GREMLIN Database
PCNA - DNA polymerase sliding clamp
UniProt: Q9HN45 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 247 (239)
Sequences: 637 (440)
Seq/√Len: 28.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_A156_V4.8961.00
215_L223_I4.3201.00
128_P190_D3.5461.00
154_L165_V3.3221.00
8_A86_I3.1001.00
154_L163_F3.0471.00
11_L86_I2.8101.00
131_V163_F2.7861.00
29_L59_Y2.6471.00
229_I234_G2.5450.99
153_A192_H2.5270.99
226_H237_T2.4880.99
30_D53_A2.4680.99
68_V97_L2.4570.99
51_L234_G2.3870.99
27_I36_I2.3580.99
195_F217_L2.3560.99
49_L236_V2.3540.99
207_I227_F2.3130.99
149_S167_A2.2240.98
42_A199_Y2.2070.98
32_D142_V2.1990.98
40_D199_Y2.1740.98
43_S46_M2.1160.98
30_D59_Y2.0150.97
42_A239_M1.9850.96
88_L99_I1.9770.96
14_T124_D1.9590.96
79_M104_L1.9070.95
3_K89_E1.8800.95
50_D235_H1.8170.94
222_P242_P1.8160.94
15_L27_I1.8150.94
131_V156_V1.8070.94
51_L142_V1.8050.94
43_S123_P1.7510.93
39_V43_S1.7350.92
40_D44_V1.7000.92
73_L99_I1.6990.92
224_K227_F1.6970.92
214_E226_H1.6860.91
215_L225_L1.6530.90
128_P218_G1.6470.90
131_V186_L1.5970.89
28_H119_E1.5940.89
106_Y167_A1.5870.89
72_R174_V1.5850.89
67_G169_G1.5530.87
26_K113_P1.5430.87
126_D189_G1.5410.87
110_L205_K1.5400.87
11_L36_I1.5390.87
195_F200_L1.5370.87
204_N207_I1.5360.87
40_D67_G1.5310.87
44_V199_Y1.5120.86
114_D138_I1.5060.86
79_M144_A1.5000.86
68_V231_D1.4420.83
39_V44_V1.4340.83
2_F29_L1.4260.82
29_L61_A1.4240.82
131_V184_I1.3880.81
135_G209_T1.3700.80
70_L84_Q1.3460.79
30_D35_S1.3440.79
77_A154_L1.3420.78
32_D54_T1.3360.78
46_M123_P1.3270.78
27_I66_I1.3010.76
105_E175_H1.2980.76
45_G199_Y1.2960.76
14_T210_T1.2810.75
45_G240_L1.2640.74
133_I138_I1.2630.74
43_S196_S1.2520.73
24_E69_N1.2470.73
61_A64_G1.2410.73
106_Y132_A1.2390.73
142_V201_K1.2330.72
25_C36_I1.2240.72
34_L97_L1.2210.71
18_V29_L1.2200.71
75_D120_P1.2130.71
149_S204_N1.1920.70
55_A234_G1.1870.69
220_E244_I1.1850.69
121_D221_F1.1850.69
126_D231_D1.1730.68
14_T96_K1.1710.68
167_A195_F1.1640.68
162_L177_E1.1600.67
62_D92_E1.1590.67
135_G229_I1.1480.67
123_P244_I1.1240.65
203_M240_L1.1210.65
235_H239_M1.1180.64
78_G84_Q1.0760.61
18_V36_I1.0620.60
25_C70_L1.0600.60
123_P203_M1.0530.60
37_R243_R1.0310.58
155_G168_E1.0310.58
15_L238_Y1.0270.58
31_D41_P1.0250.58
11_L168_E1.0230.57
136_R152_I1.0190.57
148_V174_V1.0170.57
156_V188_A1.0090.56
21_L48_D0.9920.55
14_T230_A0.9880.55
139_D197_L0.9870.55
44_V241_A0.9820.54
22_V25_C0.9740.54
224_K237_T0.9720.54
167_A198_D0.9700.53
2_F45_G0.9700.53
57_E86_I0.9690.53
148_V183_L0.9670.53
93_E131_V0.9660.53
47_V147_M0.9580.53
161_D188_A0.9570.52
14_T27_I0.9520.52
156_V180_P0.9490.52
228_D235_H0.9390.51
88_L192_H0.9290.50
8_A111_I0.9270.50
139_D143_T0.9270.50
127_L218_G0.9250.50
5_I105_E0.9130.49
40_D43_S0.9130.49
155_G215_L0.9110.49
44_V222_P0.9100.49
77_A132_A0.9080.49
133_I141_A0.9070.49
20_V202_D0.9000.48
190_D229_I0.8950.48
131_V233_Q0.8940.48
2_F206_A0.8920.47
72_R144_A0.8910.47
153_A187_D0.8880.47
39_V42_A0.8870.47
12_Q240_L0.8870.47
80_A184_I0.8860.47
47_V68_V0.8860.47
5_I141_A0.8840.47
24_E150_D0.8830.47
42_A172_D0.8720.46
82_A101_I0.8720.46
73_L114_D0.8690.46
17_S105_E0.8690.46
164_Y175_H0.8590.45
130_H214_E0.8580.45
43_S243_R0.8570.45
11_L80_A0.8560.45
47_V195_F0.8550.45
68_V93_E0.8480.44
53_A59_Y0.8470.44
58_S106_Y0.8450.44
93_E136_R0.8370.43
5_I148_V0.8320.43
109_A154_L0.8310.43
70_L88_L0.8280.43
68_V181_D0.8250.42
162_L192_H0.8200.42
170_D223_I0.8190.42
55_A77_A0.8150.42
43_S109_A0.8070.41
55_A230_A0.7990.40
34_L181_D0.7950.40
26_K65_L0.7920.40
15_L25_C0.7920.40
121_D124_D0.7920.40
132_A212_E0.7920.40
122_I205_K0.7880.40
29_L66_I0.7830.39
105_E227_F0.7820.39
150_D238_Y0.7820.39
200_L206_A0.7820.39
14_T189_G0.7790.39
121_D234_G0.7770.39
16_D32_D0.7770.39
88_L191_A0.7760.39
88_L181_D0.7740.38
219_D238_Y0.7720.38
15_L180_P0.7720.38
39_V118_Q0.7710.38
47_V200_L0.7710.38
22_V113_P0.7700.38
75_D144_A0.7660.38
168_E216_E0.7640.38
186_L189_G0.7630.38
141_A178_L0.7620.38
238_Y244_I0.7580.37
131_V187_D0.7560.37
23_D71_S0.7520.37
154_L160_D0.7500.37
43_S199_Y0.7410.36
106_Y238_Y0.7350.36
145_A165_V0.7340.36
142_V217_L0.7340.36
29_L34_L0.7310.35
126_D187_D0.7300.35
37_R46_M0.7290.35
40_D169_G0.7260.35
229_I233_Q0.7250.35
206_A238_Y0.7240.35
199_Y239_M0.7230.35
76_I197_L0.7180.34
108_L204_N0.7140.34
26_K106_Y0.7130.34
77_A187_D0.7130.34
139_D207_I0.7120.34
42_A131_V0.7110.34
16_D229_I0.7060.34
10_T157_D0.7060.34
16_D154_L0.7050.34
7_S148_V0.7040.34
5_I139_D0.7020.33
65_L99_I0.7000.33
152_I165_V0.6970.33
52_A182_Q0.6960.33
222_P241_A0.6940.33
85_L124_D0.6910.33
24_E238_Y0.6900.33
14_T167_A0.6840.32
55_A193_S0.6840.32
55_A233_Q0.6830.32
20_V82_A0.6830.32
24_E197_L0.6780.32
9_D74_E0.6750.32
49_L164_Y0.6740.31
192_H211_A0.6730.31
145_A167_A0.6720.31
134_E217_L0.6720.31
26_K129_A0.6710.31
193_S197_L0.6670.31
21_L194_L0.6670.31
43_S240_L0.6660.31
127_L131_V0.6630.31
15_L36_I0.6590.30
17_S27_I0.6530.30
110_L122_I0.6500.30
124_D170_D0.6490.30
34_L60_E0.6470.30
88_L93_E0.6470.30
223_I244_I0.6460.30
178_L181_D0.6440.30
88_L220_E0.6420.29
128_P209_T0.6410.29
88_L173_D0.6380.29
4_A29_L0.6370.29
48_D237_T0.6350.29
163_F245_Q0.6350.29
86_I130_H0.6330.29
12_Q56_F0.6300.29
34_L76_I0.6290.29
153_A225_L0.6280.28
30_D64_G0.6270.28
147_M173_D0.6270.28
61_A165_V0.6240.28
34_L236_V0.6240.28
80_A226_H0.6210.28
41_P218_G0.6210.28
102_D144_A0.6200.28
163_F186_L0.6170.28
2_F224_K0.6160.28
98_H148_V0.6150.28
166_N204_N0.6150.28
146_D167_A0.6130.28
63_G143_T0.6130.28
80_A84_Q0.6110.27
24_E179_A0.6100.27
97_L208_P0.6100.27
67_G113_P0.6060.27
186_L245_Q0.6060.27
155_G166_N0.6060.27
106_Y150_D0.6050.27
10_T148_V0.6010.27
34_L110_L0.5930.26
43_S150_D0.5910.26
27_I151_H0.5900.26
80_A90_L0.5880.26
19_S137_D0.5870.26
129_A150_D0.5870.26
129_A188_A0.5860.26
151_H196_S0.5860.26
189_G194_L0.5830.26
56_F199_Y0.5800.26
79_M87_Q0.5780.25
77_A114_D0.5760.25
200_L223_I0.5750.25
2_F177_E0.5740.25
108_L182_Q0.5720.25
21_L50_D0.5720.25
36_I47_V0.5720.25
31_D35_S0.5710.25
75_D110_L0.5710.25
200_L207_I0.5710.25
52_A65_L0.5700.25
125_L128_P0.5690.25
5_I87_Q0.5690.25
181_D211_A0.5670.25
81_D208_P0.5630.25
10_T103_G0.5620.25
71_S215_L0.5620.25
7_S12_Q0.5610.24
130_H223_I0.5590.24
59_Y213_V0.5590.24
45_G63_G0.5590.24
66_I241_A0.5580.24
115_S197_L0.5570.24
17_S124_D0.5560.24
98_H154_L0.5560.24
60_E138_I0.5560.24
143_T178_L0.5560.24
28_H39_V0.5560.24
88_L118_Q0.5540.24
43_S239_M0.5540.24
24_E41_P0.5490.24
67_G112_D0.5490.24
130_H211_A0.5450.24
64_G190_D0.5450.24
23_D125_L0.5430.23
140_R149_S0.5430.23
80_A114_D0.5420.23
58_S112_D0.5410.23
76_I156_V0.5370.23
143_T156_V0.5320.23
17_S236_V0.5320.23
37_R160_D0.5310.23
44_V137_D0.5290.23
150_D217_L0.5280.23
138_I216_E0.5280.23
5_I62_D0.5280.23
41_P101_I0.5270.23
212_E238_Y0.5270.23
154_L217_L0.5250.22
22_V197_L0.5240.22
88_L133_I0.5220.22
22_V26_K0.5220.22
86_I167_A0.5180.22
88_L160_D0.5170.22
153_A166_N0.5170.22
68_V167_A0.5160.22
11_L75_D0.5150.22
40_D222_P0.5150.22
211_A231_D0.5110.22
18_V71_S0.5080.22
114_D121_D0.5070.22
62_D223_I0.5070.22
150_D199_Y0.5020.21
32_D133_I0.5020.21
176_L227_F0.5010.21
145_A149_S0.5010.21
80_A86_I0.5010.21
170_D199_Y0.5000.21
199_Y241_A0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a1jC 1 0.9676 100 0.296 Contact Map
3k4xA 1 0.9555 100 0.309 Contact Map
3a1jB 1 0.9352 100 0.329 Contact Map
3g65A 1 0.9474 100 0.331 Contact Map
3a1jA 1 0.9636 100 0.357 Contact Map
3fdsC 1 0.9595 100 0.394 Contact Map
1plqA 3 0.9757 100 0.415 Contact Map
2zvvA 3 0.9676 100 0.417 Contact Map
1u7bA 3 0.9676 100 0.42 Contact Map
3ifvA 3 0.9717 100 0.424 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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