Q9HN39 - HALSA - GREMLIN Contacts

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Q9HN39 - Uncharacterized protein

UniProt:	Q9HN39	Sequences: MTRNDTPVTQVALIGLFVTALVTAQLTASKLLLFELPVSLPVTGAALVLPGAALAYAVTFFASDCYAELYGRRDAQVMVNVGFVMNLVLLALVYSTVRAPIAPFSGVGQDAFATVLLSAGNIVAGSLLAYVVSQNWDVIAFHAIRDRTGASHLWLRNIGSTATSQIIDTVIFVTVAFWAAPVLLGVGQPRTPAQLLALIVGQYLLKLAIAVGDTPFVYAVVAAARSRGLGAPAPAAD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	237 (201)
Sequences:	1613 (989)
Seq/√Len:	69.8

ECOLI - YHHQ
BACSU - YPDP
HALSA - Q9HN39

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
136_W	167_I	5.375	1.00
128_L	175_V	4.490	1.00
121_N	179_A	3.944	1.00
154_W	218_Y	3.473	1.00
143_A	146_D	3.213	1.00
66_Y	78_M	2.997	1.00
111_A	114_T	2.702	1.00
191_T	194_Q	2.697	1.00
125_G	175_V	2.655	1.00
171_I	175_V	2.617	1.00
128_L	171_I	2.539	1.00
14_I	78_M	2.397	1.00
110_D	113_A	2.310	1.00
169_T	206_K	2.216	1.00
64_D	160_S	2.136	1.00
80_N	135_N	2.125	1.00
166_I	203_Y	2.112	1.00
170_V	199_I	2.034	1.00
82_G	130_Y	1.992	1.00
132_V	171_I	1.986	1.00
109_Q	113_A	1.974	1.00
143_A	147_R	1.935	1.00
140_A	144_I	1.898	1.00
67_A	142_H	1.888	1.00
162_A	203_Y	1.887	1.00
73_R	76_Q	1.852	1.00
136_W	163_T	1.836	1.00
172_F	176_A	1.759	1.00
80_N	84_V	1.753	1.00
158_I	214_T	1.725	1.00
166_I	170_V	1.715	1.00
132_V	167_I	1.693	1.00
56_Y	133_S	1.689	1.00
152_H	155_L	1.674	1.00
162_A	207_L	1.642	0.99
223_A	227_R	1.634	0.99
121_N	177_F	1.628	0.99
50_P	202_Q	1.626	0.99
136_W	140_A	1.599	0.99
97_V	113_A	1.584	0.99
144_I	150_A	1.579	0.99
157_N	214_T	1.536	0.99
137_D	164_S	1.466	0.99
121_N	180_A	1.454	0.99
194_Q	197_A	1.449	0.99
63_S	137_D	1.447	0.99
195_L	199_I	1.442	0.99
133_S	164_S	1.436	0.98
26_L	116_L	1.433	0.98
154_W	214_T	1.431	0.98
50_P	173_V	1.425	0.98
32_L	99_A	1.421	0.98
105_S	112_F	1.389	0.98
134_Q	138_V	1.385	0.98
214_T	218_Y	1.371	0.98
64_D	161_T	1.310	0.97
126_S	168_D	1.306	0.97
122_I	176_A	1.300	0.97
157_N	213_D	1.297	0.97
104_F	107_V	1.288	0.97
18_V	22_V	1.283	0.97
51_G	96_T	1.282	0.97
165_Q	210_A	1.280	0.97
137_D	141_F	1.262	0.97
87_L	127_L	1.261	0.97
148_T	153_L	1.256	0.96
139_I	143_A	1.253	0.96
19_T	22_V	1.252	0.96
53_A	202_Q	1.249	0.96
61_F	217_V	1.245	0.96
178_W	192_P	1.245	0.96
68_E	156_R	1.230	0.96
105_S	115_V	1.210	0.96
51_G	99_A	1.208	0.96
90_L	123_V	1.195	0.95
65_C	220_V	1.189	0.95
72_R	138_V	1.178	0.95
102_A	105_S	1.164	0.95
64_D	218_Y	1.136	0.94
197_A	201_G	1.117	0.93
10_Q	74_D	1.117	0.93
83_F	175_V	1.113	0.93
122_I	126_S	1.110	0.93
192_P	196_L	1.109	0.93
213_D	216_F	1.109	0.93
105_S	108_G	1.099	0.93
153_L	217_V	1.088	0.92
86_N	90_L	1.084	0.92
13_L	62_A	1.072	0.92
153_L	157_N	1.072	0.92
105_S	109_Q	1.070	0.92
147_R	151_S	1.069	0.92
161_T	218_Y	1.064	0.91
168_D	172_F	1.059	0.91
134_Q	141_F	1.035	0.90
147_R	200_V	1.031	0.90
61_F	213_D	1.015	0.89
73_R	77_V	0.998	0.89
169_T	203_Y	0.996	0.88
204_L	208_A	0.994	0.88
174_T	195_L	0.987	0.88
148_T	152_H	0.987	0.88
97_V	116_L	0.969	0.87
170_V	174_T	0.960	0.87
101_I	105_S	0.959	0.87
222_A	226_S	0.954	0.86
15_G	19_T	0.948	0.86
83_F	127_L	0.945	0.86
49_L	205_L	0.944	0.86
216_F	220_V	0.943	0.86
128_L	132_V	0.938	0.85
72_R	76_Q	0.927	0.85
19_T	23_T	0.920	0.84
122_I	172_F	0.913	0.84
134_Q	137_D	0.909	0.83
64_D	176_A	0.905	0.83
48_V	102_A	0.902	0.83
96_T	112_F	0.899	0.83
87_L	91_A	0.898	0.83
13_L	211_V	0.894	0.82
27_T	130_Y	0.890	0.82
63_S	210_A	0.875	0.81
174_T	178_W	0.867	0.80
44_G	48_V	0.866	0.80
95_S	132_V	0.862	0.80
140_A	143_A	0.859	0.80
93_V	116_L	0.858	0.80
31_L	105_S	0.856	0.80
148_T	155_L	0.853	0.79
153_L	214_T	0.845	0.79
222_A	225_R	0.838	0.78
32_L	89_L	0.837	0.78
19_T	85_M	0.833	0.78
181_P	198_L	0.833	0.78
146_D	216_F	0.826	0.77
129_A	171_I	0.822	0.77
210_A	213_D	0.819	0.76
137_D	160_S	0.817	0.76
31_L	177_F	0.810	0.76
161_T	210_A	0.808	0.76
97_V	117_L	0.808	0.76
209_I	213_D	0.802	0.75
52_A	86_N	0.799	0.75
136_W	139_I	0.797	0.75
193_A	196_L	0.795	0.74
97_V	112_F	0.794	0.74
136_W	144_I	0.782	0.73
165_Q	213_D	0.781	0.73
56_Y	157_N	0.776	0.73
94_Y	98_R	0.776	0.73
83_F	131_V	0.769	0.72
56_Y	60_F	0.768	0.72
31_L	59_T	0.767	0.72
15_G	81_V	0.767	0.72
208_A	226_S	0.765	0.71
26_L	30_K	0.764	0.71
68_E	145_R	0.763	0.71
168_D	206_K	0.762	0.71
56_Y	206_K	0.760	0.71
78_M	221_V	0.759	0.71
130_Y	168_D	0.757	0.71
56_Y	213_D	0.755	0.70
17_F	21_L	0.753	0.70
112_F	115_V	0.751	0.70
17_F	82_G	0.743	0.69
89_L	93_V	0.737	0.69
122_I	125_G	0.735	0.68
22_V	115_V	0.729	0.68
28_A	53_A	0.725	0.67
122_I	177_F	0.724	0.67
56_Y	207_L	0.721	0.67
166_I	199_I	0.720	0.67
173_V	202_Q	0.717	0.66
57_A	133_S	0.716	0.66
160_S	210_A	0.716	0.66
76_Q	145_R	0.715	0.66
90_L	119_A	0.713	0.66
104_F	194_Q	0.713	0.66
72_R	142_H	0.711	0.66
120_G	123_V	0.706	0.65
83_F	130_Y	0.706	0.65
91_A	95_S	0.703	0.65
68_E	153_L	0.699	0.65
20_A	59_T	0.699	0.65
140_A	163_T	0.699	0.65
88_V	92_L	0.696	0.64
69_L	167_I	0.692	0.64
76_Q	80_N	0.691	0.64
198_L	202_Q	0.687	0.63
88_V	171_I	0.680	0.62
16_L	20_A	0.678	0.62
219_A	223_A	0.678	0.62
51_G	202_Q	0.675	0.62
65_C	116_L	0.673	0.62
14_I	84_V	0.663	0.60
73_R	146_D	0.661	0.60
61_F	216_F	0.660	0.60
158_I	162_A	0.656	0.60
74_D	77_V	0.655	0.60
115_V	124_A	0.654	0.59
47_L	85_M	0.653	0.59
25_Q	126_S	0.651	0.59
27_T	93_V	0.651	0.59
153_L	221_V	0.648	0.59
137_D	158_I	0.647	0.59
53_A	201_G	0.644	0.58
148_T	218_Y	0.644	0.58
137_D	210_A	0.642	0.58
219_A	222_A	0.635	0.57
69_L	224_A	0.629	0.56
172_F	177_F	0.626	0.56
208_A	211_V	0.624	0.56
12_A	81_V	0.624	0.56
96_T	167_I	0.621	0.55
142_H	146_D	0.620	0.55
15_G	18_V	0.617	0.55
40_L	45_A	0.616	0.55
59_T	86_N	0.615	0.55
98_R	103_P	0.614	0.55
108_G	114_T	0.609	0.54
63_S	138_V	0.608	0.54
129_A	168_D	0.607	0.54
142_H	213_D	0.605	0.54
208_A	212_G	0.604	0.53
66_Y	75_A	0.604	0.53
141_F	157_N	0.604	0.53
70_Y	78_M	0.602	0.53
55_A	92_L	0.601	0.53
173_V	199_I	0.600	0.53
64_D	137_D	0.599	0.53
11_V	14_I	0.598	0.53
134_Q	169_T	0.597	0.53
56_Y	126_S	0.595	0.52
158_I	213_D	0.591	0.52
138_V	141_F	0.590	0.52
23_T	89_L	0.588	0.52
46_A	198_L	0.586	0.51
225_R	228_G	0.585	0.51
82_G	165_Q	0.582	0.51
52_A	135_N	0.581	0.51
130_Y	205_L	0.579	0.50
181_P	191_T	0.577	0.50
18_V	25_Q	0.577	0.50
133_S	157_N	0.573	0.50
43_T	46_A	0.572	0.50
79_V	138_V	0.571	0.49
114_T	207_L	0.570	0.49
25_Q	217_V	0.570	0.49
203_Y	207_L	0.568	0.49
166_I	196_L	0.567	0.49
91_A	192_P	0.566	0.49
27_T	52_A	0.565	0.49
179_A	195_L	0.563	0.48
72_R	146_D	0.561	0.48
63_S	134_Q	0.561	0.48
16_L	58_V	0.557	0.48
63_S	141_F	0.556	0.48
162_A	211_V	0.554	0.47
153_L	156_R	0.554	0.47
118_S	171_I	0.553	0.47
126_S	172_F	0.545	0.46
181_P	201_G	0.545	0.46
97_V	109_Q	0.545	0.46
69_L	225_R	0.545	0.46
83_F	168_D	0.544	0.46
144_I	159_G	0.542	0.46
53_A	205_L	0.541	0.46
195_L	202_Q	0.539	0.46
144_I	155_L	0.538	0.45
88_V	225_R	0.536	0.45
164_S	210_A	0.533	0.45
25_Q	62_A	0.532	0.45
85_M	112_F	0.530	0.45
63_S	213_D	0.528	0.44
150_A	225_R	0.528	0.44
145_R	156_R	0.528	0.44
44_G	49_L	0.527	0.44
158_I	211_V	0.527	0.44
137_D	154_W	0.525	0.44
61_F	133_S	0.524	0.44
72_R	145_R	0.522	0.44
197_A	200_V	0.520	0.43
66_Y	224_A	0.520	0.43
32_L	200_V	0.520	0.43
125_G	172_F	0.514	0.43
69_L	217_V	0.512	0.42
125_G	129_A	0.510	0.42
82_G	179_A	0.510	0.42
169_T	209_I	0.510	0.42
91_A	146_D	0.508	0.42
125_G	192_P	0.507	0.42
76_Q	196_L	0.507	0.42
52_A	163_T	0.506	0.42
48_V	86_N	0.503	0.41
69_L	221_V	0.503	0.41
69_L	164_S	0.503	0.41
88_V	128_L	0.502	0.41
169_T	195_L	0.502	0.41
134_Q	206_K	0.501	0.41
69_L	176_A	0.501	0.41
216_F	219_A	0.501	0.41
98_R	113_A	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2cfqA	1	0.8565	38.5	0.947	Contact Map
4rfsS	1	0.7553	23.6	0.952	Contact Map
4huqS	1	0.6245	19.6	0.954	Contact Map
3o7qA	1	0.9156	14	0.957	Contact Map
4ldsA	2	0.8143	13.8	0.957	Contact Map
4lz6A	1	0.9156	10.9	0.959	Contact Map
3mktA	1	0.9241	9.8	0.96	Contact Map
4xnjA	1	0.8059	8.3	0.961	Contact Map
4z7fA	2	0.6962	7.9	0.962	Contact Map
4j05A	3	0.8143	7.5	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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