Q9HN35 - HALSA - GREMLIN Contacts

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Q9HN35 - DNA-binding protein MutS2

UniProt:	Q9HN35	Sequences: MDLQAIPGVGAKTADALGSLDDPEGALERGDVAAVAGAPGVSEGRAARIVRNAIRVRHDDPGGFLATDRAAEIHERVLGLLQERAVTEYARQRLRTFYPSAADSRIAEVNAFVADAMQRTPRDDVLEALAGVEPLSAPSGVSVRERCVATTDAETYSDAAAAFPELSVEIVEDARDLAELARGYTTVVALDEAFVGVEVEGDVRVEPDAMERPAEVVPERVLSFFAANRDRIRAAVSVHEAAGIDTDVDLDALDGALAHLEGDGSVAGDDELDRLTRAVNDLDAAVSDAESVANDRLREAIGEQDVTIEGADLLSLVERGAGVDSLLGRELADEYDDAVGAARDALEEQLGLRGEAAKLARRVFGDEPTFPVARDDDAMARVRESLTAARDRRAAGRKRELAATLADLRAPTEALVHDALEVDVALAVARFAADFDCVLAERGGRGFRIEGGRNPLLDVAFAETEPVEYGVDGVALLSGVNSGGKTSTLDLVAVVVVLAHMGLPVPAEAARVPAIAELHYYAKSQGTLDAGAFEATLRDFASLTERVADDEGGEESAASRLVLVDELESITEPGASAKIIAGILEALHEAGASGVFVSHLAGEIRDQCGFGVTVDGIHAAGLEDGELVVERSPVKDHLARSTPELIVEKLAEADGAVGEGFYERLLEKF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	669 (532)
Sequences:	4485 (2966)
Seq/√Len:	128.6

ECOLI - MUTS
BACSU - MUTS
HALSA - Q9HN35 MUTS2 MUTS1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
451_G	508_E	5.210	1.00
449_I	452_G	4.617	1.00
211_E	214_A	4.556	1.00
432_A	503_L	4.444	1.00
215_E	439_L	4.147	1.00
218_P	439_L	3.542	1.00
325_S	356_A	3.424	1.00
441_E	511_R	3.398	1.00
448_R	511_R	3.387	1.00
298_R	393_R	3.254	1.00
183_G	498_L	3.246	1.00
450_E	509_A	3.166	1.00
207_P	211_E	3.041	1.00
516_A	557_A	2.960	1.00
218_P	222_L	2.958	1.00
496_V	515_I	2.887	1.00
271_E	276_T	2.758	1.00
279_V	283_D	2.736	1.00
180_L	184_Y	2.723	1.00
217_V	428_V	2.686	1.00
280_N	283_D	2.675	1.00
296_R	302_G	2.654	1.00
303_E	385_S	2.654	1.00
283_D	287_S	2.642	1.00
428_V	503_L	2.551	1.00
207_P	442_R	2.523	1.00
442_R	512_V	2.501	1.00
450_E	508_E	2.453	1.00
284_A	287_S	2.443	1.00
469_Y	492_V	2.398	1.00
443_G	511_R	2.379	1.00
450_E	468_E	2.373	1.00
350_L	374_R	2.368	1.00
214_A	442_R	2.291	1.00
497_V	518_L	2.288	1.00
166_L	199_V	2.269	1.00
185_T	434_D	2.262	1.00
280_N	284_A	2.253	1.00
161_A	166_L	2.210	1.00
448_R	470_G	2.160	1.00
223_S	226_A	2.157	1.00
495_V	505_V	2.154	1.00
473_G	613_T	2.149	1.00
320_G	378_A	2.098	1.00
166_L	501_M	2.034	1.00
474_V	584_L	2.032	1.00
167_S	200_E	2.018	1.00
306_V	310_G	2.017	1.00
221_V	433_A	1.968	1.00
452_G	495_V	1.933	1.00
475_A	617_I	1.928	1.00
362_R	365_G	1.925	1.00
611_G	614_V	1.911	1.00
156_Y	160_A	1.892	1.00
155_T	517_E	1.892	1.00
211_E	439_L	1.882	1.00
209_A	212_R	1.880	1.00
451_G	468_E	1.875	1.00
229_R	426_L	1.874	1.00
408_L	411_P	1.862	1.00
588_H	611_G	1.859	1.00
282_L	287_S	1.853	1.00
345_A	353_R	1.847	1.00
430_R	434_D	1.844	1.00
198_E	425_A	1.843	1.00
347_E	350_L	1.843	1.00
198_E	424_V	1.832	1.00
214_A	218_P	1.831	1.00
301_I	390_R	1.819	1.00
316_L	320_G	1.796	1.00
477_L	595_V	1.787	1.00
453_R	458_D	1.786	1.00
207_P	514_A	1.782	1.00
218_P	504_P	1.770	1.00
186_T	192_E	1.762	1.00
279_V	282_L	1.752	1.00
299_E	303_E	1.741	1.00
236_V	256_A	1.737	1.00
283_D	288_D	1.735	1.00
282_L	286_V	1.732	1.00
404_T	407_D	1.732	1.00
152_D	206_E	1.730	1.00
562_V	587_L	1.717	1.00
549_D	555_E	1.713	1.00
553_G	656_A	1.698	1.00
441_E	509_A	1.689	1.00
476_L	614_V	1.688	1.00
377_D	381_R	1.684	1.00
279_V	285_A	1.683	1.00
278_A	283_D	1.682	1.00
558_A	591_G	1.676	1.00
448_R	509_A	1.667	1.00
187_V	229_R	1.667	1.00
187_V	233_R	1.653	1.00
273_D	276_T	1.642	1.00
585_E	659_E	1.636	1.00
437_C	498_L	1.627	1.00
154_E	204_R	1.626	1.00
203_V	209_A	1.618	1.00
276_T	279_V	1.613	1.00
654_D	658_G	1.612	1.00
562_V	592_A	1.612	1.00
659_E	662_Y	1.606	1.00
396_G	400_E	1.604	1.00
280_N	285_A	1.597	1.00
251_D	254_D	1.594	1.00
295_D	306_V	1.591	1.00
437_C	455_P	1.586	1.00
452_G	491_L	1.583	1.00
312_D	316_L	1.581	1.00
206_E	209_A	1.576	1.00
321_A	325_S	1.573	1.00
428_V	501_M	1.571	1.00
228_N	263_D	1.568	1.00
564_V	567_L	1.567	1.00
169_E	174_A	1.566	1.00
547_V	583_I	1.565	1.00
334_E	342_A	1.565	1.00
400_E	404_T	1.550	1.00
210_M	442_R	1.534	1.00
620_A	634_V	1.530	1.00
295_D	305_D	1.522	1.00
194_F	424_V	1.520	1.00
496_V	561_L	1.520	1.00
284_A	288_D	1.519	1.00
169_E	178_A	1.516	1.00
300_A	303_E	1.516	1.00
319_R	324_D	1.514	1.00
229_R	430_R	1.506	1.00
450_E	470_G	1.505	1.00
194_F	420_L	1.488	1.00
271_E	279_V	1.482	1.00
234_A	259_H	1.469	1.00
285_A	288_D	1.467	1.00
275_L	284_A	1.463	1.00
588_H	613_T	1.447	1.00
451_G	632_S	1.447	1.00
281_D	285_A	1.441	1.00
275_L	282_L	1.436	1.00
274_R	278_A	1.433	1.00
349_Q	352_L	1.427	1.00
280_N	287_S	1.427	1.00
214_A	439_L	1.426	1.00
547_V	564_V	1.424	1.00
276_T	280_N	1.421	1.00
359_L	362_R	1.418	1.00
493_A	563_L	1.414	1.00
199_V	501_M	1.408	1.00
346_L	349_Q	1.402	1.00
282_L	288_D	1.401	1.00
282_L	285_A	1.396	1.00
626_E	648_E	1.387	1.00
488_T	633_P	1.383	1.00
278_A	284_A	1.380	1.00
275_L	283_D	1.363	1.00
279_V	284_A	1.350	1.00
330_E	348_E	1.349	1.00
283_D	286_V	1.339	1.00
215_E	218_P	1.336	1.00
344_D	371_P	1.333	1.00
586_A	590_A	1.333	1.00
220_R	228_N	1.324	1.00
648_E	654_D	1.323	1.00
185_T	431_F	1.319	1.00
121_P	147_C	1.315	1.00
216_V	425_A	1.311	1.00
431_F	435_F	1.308	1.00
472_D	615_D	1.306	1.00
293_A	397_R	1.297	1.00
447_F	496_V	1.295	1.00
204_R	514_A	1.290	1.00
183_G	431_F	1.286	1.00
617_I	635_K	1.284	1.00
203_V	210_M	1.284	1.00
615_D	635_K	1.283	1.00
469_Y	488_T	1.277	1.00
280_N	288_D	1.276	1.00
472_D	635_K	1.271	1.00
122_R	126_L	1.265	1.00
153_A	201_G	1.264	1.00
183_G	501_M	1.264	1.00
618_H	634_V	1.262	1.00
271_E	275_L	1.258	1.00
361_R	365_G	1.258	1.00
579_I	583_I	1.253	1.00
547_V	567_L	1.246	1.00
645_L	661_F	1.242	1.00
587_L	594_G	1.241	1.00
588_H	614_V	1.239	1.00
190_L	420_L	1.239	1.00
279_V	287_S	1.238	1.00
606_D	609_G	1.238	1.00
449_I	495_V	1.233	1.00
228_N	426_L	1.230	1.00
474_V	588_H	1.230	1.00
211_E	215_E	1.228	1.00
403_A	407_D	1.197	0.99
275_L	278_A	1.194	0.99
393_R	396_G	1.194	0.99
500_H	515_I	1.191	0.99
210_M	214_A	1.190	0.99
207_P	214_A	1.182	0.99
169_E	177_L	1.179	0.99
247_D	292_V	1.178	0.99
375_D	380_A	1.176	0.99
231_R	259_H	1.174	0.99
214_A	217_V	1.174	0.99
320_G	325_S	1.160	0.99
278_A	288_D	1.159	0.99
619_A	633_P	1.147	0.99
273_D	277_R	1.140	0.99
452_G	469_Y	1.136	0.99
278_A	281_D	1.126	0.99
161_A	200_E	1.126	0.99
278_A	286_V	1.124	0.99
314_L	317_V	1.120	0.99
250_L	405_L	1.119	0.99
276_T	283_D	1.118	0.99
272_L	276_T	1.116	0.99
281_D	288_D	1.114	0.99
276_T	282_L	1.113	0.99
520_Y	527_T	1.107	0.99
357_A	362_R	1.105	0.99
449_I	469_Y	1.101	0.99
271_E	274_R	1.101	0.99
343_R	357_A	1.100	0.99
235_A	256_A	1.099	0.99
177_L	181_A	1.098	0.99
315_S	318_E	1.098	0.99
443_G	446_G	1.097	0.99
271_E	284_A	1.092	0.99
328_G	345_A	1.091	0.99
231_R	263_D	1.088	0.99
648_E	661_F	1.086	0.99
278_A	287_S	1.086	0.99
161_A	167_S	1.083	0.99
318_E	322_G	1.080	0.99
500_H	514_A	1.080	0.99
442_R	513_P	1.074	0.99
275_L	280_N	1.072	0.99
625_G	661_F	1.071	0.99
381_R	385_S	1.071	0.99
469_Y	491_L	1.070	0.99
585_E	589_E	1.070	0.99
298_R	400_E	1.066	0.99
245_D	406_A	1.060	0.99
311_A	387_T	1.054	0.99
451_G	466_P	1.054	0.99
330_E	349_Q	1.049	0.98
194_F	198_E	1.048	0.98
398_K	402_A	1.047	0.98
214_A	501_M	1.046	0.98
436_D	508_E	1.044	0.98
270_D	274_R	1.040	0.98
361_R	364_F	1.036	0.98
277_R	283_D	1.032	0.98
537_L	545_E	1.023	0.98
220_R	426_L	1.021	0.98
295_D	309_E	1.016	0.98
513_P	593_S	1.012	0.98
152_D	209_A	1.009	0.98
271_E	282_L	1.007	0.98
273_D	279_V	1.005	0.98
277_R	282_L	1.003	0.98
265_S	268_G	1.002	0.98
532_A	537_L	1.001	0.98
160_A	520_Y	1.001	0.98
278_A	282_L	1.000	0.98
247_D	395_A	0.994	0.98
608_C	614_V	0.992	0.98
280_N	286_V	0.990	0.98
608_C	635_K	0.988	0.98
279_V	286_V	0.987	0.98
439_L	504_P	0.986	0.98
167_S	180_L	0.985	0.98
214_A	428_V	0.985	0.98
307_T	385_S	0.984	0.98
395_A	399_R	0.983	0.98
275_L	279_V	0.980	0.98
495_V	506_P	0.978	0.98
404_T	408_L	0.977	0.98
168_V	173_D	0.976	0.98
313_L	317_V	0.974	0.98
354_G	359_L	0.973	0.97
548_A	554_E	0.970	0.97
303_E	307_T	0.967	0.97
313_L	382_V	0.967	0.97
495_V	510_A	0.966	0.97
557_A	560_R	0.956	0.97
198_E	203_V	0.955	0.97
178_A	181_A	0.954	0.97
359_L	365_G	0.953	0.97
214_A	504_P	0.951	0.97
207_P	444_G	0.948	0.97
217_V	221_V	0.948	0.97
193_A	237_S	0.945	0.97
468_E	632_S	0.941	0.97
281_D	294_N	0.941	0.97
279_V	288_D	0.939	0.97
123_D	127_E	0.936	0.97
211_E	441_E	0.935	0.97
425_A	428_V	0.934	0.97
357_A	361_R	0.931	0.97
359_L	363_V	0.928	0.97
623_E	640_R	0.927	0.97
346_L	350_L	0.920	0.96
271_E	280_N	0.920	0.96
198_E	421_E	0.917	0.96
471_V	475_A	0.916	0.96
163_F	170_I	0.916	0.96
336_D	342_A	0.914	0.96
617_I	633_P	0.914	0.96
447_F	492_V	0.912	0.96
231_R	262_G	0.910	0.96
365_G	371_P	0.910	0.96
321_A	357_A	0.906	0.96
301_I	397_R	0.905	0.96
360_A	363_V	0.905	0.96
242_A	412_T	0.902	0.96
300_A	389_A	0.902	0.96
277_R	280_N	0.900	0.96
255_G	258_A	0.899	0.96
605_R	637_H	0.898	0.96
475_A	488_T	0.895	0.96
270_D	282_L	0.895	0.96
648_E	657_V	0.895	0.96
618_H	637_H	0.894	0.96
274_R	283_D	0.893	0.96
427_A	431_F	0.893	0.96
262_G	265_S	0.890	0.96
307_T	317_V	0.887	0.96
444_G	559_S	0.887	0.96
532_A	535_A	0.881	0.96
505_V	510_A	0.881	0.96
330_E	346_L	0.880	0.95
424_V	428_V	0.878	0.95
500_H	512_V	0.875	0.95
578_K	581_A	0.874	0.95
496_V	512_V	0.874	0.95
438_V	504_P	0.867	0.95
263_D	419_A	0.867	0.95
360_A	365_G	0.860	0.95
242_A	409_R	0.859	0.95
359_L	372_V	0.858	0.95
437_C	458_D	0.858	0.95
574_G	600_L	0.856	0.95
477_L	633_P	0.854	0.95
157_S	517_E	0.853	0.95
359_L	364_F	0.849	0.95
489_L	597_V	0.849	0.95
293_A	401_L	0.848	0.94
221_V	504_P	0.847	0.94
467_V	491_L	0.847	0.94
275_L	286_V	0.846	0.94
382_V	385_S	0.845	0.94
169_E	172_E	0.841	0.94
153_A	203_V	0.840	0.94
360_A	364_F	0.836	0.94
317_V	320_G	0.835	0.94
281_D	284_A	0.832	0.94
275_L	285_A	0.828	0.94
292_V	395_A	0.828	0.94
539_D	570_I	0.823	0.94
378_A	381_R	0.822	0.94
204_R	559_S	0.821	0.93
464_T	487_S	0.820	0.93
183_G	427_A	0.816	0.93
211_E	442_R	0.815	0.93
272_L	284_A	0.814	0.93
175_R	180_L	0.814	0.93
281_D	286_V	0.813	0.93
154_E	518_L	0.813	0.93
446_G	559_S	0.813	0.93
270_D	276_T	0.811	0.93
148_V	153_A	0.808	0.93
445_R	511_R	0.805	0.93
186_T	427_A	0.804	0.93
210_M	514_A	0.802	0.93
489_L	492_V	0.800	0.93
519_H	555_E	0.800	0.93
249_D	252_A	0.797	0.92
305_D	390_R	0.797	0.92
185_T	427_A	0.797	0.92
251_D	255_G	0.795	0.92
442_R	499_A	0.793	0.92
492_V	561_L	0.793	0.92
217_V	429_A	0.792	0.92
184_Y	192_E	0.787	0.92
276_T	288_D	0.783	0.92
452_G	492_V	0.782	0.92
621_G	627_L	0.781	0.92
652_E	656_A	0.781	0.92
358_K	362_R	0.778	0.92
271_E	278_A	0.778	0.92
214_A	221_V	0.778	0.92
314_L	318_E	0.777	0.91
210_M	501_M	0.775	0.91
214_A	498_L	0.775	0.91
357_A	365_G	0.774	0.91
445_R	593_S	0.774	0.91
442_R	514_A	0.774	0.91
259_H	262_G	0.773	0.91
483_G	618_H	0.771	0.91
417_H	421_E	0.770	0.91
556_S	592_A	0.767	0.91
475_A	615_D	0.764	0.91
221_V	429_A	0.763	0.91
446_G	593_S	0.763	0.91
513_P	559_S	0.762	0.91
433_A	436_D	0.762	0.91
620_A	632_S	0.762	0.91
227_A	266_V	0.759	0.91
618_H	621_G	0.758	0.90
431_F	437_C	0.758	0.90
326_L	329_R	0.757	0.90
271_E	285_A	0.756	0.90
273_D	278_A	0.756	0.90
217_V	504_P	0.756	0.90
277_R	284_A	0.756	0.90
446_G	513_P	0.754	0.90
154_E	497_V	0.752	0.90
203_V	500_H	0.750	0.90
587_L	592_A	0.750	0.90
569_S	572_E	0.748	0.90
238_V	412_T	0.747	0.90
303_E	306_V	0.746	0.90
482_S	487_S	0.746	0.90
235_A	419_A	0.743	0.90
581_A	585_E	0.743	0.90
274_R	277_R	0.743	0.90
276_T	285_A	0.742	0.89
260_L	415_L	0.739	0.89
618_H	636_D	0.739	0.89
154_E	501_M	0.739	0.89
260_L	419_A	0.738	0.89
658_G	662_Y	0.737	0.89
515_I	593_S	0.737	0.89
219_E	223_S	0.734	0.89
277_R	286_V	0.734	0.89
658_G	661_F	0.732	0.89
197_V	201_G	0.731	0.89
204_R	500_H	0.731	0.89
156_Y	161_A	0.730	0.89
627_L	645_L	0.729	0.89
241_A	253_L	0.729	0.89
274_R	281_D	0.727	0.89
249_D	257_L	0.727	0.89
447_F	513_P	0.726	0.88
120_T	123_D	0.723	0.88
149_A	152_D	0.722	0.88
577_A	581_A	0.719	0.88
400_E	403_A	0.717	0.88
410_A	413_E	0.716	0.88
194_F	197_V	0.715	0.88
160_A	549_D	0.714	0.88
314_L	320_G	0.714	0.88
350_L	353_R	0.711	0.87
473_G	591_G	0.709	0.87
121_P	124_D	0.709	0.87
231_R	266_V	0.707	0.87
405_L	412_T	0.707	0.87
300_A	396_G	0.706	0.87
458_D	495_V	0.706	0.87
657_V	661_F	0.705	0.87
447_F	512_V	0.703	0.87
256_A	419_A	0.702	0.87
166_L	497_V	0.702	0.87
173_D	176_D	0.701	0.87
424_V	427_A	0.700	0.87
273_D	280_N	0.700	0.87
357_A	360_A	0.696	0.86
167_S	199_V	0.696	0.86
357_A	363_V	0.696	0.86
174_A	388_A	0.696	0.86
578_K	582_G	0.696	0.86
292_V	305_D	0.695	0.86
208_D	211_E	0.694	0.86
446_G	558_A	0.694	0.86
221_V	432_A	0.693	0.86
331_L	340_G	0.692	0.86
477_L	617_I	0.692	0.86
154_E	500_H	0.687	0.86
644_E	657_V	0.685	0.85
482_S	650_L	0.685	0.85
175_R	178_A	0.685	0.85
480_V	650_L	0.684	0.85
480_V	491_L	0.684	0.85
625_G	645_L	0.683	0.85
653_A	656_A	0.682	0.85
154_E	496_V	0.680	0.85
492_V	595_V	0.678	0.85
271_E	283_D	0.677	0.85
499_A	505_V	0.676	0.85
531_G	539_D	0.676	0.85
474_V	614_V	0.673	0.84
160_A	163_F	0.672	0.84
194_F	417_H	0.672	0.84
438_V	509_A	0.671	0.84
176_D	181_A	0.671	0.84
328_G	331_L	0.670	0.84
304_Q	308_I	0.670	0.84
471_V	593_S	0.670	0.84
306_V	312_D	0.668	0.84
546_R	596_F	0.667	0.84
198_E	213_P	0.667	0.84
472_D	617_I	0.664	0.84
457_L	464_T	0.663	0.84
354_G	357_A	0.663	0.84
272_L	282_L	0.662	0.83
623_E	645_L	0.661	0.83
606_D	610_F	0.659	0.83
527_T	601_A	0.659	0.83
443_G	513_P	0.658	0.83
589_E	611_G	0.655	0.83
310_G	382_V	0.653	0.83
214_A	503_L	0.653	0.83
580_I	596_F	0.651	0.82
272_L	283_D	0.650	0.82
273_D	282_L	0.650	0.82
315_S	319_R	0.650	0.82
392_R	396_G	0.647	0.82
497_V	500_H	0.647	0.82
170_I	527_T	0.646	0.82
347_E	372_V	0.646	0.82
208_D	212_R	0.646	0.82
175_R	196_G	0.646	0.82
307_T	313_L	0.645	0.82
272_L	280_N	0.645	0.82
328_G	349_Q	0.645	0.82
449_I	492_V	0.645	0.82
270_D	273_D	0.645	0.82
395_A	402_A	0.644	0.82
194_F	421_E	0.643	0.82
528_L	539_D	0.642	0.82
154_E	515_I	0.639	0.81
586_A	655_G	0.638	0.81
275_L	288_D	0.637	0.81
543_L	569_S	0.636	0.81
276_T	286_V	0.635	0.81
144_R	413_E	0.634	0.81
188_V	232_I	0.633	0.81
301_I	305_D	0.632	0.81
472_D	475_A	0.631	0.80
216_V	220_R	0.631	0.80
168_V	196_G	0.630	0.80
271_E	287_S	0.629	0.80
276_T	281_D	0.629	0.80
277_R	287_S	0.629	0.80
153_A	204_R	0.626	0.80
446_G	511_R	0.626	0.80
333_D	343_R	0.624	0.80
353_R	356_A	0.623	0.80
203_V	213_P	0.623	0.80
254_D	258_A	0.623	0.80
311_A	315_S	0.622	0.79
289_A	395_A	0.622	0.79
171_V	532_A	0.621	0.79
173_D	178_A	0.620	0.79
235_A	259_H	0.619	0.79
186_T	424_V	0.618	0.79
420_L	424_V	0.618	0.79
427_A	430_R	0.617	0.79
207_P	443_G	0.617	0.79
272_L	279_V	0.615	0.79
271_E	277_R	0.615	0.79
272_L	288_D	0.614	0.79
567_L	583_I	0.613	0.78
227_A	231_R	0.613	0.78
438_V	505_V	0.612	0.78
297_L	397_R	0.612	0.78
489_L	520_Y	0.611	0.78
196_G	200_E	0.610	0.78
121_P	125_V	0.609	0.78
156_Y	520_Y	0.608	0.78
493_A	541_A	0.608	0.78
250_L	256_A	0.608	0.78
272_L	275_L	0.607	0.78
488_T	492_V	0.607	0.78
270_D	278_A	0.607	0.78
647_V	652_E	0.607	0.78
277_R	288_D	0.607	0.78
271_E	281_D	0.604	0.77
332_A	336_D	0.604	0.77
203_V	207_P	0.603	0.77
210_M	500_H	0.603	0.77
338_A	342_A	0.602	0.77
428_V	431_F	0.602	0.77
281_D	287_S	0.601	0.77
160_A	167_S	0.601	0.77
574_G	640_R	0.600	0.77
564_V	583_I	0.599	0.77
577_A	597_V	0.599	0.77
275_L	287_S	0.597	0.77
273_D	286_V	0.596	0.77
609_G	613_T	0.596	0.77
619_A	639_A	0.595	0.76
132_V	143_V	0.595	0.76
198_E	428_V	0.595	0.76
334_E	375_D	0.594	0.76
343_R	346_L	0.593	0.76
443_G	559_S	0.593	0.76
487_S	490_D	0.593	0.76
169_E	176_D	0.592	0.76
272_L	278_A	0.592	0.76
339_V	364_F	0.591	0.76
167_S	170_I	0.591	0.76
316_L	319_R	0.591	0.76
654_D	657_V	0.591	0.76
216_V	219_E	0.591	0.76
409_R	413_E	0.590	0.76
482_S	646_I	0.589	0.76
276_T	284_A	0.589	0.76
197_V	421_E	0.589	0.76
569_S	580_I	0.588	0.76
253_L	256_A	0.587	0.75
237_S	240_E	0.587	0.75
517_E	555_E	0.587	0.75
220_R	425_A	0.587	0.75
338_A	341_A	0.586	0.75
277_R	411_P	0.586	0.75
495_V	512_V	0.586	0.75
185_T	430_R	0.585	0.75
157_S	160_A	0.585	0.75
377_D	380_A	0.584	0.75
244_I	249_D	0.581	0.75
250_L	402_A	0.581	0.75
482_S	528_L	0.579	0.74
214_A	512_V	0.579	0.74
437_C	494_V	0.579	0.74
403_A	406_A	0.579	0.74
183_G	503_L	0.578	0.74
241_A	244_I	0.578	0.74
550_D	562_V	0.577	0.74
444_G	511_R	0.576	0.74
591_G	613_T	0.576	0.74
227_A	262_G	0.575	0.74
264_G	268_G	0.574	0.74
175_R	181_A	0.573	0.74
397_R	400_E	0.573	0.74
204_R	518_L	0.572	0.74
556_S	587_L	0.570	0.73
418_D	421_E	0.570	0.73
324_D	329_R	0.569	0.73
597_V	621_G	0.569	0.73
167_S	196_G	0.569	0.73
197_V	239_H	0.567	0.73
328_G	353_R	0.567	0.73
344_D	373_A	0.567	0.73
120_T	124_D	0.567	0.73
177_L	180_L	0.567	0.73
185_T	435_F	0.566	0.73
608_C	616_G	0.566	0.73
492_V	496_V	0.564	0.73
260_L	264_G	0.563	0.72
216_V	421_E	0.563	0.72
258_A	273_D	0.561	0.72
308_I	390_R	0.561	0.72
245_D	405_L	0.559	0.72
274_R	404_T	0.559	0.72
297_L	400_E	0.558	0.72
325_S	353_R	0.557	0.72
247_D	398_K	0.557	0.72
293_A	301_I	0.556	0.71
532_A	631_R	0.555	0.71
491_L	495_V	0.555	0.71
474_V	592_A	0.555	0.71
539_D	569_S	0.553	0.71
290_E	394_A	0.553	0.71
154_E	203_V	0.552	0.71
497_V	501_M	0.552	0.71
173_D	177_L	0.552	0.71
119_R	123_D	0.552	0.71
579_I	640_R	0.551	0.71
144_R	417_H	0.550	0.71
380_A	383_R	0.550	0.71
563_L	618_H	0.549	0.71
172_E	176_D	0.549	0.71
476_L	584_L	0.549	0.71
622_L	628_V	0.549	0.71
120_T	221_V	0.547	0.70
300_A	304_Q	0.547	0.70
245_D	253_L	0.546	0.70
297_L	302_G	0.546	0.70
402_A	405_L	0.546	0.70
639_A	642_T	0.545	0.70
274_R	279_V	0.544	0.70
426_L	430_R	0.544	0.70
324_D	327_L	0.544	0.70
432_A	504_P	0.544	0.70
250_L	253_L	0.543	0.70
355_E	358_K	0.543	0.70
564_V	575_A	0.542	0.70
168_V	172_E	0.542	0.70
464_T	567_L	0.541	0.69
199_V	498_L	0.540	0.69
577_A	584_L	0.540	0.69
317_V	321_A	0.539	0.69
335_Y	338_A	0.539	0.69
312_D	315_S	0.539	0.69
161_A	201_G	0.538	0.69
326_L	333_D	0.538	0.69
236_V	241_A	0.537	0.69
327_L	330_E	0.537	0.69
129_L	143_V	0.537	0.69
134_P	137_A	0.536	0.69
619_A	645_L	0.536	0.69
574_G	619_A	0.536	0.69
228_N	266_V	0.536	0.69
180_L	196_G	0.535	0.69
247_D	289_A	0.535	0.69
178_A	232_I	0.535	0.69
543_L	546_R	0.535	0.69
510_A	514_A	0.535	0.69
190_L	416_V	0.535	0.69
165_E	170_I	0.535	0.69
183_G	437_C	0.534	0.68
190_L	419_A	0.532	0.68
496_V	513_P	0.532	0.68
496_V	500_H	0.531	0.68
293_A	296_R	0.530	0.68
145_E	554_E	0.529	0.68
230_D	234_A	0.529	0.68
317_V	333_D	0.528	0.68
482_S	573_P	0.528	0.68
536_T	573_P	0.528	0.68
237_S	569_S	0.527	0.67
568_E	641_S	0.526	0.67
207_P	500_H	0.525	0.67
278_A	285_A	0.525	0.67
292_V	398_K	0.524	0.67
354_G	362_R	0.524	0.67
481_N	599_H	0.524	0.67
201_G	488_T	0.524	0.67
483_G	619_A	0.524	0.67
265_S	441_E	0.523	0.67
569_S	576_S	0.522	0.67
459_V	462_A	0.522	0.67
399_R	403_A	0.521	0.67
190_L	409_R	0.521	0.67
428_V	626_E	0.520	0.66
342_A	383_R	0.520	0.66
375_D	379_M	0.520	0.66
183_G	199_V	0.520	0.66
266_V	269_D	0.519	0.66
171_V	537_L	0.519	0.66
343_R	349_Q	0.519	0.66
275_L	281_D	0.519	0.66
206_E	212_R	0.518	0.66
314_L	321_A	0.518	0.66
157_S	581_A	0.518	0.66
574_G	605_R	0.518	0.66
329_R	352_L	0.517	0.66
392_R	395_A	0.517	0.66
318_E	334_E	0.517	0.66
340_G	394_A	0.516	0.66
329_R	349_Q	0.516	0.66
581_A	584_L	0.515	0.66
437_C	503_L	0.514	0.66
308_I	382_V	0.514	0.66
262_G	266_V	0.514	0.66
373_A	629_V	0.513	0.65
274_R	287_S	0.513	0.65
483_G	631_R	0.512	0.65
581_A	607_Q	0.512	0.65
407_D	444_G	0.512	0.65
341_A	345_A	0.511	0.65
298_R	397_R	0.511	0.65
508_E	511_R	0.511	0.65
270_D	284_A	0.510	0.65
165_E	168_V	0.510	0.65
639_A	645_L	0.510	0.65
256_A	260_L	0.510	0.65
345_A	349_Q	0.509	0.65
157_S	549_D	0.509	0.65
474_V	613_T	0.509	0.65
384_E	389_A	0.509	0.65
483_G	637_H	0.508	0.65
347_E	351_G	0.508	0.65
605_R	638_L	0.508	0.65
449_I	496_V	0.508	0.65
337_D	364_F	0.508	0.65
274_R	280_N	0.508	0.65
325_S	357_A	0.507	0.64
208_D	441_E	0.507	0.64
358_K	361_R	0.506	0.64
521_Y	546_R	0.506	0.64
198_E	375_D	0.506	0.64
442_R	445_R	0.506	0.64
498_L	501_M	0.506	0.64
528_L	546_R	0.506	0.64
263_D	422_V	0.504	0.64
308_I	578_K	0.502	0.64
192_E	427_A	0.502	0.64
321_A	331_L	0.502	0.64
341_A	348_E	0.502	0.64
291_S	294_N	0.501	0.64
304_Q	307_T	0.500	0.63
343_R	379_M	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1wb9A	2	0.9522	100	0.351	Contact Map
3thxA	1	0.9297	100	0.351	Contact Map
2o8bB	1	0.9417	100	0.361	Contact Map
3thxB	1	0.9537	100	0.383	Contact Map
1ewqA	2	0.9447	100	0.391	Contact Map
2r8rA	1	0.2541	99	0.937	Contact Map
4uxhA	3	0.2436	98.8	0.941	Contact Map
4hseA	1	0.3244	98.7	0.943	Contact Map
4rvcA	4	0.296	98.7	0.943	Contact Map
2i3bA	1	0.2048	98.7	0.943	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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