GREMLIN Database
Q9HN36 - Protein export
UniProt: Q9HN36 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (280)
Sequences: 225 (147)
Seq/√Len: 8.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_I194_E4.7950.99
297_R333_E4.0200.98
136_S183_G3.4900.95
230_F312_S3.2910.94
208_R259_F3.0790.91
116_E223_V2.7050.84
66_T69_D2.5910.81
153_Y230_F2.5740.81
74_G78_A2.5030.79
311_F324_V2.4380.77
195_S214_S2.4320.77
223_V227_L2.3170.73
222_S273_F2.3090.73
64_T67_P2.3030.73
143_T146_L2.2150.70
60_D63_Q2.2060.69
62_H67_P2.1820.69
270_A327_T2.1780.68
320_V335_T2.1610.68
62_H66_T2.1190.66
279_I293_L2.1000.65
253_F312_S2.0810.65
64_T68_R2.0300.63
97_A100_G2.0010.62
192_V310_T1.9570.60
170_E174_T1.9130.58
312_S323_I1.9050.58
282_A312_S1.7980.53
85_G97_A1.7720.52
124_R208_R1.7560.51
270_A309_F1.7440.51
312_S317_T1.7360.50
117_H201_P1.7340.50
116_E137_I1.7030.49
267_G332_F1.6850.48
67_P70_H1.6820.48
66_T73_G1.6770.48
282_A317_T1.6710.48
60_D69_D1.6640.47
181_L300_F1.6630.47
61_R66_T1.6610.47
293_L296_R1.6560.47
122_V222_S1.6430.46
299_L323_I1.6290.46
101_I271_V1.6200.45
310_T313_A1.6070.45
229_A266_M1.6070.45
287_V323_I1.5980.44
117_H331_L1.5750.43
61_R70_H1.5680.43
338_L342_T1.5540.43
219_L342_T1.5380.42
127_I190_A1.5250.41
273_F331_L1.5210.41
122_V317_T1.5050.41
148_T231_F1.4880.40
89_G93_D1.4820.40
71_E308_A1.4770.39
139_V219_L1.4750.39
81_P84_G1.4740.39
230_F271_V1.4720.39
258_T261_L1.4700.39
63_Q75_P1.4580.39
63_Q66_T1.4560.39
64_T78_A1.4560.39
118_I317_T1.4540.38
66_T77_A1.4420.38
203_L207_E1.4350.38
63_Q70_H1.4340.38
207_E331_L1.4270.37
166_Y293_L1.4130.37
136_S180_S1.4070.37
82_T86_V1.3990.36
272_V324_V1.3940.36
242_Q319_I1.3790.35
85_G89_G1.3720.35
88_A94_P1.3660.35
170_E235_P1.3630.35
85_G96_A1.3510.34
176_V320_V1.3500.34
75_P80_Q1.3270.33
290_R339_L1.3190.33
163_P175_Q1.3130.33
71_E101_I1.3100.33
85_G99_G1.3040.33
269_L272_V1.2980.32
182_A219_L1.2720.31
77_A84_G1.2690.31
100_G305_A1.2670.31
93_D97_A1.2620.31
60_D65_A1.2550.31
115_G294_E1.2470.30
96_A305_A1.2460.30
80_Q88_A1.2440.30
257_T342_T1.2410.30
85_G88_A1.2340.30
76_T337_A1.2220.30
152_N307_I1.2140.29
297_R301_W1.2120.29
90_A93_D1.2110.29
74_G77_A1.2100.29
289_T335_T1.2060.29
81_P138_V1.2020.29
196_Y327_T1.2000.29
117_H207_E1.1910.28
73_G77_A1.1890.28
90_A96_A1.1870.28
66_T70_H1.1790.28
117_H258_T1.1740.28
77_A80_Q1.1720.28
114_L131_I1.1640.28
76_T104_D1.1570.27
75_P81_P1.1460.27
200_R267_G1.1420.27
198_F207_E1.1350.27
217_T231_F1.1350.27
62_H68_R1.1260.26
73_G81_P1.1180.26
275_I281_L1.1140.26
93_D96_A1.1080.26
278_F282_A1.1010.25
139_V264_L1.0940.25
287_V311_F1.0910.25
187_A288_T1.0890.25
286_G299_L1.0890.25
207_E273_F1.0870.25
219_L233_V1.0830.25
206_N338_L1.0830.25
176_V310_T1.0810.25
63_Q77_A1.0790.25
233_V269_L1.0790.25
293_L329_V1.0600.24
61_R74_G1.0600.24
300_F335_T1.0530.24
77_A134_L1.0530.24
193_Y197_V1.0510.24
300_F336_L1.0500.24
60_D66_T1.0470.24
190_A194_E1.0460.24
87_A90_A1.0440.24
104_D337_A1.0440.24
153_Y273_F1.0360.23
276_P331_L1.0350.23
74_G83_P1.0340.23
233_V264_L1.0230.23
86_V95_D1.0220.23
164_R312_S1.0190.23
203_L325_A1.0180.23
95_D130_A1.0160.23
181_L219_L1.0140.23
143_T272_V1.0110.23
109_D214_S1.0110.23
61_R67_P1.0050.22
60_D70_H1.0050.22
89_G92_S1.0010.22
65_A223_V1.0010.22
311_F323_I0.9930.22
228_F331_L0.9910.22
297_R320_V0.9860.22
208_R252_A0.9790.22
137_I312_S0.9770.22
64_T70_H0.9750.22
197_V214_S0.9700.21
79_T87_A0.9670.21
219_L338_L0.9540.21
64_T75_P0.9510.21
131_I241_F0.9470.21
196_Y275_I0.9380.20
226_V340_R0.9330.20
73_G224_V0.9310.20
311_F325_A0.9290.20
65_A74_G0.9180.20
188_L219_L0.9180.20
120_E194_E0.9140.20
150_M265_V0.9070.20
316_P333_E0.9020.19
139_V311_F0.9020.19
192_V305_A0.9000.19
118_I306_G0.8990.19
132_A174_T0.8950.19
283_I321_P0.8940.19
162_D174_T0.8880.19
79_T96_A0.8880.19
63_Q73_G0.8870.19
91_S96_A0.8840.19
301_W329_V0.8780.19
114_L233_V0.8760.19
120_E124_R0.8750.19
94_P102_G0.8740.19
62_H65_A0.8730.19
83_P89_G0.8710.19
112_A207_E0.8710.19
78_A134_L0.8700.19
281_L336_L0.8670.19
234_L336_L0.8650.19
165_V269_L0.8620.18
96_A100_G0.8600.18
69_D74_G0.8570.18
250_D256_G0.8570.18
166_Y229_A0.8550.18
210_Y333_E0.8540.18
66_T84_G0.8470.18
86_V90_A0.8470.18
296_R299_L0.8460.18
108_S250_D0.8420.18
70_H73_G0.8420.18
133_A287_V0.8390.18
99_G247_P0.8360.18
71_E82_T0.8360.18
68_R73_G0.8330.18
140_F166_Y0.8330.18
196_Y270_A0.8290.18
181_L237_T0.8280.18
275_I336_L0.8270.18
80_Q83_P0.8250.18
66_T338_L0.8240.17
187_A230_F0.8180.17
323_I338_L0.8120.17
230_F286_G0.8120.17
157_G243_S0.8100.17
111_E178_V0.8080.17
90_A100_G0.8050.17
167_Q179_A0.8040.17
82_T92_S0.8030.17
263_L330_V0.8010.17
67_P85_G0.7970.17
63_Q67_P0.7950.17
265_V311_F0.7940.17
73_G80_Q0.7940.17
98_G133_A0.7940.17
90_A239_G0.7940.17
89_G97_A0.7930.17
296_R339_L0.7900.17
101_I123_T0.7900.17
61_R65_A0.7880.17
92_S99_G0.7880.17
106_P109_D0.7860.17
203_L273_F0.7850.17
167_Q254_A0.7800.16
185_V289_T0.7770.16
188_L259_F0.7750.16
251_V324_V0.7700.16
253_F339_L0.7670.16
286_G323_I0.7670.16
86_V97_A0.7670.16
96_A101_I0.7640.16
191_F278_F0.7610.16
245_T325_A0.7590.16
201_P207_E0.7590.16
117_H273_F0.7570.16
154_V168_P0.7550.16
168_P208_R0.7540.16
132_A266_M0.7540.16
83_P337_A0.7540.16
150_M245_T0.7540.16
316_P331_L0.7530.16
204_Y316_P0.7520.16
164_R304_F0.7470.16
231_F291_E0.7440.16
198_F201_P0.7380.15
86_V89_G0.7350.15
336_L339_L0.7320.15
102_G133_A0.7310.15
104_D110_E0.7280.15
207_E215_V0.7240.15
207_E316_P0.7230.15
264_L286_G0.7210.15
234_L253_F0.7150.15
131_I153_Y0.7070.15
179_A229_A0.7060.15
228_F233_V0.7050.15
121_M208_R0.7050.15
112_A193_Y0.7050.15
224_V308_A0.7050.15
88_A93_D0.7040.15
224_V227_L0.7000.15
237_T261_L0.6990.15
78_A183_G0.6990.15
330_V338_L0.6980.15
280_M333_E0.6980.15
135_V219_L0.6920.14
112_A120_E0.6860.14
188_L280_M0.6850.14
75_P79_T0.6840.14
74_G79_T0.6830.14
231_F273_F0.6810.14
92_S97_A0.6810.14
66_T81_P0.6810.14
70_H130_A0.6780.14
91_S94_P0.6770.14
274_Q316_P0.6770.14
124_R202_G0.6750.14
211_Y319_I0.6750.14
129_V239_G0.6710.14
288_T335_T0.6700.14
66_T76_T0.6650.14
77_A81_P0.6620.14
201_P331_L0.6610.14
153_Y317_T0.6610.14
163_P267_G0.6600.14
152_N248_T0.6590.14
85_G98_G0.6580.14
78_A209_R0.6580.14
230_F273_F0.6550.14
109_D113_P0.6540.14
180_S271_V0.6530.14
158_G161_I0.6520.14
88_A97_A0.6500.14
91_S104_D0.6500.14
60_D80_Q0.6490.14
268_Y311_F0.6460.13
131_I310_T0.6460.13
173_I230_F0.6430.13
149_W158_G0.6410.13
162_D287_V0.6400.13
274_Q322_V0.6390.13
174_T194_E0.6380.13
86_V92_S0.6340.13
61_R78_A0.6330.13
117_H198_F0.6310.13
99_G116_E0.6290.13
263_L287_V0.6280.13
194_E251_V0.6270.13
141_P202_G0.6270.13
73_G76_T0.6250.13
67_P73_G0.6210.13
207_E274_Q0.6210.13
79_T104_D0.6170.13
67_P83_P0.6170.13
138_V329_V0.6150.13
242_Q259_F0.6120.13
223_V308_A0.6120.13
61_R69_D0.6100.13
114_L212_L0.6080.13
76_T99_G0.6080.13
224_V326_I0.6030.13
95_D330_V0.6010.13
189_P225_G0.6010.13
88_A138_V0.5990.13
133_A208_R0.5970.13
123_T134_L0.5960.13
296_R336_L0.5960.13
174_T245_T0.5930.12
291_E308_A0.5920.12
126_G281_L0.5870.12
60_D256_G0.5860.12
78_A91_S0.5850.12
235_P332_F0.5850.12
155_L161_I0.5850.12
220_V264_L0.5840.12
88_A330_V0.5840.12
62_H99_G0.5830.12
153_Y312_S0.5820.12
207_E282_A0.5810.12
224_V337_A0.5790.12
242_Q245_T0.5780.12
203_L231_F0.5780.12
282_A320_V0.5750.12
214_S298_L0.5740.12
180_S217_T0.5710.12
76_T89_G0.5650.12
260_N339_L0.5640.12
143_T308_A0.5630.12
140_F170_E0.5620.12
164_R185_V0.5600.12
197_V239_G0.5590.12
240_Y255_L0.5570.12
113_P116_E0.5560.12
135_V139_V0.5560.12
182_A326_I0.5550.12
68_R84_G0.5520.12
151_W203_L0.5510.12
249_A268_Y0.5500.12
233_V251_V0.5490.12
263_L273_F0.5470.12
242_Q251_V0.5470.12
274_Q331_L0.5440.12
141_P325_A0.5420.12
96_A330_V0.5420.12
146_L266_M0.5410.12
61_R68_R0.5400.12
85_G91_S0.5340.11
154_V254_A0.5330.11
149_W197_V0.5330.11
316_P328_M0.5320.11
327_T335_T0.5320.11
64_T91_S0.5300.11
66_T71_E0.5300.11
187_A190_A0.5290.11
121_M325_A0.5280.11
270_A335_T0.5270.11
177_K208_R0.5260.11
171_L180_S0.5260.11
73_G78_A0.5250.11
168_P339_L0.5230.11
80_Q94_P0.5210.11
118_I274_Q0.5200.11
281_L324_V0.5180.11
65_A73_G0.5170.11
118_I300_F0.5160.11
84_G134_L0.5150.11
305_A330_V0.5150.11
248_T271_V0.5150.11
65_A69_D0.5150.11
63_Q69_D0.5140.11
148_T210_Y0.5140.11
236_Y310_T0.5130.11
198_F331_L0.5120.11
194_E243_S0.5100.11
121_M222_S0.5100.11
302_G305_A0.5080.11
169_L289_T0.5070.11
69_D84_G0.5070.11
255_L277_L0.5060.11
179_A253_F0.5040.11
174_T229_A0.5040.11
70_H87_A0.5020.11
71_E75_P0.5020.11
173_I238_M0.5000.11
199_M305_A0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4httA 1 0.6483 100 0.402 Contact Map
4b4aA 1 0.6483 100 0.422 Contact Map
5a63B 1 0.3169 63 0.962 Contact Map
4ea3A 2 0.7965 51.8 0.965 Contact Map
4yayA 1 0.8779 50.6 0.965 Contact Map
4fp9B 2 0.1047 42.3 0.967 Contact Map
4p02A 1 0.1337 21.1 0.971 Contact Map
2rh1A 1 0.6017 16.8 0.973 Contact Map
4pj3A 1 0.0465 13.5 0.974 Contact Map
2zjrS 1 0.093 13.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.