GREMLIN Database
Q9HN26 - Uncharacterized protein
UniProt: Q9HN26 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 327 (299)
Sequences: 2136 (1279)
Seq/√Len: 74.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_A72_A3.5531.00
254_R257_D3.4431.00
181_I211_Y3.3191.00
180_P207_A3.2621.00
108_R112_T3.1321.00
176_D210_H3.0961.00
65_A70_E3.0491.00
202_D302_T2.8631.00
105_T109_D2.7481.00
162_Y167_R2.7011.00
114_A134_T2.6801.00
23_A199_N2.6651.00
102_F133_D2.5471.00
162_Y171_D2.5221.00
175_E179_D2.5121.00
173_L177_I2.4611.00
107_L126_V2.4341.00
219_R267_E2.4101.00
292_G298_R2.4051.00
61_L75_V2.3771.00
42_A131_D2.3631.00
165_G225_V2.3191.00
63_V144_M2.3021.00
198_D302_T2.3021.00
263_P313_D2.2701.00
179_D187_R2.2671.00
176_D207_A2.2281.00
52_Y279_Y2.1991.00
63_V231_V2.0531.00
211_Y261_L2.0411.00
50_V61_L1.9981.00
253_K258_Y1.9871.00
267_E271_L1.9791.00
65_A276_D1.9621.00
231_V268_L1.9551.00
181_I207_A1.9461.00
262_W265_L1.9241.00
289_R298_R1.9011.00
63_V161_L1.9001.00
181_I204_L1.8781.00
113_E133_D1.8521.00
164_E167_R1.7971.00
53_A286_H1.7861.00
255_I265_L1.7841.00
234_F278_L1.7591.00
145_R228_E1.7391.00
216_A260_N1.7341.00
180_P203_D1.6931.00
37_D153_D1.6861.00
34_W146_M1.6791.00
173_L214_V1.6721.00
173_L222_A1.6621.00
256_S262_W1.6541.00
148_D160_D1.6471.00
50_V77_V1.6261.00
188_A201_V1.6231.00
193_S196_A1.6040.99
281_E285_Q1.5800.99
47_H76_S1.5670.99
246_T288_Y1.5500.99
201_V252_R1.5470.99
104_G113_E1.5420.99
187_R203_D1.5390.99
237_L264_Y1.5360.99
285_Q289_R1.4920.99
104_G110_V1.4810.99
212_D259_D1.4310.99
286_H291_H1.4270.99
247_H291_H1.4250.99
81_V285_Q1.4190.99
39_V132_A1.4190.99
102_F113_E1.4120.99
36_G40_P1.3950.98
176_D180_P1.3900.98
196_A200_A1.3870.98
226_L268_L1.3770.98
79_D90_D1.3730.98
169_E172_R1.3680.98
262_W266_R1.3670.98
80_P285_Q1.3610.98
209_A253_K1.3470.98
52_Y61_L1.3370.98
76_S100_H1.3270.98
58_H277_T1.3250.98
26_R183_N1.3180.98
97_T100_H1.3160.98
137_N146_M1.2940.98
226_L271_L1.2850.97
76_S97_T1.2830.97
17_E20_D1.2760.97
174_I232_A1.2750.97
243_V247_H1.2520.97
265_L308_F1.2440.97
67_L152_D1.2400.97
36_G41_P1.2360.97
238_Y265_L1.2340.97
242_E308_F1.2340.97
47_H130_T1.2260.97
267_E270_Q1.2210.96
207_A210_H1.2200.96
156_A159_V1.2140.96
161_L231_V1.2060.96
169_E214_V1.2040.96
85_Q106_H1.2020.96
270_Q312_H1.2020.96
212_D260_N1.1920.96
214_V222_A1.1870.96
274_V278_L1.1650.95
58_H235_T1.1630.95
52_Y77_V1.1520.95
226_L231_V1.1500.95
126_V135_I1.1470.95
286_H290_S1.1440.95
252_R258_Y1.1440.95
180_P210_H1.1420.95
284_K303_G1.1400.95
58_H278_L1.1330.95
38_D41_P1.1280.95
74_S100_H1.1260.94
252_R302_T1.1250.94
247_H286_H1.1170.94
81_V289_R1.1020.94
251_N303_G1.1000.94
213_D217_E1.0930.94
173_L211_Y1.0910.93
275_A309_F1.0910.93
85_Q88_T1.0900.93
155_A159_V1.0900.93
219_R314_R1.0860.93
85_Q108_R1.0830.93
62_L231_V1.0820.93
17_E21_D1.0540.92
209_A258_Y1.0490.92
262_W308_F1.0450.92
238_Y308_F1.0440.92
53_A291_H1.0380.92
60_T143_I1.0370.92
102_F110_V1.0370.92
213_D216_A1.0230.91
53_A243_V1.0100.91
245_H254_R1.0100.91
267_E314_R1.0080.90
219_R312_H1.0040.90
201_V253_K1.0030.90
238_Y280_M1.0020.90
246_T297_K1.0020.90
188_A204_L0.9980.90
37_D150_A0.9960.90
268_L274_V0.9950.90
288_Y300_V0.9930.90
154_H157_R0.9860.89
243_V286_H0.9840.89
72_A155_A0.9830.89
255_I258_Y0.9810.89
263_P267_E0.9800.89
212_D263_P0.9800.89
33_H39_V0.9790.89
56_W183_N0.9740.89
49_Y102_F0.9740.89
152_D159_V0.9720.89
16_N20_D0.9680.89
19_S23_A0.9640.88
31_F114_A0.9570.88
268_L271_L0.9560.88
243_V291_H0.9530.88
179_D203_D0.9500.88
252_R305_N0.9490.88
170_V174_I0.9420.87
43_A71_D0.9360.87
167_R171_D0.9350.87
222_A229_A0.9310.87
187_R200_A0.9240.86
93_K96_C0.9230.86
289_R292_G0.9200.86
247_H294_L0.9190.86
74_S130_T0.9180.86
49_Y99_D0.9170.86
73_I147_L0.9160.86
155_A158_D0.9140.86
68_G156_A0.9120.85
53_A290_S0.8980.85
101_V104_G0.8960.84
53_A247_H0.8950.84
29_T141_E0.8940.84
231_V271_L0.8940.84
168_D172_R0.8820.83
211_Y214_V0.8790.83
67_L148_D0.8790.83
162_Y170_V0.8780.83
40_P132_A0.8760.83
234_F274_V0.8740.83
291_H294_L0.8720.83
47_H74_S0.8650.82
62_L235_T0.8640.82
110_V128_Y0.8620.82
201_V302_T0.8600.82
273_G276_D0.8580.82
238_Y278_L0.8570.82
19_S25_E0.8560.82
206_E210_H0.8550.81
251_N284_K0.8540.81
79_D96_C0.8540.81
219_R263_P0.8520.81
289_R300_V0.8510.81
207_A211_Y0.8470.81
263_P314_R0.8450.81
16_N19_S0.8440.81
74_S110_V0.8440.81
62_L268_L0.8440.81
51_S286_H0.8440.81
249_K295_N0.8430.81
26_R56_W0.8410.80
173_L210_H0.8380.80
220_Y268_L0.8360.80
256_S310_A0.8350.80
273_G278_L0.8320.80
89_F107_L0.8220.79
72_A154_H0.8210.79
263_P312_H0.8200.79
177_I229_A0.8170.78
100_H104_G0.8100.78
180_P211_Y0.8060.78
60_T147_L0.8000.77
220_Y267_E0.8000.77
114_A128_Y0.7980.77
31_F134_T0.7980.77
91_P98_P0.7950.77
36_G150_A0.7930.76
44_G74_S0.7920.76
198_D201_V0.7920.76
178_Y183_N0.7910.76
202_D252_R0.7910.76
104_G109_D0.7900.76
77_V282_H0.7900.76
173_L221_L0.7880.76
168_D171_D0.7850.76
49_Y76_S0.7850.76
180_P206_E0.7850.76
182_N236_T0.7840.76
43_A154_H0.7810.75
27_D119_T0.7810.75
279_Y282_H0.7790.75
262_W306_P0.7760.75
107_L110_V0.7720.74
234_F238_Y0.7720.74
40_P131_D0.7710.74
270_Q314_R0.7710.74
272_P276_D0.7700.74
101_V113_E0.7690.74
267_E312_H0.7690.74
16_N21_D0.7680.74
17_E27_D0.7620.73
34_W150_A0.7560.73
21_D25_E0.7450.72
63_V268_L0.7430.72
140_S178_Y0.7420.71
88_T106_H0.7420.71
91_P94_P0.7420.71
210_H214_V0.7420.71
96_C100_H0.7410.71
148_D152_D0.7380.71
243_V283_V0.7380.71
152_D155_A0.7340.71
27_D30_S0.7330.71
62_L274_V0.7290.70
32_R142_E0.7260.70
75_V97_T0.7240.70
219_R270_Q0.7240.70
294_L297_K0.7240.70
57_A124_V0.7190.69
34_W137_N0.7170.69
288_Y297_K0.7160.69
141_E232_A0.7150.69
172_R176_D0.7120.68
18_H21_D0.7100.68
83_Y289_R0.7090.68
60_T64_R0.7090.68
280_M308_F0.7080.68
214_V218_Q0.7080.68
82_R290_S0.7050.68
208_L255_I0.7040.67
186_Y190_F0.7010.67
89_F99_D0.7000.67
284_K301_P0.6980.67
310_A313_D0.6980.67
79_D88_T0.6970.67
260_N263_P0.6940.66
169_E218_Q0.6930.66
72_A156_A0.6880.66
30_S118_Y0.6880.66
58_H62_L0.6860.65
154_H158_D0.6850.65
186_Y244_Y0.6810.65
112_T122_V0.6810.65
48_L60_T0.6790.65
280_M283_V0.6790.65
160_D167_R0.6760.64
83_Y286_H0.6750.64
263_P266_R0.6740.64
255_I262_W0.6740.64
253_K257_D0.6730.64
204_L250_C0.6690.64
30_S115_D0.6690.64
22_G196_A0.6650.63
198_D284_K0.6640.63
139_E142_E0.6620.63
17_E293_H0.6610.63
199_N203_D0.6600.62
166_Y169_E0.6600.62
141_E174_I0.6580.62
56_W178_Y0.6560.62
42_A45_R0.6540.62
35_V41_P0.6490.61
284_K288_Y0.6490.61
246_T249_K0.6480.61
102_F128_Y0.6470.61
166_Y227_T0.6450.61
39_V146_M0.6450.61
248_F287_Y0.6450.61
238_Y242_E0.6420.60
39_V42_A0.6410.60
112_T119_T0.6410.60
228_E232_A0.6400.60
16_N293_H0.6320.59
219_R224_D0.6320.59
242_E306_P0.6320.59
263_P270_Q0.6310.59
144_M232_A0.6310.59
35_V39_V0.6290.59
194_Q198_D0.6280.59
266_R310_A0.6280.59
205_F240_F0.6260.58
229_A233_M0.6230.58
308_F313_D0.6230.58
107_L122_V0.6200.58
25_E28_T0.6200.58
98_P104_G0.6190.58
311_P314_R0.6180.57
152_D157_R0.6140.57
174_I228_E0.6140.57
142_E145_R0.6130.57
307_A310_A0.6070.56
27_D115_D0.6070.56
20_D25_E0.6060.56
218_Q267_E0.6030.56
23_A187_R0.6010.55
152_D158_D0.6000.55
172_R175_E0.5980.55
265_L306_P0.5970.55
51_S78_V0.5960.55
73_I127_L0.5940.54
58_H234_F0.5940.54
49_Y78_V0.5930.54
44_G130_T0.5930.54
189_G287_Y0.5920.54
108_R122_V0.5910.54
174_I229_A0.5900.54
85_Q109_D0.5900.54
288_Y301_P0.5900.54
80_P289_R0.5870.54
144_M148_D0.5860.53
144_M229_A0.5860.53
39_V46_Y0.5850.53
205_F251_N0.5850.53
99_D102_F0.5840.53
101_V133_D0.5820.53
68_G155_A0.5820.53
184_G200_A0.5770.52
44_G71_D0.5760.52
264_Y268_L0.5760.52
177_I214_V0.5750.52
246_T251_N0.5750.52
245_H251_N0.5730.52
243_V290_S0.5720.52
176_D181_I0.5720.52
177_I222_A0.5710.52
18_H25_E0.5710.52
68_G159_V0.5710.52
110_V113_E0.5700.52
83_Y88_T0.5700.52
50_V75_V0.5690.51
24_F27_D0.5680.51
185_V189_G0.5680.51
194_Q197_Y0.5660.51
152_D160_D0.5650.51
192_D297_K0.5630.51
27_D118_Y0.5630.51
113_E134_T0.5620.51
251_N304_P0.5620.51
169_E222_A0.5610.50
148_D174_I0.5610.50
210_H213_D0.5610.50
79_D92_E0.5590.50
231_V274_V0.5590.50
139_E144_M0.5590.50
260_N313_D0.5570.50
246_T300_V0.5560.50
152_D156_A0.5550.50
246_T303_G0.5540.50
195_R199_N0.5530.49
242_E280_M0.5520.49
44_G72_A0.5510.49
246_T284_K0.5500.49
95_G99_D0.5500.49
306_P309_F0.5480.49
202_D206_E0.5470.49
91_P96_C0.5460.49
128_Y134_T0.5460.49
33_H137_N0.5440.48
170_V222_A0.5440.48
70_E74_S0.5420.48
237_L261_L0.5420.48
251_N301_P0.5420.48
231_V235_T0.5390.48
29_T137_N0.5360.47
83_Y290_S0.5350.47
185_V248_F0.5320.47
126_V143_I0.5310.47
146_M150_A0.5300.47
190_F244_Y0.5300.47
270_Q308_F0.5270.46
92_E98_P0.5270.46
184_G190_F0.5260.46
186_Y248_F0.5250.46
184_G187_R0.5240.46
201_V305_N0.5230.46
47_H102_F0.5200.45
269_C278_L0.5200.45
244_Y248_F0.5180.45
123_T196_A0.5180.45
215_L221_L0.5170.45
247_H290_S0.5130.44
72_A147_L0.5130.44
238_Y283_V0.5130.44
173_L176_D0.5120.44
270_Q311_P0.5090.44
220_Y312_H0.5080.44
33_H36_G0.5070.44
189_G248_F0.5070.44
150_A153_D0.5050.43
189_G194_Q0.5050.43
41_P132_A0.5040.43
140_S144_M0.5040.43
218_Q313_D0.5020.43
182_N232_A0.5020.43
64_R70_E0.5010.43
51_S77_V0.5010.43
82_R86_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g0iA 2 0.9664 100 0.335 Contact Map
3m1gA 2 0.7982 100 0.391 Contact Map
4ptsA 2 0.945 100 0.413 Contact Map
3ppuA 2 0.9297 100 0.428 Contact Map
4ussA 2 0.8899 100 0.602 Contact Map
4fquA 2 0.9541 100 0.617 Contact Map
2yv9A 2 0.7706 100 0.684 Contact Map
1b8xA 2 0.7278 100 0.735 Contact Map
4bl7A 1 0.6116 100 0.801 Contact Map
4puaA 2 0.737 99.9 0.817 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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