GREMLIN Database
CAPPA - Phosphoenolpyruvate carboxylase
UniProt: Q9HN43 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 492 (470)
Sequences: 108 (94)
Seq/√Len: 4.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
414_F420_H4.1110.87
200_V241_L3.8490.83
46_D308_R3.7670.82
261_A490_F3.7420.82
7_L308_R3.6970.81
221_P230_A3.6120.79
200_V298_E3.1190.68
32_E35_E2.9460.63
249_G349_L2.8770.61
101_L130_I2.6960.56
197_D240_R2.6900.55
57_G363_V2.6590.55
231_D414_F2.6020.53
353_V385_A2.5910.52
200_V446_A2.5840.52
193_M240_R2.5810.52
58_D65_L2.5670.52
488_R492_G2.5050.50
218_R230_A2.4180.47
232_L328_I2.3930.46
252_V410_V2.3490.45
130_I390_V2.3300.45
57_G61_A2.2460.42
273_A372_V2.2390.42
256_L487_E2.2310.42
138_V278_A2.2300.42
216_L451_D2.2260.42
218_R221_P2.1400.39
325_L417_Y2.1310.39
239_Q489_Q2.1300.39
308_R375_N2.0960.38
50_W58_D2.0900.38
197_D247_A2.0580.37
202_E205_T2.0480.36
223_L331_T2.0430.36
230_A361_L2.0090.35
245_S349_L2.0050.35
278_A395_T2.0040.35
228_L243_E1.9980.35
52_F86_V1.9620.34
84_L482_R1.9510.34
11_Q14_D1.9360.33
106_E158_K1.9300.33
221_P365_L1.8680.32
58_D61_A1.8630.31
129_P300_V1.8490.31
50_W65_L1.8120.30
26_V358_A1.8110.30
183_V203_Y1.7880.30
7_L307_L1.7460.28
144_L246_E1.7400.28
63_K98_A1.7300.28
426_R441_D1.7290.28
195_A198_D1.7020.27
9_S292_K1.7020.27
272_A306_T1.6850.27
100_I482_R1.6850.27
216_L234_N1.6770.27
465_A484_G1.6680.27
238_L254_P1.6670.27
224_N366_F1.6620.26
149_E189_E1.6570.26
241_L406_D1.6330.26
352_Y444_A1.6330.26
65_L73_F1.6270.26
304_V308_R1.6260.26
45_C427_Y1.6180.25
104_I223_L1.6160.25
57_G361_L1.6120.25
224_N365_L1.6060.25
195_A240_R1.5930.25
214_V390_V1.5720.24
206_A287_V1.5550.24
116_R177_D1.5430.24
324_A448_E1.5400.24
61_A65_L1.5340.24
33_I382_G1.5250.23
62_V84_L1.5100.23
223_L227_C1.5010.23
40_Y146_A1.4960.23
130_I346_V1.4910.23
236_V363_V1.4910.23
240_R422_A1.4870.23
80_T271_R1.4840.22
84_L217_A1.4810.22
8_M14_D1.4680.22
8_M13_P1.4680.22
8_M11_Q1.4680.22
8_M12_H1.4680.22
216_L491_L1.4590.22
404_D410_V1.4470.22
109_P155_V1.4460.22
50_W131_F1.4450.22
296_P416_A1.4420.22
58_D73_F1.4390.22
349_L427_Y1.4390.22
64_K360_K1.4360.21
198_D252_V1.4310.21
90_N135_V1.4290.21
349_L426_R1.4250.21
19_P58_D1.4250.21
342_I350_S1.4250.21
190_R233_I1.4240.21
352_Y427_Y1.4210.21
205_T309_D1.4200.21
227_C414_F1.4140.21
231_D421_L1.4140.21
109_P151_Y1.4130.21
7_L46_D1.4070.21
277_D386_S1.4020.21
235_K278_A1.3940.21
72_F277_D1.3930.21
50_W356_R1.3840.20
10_T14_D1.3770.20
10_T13_P1.3770.20
266_N423_D1.3730.20
91_P151_Y1.3730.20
21_F56_E1.3720.20
179_A373_G1.3720.20
64_K99_K1.3660.20
287_V382_G1.3640.20
78_L428_F1.3620.20
375_N396_L1.3610.20
45_C429_N1.3590.20
330_R406_D1.3500.20
258_A361_L1.3480.20
66_L84_L1.3480.20
58_D291_F1.3370.20
285_F292_K1.3340.19
360_K366_F1.3330.19
214_V241_L1.3320.19
287_V475_D1.3260.19
230_A363_V1.3260.19
40_Y305_A1.3230.19
52_F104_I1.3100.19
67_S386_S1.3060.19
309_D392_C1.2860.19
65_L131_F1.2860.19
39_V154_F1.2840.19
7_L45_C1.2830.19
90_N217_A1.2720.18
211_A392_C1.2690.18
111_S157_G1.2690.18
302_D411_R1.2670.18
275_T285_F1.2650.18
76_H118_F1.2620.18
132_E368_Y1.2580.18
364_G369_A1.2500.18
19_P65_L1.2500.18
323_R447_V1.2490.18
52_F137_M1.2460.18
32_E36_A1.2420.18
287_V313_G1.2410.18
221_P377_L1.2390.18
65_L291_F1.2340.18
16_A195_A1.2330.18
187_I480_A1.2320.18
273_A451_D1.2320.18
295_Y321_E1.2300.18
293_Y429_N1.2260.18
270_E487_E1.2250.17
144_L203_Y1.2210.17
271_R274_A1.2190.17
50_W291_F1.2160.17
82_V236_V1.2160.17
144_L448_E1.2150.17
48_Q63_K1.2110.17
58_D362_H1.2080.17
221_P224_N1.2080.17
5_P8_M1.2080.17
64_K224_N1.2030.17
157_G285_F1.2020.17
82_V142_D1.1940.17
251_D333_D1.1940.17
138_V395_T1.1900.17
28_E173_V1.1900.17
137_M491_L1.1900.17
216_L241_L1.1900.17
48_Q98_A1.1890.17
232_L386_S1.1810.17
4_V7_L1.1770.17
327_V375_N1.1750.17
348_R355_D1.1710.17
35_E367_G1.1670.17
464_D484_G1.1620.16
58_D356_R1.1610.16
243_E339_V1.1580.16
16_A482_R1.1580.16
73_F362_H1.1570.16
301_R353_V1.1500.16
19_P50_W1.1470.16
299_T302_D1.1440.16
155_V406_D1.1390.16
334_A400_H1.1380.16
198_D287_V1.1380.16
211_A251_D1.1360.16
317_F397_L1.1310.16
37_Y58_D1.1280.16
140_D187_I1.1270.16
223_L491_L1.1270.16
138_V383_Y1.1270.16
75_D451_D1.1240.16
137_M384_T1.1190.16
383_Y395_T1.1170.16
58_D64_K1.1170.16
80_T434_D1.1170.16
62_V78_L1.1090.16
116_R385_A1.1040.15
52_F489_Q1.1040.15
305_A309_D1.1030.15
32_E367_G1.1020.15
154_F266_N1.0960.15
109_P225_Y1.0950.15
193_M216_L1.0950.15
52_F59_E1.0940.15
110_R292_K1.0930.15
76_H444_A1.0900.15
115_A238_L1.0900.15
9_S129_P1.0890.15
252_V426_R1.0860.15
40_Y46_D1.0840.15
80_T201_R1.0830.15
342_I414_F1.0820.15
30_E155_V1.0770.15
84_L380_A1.0730.15
131_F235_K1.0730.15
37_Y42_H1.0720.15
278_A414_F1.0660.15
278_A420_H1.0660.15
198_D302_D1.0660.15
38_Y43_L1.0610.15
221_P366_F1.0610.15
202_E348_R1.0580.15
138_V339_V1.0580.15
56_E137_M1.0560.15
65_L362_H1.0510.15
39_V479_S1.0470.15
248_T267_L1.0380.14
101_L481_I1.0360.14
110_R172_W1.0230.14
228_L410_V1.0200.14
101_L490_F1.0190.14
58_D129_P1.0170.14
132_E370_R1.0170.14
63_K91_P1.0160.14
142_D305_A1.0150.14
73_F356_R1.0110.14
27_I144_L1.0070.14
234_N261_A1.0070.14
46_D415_P1.0070.14
332_A413_A1.0060.14
50_W362_H1.0030.14
4_V252_V1.0020.14
253_H385_A1.0020.14
287_V450_V1.0010.14
116_R270_E1.0000.14
291_F362_H0.9970.14
32_E269_P0.9960.14
92_D143_Q0.9950.14
241_L491_L0.9950.14
273_A310_A0.9910.14
9_S103_E0.9890.14
46_D183_V0.9880.14
279_Y384_T0.9870.14
31_D64_K0.9790.14
131_F291_F0.9770.14
133_V183_V0.9750.14
50_W73_F0.9640.13
28_E223_L0.9630.13
356_R362_H0.9620.13
210_D249_G0.9590.13
222_A354_P0.9580.13
222_A393_P0.9580.13
354_P393_P0.9580.13
384_T433_T0.9580.13
58_D217_A0.9560.13
50_W61_A0.9550.13
4_V184_I0.9530.13
155_V225_Y0.9500.13
159_A462_T0.9490.13
410_V420_H0.9460.13
235_K362_H0.9450.13
45_C285_F0.9400.13
292_K360_K0.9350.13
65_L356_R0.9350.13
385_A491_L0.9320.13
392_C432_C0.9310.13
144_L273_A0.9280.13
16_A433_T0.9270.13
320_D324_A0.9240.13
103_E151_Y0.9230.13
149_E384_T0.9220.13
267_L287_V0.9210.13
50_W151_Y0.9180.13
228_L396_L0.9160.13
140_D160_D0.9150.13
151_Y362_H0.9120.13
141_A201_R0.9110.13
49_M286_T0.9110.13
143_Q332_A0.9090.13
286_T335_Y0.9080.13
37_Y65_L0.9070.13
434_D485_A0.9060.13
200_V328_I0.9020.13
100_I154_F0.9010.13
115_A118_F0.8970.12
104_I212_V0.8970.12
193_M319_I0.8960.12
189_E375_N0.8950.12
83_R290_A0.8940.12
21_F490_F0.8910.12
73_F291_F0.8910.12
29_G103_E0.8890.12
224_N343_A0.8870.12
47_E53_E0.8860.12
47_E51_D0.8860.12
47_E54_G0.8860.12
47_E55_K0.8860.12
51_D55_K0.8860.12
51_D54_G0.8860.12
429_N458_H0.8860.12
225_Y285_F0.8850.12
73_F134_I0.8830.12
315_P349_L0.8820.12
218_R458_H0.8810.12
99_K109_P0.8810.12
20_F490_F0.8810.12
196_A340_D0.8810.12
427_Y477_L0.8800.12
31_D62_V0.8790.12
449_R464_D0.8730.12
385_A484_G0.8680.12
196_A333_D0.8650.12
326_A330_R0.8640.12
4_V211_A0.8640.12
200_V396_L0.8610.12
48_Q56_E0.8600.12
56_E98_A0.8600.12
62_V361_L0.8570.12
65_L76_H0.8570.12
9_S15_N0.8520.12
349_L392_C0.8500.12
141_A322_A0.8500.12
252_V434_D0.8490.12
65_L269_P0.8460.12
231_D420_H0.8450.12
280_S416_A0.8430.12
335_Y491_L0.8410.12
363_V366_F0.8390.12
214_V335_Y0.8370.12
83_R308_R0.8370.12
58_D131_F0.8340.12
211_A253_H0.8340.12
206_A212_V0.8330.12
152_E425_A0.8320.12
205_T315_P0.8320.12
251_D352_Y0.8280.12
40_Y313_G0.8280.12
102_L268_T0.8270.12
37_Y290_A0.8260.12
230_A366_F0.8250.12
420_H449_R0.8220.12
33_I202_E0.8220.12
488_R491_L0.8220.12
302_D372_V0.8210.12
252_V293_Y0.8210.12
440_D450_V0.8190.11
33_I93_V0.8180.11
72_F397_L0.8180.11
174_G178_P0.8170.11
307_L483_R0.8160.11
183_V324_A0.8160.11
58_D134_I0.8160.11
198_D392_C0.8150.11
83_R271_R0.8140.11
194_L434_D0.8140.11
228_L421_L0.8130.11
45_C229_A0.8120.11
246_E273_A0.8110.11
298_E320_D0.8110.11
57_G65_L0.8110.11
401_A427_Y0.8090.11
96_S223_L0.8080.11
61_A278_A0.8080.11
37_Y50_W0.8060.11
151_Y291_F0.8040.11
189_E244_M0.8040.11
65_L300_V0.8030.11
269_P367_G0.8020.11
10_T15_N0.8000.11
29_G178_P0.7990.11
325_L468_A0.7980.11
318_P386_S0.7980.11
65_L134_I0.7970.11
74_A121_E0.7970.11
49_M215_F0.7940.11
232_L263_F0.7930.11
121_E341_A0.7930.11
187_I196_A0.7910.11
347_N377_L0.7890.11
395_T414_F0.7890.11
21_F340_D0.7870.11
50_W84_L0.7870.11
328_I421_L0.7860.11
413_A425_A0.7860.11
131_F217_A0.7850.11
23_A324_A0.7830.11
326_A345_T0.7820.11
72_F267_L0.7790.11
273_A298_E0.7780.11
34_Q273_A0.7760.11
98_A176_F0.7760.11
302_D309_D0.7750.11
218_R229_A0.7750.11
200_V455_N0.7750.11
246_E250_V0.7740.11
324_A409_F0.7740.11
67_S433_T0.7730.11
269_P356_R0.7710.11
339_V472_G0.7700.11
86_V100_I0.7690.11
64_K361_L0.7690.11
266_N436_L0.7690.11
178_P360_K0.7670.11
295_Y444_A0.7670.11
64_K366_F0.7660.11
74_A299_T0.7640.11
212_V417_Y0.7630.11
9_S360_K0.7620.11
68_R346_V0.7600.11
5_P14_D0.7590.11
5_P11_Q0.7590.11
5_P13_P0.7590.11
5_P12_H0.7590.11
38_Y238_L0.7570.11
131_F269_P0.7570.11
182_T337_D0.7570.11
113_D178_P0.7550.11
244_M248_T0.7520.11
19_P356_R0.7510.11
300_V356_R0.7500.11
221_P347_N0.7490.11
422_A477_L0.7480.11
73_F235_K0.7450.11
301_R350_S0.7450.11
50_W217_A0.7450.11
309_D411_R0.7450.11
296_P325_L0.7420.11
73_F131_F0.7420.11
84_L448_E0.7390.11
245_S352_Y0.7380.11
248_T468_A0.7370.11
347_N365_L0.7340.10
62_V217_A0.7330.10
91_P97_E0.7330.10
244_M252_V0.7310.10
212_V338_Q0.7310.10
233_I266_N0.7310.10
270_E299_T0.7310.10
246_E251_D0.7290.10
21_F48_Q0.7250.10
95_G384_T0.7230.10
327_V489_Q0.7180.10
197_D422_A0.7170.10
230_A458_H0.7170.10
151_Y225_Y0.7150.10
190_R331_T0.7140.10
67_S267_L0.7130.10
93_V137_M0.7120.10
193_M285_F0.7110.10
64_K130_I0.7110.10
106_E111_S0.7090.10
121_E441_D0.7090.10
76_H319_I0.7080.10
235_K364_G0.7080.10
20_F137_M0.7070.10
58_D62_V0.7060.10
329_D456_S0.7060.10
16_A207_H0.7060.10
19_P73_F0.7040.10
242_Y386_S0.7030.10
193_M230_A0.7010.10
281_E404_D0.7000.10
151_Y360_K0.6990.10
21_F216_L0.6960.10
291_F356_R0.6950.10
321_E325_L0.6940.10
269_P291_F0.6940.10
183_V375_N0.6930.10
103_E292_K0.6930.10
114_A233_I0.6920.10
201_R247_A0.6910.10
69_Y424_A0.6900.10
287_V472_G0.6900.10
80_T98_A0.6890.10
25_D478_R0.6890.10
203_Y236_V0.6890.10
355_D384_T0.6880.10
218_R279_Y0.6880.10
88_G114_A0.6850.10
105_L490_F0.6850.10
463_D467_D0.6830.10
343_A366_F0.6830.10
52_F93_V0.6790.10
298_E326_A0.6780.10
29_G38_Y0.6780.10
245_S251_D0.6770.10
52_F149_E0.6760.10
242_Y390_V0.6750.10
326_A397_L0.6740.10
65_L129_P0.6730.10
149_E351_S0.6690.10
256_L392_C0.6690.10
86_V192_A0.6670.10
293_Y349_L0.6620.10
58_D151_Y0.6620.10
63_K102_L0.6600.10
305_A369_A0.6580.10
40_Y74_A0.6570.10
230_A258_A0.6560.10
368_Y395_T0.6550.10
28_E242_Y0.6540.10
450_V468_A0.6540.10
206_A349_L0.6540.10
313_G321_E0.6540.10
455_N481_I0.6540.10
73_F129_P0.6510.10
16_A465_A0.6480.10
196_A431_R0.6480.10
38_Y292_K0.6470.10
21_F27_I0.6460.10
64_K69_Y0.6450.10
27_I410_V0.6450.10
144_L469_L0.6440.10
149_E160_D0.6440.10
317_F485_A0.6440.10
217_A223_L0.6430.10
272_A349_L0.6420.09
406_D417_Y0.6420.09
64_K113_D0.6410.09
91_P147_V0.6410.09
189_E192_A0.6410.09
40_Y308_R0.6400.09
48_Q176_F0.6380.09
273_A306_T0.6370.09
151_Y356_R0.6360.09
29_G174_G0.6360.09
172_W176_F0.6340.09
283_E349_L0.6340.09
210_D418_F0.6320.09
332_A344_G0.6300.09
371_E431_R0.6290.09
104_I112_F0.6290.09
64_K356_R0.6280.09
21_F101_L0.6280.09
31_D65_L0.6260.09
283_E312_L0.6260.09
58_D300_V0.6250.09
192_A478_R0.6230.09
61_A131_F0.6230.09
313_G385_A0.6220.09
292_K312_L0.6200.09
212_V272_A0.6200.09
266_N296_P0.6190.09
355_D470_Q0.6180.09
20_F48_Q0.6170.09
64_K178_P0.6150.09
99_K178_P0.6150.09
121_E451_D0.6140.09
19_P362_H0.6130.09
131_F211_A0.6130.09
327_V445_A0.6130.09
131_F362_H0.6120.09
231_D431_R0.6110.09
135_V346_V0.6100.09
301_R417_Y0.6100.09
64_K91_P0.6100.09
22_T96_S0.6070.09
72_F78_L0.6040.09
130_I225_Y0.6040.09
240_R243_E0.6040.09
129_P292_K0.6020.09
174_G194_L0.6020.09
333_D444_A0.6020.09
77_Q485_A0.6020.09
103_E113_D0.6010.09
45_C301_R0.6010.09
118_F485_A0.6000.09
48_Q110_R0.6000.09
193_M234_N0.5990.09
326_A417_Y0.5980.09
323_R408_A0.5980.09
142_D441_D0.5970.09
45_C243_E0.5970.09
201_R390_V0.5960.09
39_V155_V0.5960.09
231_D387_L0.5940.09
109_P157_G0.5940.09
4_V313_G0.5910.09
141_A307_L0.5910.09
115_A203_Y0.5900.09
240_R413_A0.5880.09
151_Y174_G0.5880.09
6_R29_G0.5870.09
433_T436_L0.5870.09
358_A485_A0.5850.09
253_H272_A0.5830.09
36_A46_D0.5800.09
350_S421_L0.5780.09
33_I338_Q0.5780.09
198_D451_D0.5770.09
33_I147_V0.5770.09
73_F217_A0.5770.09
276_A475_D0.5770.09
8_M410_V0.5770.09
67_S450_V0.5750.09
137_M161_E0.5750.09
7_L337_D0.5750.09
368_Y398_G0.5740.09
421_L441_D0.5720.09
140_D304_V0.5720.09
152_E457_E0.5720.09
151_Y178_P0.5700.09
194_L274_A0.5670.09
93_V396_L0.5670.09
306_T487_E0.5640.09
232_L324_A0.5630.09
420_H487_E0.5630.09
99_K224_N0.5620.09
96_S331_T0.5620.09
65_L217_A0.5600.09
74_A251_D0.5600.09
423_D482_R0.5590.09
411_R418_F0.5590.09
224_N360_K0.5590.09
318_P434_D0.5580.09
189_E232_L0.5580.09
249_G431_R0.5570.09
132_E395_T0.5570.09
80_T108_I0.5560.09
453_T456_S0.5560.09
56_E101_L0.5560.09
370_R395_T0.5540.09
307_L411_R0.5510.09
151_Y361_L0.5490.09
395_T420_H0.5470.09
418_F468_A0.5470.09
19_P32_E0.5470.09
485_A492_G0.5460.09
485_A488_R0.5460.09
29_G99_K0.5460.09
319_I445_A0.5460.09
39_V301_R0.5450.09
101_L137_M0.5430.09
154_F358_A0.5420.09
247_A324_A0.5410.08
214_V237_A0.5410.08
15_N129_P0.5400.08
86_V137_M0.5360.08
313_G353_V0.5350.08
43_L187_I0.5350.08
212_V287_V0.5350.08
56_E103_E0.5320.08
336_A420_H0.5310.08
65_L151_Y0.5300.08
99_K370_R0.5300.08
152_E183_V0.5300.08
92_D140_D0.5300.08
210_D290_A0.5290.08
375_N392_C0.5290.08
154_F196_A0.5280.08
101_L456_S0.5280.08
310_A471_R0.5260.08
305_A396_L0.5250.08
429_N462_T0.5230.08
211_A231_D0.5170.08
248_T373_G0.5160.08
247_A442_T0.5160.08
157_G330_R0.5150.08
410_V457_E0.5150.08
200_V355_D0.5120.08
90_N303_G0.5110.08
42_H154_F0.5110.08
365_L377_L0.5110.08
155_V348_R0.5110.08
263_F354_P0.5100.08
263_F393_P0.5100.08
222_A263_F0.5100.08
58_D76_H0.5100.08
250_V346_V0.5090.08
103_E366_F0.5090.08
145_N324_A0.5070.08
145_N209_Q0.5060.08
129_P291_F0.5060.08
224_N377_L0.5060.08
205_T333_D0.5040.08
56_E63_K0.5040.08
90_N363_V0.5040.08
105_L397_L0.5030.08
146_A490_F0.5020.08
206_A444_A0.5010.08
144_L304_V0.5010.08
86_V384_T0.5010.08
481_I490_F0.5000.08
315_P451_D0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3odmA 6 0.9309 100 0.449 Contact Map
1jqnA 3 0.811 100 0.792 Contact Map
4bxhA 3 0.872 100 0.793 Contact Map
4roqA 5 0.565 97.6 0.962 Contact Map
3qllA 3 0.4106 97.4 0.963 Contact Map
1u5hA 3 0.4126 97.3 0.964 Contact Map
3qz6A 5 0.5102 96.8 0.967 Contact Map
4l9zA 5 0.5549 96.8 0.967 Contact Map
3r4iA 5 0.5854 96.7 0.967 Contact Map
4l80A 5 0.5955 96.7 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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