GREMLIN Database
RPIA - Ribose-5-phosphate isomerase A
UniProt: Q9HN33 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (212)
Sequences: 2434 (1440)
Seq/√Len: 98.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_A167_V4.7281.00
17_A21_E3.8591.00
82_A112_A3.2931.00
78_S113_D3.2761.00
43_A46_A3.0871.00
190_A202_H3.0121.00
145_V176_V2.8191.00
119_A214_V2.7821.00
185_T188_A2.7491.00
28_V79_V2.6821.00
16_E43_A2.4701.00
40_A83_I2.4011.00
88_Q129_D2.3481.00
55_A61_R2.2831.00
42_R63_R2.2651.00
89_V94_L2.2521.00
194_S202_H2.2381.00
89_V212_V2.2171.00
89_V119_A2.1191.00
41_I60_S2.1061.00
148_V193_L2.0901.00
93_V212_V2.0861.00
53_G69_V1.9741.00
33_T101_A1.9481.00
61_R65_V1.9421.00
29_V81_V1.9281.00
56_T108_V1.9141.00
114_R211_A1.8381.00
12_R16_E1.8311.00
14_A213_Y1.8161.00
58_F61_R1.8091.00
31_L64_A1.8061.00
10_Q121_P1.8051.00
98_G130_V1.7961.00
8_A39_H1.7801.00
153_G178_C1.7641.00
147_R150_A1.6681.00
191_A195_A1.6631.00
216_T221_R1.6381.00
91_D126_D1.6351.00
94_L117_V1.6311.00
137_V200_V1.6251.00
188_A192_S1.6051.00
83_I118_V1.5211.00
40_A118_V1.5061.00
25_E50_D1.5001.00
157_L166_P1.4811.00
103_T137_V1.4531.00
124_E214_V1.4341.00
104_R171_T1.4201.00
16_E46_A1.4191.00
10_Q217_D1.3780.99
24_T27_A1.3650.99
80_D113_D1.3630.99
136_V176_V1.3490.99
82_A115_F1.3450.99
134_V178_C1.3230.99
22_E116_V1.3050.99
52_S72_T1.3010.99
37_V40_A1.3000.99
12_R39_H1.2900.99
143_V197_P1.2750.99
151_L192_S1.2690.99
19_V40_A1.2590.99
121_P216_T1.2490.99
9_E12_R1.2360.99
160_A163_K1.2260.99
190_A194_S1.2190.99
19_V43_A1.2100.99
194_S197_P1.1980.98
74_L111_S1.1940.98
153_G180_F1.1920.98
100_A175_V1.1850.98
37_V55_A1.1840.98
62_R66_D1.1830.98
145_V149_E1.1800.98
38_A59_E1.1740.98
110_A197_P1.1710.98
187_E207_G1.1700.98
40_A44_L1.1610.98
119_A212_V1.1530.98
89_V214_V1.1470.98
213_Y220_V1.1430.98
45_G67_A1.1220.98
143_V147_R1.1140.98
86_A119_A1.1070.97
89_V124_E1.1030.97
121_P217_D1.1010.97
121_P124_E1.0990.97
33_T56_T1.0870.97
149_E154_T1.0850.97
88_Q125_S1.0770.97
58_F62_R1.0710.97
193_L199_V1.0710.97
54_V79_V1.0660.97
82_A109_A1.0560.97
27_A81_V1.0470.96
141_W145_V1.0460.96
25_E49_S1.0420.96
29_V51_V1.0350.96
155_A176_V1.0350.96
15_G19_V1.0350.96
216_T220_V1.0240.96
64_A71_V1.0210.96
183_I186_P1.0170.96
215_G220_V1.0150.96
102_H134_V1.0100.96
102_H175_V1.0090.96
38_A42_R0.9970.95
115_F208_M0.9950.95
39_H42_R0.9880.95
25_E48_A0.9880.95
56_T82_A0.9720.95
183_I189_V0.9720.95
114_R210_D0.9700.94
22_E211_A0.9640.94
38_A63_R0.9570.94
22_E81_V0.9460.94
112_A115_F0.9460.94
127_V184_E0.9390.93
22_E213_Y0.9340.93
157_L174_L0.9340.93
144_V196_V0.9320.93
168_V172_G0.9220.93
73_S76_A0.9170.93
145_V155_A0.9160.93
10_Q215_G0.9050.92
90_A93_V0.9050.92
141_W157_L0.9050.92
26_G50_D0.8980.92
15_G39_H0.8770.91
141_W176_V0.8670.90
127_V182_A0.8660.90
10_Q220_V0.8590.90
77_A146_D0.8580.90
41_I63_R0.8560.90
31_L60_S0.8530.90
160_A165_G0.8500.90
110_A147_R0.8480.89
17_A213_Y0.8440.89
39_H43_A0.8310.88
82_A108_V0.8240.88
167_V175_V0.8240.88
22_E114_R0.8240.88
10_Q216_T0.8230.88
168_V174_L0.8220.88
62_R65_V0.8190.88
12_R42_R0.8170.88
131_P179_D0.8140.87
42_R67_A0.8130.87
63_R67_A0.8110.87
132_V204_L0.8060.87
8_A12_R0.8050.87
136_V144_V0.8040.87
104_R139_D0.8000.86
88_Q130_V0.7990.86
27_A80_D0.7950.86
23_V81_V0.7870.86
146_D149_E0.7860.85
77_A111_S0.7860.85
193_L202_H0.7800.85
188_A191_A0.7790.85
159_D166_P0.7780.85
154_T179_D0.7780.85
97_G203_G0.7750.85
103_T169_T0.7670.84
141_W174_L0.7670.84
111_S143_V0.7610.84
63_R66_D0.7590.83
13_R215_G0.7590.83
134_V193_L0.7550.83
94_L209_A0.7500.83
72_T76_A0.7500.83
33_T37_V0.7490.83
11_K35_S0.7470.82
52_S70_T0.7460.82
137_V171_T0.7410.82
134_V199_V0.7400.82
14_A118_V0.7380.82
54_V74_L0.7370.82
146_D150_A0.7350.81
37_V41_I0.7330.81
155_A178_C0.7330.81
24_T114_R0.7290.81
33_T39_H0.7290.81
160_A164_D0.7280.81
45_G69_V0.7270.81
148_V153_G0.7240.80
124_E221_R0.7210.80
59_E62_R0.7180.80
42_R66_D0.7170.80
103_T200_V0.7170.80
22_E222_V0.7160.80
15_G43_A0.7110.79
93_V214_V0.7070.79
51_V70_T0.7070.79
213_Y222_V0.7050.79
218_D221_R0.7040.79
216_T219_G0.7030.79
148_V199_V0.7030.79
119_A124_E0.7020.78
97_G133_P0.6970.78
169_T175_V0.6960.78
11_K36_T0.6950.78
183_I204_L0.6900.77
189_V204_L0.6890.77
23_V47_E0.6870.77
133_P203_G0.6830.76
75_E141_W0.6790.76
156_T179_D0.6780.76
10_Q13_R0.6720.75
55_A73_S0.6700.75
187_E191_A0.6670.75
186_P189_V0.6640.74
132_V181_G0.6630.74
23_V26_G0.6550.73
125_S129_D0.6540.73
17_A222_V0.6530.73
134_V148_V0.6530.73
139_D144_V0.6480.73
53_G70_T0.6460.72
163_K167_V0.6450.72
202_H206_V0.6410.72
145_V157_L0.6380.72
10_Q219_G0.6380.72
24_T191_A0.6370.71
140_A144_V0.6310.71
194_S201_E0.6250.70
74_L143_V0.6240.70
45_G48_A0.6220.70
61_R71_V0.6180.69
24_T80_D0.6170.69
152_G155_A0.6160.69
88_Q128_V0.6150.69
55_A58_F0.6130.68
93_V209_A0.6080.68
31_L38_A0.6080.68
58_F104_R0.6080.68
136_V145_V0.6070.68
74_L108_V0.6060.68
13_R16_E0.6060.68
52_S55_A0.6030.67
142_P145_V0.6020.67
95_V101_A0.6000.67
92_G187_E0.6000.67
10_Q14_A0.5990.67
14_A215_G0.5960.66
51_V69_V0.5930.66
140_A143_V0.5860.65
138_P174_L0.5850.65
151_L193_L0.5830.65
55_A71_V0.5820.65
103_T201_E0.5810.64
148_V176_V0.5810.64
104_R170_D0.5790.64
23_V51_V0.5770.64
101_A203_G0.5730.63
33_T203_G0.5710.63
91_D124_E0.5710.63
37_V61_R0.5640.62
33_T175_V0.5620.62
72_T77_A0.5610.62
14_A39_H0.5610.62
86_A117_V0.5600.62
97_G101_A0.5580.61
26_G29_V0.5580.61
41_I67_A0.5570.61
134_V176_V0.5550.61
10_Q89_V0.5530.61
126_D182_A0.5510.60
19_V46_A0.5510.60
14_A37_V0.5510.60
31_L37_V0.5500.60
19_V22_E0.5490.60
95_V100_A0.5470.60
37_V45_G0.5470.60
107_Y197_P0.5460.60
217_D220_V0.5450.59
42_R46_A0.5430.59
144_V176_V0.5430.59
54_V72_T0.5420.59
58_F174_L0.5370.58
37_V59_E0.5350.58
12_R43_A0.5340.58
96_K99_G0.5320.58
95_V132_V0.5290.57
26_G51_V0.5290.57
127_V183_I0.5290.57
150_A182_A0.5280.57
40_A60_S0.5270.57
25_E156_T0.5260.57
90_A186_P0.5260.57
18_A109_A0.5260.57
173_S200_V0.5250.57
29_V43_A0.5250.57
47_E50_D0.5240.57
64_A139_D0.5190.56
190_A206_V0.5180.56
151_L180_F0.5180.56
109_A208_M0.5160.55
91_D127_V0.5150.55
159_D164_D0.5150.55
132_V183_I0.5130.55
45_G64_A0.5110.55
35_S164_D0.5100.55
86_A203_G0.5090.54
19_V47_E0.5080.54
31_L71_V0.5070.54
135_A173_S0.5070.54
138_P168_V0.5050.54
84_D105_E0.5040.54
33_T97_G0.5030.54
94_L119_A0.5030.54
147_R196_V0.5030.54
60_S63_R0.5030.54
55_A60_S0.5020.53
141_W155_A0.5010.53
16_E39_H0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2f8mA 2 0.9778 100 0.227 Contact Map
1xtzA 3 0.9644 100 0.231 Contact Map
1uj6A 2 0.9689 100 0.242 Contact Map
1lk5A 4 0.9778 100 0.244 Contact Map
3hheA 2 0.9644 100 0.251 Contact Map
4x84A 2 0.9689 100 0.253 Contact Map
4nmlA 2 0.9733 100 0.258 Contact Map
3uw1A 2 0.9822 100 0.259 Contact Map
3l7oA 2 0.9556 100 0.264 Contact Map
4gmkA 2 0.9733 100 0.267 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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