GREMLIN Database
Q9HN39 - Uncharacterized protein
UniProt: Q9HN39 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 237 (201)
Sequences: 1613 (989)
Seq/√Len: 69.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_W167_I5.3751.00
128_L175_V4.4901.00
121_N179_A3.9441.00
154_W218_Y3.4731.00
143_A146_D3.2131.00
66_Y78_M2.9971.00
111_A114_T2.7021.00
191_T194_Q2.6971.00
125_G175_V2.6551.00
171_I175_V2.6171.00
128_L171_I2.5391.00
14_I78_M2.3971.00
110_D113_A2.3101.00
169_T206_K2.2161.00
64_D160_S2.1361.00
80_N135_N2.1251.00
166_I203_Y2.1121.00
170_V199_I2.0341.00
82_G130_Y1.9921.00
132_V171_I1.9861.00
109_Q113_A1.9741.00
143_A147_R1.9351.00
140_A144_I1.8981.00
67_A142_H1.8881.00
162_A203_Y1.8871.00
73_R76_Q1.8521.00
136_W163_T1.8361.00
172_F176_A1.7591.00
80_N84_V1.7531.00
158_I214_T1.7251.00
166_I170_V1.7151.00
132_V167_I1.6931.00
56_Y133_S1.6891.00
152_H155_L1.6741.00
162_A207_L1.6420.99
223_A227_R1.6340.99
121_N177_F1.6280.99
50_P202_Q1.6260.99
136_W140_A1.5990.99
97_V113_A1.5840.99
144_I150_A1.5790.99
157_N214_T1.5360.99
137_D164_S1.4660.99
121_N180_A1.4540.99
194_Q197_A1.4490.99
63_S137_D1.4470.99
195_L199_I1.4420.99
133_S164_S1.4360.98
26_L116_L1.4330.98
154_W214_T1.4310.98
50_P173_V1.4250.98
32_L99_A1.4210.98
105_S112_F1.3890.98
134_Q138_V1.3850.98
214_T218_Y1.3710.98
64_D161_T1.3100.97
126_S168_D1.3060.97
122_I176_A1.3000.97
157_N213_D1.2970.97
104_F107_V1.2880.97
18_V22_V1.2830.97
51_G96_T1.2820.97
165_Q210_A1.2800.97
137_D141_F1.2620.97
87_L127_L1.2610.97
148_T153_L1.2560.96
139_I143_A1.2530.96
19_T22_V1.2520.96
53_A202_Q1.2490.96
61_F217_V1.2450.96
178_W192_P1.2450.96
68_E156_R1.2300.96
105_S115_V1.2100.96
51_G99_A1.2080.96
90_L123_V1.1950.95
65_C220_V1.1890.95
72_R138_V1.1780.95
102_A105_S1.1640.95
64_D218_Y1.1360.94
197_A201_G1.1170.93
10_Q74_D1.1170.93
83_F175_V1.1130.93
122_I126_S1.1100.93
192_P196_L1.1090.93
213_D216_F1.1090.93
105_S108_G1.0990.93
153_L217_V1.0880.92
86_N90_L1.0840.92
13_L62_A1.0720.92
153_L157_N1.0720.92
105_S109_Q1.0700.92
147_R151_S1.0690.92
161_T218_Y1.0640.91
168_D172_F1.0590.91
134_Q141_F1.0350.90
147_R200_V1.0310.90
61_F213_D1.0150.89
73_R77_V0.9980.89
169_T203_Y0.9960.88
204_L208_A0.9940.88
174_T195_L0.9870.88
148_T152_H0.9870.88
97_V116_L0.9690.87
170_V174_T0.9600.87
101_I105_S0.9590.87
222_A226_S0.9540.86
15_G19_T0.9480.86
83_F127_L0.9450.86
49_L205_L0.9440.86
216_F220_V0.9430.86
128_L132_V0.9380.85
72_R76_Q0.9270.85
19_T23_T0.9200.84
122_I172_F0.9130.84
134_Q137_D0.9090.83
64_D176_A0.9050.83
48_V102_A0.9020.83
96_T112_F0.8990.83
87_L91_A0.8980.83
13_L211_V0.8940.82
27_T130_Y0.8900.82
63_S210_A0.8750.81
174_T178_W0.8670.80
44_G48_V0.8660.80
95_S132_V0.8620.80
140_A143_A0.8590.80
93_V116_L0.8580.80
31_L105_S0.8560.80
148_T155_L0.8530.79
153_L214_T0.8450.79
222_A225_R0.8380.78
32_L89_L0.8370.78
19_T85_M0.8330.78
181_P198_L0.8330.78
146_D216_F0.8260.77
129_A171_I0.8220.77
210_A213_D0.8190.76
137_D160_S0.8170.76
31_L177_F0.8100.76
161_T210_A0.8080.76
97_V117_L0.8080.76
209_I213_D0.8020.75
52_A86_N0.7990.75
136_W139_I0.7970.75
193_A196_L0.7950.74
97_V112_F0.7940.74
136_W144_I0.7820.73
165_Q213_D0.7810.73
56_Y157_N0.7760.73
94_Y98_R0.7760.73
83_F131_V0.7690.72
56_Y60_F0.7680.72
31_L59_T0.7670.72
15_G81_V0.7670.72
208_A226_S0.7650.71
26_L30_K0.7640.71
68_E145_R0.7630.71
168_D206_K0.7620.71
56_Y206_K0.7600.71
78_M221_V0.7590.71
130_Y168_D0.7570.71
56_Y213_D0.7550.70
17_F21_L0.7530.70
112_F115_V0.7510.70
17_F82_G0.7430.69
89_L93_V0.7370.69
122_I125_G0.7350.68
22_V115_V0.7290.68
28_A53_A0.7250.67
122_I177_F0.7240.67
56_Y207_L0.7210.67
166_I199_I0.7200.67
173_V202_Q0.7170.66
57_A133_S0.7160.66
160_S210_A0.7160.66
76_Q145_R0.7150.66
90_L119_A0.7130.66
104_F194_Q0.7130.66
72_R142_H0.7110.66
120_G123_V0.7060.65
83_F130_Y0.7060.65
91_A95_S0.7030.65
68_E153_L0.6990.65
20_A59_T0.6990.65
140_A163_T0.6990.65
88_V92_L0.6960.64
69_L167_I0.6920.64
76_Q80_N0.6910.64
198_L202_Q0.6870.63
88_V171_I0.6800.62
16_L20_A0.6780.62
219_A223_A0.6780.62
51_G202_Q0.6750.62
65_C116_L0.6730.62
14_I84_V0.6630.60
73_R146_D0.6610.60
61_F216_F0.6600.60
158_I162_A0.6560.60
74_D77_V0.6550.60
115_V124_A0.6540.59
47_L85_M0.6530.59
25_Q126_S0.6510.59
27_T93_V0.6510.59
153_L221_V0.6480.59
137_D158_I0.6470.59
53_A201_G0.6440.58
148_T218_Y0.6440.58
137_D210_A0.6420.58
219_A222_A0.6350.57
69_L224_A0.6290.56
172_F177_F0.6260.56
208_A211_V0.6240.56
12_A81_V0.6240.56
96_T167_I0.6210.55
142_H146_D0.6200.55
15_G18_V0.6170.55
40_L45_A0.6160.55
59_T86_N0.6150.55
98_R103_P0.6140.55
108_G114_T0.6090.54
63_S138_V0.6080.54
129_A168_D0.6070.54
142_H213_D0.6050.54
208_A212_G0.6040.53
66_Y75_A0.6040.53
141_F157_N0.6040.53
70_Y78_M0.6020.53
55_A92_L0.6010.53
173_V199_I0.6000.53
64_D137_D0.5990.53
11_V14_I0.5980.53
134_Q169_T0.5970.53
56_Y126_S0.5950.52
158_I213_D0.5910.52
138_V141_F0.5900.52
23_T89_L0.5880.52
46_A198_L0.5860.51
225_R228_G0.5850.51
82_G165_Q0.5820.51
52_A135_N0.5810.51
130_Y205_L0.5790.50
181_P191_T0.5770.50
18_V25_Q0.5770.50
133_S157_N0.5730.50
43_T46_A0.5720.50
79_V138_V0.5710.49
114_T207_L0.5700.49
25_Q217_V0.5700.49
203_Y207_L0.5680.49
166_I196_L0.5670.49
91_A192_P0.5660.49
27_T52_A0.5650.49
179_A195_L0.5630.48
72_R146_D0.5610.48
63_S134_Q0.5610.48
16_L58_V0.5570.48
63_S141_F0.5560.48
162_A211_V0.5540.47
153_L156_R0.5540.47
118_S171_I0.5530.47
126_S172_F0.5450.46
181_P201_G0.5450.46
97_V109_Q0.5450.46
69_L225_R0.5450.46
83_F168_D0.5440.46
144_I159_G0.5420.46
53_A205_L0.5410.46
195_L202_Q0.5390.46
144_I155_L0.5380.45
88_V225_R0.5360.45
164_S210_A0.5330.45
25_Q62_A0.5320.45
85_M112_F0.5300.45
63_S213_D0.5280.44
150_A225_R0.5280.44
145_R156_R0.5280.44
44_G49_L0.5270.44
158_I211_V0.5270.44
137_D154_W0.5250.44
61_F133_S0.5240.44
72_R145_R0.5220.44
197_A200_V0.5200.43
66_Y224_A0.5200.43
32_L200_V0.5200.43
125_G172_F0.5140.43
69_L217_V0.5120.42
125_G129_A0.5100.42
82_G179_A0.5100.42
169_T209_I0.5100.42
91_A146_D0.5080.42
125_G192_P0.5070.42
76_Q196_L0.5070.42
52_A163_T0.5060.42
48_V86_N0.5030.41
69_L221_V0.5030.41
69_L164_S0.5030.41
88_V128_L0.5020.41
169_T195_L0.5020.41
134_Q206_K0.5010.41
69_L176_A0.5010.41
216_F219_A0.5010.41
98_R113_A0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.8565 38.5 0.947 Contact Map
4rfsS 1 0.7553 23.6 0.952 Contact Map
4huqS 1 0.6245 19.6 0.954 Contact Map
3o7qA 1 0.9156 14 0.957 Contact Map
4ldsA 2 0.8143 13.8 0.957 Contact Map
4lz6A 1 0.9156 10.9 0.959 Contact Map
3mktA 1 0.9241 9.8 0.96 Contact Map
4xnjA 1 0.8059 8.3 0.961 Contact Map
4z7fA 2 0.6962 7.9 0.962 Contact Map
4j05A 3 0.8143 7.5 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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