GREMLIN Database
Q9HN44 - Na+/Ca2+-exchanging protein
UniProt: Q9HN44 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (299)
Sequences: 5291 (3670)
Seq/√Len: 212.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_D154_L4.2211.00
155_A275_V3.9801.00
89_F93_V3.8431.00
89_F233_A3.3011.00
167_F171_Q3.1321.00
295_L299_T2.8221.00
53_I56_A2.7831.00
217_A223_S2.7831.00
14_H214_G2.5901.00
47_A251_H2.5251.00
206_E210_G2.4961.00
159_L163_G2.4901.00
187_V191_W2.3451.00
211_A214_G2.3411.00
75_S223_S2.2951.00
99_G317_S2.2831.00
156_L160_L2.2831.00
127_L130_T2.2801.00
191_W195_A2.2511.00
130_T154_L2.2411.00
308_T316_E2.2151.00
221_I225_L2.1981.00
162_Y269_V2.1871.00
286_A290_P2.1741.00
126_T130_T2.1651.00
188_P192_A2.1301.00
100_I321_L2.0831.00
212_V231_L2.0821.00
288_A291_L2.0301.00
17_V211_A1.9941.00
203_V207_L1.9771.00
92_L320_L1.9661.00
123_A268_L1.9191.00
18_V211_A1.9111.00
189_R193_R1.8871.00
293_G297_L1.8801.00
104_Q250_G1.8741.00
59_S239_D1.8401.00
215_L219_F1.8101.00
92_L298_A1.7871.00
27_A31_W1.7671.00
127_L267_L1.7211.00
67_V82_A1.7161.00
163_G167_F1.7161.00
283_V287_V1.7121.00
28_G200_A1.7051.00
216_A226_A1.6991.00
128_L131_F1.6841.00
16_A20_V1.6281.00
120_Y124_V1.6151.00
99_G312_L1.6121.00
151_T154_L1.5921.00
28_G204_A1.5791.00
313_T316_E1.5781.00
309_G316_E1.5671.00
27_A30_S1.5571.00
35_A194_L1.5461.00
35_A197_G1.5431.00
159_L276_L1.5151.00
122_L126_T1.5081.00
186_D189_R1.4761.00
153_P329_A1.4661.00
100_I318_Y1.4591.00
147_D150_V1.4541.00
322_V326_G1.4541.00
156_L276_L1.4471.00
15_V19_V1.4261.00
31_W193_R1.4231.00
325_L329_A1.4161.00
42_H187_V1.4111.00
21_A25_I1.3941.00
127_L131_F1.3851.00
286_A289_A1.3771.00
78_L227_G1.3751.00
198_L202_S1.3731.00
283_V290_P1.3591.00
152_R276_L1.3561.00
87_A266_D1.3491.00
294_V297_L1.3411.00
315_A318_Y1.3361.00
83_I271_I1.3261.00
24_L27_A1.3231.00
63_E239_D1.3161.00
93_V233_A1.3081.00
90_N263_N1.3001.00
243_S258_N1.2961.00
185_V189_R1.2931.00
97_L244_V1.2921.00
75_S213_T1.2911.00
86_S90_N1.2811.00
39_L194_L1.2811.00
68_L277_I1.2771.00
297_L301_L1.2731.00
77_G81_G1.2691.00
18_V215_L1.2431.00
39_L190_A1.2271.00
31_W196_A1.2191.00
68_L72_L1.2151.00
22_T26_W1.2141.00
104_Q107_D1.2111.00
297_L300_V1.2071.00
107_D311_S1.2061.00
21_A24_L1.2041.00
38_Q190_A1.1961.00
177_D182_T1.1921.00
32_L201_I1.1891.00
69_V73_D1.1871.00
155_A272_P1.1861.00
192_A196_A1.1801.00
57_I265_F1.1801.00
57_I61_F1.1801.00
213_T217_A1.1791.00
21_A204_A1.1781.00
147_D151_T1.1711.00
214_G217_A1.1671.00
109_T253_V1.1651.00
36_A55_V1.1511.00
289_A292_M1.1461.00
64_L68_L1.1411.00
287_V290_P1.1401.00
152_R156_L1.1371.00
221_I226_A1.1361.00
113_V117_A1.1351.00
55_V254_T1.1261.00
266_D270_A1.1251.00
283_V288_A1.1241.00
64_L83_I1.1241.00
60_S262_S1.1171.00
322_V329_A1.1151.00
225_L332_I1.1151.00
242_V246_A1.1141.00
96_G317_S1.0951.00
111_T115_K1.0931.00
24_L200_A1.0891.00
185_V190_A1.0811.00
284_S289_A1.0801.00
105_P311_S1.0791.00
64_L270_A1.0751.00
31_W200_A1.0731.00
168_I172_D1.0701.00
41_A50_Q1.0691.00
65_L205_V1.0661.00
120_Y260_L1.0551.00
152_R279_G1.0531.00
299_T306_L1.0531.00
125_S129_L1.0531.00
154_L157_V1.0511.00
155_A158_P1.0481.00
17_V207_L1.0421.00
283_V289_A1.0351.00
98_A243_S1.0331.00
215_L218_T1.0281.00
63_E238_P1.0201.00
123_A264_T1.0151.00
287_V291_L1.0011.00
26_W29_S1.0011.00
30_S34_A0.9951.00
83_I274_G0.9891.00
262_S265_F0.9881.00
293_G298_A0.9871.00
214_G218_T0.9841.00
315_A319_A0.9821.00
282_P286_A0.9801.00
59_S62_P0.9801.00
20_V23_L0.9791.00
166_L170_W0.9791.00
287_V292_M0.9781.00
316_E320_L0.9711.00
24_L207_L0.9691.00
207_L211_A0.9691.00
189_R196_A0.9621.00
265_F269_V0.9591.00
37_E251_H0.9581.00
21_A29_S0.9541.00
65_L201_I0.9531.00
52_S55_V0.9521.00
90_N262_S0.9501.00
300_V304_T0.9380.99
56_A59_S0.9360.99
160_L164_L0.9340.99
283_V286_A0.9330.99
229_T232_A0.9320.99
78_L231_L0.9250.99
217_A226_A0.9170.99
126_T161_L0.9130.99
193_R196_A0.9100.99
165_Y168_I0.9100.99
180_T184_D0.9070.99
110_R114_Y0.9010.99
283_V291_L0.8960.99
59_S238_P0.8960.99
295_L302_L0.8930.99
236_S240_A0.8890.99
95_P256_L0.8890.99
64_L90_N0.8840.99
60_S236_S0.8830.99
65_L202_S0.8830.99
286_A291_L0.8820.99
14_H211_A0.8800.99
165_Y264_T0.8800.99
86_S236_S0.8800.99
98_A247_A0.8780.99
61_F277_I0.8770.99
179_T182_T0.8760.99
174_G181_D0.8760.99
246_A254_T0.8700.99
28_G197_G0.8700.99
302_L306_L0.8690.99
244_V248_R0.8660.99
210_G214_G0.8650.99
31_W34_A0.8610.99
305_V308_T0.8570.99
35_A193_R0.8570.99
164_L318_Y0.8520.99
41_A47_A0.8460.99
296_T300_V0.8440.99
295_L305_V0.8370.99
63_E235_T0.8340.99
203_V206_E0.8340.99
129_L147_D0.8330.99
126_T158_P0.8320.99
38_Q42_H0.8290.99
129_L132_A0.8250.99
303_F307_R0.8230.99
48_V52_S0.8220.99
95_P312_L0.8110.98
193_R200_A0.8060.98
235_T238_P0.8040.98
299_T308_T0.8010.98
202_S206_E0.8000.98
71_A278_A0.7960.98
94_V240_A0.7930.98
42_H47_A0.7930.98
86_S263_N0.7910.98
294_V299_T0.7900.98
60_S263_N0.7890.98
290_P327_F0.7870.98
317_S321_L0.7850.98
57_I162_Y0.7850.98
52_S56_A0.7840.98
238_P263_N0.7830.98
177_D181_D0.7820.98
152_R155_A0.7800.98
256_L305_V0.7790.98
36_A246_A0.7780.98
115_K119_F0.7770.98
91_I262_S0.7770.98
71_A274_G0.7760.98
199_A202_S0.7720.98
170_W173_V0.7710.98
164_L168_I0.7680.98
77_G283_V0.7680.98
319_A323_A0.7650.98
56_A62_P0.7620.98
100_I317_S0.7610.98
49_V170_W0.7600.98
38_Q185_V0.7590.98
309_G315_A0.7580.98
120_Y299_T0.7570.98
200_A203_V0.7550.98
196_A200_A0.7530.98
21_A211_A0.7510.97
130_T157_V0.7510.97
216_A227_G0.7490.97
207_L210_G0.7480.97
29_S37_E0.7480.97
155_A162_Y0.7440.97
17_V210_G0.7430.97
188_P191_W0.7420.97
205_V269_V0.7380.97
84_V271_I0.7380.97
39_L43_Y0.7360.97
160_L163_G0.7280.97
282_P289_A0.7240.97
54_V194_L0.7220.97
189_R192_A0.7210.97
200_A204_A0.7190.97
89_F92_L0.7180.97
113_V116_E0.7150.97
232_A236_S0.7100.96
59_S235_T0.7080.96
36_A50_Q0.7060.96
65_L69_V0.7040.96
225_L331_I0.7030.96
61_F265_F0.6990.96
178_P181_D0.6990.96
162_Y166_L0.6970.96
87_A262_S0.6970.96
52_S58_G0.6950.96
80_V271_I0.6950.96
285_F289_A0.6930.96
150_V154_L0.6880.96
282_P290_P0.6850.96
79_G82_A0.6850.96
328_V332_I0.6820.96
201_I241_L0.6810.96
22_T233_A0.6810.96
21_A28_G0.6800.95
238_P258_N0.6780.95
153_P157_V0.6740.95
147_D157_V0.6730.95
90_N235_T0.6730.95
284_S288_A0.6710.95
239_D270_A0.6700.95
89_F240_A0.6690.95
159_L269_V0.6670.95
26_W30_S0.6660.95
247_A252_G0.6630.95
89_F236_S0.6630.95
88_I327_F0.6630.95
25_I28_G0.6620.95
229_T328_V0.6620.95
239_D262_S0.6610.95
127_L271_I0.6600.95
231_L235_T0.6600.95
60_S87_A0.6590.95
78_L212_V0.6590.95
181_D184_D0.6580.95
293_G304_T0.6560.95
210_G213_T0.6560.95
174_G177_D0.6560.95
101_T104_Q0.6540.94
55_V60_S0.6540.94
226_A234_A0.6520.94
257_G261_G0.6510.94
238_P261_G0.6470.94
245_R248_R0.6450.94
27_A34_A0.6430.94
161_L164_L0.6420.94
25_I33_E0.6420.94
92_L98_A0.6400.94
276_L280_R0.6360.94
41_A179_T0.6330.93
178_P184_D0.6320.93
108_A256_L0.6310.93
73_D206_E0.6300.93
305_V319_A0.6300.93
63_E90_N0.6290.93
324_Y327_F0.6280.93
51_G242_V0.6280.93
321_L325_L0.6270.93
47_A50_Q0.6240.93
162_Y165_Y0.6200.93
32_L39_L0.6110.92
48_V112_V0.6070.92
97_L101_T0.6060.92
297_L304_T0.6050.92
36_A40_S0.6050.92
236_S266_D0.6040.92
63_E262_S0.6020.92
294_V298_A0.5990.91
201_I269_V0.5990.91
178_P183_T0.5990.91
148_G152_R0.5970.91
215_L226_A0.5970.91
77_G224_F0.5960.91
295_L300_V0.5950.91
41_A181_D0.5930.91
97_L100_I0.5930.91
23_L27_A0.5900.91
259_V263_N0.5890.91
57_I60_S0.5880.91
93_V321_L0.5840.90
65_L250_G0.5820.90
30_S245_R0.5800.90
34_A69_V0.5800.90
227_G232_A0.5790.90
91_I95_P0.5790.90
70_T209_V0.5790.90
166_L265_F0.5790.90
80_V272_P0.5760.90
184_D187_V0.5740.90
158_P162_Y0.5730.90
255_S271_I0.5730.90
22_T25_I0.5720.89
17_V21_A0.5710.89
186_D190_A0.5710.89
97_L240_A0.5700.89
109_T112_V0.5690.89
18_V208_L0.5690.89
269_V273_I0.5680.89
19_V23_L0.5680.89
299_T304_T0.5680.89
128_L132_A0.5670.89
157_V214_G0.5670.89
243_S255_S0.5650.89
34_A249_S0.5640.89
120_Y123_A0.5610.89
152_R277_I0.5600.88
301_L304_T0.5600.88
299_T303_F0.5590.88
329_A332_I0.5570.88
112_V118_Q0.5560.88
69_V206_E0.5560.88
69_V72_L0.5540.88
32_L83_I0.5540.88
60_S90_N0.5540.88
309_G313_T0.5500.88
282_P288_A0.5480.87
291_L295_L0.5470.87
296_T299_T0.5440.87
124_V132_A0.5420.87
59_S94_V0.5410.87
235_T263_N0.5400.87
152_R160_L0.5390.87
58_G62_P0.5390.87
91_I120_Y0.5380.86
236_S263_N0.5330.86
114_Y132_A0.5330.86
39_L54_V0.5330.86
224_F227_G0.5330.86
25_I29_S0.5310.86
42_H190_A0.5310.86
158_P268_L0.5310.86
117_A260_L0.5310.86
67_V274_G0.5300.86
317_S320_L0.5290.85
98_A242_V0.5250.85
106_L252_G0.5230.85
178_P182_T0.5220.85
161_L315_A0.5220.85
126_T132_A0.5210.85
81_G224_F0.5210.85
227_G262_S0.5210.85
94_V234_A0.5210.85
90_N238_P0.5200.85
149_A156_L0.5200.85
159_L162_Y0.5190.84
212_V235_T0.5190.84
168_I171_Q0.5190.84
150_V271_I0.5190.84
228_V290_P0.5140.84
119_F264_T0.5120.84
75_S78_L0.5120.84
67_V71_A0.5110.83
68_L274_G0.5100.83
20_V121_M0.5100.83
293_G296_T0.5100.83
282_P285_F0.5090.83
17_V20_V0.5080.83
289_A293_G0.5060.83
94_V236_S0.5050.83
58_G262_S0.5030.83
174_G178_P0.5020.82
96_G101_T0.5010.82
83_I198_L0.5010.82
29_S58_G0.5010.82
14_H199_A0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v5uA 1 0.8605 100 0.24 Contact Map
4kjrA 3 0.8924 100 0.28 Contact Map
4k1cA 4 0.9564 100 0.291 Contact Map
4kppA 1 0.9244 100 0.312 Contact Map
3pjzA 2 0.2733 7.8 0.963 Contact Map
3l1lA 2 0.4506 6.9 0.964 Contact Map
4pgrA 1 0.4273 6.7 0.964 Contact Map
3o7qA 1 0.4477 5.8 0.965 Contact Map
3j1zP 8 0.6541 5.5 0.965 Contact Map
2kncA 1 0.1483 5.2 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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