Q9HN26 - HALSA - GREMLIN Contacts

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Q9HN26 - Uncharacterized protein

UniProt:	Q9HN26	Sequences: MGRMIDGDWRTEADMNEHSDDGAFERDTTSFRHWVGDDVPPAAGRYHLYVSYACPWAHRTLLVRALLGLEDAISVSVVDPVRYDQGWTFDPEKPGCTPDHVFGGTHLRDVYTEADPEYTGRVTVPVLYDTDADTIVNNESEEIMRMLDVAFDDHAARDVDLYPEGYRDEVDRLIEDIYDPINNGVYRAGFADSQRAYDNAVDDLFEALAHYDDVLAEQRYLAGDVLTEADVAMFTTLYRFDEVYHTHFKCNRKRISDYDNLWPYLRELCQLPGVADTLYMEHVKQHYYRSHGHLNPKRLVPTGPNPAFFAPHDRDQLPGGPPAALNQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	327 (299)
Sequences:	2136 (1279)
Seq/√Len:	74.0

ECOLI - YQJG
HALSA - Q9HN26

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_A	72_A	3.553	1.00
254_R	257_D	3.443	1.00
181_I	211_Y	3.319	1.00
180_P	207_A	3.262	1.00
108_R	112_T	3.132	1.00
176_D	210_H	3.096	1.00
65_A	70_E	3.049	1.00
202_D	302_T	2.863	1.00
105_T	109_D	2.748	1.00
162_Y	167_R	2.701	1.00
114_A	134_T	2.680	1.00
23_A	199_N	2.665	1.00
102_F	133_D	2.547	1.00
162_Y	171_D	2.522	1.00
175_E	179_D	2.512	1.00
173_L	177_I	2.461	1.00
107_L	126_V	2.434	1.00
219_R	267_E	2.410	1.00
292_G	298_R	2.405	1.00
61_L	75_V	2.377	1.00
42_A	131_D	2.363	1.00
165_G	225_V	2.319	1.00
63_V	144_M	2.302	1.00
198_D	302_T	2.302	1.00
263_P	313_D	2.270	1.00
179_D	187_R	2.267	1.00
176_D	207_A	2.228	1.00
52_Y	279_Y	2.199	1.00
63_V	231_V	2.053	1.00
211_Y	261_L	2.041	1.00
50_V	61_L	1.998	1.00
253_K	258_Y	1.987	1.00
267_E	271_L	1.979	1.00
65_A	276_D	1.962	1.00
231_V	268_L	1.955	1.00
181_I	207_A	1.946	1.00
262_W	265_L	1.924	1.00
289_R	298_R	1.901	1.00
63_V	161_L	1.900	1.00
181_I	204_L	1.878	1.00
113_E	133_D	1.852	1.00
164_E	167_R	1.797	1.00
53_A	286_H	1.786	1.00
255_I	265_L	1.784	1.00
234_F	278_L	1.759	1.00
145_R	228_E	1.739	1.00
216_A	260_N	1.734	1.00
180_P	203_D	1.693	1.00
37_D	153_D	1.686	1.00
34_W	146_M	1.679	1.00
173_L	214_V	1.672	1.00
173_L	222_A	1.662	1.00
256_S	262_W	1.654	1.00
148_D	160_D	1.647	1.00
50_V	77_V	1.626	1.00
188_A	201_V	1.623	1.00
193_S	196_A	1.604	0.99
281_E	285_Q	1.580	0.99
47_H	76_S	1.567	0.99
246_T	288_Y	1.550	0.99
201_V	252_R	1.547	0.99
104_G	113_E	1.542	0.99
187_R	203_D	1.539	0.99
237_L	264_Y	1.536	0.99
285_Q	289_R	1.492	0.99
104_G	110_V	1.481	0.99
212_D	259_D	1.431	0.99
286_H	291_H	1.427	0.99
247_H	291_H	1.425	0.99
81_V	285_Q	1.419	0.99
39_V	132_A	1.419	0.99
102_F	113_E	1.412	0.99
36_G	40_P	1.395	0.98
176_D	180_P	1.390	0.98
196_A	200_A	1.387	0.98
226_L	268_L	1.377	0.98
79_D	90_D	1.373	0.98
169_E	172_R	1.368	0.98
262_W	266_R	1.367	0.98
80_P	285_Q	1.361	0.98
209_A	253_K	1.347	0.98
52_Y	61_L	1.337	0.98
76_S	100_H	1.327	0.98
58_H	277_T	1.325	0.98
26_R	183_N	1.318	0.98
97_T	100_H	1.316	0.98
137_N	146_M	1.294	0.98
226_L	271_L	1.285	0.97
76_S	97_T	1.283	0.97
17_E	20_D	1.276	0.97
174_I	232_A	1.275	0.97
243_V	247_H	1.252	0.97
265_L	308_F	1.244	0.97
67_L	152_D	1.240	0.97
36_G	41_P	1.236	0.97
238_Y	265_L	1.234	0.97
242_E	308_F	1.234	0.97
47_H	130_T	1.226	0.97
267_E	270_Q	1.221	0.96
207_A	210_H	1.220	0.96
156_A	159_V	1.214	0.96
161_L	231_V	1.206	0.96
169_E	214_V	1.204	0.96
85_Q	106_H	1.202	0.96
270_Q	312_H	1.202	0.96
212_D	260_N	1.192	0.96
214_V	222_A	1.187	0.96
274_V	278_L	1.165	0.95
58_H	235_T	1.163	0.95
52_Y	77_V	1.152	0.95
226_L	231_V	1.150	0.95
126_V	135_I	1.147	0.95
286_H	290_S	1.144	0.95
252_R	258_Y	1.144	0.95
180_P	210_H	1.142	0.95
284_K	303_G	1.140	0.95
58_H	278_L	1.133	0.95
38_D	41_P	1.128	0.95
74_S	100_H	1.126	0.94
252_R	302_T	1.125	0.94
247_H	286_H	1.117	0.94
81_V	289_R	1.102	0.94
251_N	303_G	1.100	0.94
213_D	217_E	1.093	0.94
173_L	211_Y	1.091	0.93
275_A	309_F	1.091	0.93
85_Q	88_T	1.090	0.93
155_A	159_V	1.090	0.93
219_R	314_R	1.086	0.93
85_Q	108_R	1.083	0.93
62_L	231_V	1.082	0.93
17_E	21_D	1.054	0.92
209_A	258_Y	1.049	0.92
262_W	308_F	1.045	0.92
238_Y	308_F	1.044	0.92
53_A	291_H	1.038	0.92
60_T	143_I	1.037	0.92
102_F	110_V	1.037	0.92
213_D	216_A	1.023	0.91
53_A	243_V	1.010	0.91
245_H	254_R	1.010	0.91
267_E	314_R	1.008	0.90
219_R	312_H	1.004	0.90
201_V	253_K	1.003	0.90
238_Y	280_M	1.002	0.90
246_T	297_K	1.002	0.90
188_A	204_L	0.998	0.90
37_D	150_A	0.996	0.90
268_L	274_V	0.995	0.90
288_Y	300_V	0.993	0.90
154_H	157_R	0.986	0.89
243_V	286_H	0.984	0.89
72_A	155_A	0.983	0.89
255_I	258_Y	0.981	0.89
263_P	267_E	0.980	0.89
212_D	263_P	0.980	0.89
33_H	39_V	0.979	0.89
56_W	183_N	0.974	0.89
49_Y	102_F	0.974	0.89
152_D	159_V	0.972	0.89
16_N	20_D	0.968	0.89
19_S	23_A	0.964	0.88
31_F	114_A	0.957	0.88
268_L	271_L	0.956	0.88
243_V	291_H	0.953	0.88
179_D	203_D	0.950	0.88
252_R	305_N	0.949	0.88
170_V	174_I	0.942	0.87
43_A	71_D	0.936	0.87
167_R	171_D	0.935	0.87
222_A	229_A	0.931	0.87
187_R	200_A	0.924	0.86
93_K	96_C	0.923	0.86
289_R	292_G	0.920	0.86
247_H	294_L	0.919	0.86
74_S	130_T	0.918	0.86
49_Y	99_D	0.917	0.86
73_I	147_L	0.916	0.86
155_A	158_D	0.914	0.86
68_G	156_A	0.912	0.85
53_A	290_S	0.898	0.85
101_V	104_G	0.896	0.84
53_A	247_H	0.895	0.84
29_T	141_E	0.894	0.84
231_V	271_L	0.894	0.84
168_D	172_R	0.882	0.83
211_Y	214_V	0.879	0.83
67_L	148_D	0.879	0.83
162_Y	170_V	0.878	0.83
40_P	132_A	0.876	0.83
234_F	274_V	0.874	0.83
291_H	294_L	0.872	0.83
47_H	74_S	0.865	0.82
62_L	235_T	0.864	0.82
110_V	128_Y	0.862	0.82
201_V	302_T	0.860	0.82
273_G	276_D	0.858	0.82
238_Y	278_L	0.857	0.82
19_S	25_E	0.856	0.82
206_E	210_H	0.855	0.81
251_N	284_K	0.854	0.81
79_D	96_C	0.854	0.81
219_R	263_P	0.852	0.81
289_R	300_V	0.851	0.81
207_A	211_Y	0.847	0.81
263_P	314_R	0.845	0.81
16_N	19_S	0.844	0.81
74_S	110_V	0.844	0.81
62_L	268_L	0.844	0.81
51_S	286_H	0.844	0.81
249_K	295_N	0.843	0.81
26_R	56_W	0.841	0.80
173_L	210_H	0.838	0.80
220_Y	268_L	0.836	0.80
256_S	310_A	0.835	0.80
273_G	278_L	0.832	0.80
89_F	107_L	0.822	0.79
72_A	154_H	0.821	0.79
263_P	312_H	0.820	0.79
177_I	229_A	0.817	0.78
100_H	104_G	0.810	0.78
180_P	211_Y	0.806	0.78
60_T	147_L	0.800	0.77
220_Y	267_E	0.800	0.77
114_A	128_Y	0.798	0.77
31_F	134_T	0.798	0.77
91_P	98_P	0.795	0.77
36_G	150_A	0.793	0.76
44_G	74_S	0.792	0.76
198_D	201_V	0.792	0.76
178_Y	183_N	0.791	0.76
202_D	252_R	0.791	0.76
104_G	109_D	0.790	0.76
77_V	282_H	0.790	0.76
173_L	221_L	0.788	0.76
168_D	171_D	0.785	0.76
49_Y	76_S	0.785	0.76
180_P	206_E	0.785	0.76
182_N	236_T	0.784	0.76
43_A	154_H	0.781	0.75
27_D	119_T	0.781	0.75
279_Y	282_H	0.779	0.75
262_W	306_P	0.776	0.75
107_L	110_V	0.772	0.74
234_F	238_Y	0.772	0.74
40_P	131_D	0.771	0.74
270_Q	314_R	0.771	0.74
272_P	276_D	0.770	0.74
101_V	113_E	0.769	0.74
267_E	312_H	0.769	0.74
16_N	21_D	0.768	0.74
17_E	27_D	0.762	0.73
34_W	150_A	0.756	0.73
21_D	25_E	0.745	0.72
63_V	268_L	0.743	0.72
140_S	178_Y	0.742	0.71
88_T	106_H	0.742	0.71
91_P	94_P	0.742	0.71
210_H	214_V	0.742	0.71
96_C	100_H	0.741	0.71
148_D	152_D	0.738	0.71
243_V	283_V	0.738	0.71
152_D	155_A	0.734	0.71
27_D	30_S	0.733	0.71
62_L	274_V	0.729	0.70
32_R	142_E	0.726	0.70
75_V	97_T	0.724	0.70
219_R	270_Q	0.724	0.70
294_L	297_K	0.724	0.70
57_A	124_V	0.719	0.69
34_W	137_N	0.717	0.69
288_Y	297_K	0.716	0.69
141_E	232_A	0.715	0.69
172_R	176_D	0.712	0.68
18_H	21_D	0.710	0.68
83_Y	289_R	0.709	0.68
60_T	64_R	0.709	0.68
280_M	308_F	0.708	0.68
214_V	218_Q	0.708	0.68
82_R	290_S	0.705	0.68
208_L	255_I	0.704	0.67
186_Y	190_F	0.701	0.67
89_F	99_D	0.700	0.67
284_K	301_P	0.698	0.67
310_A	313_D	0.698	0.67
79_D	88_T	0.697	0.67
260_N	263_P	0.694	0.66
169_E	218_Q	0.693	0.66
72_A	156_A	0.688	0.66
30_S	118_Y	0.688	0.66
58_H	62_L	0.686	0.65
154_H	158_D	0.685	0.65
186_Y	244_Y	0.681	0.65
112_T	122_V	0.681	0.65
48_L	60_T	0.679	0.65
280_M	283_V	0.679	0.65
160_D	167_R	0.676	0.64
83_Y	286_H	0.675	0.64
263_P	266_R	0.674	0.64
255_I	262_W	0.674	0.64
253_K	257_D	0.673	0.64
204_L	250_C	0.669	0.64
30_S	115_D	0.669	0.64
22_G	196_A	0.665	0.63
198_D	284_K	0.664	0.63
139_E	142_E	0.662	0.63
17_E	293_H	0.661	0.63
199_N	203_D	0.660	0.62
166_Y	169_E	0.660	0.62
141_E	174_I	0.658	0.62
56_W	178_Y	0.656	0.62
42_A	45_R	0.654	0.62
35_V	41_P	0.649	0.61
284_K	288_Y	0.649	0.61
246_T	249_K	0.648	0.61
102_F	128_Y	0.647	0.61
166_Y	227_T	0.645	0.61
39_V	146_M	0.645	0.61
248_F	287_Y	0.645	0.61
238_Y	242_E	0.642	0.60
39_V	42_A	0.641	0.60
112_T	119_T	0.641	0.60
228_E	232_A	0.640	0.60
16_N	293_H	0.632	0.59
219_R	224_D	0.632	0.59
242_E	306_P	0.632	0.59
263_P	270_Q	0.631	0.59
144_M	232_A	0.631	0.59
35_V	39_V	0.629	0.59
194_Q	198_D	0.628	0.59
266_R	310_A	0.628	0.59
205_F	240_F	0.626	0.58
229_A	233_M	0.623	0.58
308_F	313_D	0.623	0.58
107_L	122_V	0.620	0.58
25_E	28_T	0.620	0.58
98_P	104_G	0.619	0.58
311_P	314_R	0.618	0.57
152_D	157_R	0.614	0.57
174_I	228_E	0.614	0.57
142_E	145_R	0.613	0.57
307_A	310_A	0.607	0.56
27_D	115_D	0.607	0.56
20_D	25_E	0.606	0.56
218_Q	267_E	0.603	0.56
23_A	187_R	0.601	0.55
152_D	158_D	0.600	0.55
172_R	175_E	0.598	0.55
265_L	306_P	0.597	0.55
51_S	78_V	0.596	0.55
73_I	127_L	0.594	0.54
58_H	234_F	0.594	0.54
49_Y	78_V	0.593	0.54
44_G	130_T	0.593	0.54
189_G	287_Y	0.592	0.54
108_R	122_V	0.591	0.54
174_I	229_A	0.590	0.54
85_Q	109_D	0.590	0.54
288_Y	301_P	0.590	0.54
80_P	289_R	0.587	0.54
144_M	148_D	0.586	0.53
144_M	229_A	0.586	0.53
39_V	46_Y	0.585	0.53
205_F	251_N	0.585	0.53
99_D	102_F	0.584	0.53
101_V	133_D	0.582	0.53
68_G	155_A	0.582	0.53
184_G	200_A	0.577	0.52
44_G	71_D	0.576	0.52
264_Y	268_L	0.576	0.52
177_I	214_V	0.575	0.52
246_T	251_N	0.575	0.52
245_H	251_N	0.573	0.52
243_V	290_S	0.572	0.52
176_D	181_I	0.572	0.52
177_I	222_A	0.571	0.52
18_H	25_E	0.571	0.52
68_G	159_V	0.571	0.52
110_V	113_E	0.570	0.52
83_Y	88_T	0.570	0.52
50_V	75_V	0.569	0.51
24_F	27_D	0.568	0.51
185_V	189_G	0.568	0.51
194_Q	197_Y	0.566	0.51
152_D	160_D	0.565	0.51
192_D	297_K	0.563	0.51
27_D	118_Y	0.563	0.51
113_E	134_T	0.562	0.51
251_N	304_P	0.562	0.51
169_E	222_A	0.561	0.50
148_D	174_I	0.561	0.50
210_H	213_D	0.561	0.50
79_D	92_E	0.559	0.50
231_V	274_V	0.559	0.50
139_E	144_M	0.559	0.50
260_N	313_D	0.557	0.50
246_T	300_V	0.556	0.50
152_D	156_A	0.555	0.50
246_T	303_G	0.554	0.50
195_R	199_N	0.553	0.49
242_E	280_M	0.552	0.49
44_G	72_A	0.551	0.49
246_T	284_K	0.550	0.49
95_G	99_D	0.550	0.49
306_P	309_F	0.548	0.49
202_D	206_E	0.547	0.49
91_P	96_C	0.546	0.49
128_Y	134_T	0.546	0.49
33_H	137_N	0.544	0.48
170_V	222_A	0.544	0.48
70_E	74_S	0.542	0.48
237_L	261_L	0.542	0.48
251_N	301_P	0.542	0.48
231_V	235_T	0.539	0.48
29_T	137_N	0.536	0.47
83_Y	290_S	0.535	0.47
185_V	248_F	0.532	0.47
126_V	143_I	0.531	0.47
146_M	150_A	0.530	0.47
190_F	244_Y	0.530	0.47
270_Q	308_F	0.527	0.46
92_E	98_P	0.527	0.46
184_G	190_F	0.526	0.46
186_Y	248_F	0.525	0.46
184_G	187_R	0.524	0.46
201_V	305_N	0.523	0.46
47_H	102_F	0.520	0.45
269_C	278_L	0.520	0.45
244_Y	248_F	0.518	0.45
123_T	196_A	0.518	0.45
215_L	221_L	0.517	0.45
247_H	290_S	0.513	0.44
72_A	147_L	0.513	0.44
238_Y	283_V	0.513	0.44
173_L	176_D	0.512	0.44
270_Q	311_P	0.509	0.44
220_Y	312_H	0.508	0.44
33_H	36_G	0.507	0.44
189_G	248_F	0.507	0.44
150_A	153_D	0.505	0.43
189_G	194_Q	0.505	0.43
41_P	132_A	0.504	0.43
140_S	144_M	0.504	0.43
218_Q	313_D	0.502	0.43
182_N	232_A	0.502	0.43
64_R	70_E	0.501	0.43
51_S	77_V	0.501	0.43
82_R	86_G	0.500	0.43

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4g0iA	2	0.9664	100	0.335	Contact Map
3m1gA	2	0.7982	100	0.391	Contact Map
4ptsA	2	0.945	100	0.413	Contact Map
3ppuA	2	0.9297	100	0.428	Contact Map
4ussA	2	0.8899	100	0.602	Contact Map
4fquA	2	0.9541	100	0.617	Contact Map
2yv9A	2	0.7706	100	0.684	Contact Map
1b8xA	2	0.7278	100	0.735	Contact Map
4bl7A	1	0.6116	100	0.801	Contact Map
4puaA	2	0.737	99.9	0.817	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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