GREMLIN Database
Y2274 - UPF0213 protein VNG_2274C
UniProt: Q9HN31 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 77 (75)
Sequences: 1657 (1225)
Seq/√Len: 141.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_S57_E2.4941.00
63_Y67_Q2.4281.00
13_T37_Y2.4181.00
8_E45_T2.4161.00
50_E61_R2.3371.00
24_R28_E2.2451.00
6_V16_T2.2171.00
2_H18_Y2.1201.00
56_S60_R2.0621.00
18_Y59_M1.9731.00
61_R64_R1.9291.00
14_Y74_E1.8811.00
22_V49_T1.8221.00
11_D41_R1.7901.00
27_A31_A1.7741.00
4_V65_I1.7491.00
70_R74_E1.7031.00
69_S72_Q1.6031.00
26_V30_N1.6021.00
8_E47_R1.5861.00
30_N44_V1.5631.00
55_K59_M1.5281.00
8_E12_G1.5211.00
6_V65_I1.4531.00
16_T65_I1.4121.00
8_E74_E1.2821.00
26_V46_L1.2711.00
9_C37_Y1.2321.00
4_V16_T1.1981.00
68_L72_Q1.1881.00
60_R64_R1.1681.00
9_C38_T1.1510.99
52_F61_R1.0980.99
72_Q75_A1.0830.99
56_S59_M1.0380.99
19_T22_V1.0380.99
30_N42_T1.0190.99
22_V46_L1.0150.99
64_R68_L0.9630.98
48_H61_R0.9420.98
18_Y55_K0.9390.98
7_I26_V0.9350.98
11_D37_Y0.9350.98
6_V14_Y0.9290.98
7_I30_N0.9060.97
10_S42_T0.9040.97
16_T73_K0.8820.97
26_V44_V0.8800.97
38_T44_V0.8660.96
35_A39_R0.8490.96
28_E42_T0.8470.96
66_K73_K0.8470.96
28_E33_D0.8290.95
13_T41_R0.8130.95
9_C13_T0.8100.95
36_K39_R0.7900.94
7_I44_V0.7780.93
38_T41_R0.7670.93
71_A75_A0.7620.93
4_V52_F0.7400.91
8_E14_Y0.7380.91
3_H49_T0.7120.90
22_V26_V0.7010.89
71_A74_E0.6900.88
61_R76_L0.6880.88
30_N41_R0.6820.88
30_N43_P0.6790.88
9_C41_R0.6760.87
34_G39_R0.6480.85
10_S30_N0.6460.85
7_I38_T0.6420.85
32_G42_T0.6400.84
52_F57_E0.6320.84
21_D24_R0.6240.83
6_V48_H0.6170.82
11_D38_T0.6130.82
14_Y47_R0.6130.82
59_M66_K0.6060.81
28_E34_G0.6050.81
65_I76_L0.6030.81
19_T24_R0.5980.80
20_T24_R0.5970.80
4_V18_Y0.5950.80
2_H66_K0.5890.79
3_H22_V0.5880.79
18_Y28_E0.5850.79
8_E70_R0.5780.78
2_H59_M0.5760.78
28_E55_K0.5740.77
26_V42_T0.5740.77
50_E64_R0.5700.77
4_V48_H0.5690.77
20_T28_E0.5670.77
35_A40_G0.5620.76
51_S75_A0.5580.75
23_Q51_S0.5560.75
24_R60_R0.5450.74
36_K48_H0.5430.73
63_Y66_K0.5380.73
27_A71_A0.5360.72
32_G59_M0.5320.72
23_Q49_T0.5280.71
36_K60_R0.5270.71
3_H46_L0.5250.71
20_T66_K0.5250.71
27_A75_A0.5220.70
23_Q31_A0.5190.70
37_Y41_R0.5190.70
64_R75_A0.5170.70
53_D57_E0.5120.69
18_Y66_K0.5020.68
14_Y70_R0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zg2A 1 1 100 0.184 Contact Map
1ywlA 1 1 100 0.185 Contact Map
4xlgA 1 0.8701 100 0.254 Contact Map
1mk0A 1 0.974 97.2 0.787 Contact Map
1yd0A 1 0.961 96.1 0.814 Contact Map
1yd6A 5 1 95.5 0.823 Contact Map
2wshA 4 0.974 55.4 0.893 Contact Map
4gbsA 1 0.4545 16.8 0.919 Contact Map
3cqlA 1 0.8442 16.4 0.92 Contact Map
3w3eA 1 0.8182 15.7 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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