720.80
28_P32_V0.8700.79
56_V128_W0.8670.79
91_V94_A0.8650.79
12_A37_A0.8630.79
51_P191_E0.8620.79
74_R127_E0.8570.78
64_V179_V0.8540.78
7_W81_M0.8500.78
80_F135_G0.8490.78
4_R8_T0.8340.77
39_F42_W0.8280.76
57_V190_G0.8250.76
34_V38_A0.8170.75
70_R169_V0.8090.74
143_P157_L0.8080.74
43_F80_F0.7950.73
27_S31_V0.7890.72
19_G33_G0.7880.72
81_M87_H0.7800.72
55_G94_A0.7790.71
124_E184_G0.7780.71
53_G180_V0.7760.71
9_W13_L0.7750.71
56_V168_V0.7730.71
35_A39_F0.7720.71
9_W24_A0.7680.70
88_V156_R0.7680.70
88_V190_G0.7620.70
81_M134_A0.7470.68
149_E155_D0.7470.68
97_V145_V0.7450.68
135_G139_R0.7450.68
79_V194_L0.7400.68
140_R162_F0.7370.67
135_G140_R0.7360.67
87_H164_S0.7350.67
43_F81_M0.7340.67
25_A28_P0.7330.67
78_G167_D0.7330.67
57_V192_T0.7310.67
43_F160_I0.7300.66
87_H138_A0.7250.66
32_V84_H0.7240.66
80_F87_H0.7180.65
12_A19_G0.7180.65
5_G72_D0.7180.65
22_A26_S0.7160.65
160_I164_S0.7140.65
61_D189_A0.7140.65
22_A28_P0.6980.63
123_I151_L0.6970.63
122_R129_T0.6960.63
51_P153_R0.6940.63
134_A160_I0.6910.62
16_A57_V0.6880.62
121_V143_P0.6870.62
9_W142_H0.6860.62
5_G74_R0.6850.62
111_F115_S0.6790.61
90_R189_A0.6790.61
54_A73_G0.6760.61
4_R89_N0.6700.60
50_S191_E0.6680.60
17_V50_S0.6650.59
135_G138_A0.6620.59
119_E133_I0.6610.59
22_A33_G0.6590.59
110_A140_R0.6580.58
8_T166_A0.6580.58
75_V174_Y0.6560.58
40_V137_F0.6520.58
156_R189_A0.6500.58
134_A167_D0.6500.58
43_F138_A0.6500.58
44_H80_F0.6490.57
22_A30_G0.6480.57
160_I166_A0.6460.57
36_L109_P0.6460.57
174_Y179_V0.6450.57
115_S133_I0.6440.57
185_Q192_T0.6430.57
90_R154_G0.6400.56
9_W12_A0.6390.56
130_V168_V0.6380.56
14_P18_V0.6380.56
58_V192_T0.6370.56
19_G22_A0.6270.55
7_W144_Y0.6250.55
57_V191_E0.6220.54
6_P10_K0.6210.54
65_S76_R0.6200.54
32_V54_A0.6180.54
83_V109_P0.6180.54
20_V24_A0.6170.54
26_S29_W0.6170.54
36_L84_H0.6170.54
109_P136_A0.6140.53
147_A192_T0.6100.53
113_K167_D0.6100.53
106_G194_L0.6090.53
74_R122_R0.6080.53
78_G82_N0.6080.53
81_M164_S0.6020.52
76_R167_D0.6010.52
120_R167_D0.6010.52
63_T82_N0.5990.52
44_H161_S0.5940.51
73_G172_P0.5900.50
105_G135_G0.5890.50
53_G153_R0.5870.50
121_V130_V0.5860.50
17_V24_A0.5810.49
109_P129_T0.5780.49
23_L34_V0.5780.49
30_G34_V0.5770.49
10_K23_L0.5750.49
115_S120_R0.5740.49
152_A179_V0.5730.48
56_V174_Y0.5730.48
116_A121_V0.5710.48
110_A165_R0.5710.48
128_W174_Y0.5690.48
25_A35_A0.5690.48
17_V52_N0.5630.47
81_M113_K0.5630.47
87_H140_R0.5620.47
97_V121_V0.5600.47
43_F135_G0.5590.47
60_A143_P0.5560.46
22_A29_W0.5550.46
96_R100_V0.5530.46
12_A17_V0.5500.46
15_P64_V0.5500.46
145_V149_E0.5500.46
22_A34_V0.5470.45
43_F132_L0.5470.45
30_G39_F0.5450.45
75_V122_R0.5430.45
4_R9_W0.5430.45
10_K24_A0.5420.45
15_P36_L0.5390.44
68_R76_R0.5390.44
37_A57_V0.5380.44
17_V146_E0.5330.44
7_W187_V0.5320.44
43_F133_I0.5310.43
122_R147_A0.5310.43
77_V168_V0.5300.43
113_K120_R0.5290.43
43_F139_R0.5270.43
43_F89_N0.5260.43
43_F110_A0.5250.43
55_G93_V0.5240.43
16_A23_L0.5230.43
43_F140_R0.5220.42
107_H134_A0.5210.42
81_M144_Y0.5210.42
49_R191_E0.5190.42
11_Y18_V0.5190.42
90_R156_R0.5180.42
27_S173_A0.5150.42
100_V122_R0.5140.42
126_A174_Y0.5100.41
114_E161_S0.5080.41
99_S129_T0.5070.41
97_V143_P0.5070.41
46_D157_L0.5070.41
67_I153_R0.5030.40
68_R183_S0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1f3zA 2 0.6684 97.6 0.883 Contact Map
1ax3A 1 0.7245 97.5 0.883 Contact Map
2gprA 1 0.7041 97.4 0.885 Contact Map
3ourB 1 0.6684 97 0.894 Contact Map
2d5dA 1 0.3418 94.9 0.911 Contact Map
1dczA 1 0.3776 93.9 0.915 Contact Map
4tkoB 1 0.7806 90.4 0.924 Contact Map
1z6hA 1 0.3469 88.3 0.927 Contact Map
2xhaA 1 0.6071 87.2 0.928 Contact Map
2jkuA 1 0.1786 86.7 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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