Q9HN44 - HALSA - GREMLIN Contacts

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Q9HN44 - Na+/Ca2+-exchanging protein

UniProt:	Q9HN44	Sequences: MGAASALVGSTPGHVAVVVVATLLIWAGSSWLEAAAEQLSAHYGLPAVVQGSIVVAIGSSFPELLSVLVTALDGSFGLGVGAIVGSAIFNILVVPGLAGITTTQPLDATRTVVYKEAQFYMLAVSTLLLTFALAVIYAPIPGGDPLDGAVTRPLALVPLLLYGLYLFIQWQDVGDHDPTTDTTDVDVPRAWARLAAGLAAISVAVELLVGAVTGLAATFDIPSFLAGVTILAAATSLPDALVSVRAARSGHGVTSLGNVLGSNTFDLLVAIPIGVLIAGRAPVSFAVAAPLMGVLTLATVLLFTVLRTGLSLTDAESYALLVAYLGFVAWIIGETLGVVGLIRV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	344 (299)
Sequences:	5291 (3670)
Seq/√Len:	212.2

ECOLI - YRBG CHAA
BACSU - CHAA
HALSA - Q9HN44 Q9HS69
SULSO - Q97YX8 Q97U31

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
147_D	154_L	4.221	1.00
155_A	275_V	3.980	1.00
89_F	93_V	3.843	1.00
89_F	233_A	3.301	1.00
167_F	171_Q	3.132	1.00
295_L	299_T	2.822	1.00
53_I	56_A	2.783	1.00
217_A	223_S	2.783	1.00
14_H	214_G	2.590	1.00
47_A	251_H	2.525	1.00
206_E	210_G	2.496	1.00
159_L	163_G	2.490	1.00
187_V	191_W	2.345	1.00
211_A	214_G	2.341	1.00
75_S	223_S	2.295	1.00
99_G	317_S	2.283	1.00
156_L	160_L	2.283	1.00
127_L	130_T	2.280	1.00
191_W	195_A	2.251	1.00
130_T	154_L	2.241	1.00
308_T	316_E	2.215	1.00
221_I	225_L	2.198	1.00
162_Y	269_V	2.187	1.00
286_A	290_P	2.174	1.00
126_T	130_T	2.165	1.00
188_P	192_A	2.130	1.00
100_I	321_L	2.083	1.00
212_V	231_L	2.082	1.00
288_A	291_L	2.030	1.00
17_V	211_A	1.994	1.00
203_V	207_L	1.977	1.00
92_L	320_L	1.966	1.00
123_A	268_L	1.919	1.00
18_V	211_A	1.911	1.00
189_R	193_R	1.887	1.00
293_G	297_L	1.880	1.00
104_Q	250_G	1.874	1.00
59_S	239_D	1.840	1.00
215_L	219_F	1.810	1.00
92_L	298_A	1.787	1.00
27_A	31_W	1.767	1.00
127_L	267_L	1.721	1.00
67_V	82_A	1.716	1.00
163_G	167_F	1.716	1.00
283_V	287_V	1.712	1.00
28_G	200_A	1.705	1.00
216_A	226_A	1.699	1.00
128_L	131_F	1.684	1.00
16_A	20_V	1.628	1.00
120_Y	124_V	1.615	1.00
99_G	312_L	1.612	1.00
151_T	154_L	1.592	1.00
28_G	204_A	1.579	1.00
313_T	316_E	1.578	1.00
309_G	316_E	1.567	1.00
27_A	30_S	1.557	1.00
35_A	194_L	1.546	1.00
35_A	197_G	1.543	1.00
159_L	276_L	1.515	1.00
122_L	126_T	1.508	1.00
186_D	189_R	1.476	1.00
153_P	329_A	1.466	1.00
100_I	318_Y	1.459	1.00
147_D	150_V	1.454	1.00
322_V	326_G	1.454	1.00
156_L	276_L	1.447	1.00
15_V	19_V	1.426	1.00
31_W	193_R	1.423	1.00
325_L	329_A	1.416	1.00
42_H	187_V	1.411	1.00
21_A	25_I	1.394	1.00
127_L	131_F	1.385	1.00
286_A	289_A	1.377	1.00
78_L	227_G	1.375	1.00
198_L	202_S	1.373	1.00
283_V	290_P	1.359	1.00
152_R	276_L	1.356	1.00
87_A	266_D	1.349	1.00
294_V	297_L	1.341	1.00
315_A	318_Y	1.336	1.00
83_I	271_I	1.326	1.00
24_L	27_A	1.323	1.00
63_E	239_D	1.316	1.00
93_V	233_A	1.308	1.00
90_N	263_N	1.300	1.00
243_S	258_N	1.296	1.00
185_V	189_R	1.293	1.00
97_L	244_V	1.292	1.00
75_S	213_T	1.291	1.00
86_S	90_N	1.281	1.00
39_L	194_L	1.281	1.00
68_L	277_I	1.277	1.00
297_L	301_L	1.273	1.00
77_G	81_G	1.269	1.00
18_V	215_L	1.243	1.00
39_L	190_A	1.227	1.00
31_W	196_A	1.219	1.00
68_L	72_L	1.215	1.00
22_T	26_W	1.214	1.00
104_Q	107_D	1.211	1.00
297_L	300_V	1.207	1.00
107_D	311_S	1.206	1.00
21_A	24_L	1.204	1.00
38_Q	190_A	1.196	1.00
177_D	182_T	1.192	1.00
32_L	201_I	1.189	1.00
69_V	73_D	1.187	1.00
155_A	272_P	1.186	1.00
192_A	196_A	1.180	1.00
57_I	265_F	1.180	1.00
57_I	61_F	1.180	1.00
213_T	217_A	1.179	1.00
21_A	204_A	1.178	1.00
147_D	151_T	1.171	1.00
214_G	217_A	1.167	1.00
109_T	253_V	1.165	1.00
36_A	55_V	1.151	1.00
289_A	292_M	1.146	1.00
64_L	68_L	1.141	1.00
287_V	290_P	1.140	1.00
152_R	156_L	1.137	1.00
221_I	226_A	1.136	1.00
113_V	117_A	1.135	1.00
55_V	254_T	1.126	1.00
266_D	270_A	1.125	1.00
283_V	288_A	1.124	1.00
64_L	83_I	1.124	1.00
60_S	262_S	1.117	1.00
322_V	329_A	1.115	1.00
225_L	332_I	1.115	1.00
242_V	246_A	1.114	1.00
96_G	317_S	1.095	1.00
111_T	115_K	1.093	1.00
24_L	200_A	1.089	1.00
185_V	190_A	1.081	1.00
284_S	289_A	1.080	1.00
105_P	311_S	1.079	1.00
64_L	270_A	1.075	1.00
31_W	200_A	1.073	1.00
168_I	172_D	1.070	1.00
41_A	50_Q	1.069	1.00
65_L	205_V	1.066	1.00
120_Y	260_L	1.055	1.00
152_R	279_G	1.053	1.00
299_T	306_L	1.053	1.00
125_S	129_L	1.053	1.00
154_L	157_V	1.051	1.00
155_A	158_P	1.048	1.00
17_V	207_L	1.042	1.00
283_V	289_A	1.035	1.00
98_A	243_S	1.033	1.00
215_L	218_T	1.028	1.00
63_E	238_P	1.020	1.00
123_A	264_T	1.015	1.00
287_V	291_L	1.001	1.00
26_W	29_S	1.001	1.00
30_S	34_A	0.995	1.00
83_I	274_G	0.989	1.00
262_S	265_F	0.988	1.00
293_G	298_A	0.987	1.00
214_G	218_T	0.984	1.00
315_A	319_A	0.982	1.00
282_P	286_A	0.980	1.00
59_S	62_P	0.980	1.00
20_V	23_L	0.979	1.00
166_L	170_W	0.979	1.00
287_V	292_M	0.978	1.00
316_E	320_L	0.971	1.00
24_L	207_L	0.969	1.00
207_L	211_A	0.969	1.00
189_R	196_A	0.962	1.00
265_F	269_V	0.959	1.00
37_E	251_H	0.958	1.00
21_A	29_S	0.954	1.00
65_L	201_I	0.953	1.00
52_S	55_V	0.952	1.00
90_N	262_S	0.950	1.00
300_V	304_T	0.938	0.99
56_A	59_S	0.936	0.99
160_L	164_L	0.934	0.99
283_V	286_A	0.933	0.99
229_T	232_A	0.932	0.99
78_L	231_L	0.925	0.99
217_A	226_A	0.917	0.99
126_T	161_L	0.913	0.99
193_R	196_A	0.910	0.99
165_Y	168_I	0.910	0.99
180_T	184_D	0.907	0.99
110_R	114_Y	0.901	0.99
283_V	291_L	0.896	0.99
59_S	238_P	0.896	0.99
295_L	302_L	0.893	0.99
236_S	240_A	0.889	0.99
95_P	256_L	0.889	0.99
64_L	90_N	0.884	0.99
60_S	236_S	0.883	0.99
65_L	202_S	0.883	0.99
286_A	291_L	0.882	0.99
14_H	211_A	0.880	0.99
165_Y	264_T	0.880	0.99
86_S	236_S	0.880	0.99
98_A	247_A	0.878	0.99
61_F	277_I	0.877	0.99
179_T	182_T	0.876	0.99
174_G	181_D	0.876	0.99
246_A	254_T	0.870	0.99
28_G	197_G	0.870	0.99
302_L	306_L	0.869	0.99
244_V	248_R	0.866	0.99
210_G	214_G	0.865	0.99
31_W	34_A	0.861	0.99
305_V	308_T	0.857	0.99
35_A	193_R	0.857	0.99
164_L	318_Y	0.852	0.99
41_A	47_A	0.846	0.99
296_T	300_V	0.844	0.99
295_L	305_V	0.837	0.99
63_E	235_T	0.834	0.99
203_V	206_E	0.834	0.99
129_L	147_D	0.833	0.99
126_T	158_P	0.832	0.99
38_Q	42_H	0.829	0.99
129_L	132_A	0.825	0.99
303_F	307_R	0.823	0.99
48_V	52_S	0.822	0.99
95_P	312_L	0.811	0.98
193_R	200_A	0.806	0.98
235_T	238_P	0.804	0.98
299_T	308_T	0.801	0.98
202_S	206_E	0.800	0.98
71_A	278_A	0.796	0.98
94_V	240_A	0.793	0.98
42_H	47_A	0.793	0.98
86_S	263_N	0.791	0.98
294_V	299_T	0.790	0.98
60_S	263_N	0.789	0.98
290_P	327_F	0.787	0.98
317_S	321_L	0.785	0.98
57_I	162_Y	0.785	0.98
52_S	56_A	0.784	0.98
238_P	263_N	0.783	0.98
177_D	181_D	0.782	0.98
152_R	155_A	0.780	0.98
256_L	305_V	0.779	0.98
36_A	246_A	0.778	0.98
115_K	119_F	0.777	0.98
91_I	262_S	0.777	0.98
71_A	274_G	0.776	0.98
199_A	202_S	0.772	0.98
170_W	173_V	0.771	0.98
164_L	168_I	0.768	0.98
77_G	283_V	0.768	0.98
319_A	323_A	0.765	0.98
56_A	62_P	0.762	0.98
100_I	317_S	0.761	0.98
49_V	170_W	0.760	0.98
38_Q	185_V	0.759	0.98
309_G	315_A	0.758	0.98
120_Y	299_T	0.757	0.98
200_A	203_V	0.755	0.98
196_A	200_A	0.753	0.98
21_A	211_A	0.751	0.97
130_T	157_V	0.751	0.97
216_A	227_G	0.749	0.97
207_L	210_G	0.748	0.97
29_S	37_E	0.748	0.97
155_A	162_Y	0.744	0.97
17_V	210_G	0.743	0.97
188_P	191_W	0.742	0.97
205_V	269_V	0.738	0.97
84_V	271_I	0.738	0.97
39_L	43_Y	0.736	0.97
160_L	163_G	0.728	0.97
282_P	289_A	0.724	0.97
54_V	194_L	0.722	0.97
189_R	192_A	0.721	0.97
200_A	204_A	0.719	0.97
89_F	92_L	0.718	0.97
113_V	116_E	0.715	0.97
232_A	236_S	0.710	0.96
59_S	235_T	0.708	0.96
36_A	50_Q	0.706	0.96
65_L	69_V	0.704	0.96
225_L	331_I	0.703	0.96
61_F	265_F	0.699	0.96
178_P	181_D	0.699	0.96
162_Y	166_L	0.697	0.96
87_A	262_S	0.697	0.96
52_S	58_G	0.695	0.96
80_V	271_I	0.695	0.96
285_F	289_A	0.693	0.96
150_V	154_L	0.688	0.96
282_P	290_P	0.685	0.96
79_G	82_A	0.685	0.96
328_V	332_I	0.682	0.96
201_I	241_L	0.681	0.96
22_T	233_A	0.681	0.96
21_A	28_G	0.680	0.95
238_P	258_N	0.678	0.95
153_P	157_V	0.674	0.95
147_D	157_V	0.673	0.95
90_N	235_T	0.673	0.95
284_S	288_A	0.671	0.95
239_D	270_A	0.670	0.95
89_F	240_A	0.669	0.95
159_L	269_V	0.667	0.95
26_W	30_S	0.666	0.95
247_A	252_G	0.663	0.95
89_F	236_S	0.663	0.95
88_I	327_F	0.663	0.95
25_I	28_G	0.662	0.95
229_T	328_V	0.662	0.95
239_D	262_S	0.661	0.95
127_L	271_I	0.660	0.95
231_L	235_T	0.660	0.95
60_S	87_A	0.659	0.95
78_L	212_V	0.659	0.95
181_D	184_D	0.658	0.95
293_G	304_T	0.656	0.95
210_G	213_T	0.656	0.95
174_G	177_D	0.656	0.95
101_T	104_Q	0.654	0.94
55_V	60_S	0.654	0.94
226_A	234_A	0.652	0.94
257_G	261_G	0.651	0.94
238_P	261_G	0.647	0.94
245_R	248_R	0.645	0.94
27_A	34_A	0.643	0.94
161_L	164_L	0.642	0.94
25_I	33_E	0.642	0.94
92_L	98_A	0.640	0.94
276_L	280_R	0.636	0.94
41_A	179_T	0.633	0.93
178_P	184_D	0.632	0.93
108_A	256_L	0.631	0.93
73_D	206_E	0.630	0.93
305_V	319_A	0.630	0.93
63_E	90_N	0.629	0.93
324_Y	327_F	0.628	0.93
51_G	242_V	0.628	0.93
321_L	325_L	0.627	0.93
47_A	50_Q	0.624	0.93
162_Y	165_Y	0.620	0.93
32_L	39_L	0.611	0.92
48_V	112_V	0.607	0.92
97_L	101_T	0.606	0.92
297_L	304_T	0.605	0.92
36_A	40_S	0.605	0.92
236_S	266_D	0.604	0.92
63_E	262_S	0.602	0.92
294_V	298_A	0.599	0.91
201_I	269_V	0.599	0.91
178_P	183_T	0.599	0.91
148_G	152_R	0.597	0.91
215_L	226_A	0.597	0.91
77_G	224_F	0.596	0.91
295_L	300_V	0.595	0.91
41_A	181_D	0.593	0.91
97_L	100_I	0.593	0.91
23_L	27_A	0.590	0.91
259_V	263_N	0.589	0.91
57_I	60_S	0.588	0.91
93_V	321_L	0.584	0.90
65_L	250_G	0.582	0.90
30_S	245_R	0.580	0.90
34_A	69_V	0.580	0.90
227_G	232_A	0.579	0.90
91_I	95_P	0.579	0.90
70_T	209_V	0.579	0.90
166_L	265_F	0.579	0.90
80_V	272_P	0.576	0.90
184_D	187_V	0.574	0.90
158_P	162_Y	0.573	0.90
255_S	271_I	0.573	0.90
22_T	25_I	0.572	0.89
17_V	21_A	0.571	0.89
186_D	190_A	0.571	0.89
97_L	240_A	0.570	0.89
109_T	112_V	0.569	0.89
18_V	208_L	0.569	0.89
269_V	273_I	0.568	0.89
19_V	23_L	0.568	0.89
299_T	304_T	0.568	0.89
128_L	132_A	0.567	0.89
157_V	214_G	0.567	0.89
243_S	255_S	0.565	0.89
34_A	249_S	0.564	0.89
120_Y	123_A	0.561	0.89
152_R	277_I	0.560	0.88
301_L	304_T	0.560	0.88
299_T	303_F	0.559	0.88
329_A	332_I	0.557	0.88
112_V	118_Q	0.556	0.88
69_V	206_E	0.556	0.88
69_V	72_L	0.554	0.88
32_L	83_I	0.554	0.88
60_S	90_N	0.554	0.88
309_G	313_T	0.550	0.88
282_P	288_A	0.548	0.87
291_L	295_L	0.547	0.87
296_T	299_T	0.544	0.87
124_V	132_A	0.542	0.87
59_S	94_V	0.541	0.87
235_T	263_N	0.540	0.87
152_R	160_L	0.539	0.87
58_G	62_P	0.539	0.87
91_I	120_Y	0.538	0.86
236_S	263_N	0.533	0.86
114_Y	132_A	0.533	0.86
39_L	54_V	0.533	0.86
224_F	227_G	0.533	0.86
25_I	29_S	0.531	0.86
42_H	190_A	0.531	0.86
158_P	268_L	0.531	0.86
117_A	260_L	0.531	0.86
67_V	274_G	0.530	0.86
317_S	320_L	0.529	0.85
98_A	242_V	0.525	0.85
106_L	252_G	0.523	0.85
178_P	182_T	0.522	0.85
161_L	315_A	0.522	0.85
126_T	132_A	0.521	0.85
81_G	224_F	0.521	0.85
227_G	262_S	0.521	0.85
94_V	234_A	0.521	0.85
90_N	238_P	0.520	0.85
149_A	156_L	0.520	0.85
159_L	162_Y	0.519	0.84
212_V	235_T	0.519	0.84
168_I	171_Q	0.519	0.84
150_V	271_I	0.519	0.84
228_V	290_P	0.514	0.84
119_F	264_T	0.512	0.84
75_S	78_L	0.512	0.84
67_V	71_A	0.511	0.83
68_L	274_G	0.510	0.83
20_V	121_M	0.510	0.83
293_G	296_T	0.510	0.83
282_P	285_F	0.509	0.83
17_V	20_V	0.508	0.83
289_A	293_G	0.506	0.83
94_V	236_S	0.505	0.83
58_G	262_S	0.503	0.83
174_G	178_P	0.502	0.82
96_G	101_T	0.501	0.82
83_I	198_L	0.501	0.82
29_S	58_G	0.501	0.82
14_H	199_A	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3v5uA	1	0.8605	100	0.24	Contact Map
4kjrA	3	0.8924	100	0.28	Contact Map
4k1cA	4	0.9564	100	0.291	Contact Map
4kppA	1	0.9244	100	0.312	Contact Map
3pjzA	2	0.2733	7.8	0.963	Contact Map
3l1lA	2	0.4506	6.9	0.964	Contact Map
4pgrA	1	0.4273	6.7	0.964	Contact Map
3o7qA	1	0.4477	5.8	0.965	Contact Map
3j1zP	8	0.6541	5.5	0.965	Contact Map
2kncA	1	0.1483	5.2	0.966	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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