GREMLIN Database
CDC66 - ORC1-type DNA replication protein 6
UniProt: Q9HN34 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 374 (294)
Sequences: 2923 (1957)
Seq/√Len: 114.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
268_S275_D3.7651.00
329_Y333_T3.5731.00
215_T237_D3.4461.00
317_V321_F3.4221.00
222_V256_L3.1411.00
208_A246_A3.0251.00
266_R275_D3.0041.00
318_Y321_F2.9441.00
218_L252_G2.8101.00
215_T219_R2.7541.00
272_E275_D2.6771.00
256_L276_V2.6731.00
238_A241_G2.5501.00
266_R278_A2.5421.00
194_R197_S2.4651.00
296_S299_E2.3751.00
222_V236_L2.2601.00
318_Y322_N2.2441.00
322_N326_D2.2411.00
237_D241_G2.1551.00
321_F324_R2.1541.00
328_G331_R2.1421.00
320_V323_D2.1171.00
192_D197_S2.1101.00
313_R316_D2.0851.00
42_L58_V2.0501.00
328_G332_Y2.0431.00
92_C143_L2.0191.00
38_Q207_S2.0071.00
194_R198_V1.9751.00
192_D195_V1.9671.00
321_F325_T1.9571.00
296_S300_R1.9521.00
210_D213_E1.9511.00
306_V345_I1.9481.00
161_S165_A1.9371.00
243_T247_G1.9061.00
329_Y332_Y1.8991.00
197_S200_R1.8761.00
331_R334_E1.8711.00
275_D279_V1.8451.00
336_V339_L1.8351.00
231_V237_D1.8211.00
192_D196_Q1.7651.00
76_F142_A1.7471.00
35_R38_Q1.7451.00
330_T334_E1.7411.00
338_K342_L1.7301.00
232_A270_T1.6701.00
274_E278_A1.6671.00
285_H288_L1.6161.00
195_V198_V1.6091.00
188_I191_L1.6001.00
244_D247_G1.5951.00
231_V234_P1.5941.00
317_V325_T1.5931.00
32_F70_T1.5881.00
247_G251_V1.5821.00
34_H216_D1.5761.00
160_Y164_R1.5721.00
332_Y336_V1.5721.00
157_D160_Y1.5181.00
327_L336_V1.5171.00
163_L166_H1.5081.00
287_H291_T1.5061.00
308_E312_D1.4931.00
336_V340_D1.4401.00
216_D219_R1.4311.00
194_R200_R1.4291.00
230_A236_L1.4291.00
333_T336_V1.4271.00
332_Y339_L1.4271.00
71_A206_F1.4221.00
125_F129_A1.4191.00
228_E271_V1.4171.00
231_V235_V1.4091.00
146_V178_V1.4061.00
319_D323_D1.4041.00
125_F128_V1.3991.00
317_V320_V1.3891.00
156_G160_Y1.3621.00
288_L291_T1.3541.00
302_L306_V1.3211.00
235_V238_A1.3191.00
268_S272_E1.3151.00
158_T161_S1.3101.00
218_L236_L1.3091.00
195_V201_P1.2920.99
59_V146_V1.2900.99
160_Y163_L1.2900.99
271_V276_V1.2870.99
333_T337_N1.2490.99
160_Y194_R1.2440.99
147_N181_S1.2310.99
244_D251_V1.2300.99
276_V281_E1.2300.99
123_K127_Q1.2230.99
318_Y325_T1.2160.99
195_V200_R1.2100.99
230_A234_P1.1910.99
289_S293_A1.1900.99
234_P237_D1.1900.99
297_D300_R1.1880.99
320_V325_T1.1870.99
248_D251_V1.1870.99
328_G336_V1.1860.99
157_D161_S1.1840.99
235_V241_G1.1830.99
230_A233_E1.1740.99
262_H275_D1.1730.99
273_M277_D1.1390.99
129_A135_D1.1360.99
142_A179_V1.1290.99
145_D181_S1.1270.99
328_G339_L1.1210.99
160_Y166_H1.1190.99
194_R199_F1.1150.98
73_Q89_R1.1140.98
238_A242_R1.1130.98
336_V342_L1.1060.98
22_V26_D1.0940.98
327_L330_T1.0930.98
298_N321_F1.0920.98
198_V201_P1.0850.98
104_R107_E1.0800.98
129_A134_D1.0790.98
195_V199_F1.0760.98
330_T333_T1.0750.98
162_L165_A1.0720.98
337_N341_E1.0720.98
262_H266_R1.0700.98
302_L332_Y1.0660.98
296_S306_V1.0650.98
158_T163_L1.0650.98
275_D281_E1.0560.98
257_R261_L1.0490.98
279_V283_A1.0430.98
158_T164_R1.0420.98
233_E237_D1.0310.97
196_Q199_F1.0270.97
239_V252_G1.0270.97
245_E251_V1.0260.97
240_G247_G1.0210.97
339_L343_G1.0210.97
192_D198_V1.0190.97
45_A58_V1.0170.97
271_V275_D1.0170.97
313_R317_V1.0080.97
39_L71_A1.0070.97
158_T162_L1.0020.97
272_E276_V1.0000.97
288_L295_L0.9980.97
160_Y165_A0.9950.97
294_A300_R0.9930.97
215_T236_L0.9920.97
275_D278_A0.9890.97
91_N160_Y0.9830.97
295_L299_E0.9740.96
329_Y339_L0.9730.96
235_V239_V0.9680.96
158_T165_A0.9680.96
211_R241_G0.9660.96
327_L332_Y0.9610.96
293_A299_E0.9600.96
274_E277_D0.9570.96
328_G333_T0.9510.96
284_K292_L0.9460.96
139_L174_V0.9450.96
328_G334_E0.9440.96
192_D201_P0.9440.96
152_E155_A0.9410.96
327_L340_D0.9400.96
276_V279_V0.9390.96
318_Y326_D0.9370.96
327_L331_R0.9330.95
297_D301_A0.9300.95
161_S164_R0.9290.95
271_V279_V0.9170.95
62_G67_G0.9170.95
193_G196_Q0.9130.95
238_A277_D0.9110.95
156_G159_L0.9100.95
222_V276_V0.9100.95
73_Q170_P0.9060.95
192_D200_R0.9050.95
58_V204_A0.9050.95
330_T335_I0.8990.94
196_Q200_R0.8990.94
300_R304_R0.8910.94
104_R108_E0.8880.94
60_A72_V0.8830.94
156_G164_R0.8730.93
329_Y335_I0.8680.93
149_L255_V0.8630.93
53_S253_I0.8630.93
322_N325_T0.8620.93
36_E213_E0.8580.93
231_V238_A0.8530.93
263_A275_D0.8530.93
194_R201_P0.8530.93
164_R198_V0.8520.93
329_Y336_V0.8520.93
295_L303_V0.8520.93
160_Y197_S0.8500.93
243_T251_V0.8390.92
87_T142_A0.8380.92
305_T324_R0.8370.92
157_D162_L0.8360.92
36_E216_D0.8340.92
234_P239_V0.8330.92
218_L239_V0.8330.92
319_D322_N0.8300.92
104_R161_S0.8280.92
58_V177_V0.8260.91
340_D345_I0.8220.91
288_L299_E0.8200.91
255_V280_Y0.8170.91
303_V306_V0.8150.91
234_P241_G0.8140.91
291_T306_V0.8140.91
23_F26_D0.8090.91
299_E306_V0.8070.90
293_A296_S0.8040.90
159_L164_R0.7960.90
108_E112_Y0.7950.90
37_S40_Q0.7940.90
332_Y342_L0.7940.90
331_R335_I0.7940.90
134_D171_G0.7930.90
280_Y283_A0.7930.90
242_R247_G0.7880.89
124_L131_R0.7880.89
298_N301_A0.7860.89
323_D326_D0.7820.89
62_G65_G0.7800.89
273_M276_V0.7780.89
192_D199_F0.7750.89
327_L335_I0.7740.89
229_G233_E0.7740.89
315_G319_D0.7730.89
303_V307_A0.7730.89
232_A236_L0.7710.88
290_R294_A0.7650.88
85_V91_N0.7640.88
290_R293_A0.7600.88
190_A195_V0.7590.88
213_E276_V0.7580.88
33_R220_D0.7570.87
233_E238_A0.7520.87
90_V176_V0.7500.87
230_A235_V0.7490.87
262_H265_S0.7450.87
57_N201_P0.7440.87
270_T279_V0.7430.86
304_R307_A0.7430.86
189_E194_R0.7350.86
327_L339_L0.7350.86
295_L306_V0.7320.86
238_A273_M0.7300.86
296_S301_A0.7300.86
254_D257_R0.7290.85
239_V242_R0.7280.85
278_A282_D0.7250.85
284_K302_L0.7240.85
341_E344_V0.7210.85
259_A279_V0.7190.85
331_R338_K0.7190.85
233_E241_G0.7180.85
258_R261_L0.7100.84
341_E349_Y0.7090.84
299_E303_V0.7090.84
45_A146_V0.7090.84
279_V282_D0.7050.83
327_L333_T0.7030.83
228_E256_L0.7020.83
231_V236_L0.7020.83
286_V289_S0.7010.83
46_L75_L0.7010.83
259_A271_V0.6980.83
149_L160_Y0.6950.83
122_K125_F0.6910.82
92_C162_L0.6880.82
231_V271_V0.6850.82
157_D163_L0.6850.82
285_H291_T0.6840.82
214_I218_L0.6840.82
334_E338_K0.6840.82
44_Y265_S0.6800.81
260_G263_A0.6790.81
335_I338_K0.6790.81
297_D304_R0.6780.81
160_Y198_V0.6730.81
294_A298_N0.6730.81
344_V347_A0.6720.80
189_E192_D0.6720.80
331_R347_A0.6700.80
161_S166_H0.6690.80
69_T145_D0.6680.80
110_F113_E0.6680.80
315_G318_Y0.6640.80
303_V321_F0.6640.80
62_G68_K0.6620.79
231_V239_V0.6600.79
246_A251_V0.6590.79
196_Q201_P0.6560.79
91_N105_V0.6560.79
197_S248_D0.6510.78
306_V328_G0.6500.78
336_V347_A0.6480.78
209_Y221_R0.6470.78
314_A318_Y0.6460.78
331_R341_E0.6410.77
329_Y337_N0.6410.77
295_L344_V0.6400.77
163_L168_T0.6400.77
262_H278_A0.6390.77
156_G161_S0.6390.77
330_T339_L0.6380.77
270_T323_D0.6380.77
291_T337_N0.6370.77
328_G343_G0.6360.77
22_V25_I0.6350.77
332_Y344_V0.6340.77
264_E268_S0.6340.77
219_R233_E0.6330.76
42_L204_A0.6310.76
327_L344_V0.6300.76
243_T246_A0.6270.76
47_R51_R0.6240.75
35_R209_Y0.6230.75
63_P253_I0.6220.75
160_Y195_V0.6180.75
85_V92_C0.6180.75
35_R253_I0.6180.75
242_R252_G0.6140.74
111_D114_P0.6090.74
232_A235_V0.6090.74
292_L295_L0.6080.74
209_Y217_I0.6080.74
245_E255_V0.6070.73
334_E342_L0.6070.73
305_T312_D0.6060.73
162_L203_E0.6050.73
291_T295_L0.6030.73
193_G197_S0.6010.73
24_E28_V0.6010.73
234_P238_A0.6000.73
237_D240_G0.5970.72
64_P181_S0.5960.72
197_S201_P0.5960.72
39_L74_K0.5950.72
23_F29_P0.5930.72
334_E337_N0.5930.72
234_P242_R0.5870.71
272_E279_V0.5850.71
284_K306_V0.5850.71
262_H279_V0.5840.71
59_V180_S0.5810.70
270_T278_A0.5800.70
144_D217_I0.5790.70
293_A300_R0.5790.70
149_L263_A0.5760.69
272_E281_E0.5760.69
46_L177_V0.5750.69
158_T166_H0.5740.69
298_N335_I0.5730.69
337_N344_V0.5730.69
212_A215_T0.5710.69
302_L305_T0.5700.69
327_L337_N0.5700.69
219_R223_E0.5700.69
256_L271_V0.5700.69
177_V293_A0.5680.68
318_Y332_Y0.5670.68
221_R253_I0.5660.68
89_R106_F0.5640.68
181_S247_G0.5630.68
272_E278_A0.5620.68
106_F110_F0.5620.68
65_G145_D0.5620.68
66_T70_T0.5620.68
105_V128_V0.5600.67
318_Y323_D0.5590.67
300_R307_A0.5580.67
270_T276_V0.5580.67
331_R336_V0.5580.67
292_L307_A0.5560.67
218_L222_V0.5560.67
295_L300_R0.5540.66
110_F128_V0.5540.66
339_L344_V0.5530.66
211_R237_D0.5520.66
29_P32_F0.5510.66
170_P177_V0.5510.66
80_S87_T0.5490.66
312_D320_V0.5490.66
40_Q43_Q0.5480.66
277_D281_E0.5470.66
61_R204_A0.5410.65
293_A304_R0.5400.65
268_S273_M0.5390.64
57_N143_L0.5390.64
21_H24_E0.5370.64
163_L198_V0.5360.64
92_C105_V0.5350.64
43_Q78_E0.5320.63
39_L174_V0.5320.63
35_R75_L0.5300.63
317_V339_L0.5300.63
61_R203_E0.5290.63
124_L127_Q0.5290.63
204_A282_D0.5290.63
90_V105_V0.5280.63
335_I342_L0.5270.63
288_L292_L0.5230.62
217_I221_R0.5230.62
333_T339_L0.5220.62
77_G84_G0.5200.62
162_L166_H0.5170.61
238_A308_E0.5160.61
263_A271_V0.5150.61
287_H290_R0.5150.61
170_P262_H0.5140.61
139_L173_K0.5130.61
209_Y248_D0.5120.60
295_L302_L0.5120.60
41_T44_Y0.5110.60
127_Q131_R0.5090.60
122_K126_G0.5090.60
315_G325_T0.5080.60
177_V255_V0.5070.60
229_G232_A0.5050.59
128_V131_R0.5040.59
110_F127_Q0.5040.59
42_L75_L0.5040.59
206_F209_Y0.5030.59
218_L228_E0.5030.59
296_S302_L0.5020.59
65_G69_T0.5020.59
248_D254_D0.5010.59
55_P79_L0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.9439 100 0.362 Contact Map
4xgcA 1 0.7861 100 0.364 Contact Map
2v1uA 1 0.9519 100 0.372 Contact Map
1w5sA 1 0.9278 100 0.402 Contact Map
2qbyB 1 0.9171 100 0.41 Contact Map
1fnnA 1 0.9225 100 0.441 Contact Map
4xgcD 1 0.9278 100 0.481 Contact Map
3te6A 1 0.7059 100 0.568 Contact Map
4xgcE 1 0.861 100 0.609 Contact Map
4ko8A 3 0.6952 100 0.654 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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