Q9HN25 - HALSA - GREMLIN Contacts

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Q9HN25 - Uncharacterized protein

UniProt:	Q9HN25	Sequences: MRPMPVGTRASGLAVGAGFDSTGYLTGDTETQAMPHRRRVLTATAAAASLSLAGCLSNDGGGDSQASSSTDAETTGDAASLADHPAAAGLDAQPVLGPDPLSADTTVVVFSDPSCPHCQDFEADVFPKLNANFIEPGSLSYVYRNMAFVAPWATGAVHAFEETYERNTDAFWALREWVYSNPDQVADDPGDAIKSYLASETDIEDPEAVRTAAAERTQSAQVSQDETAAKNAGINSTPGFVVAADGVVTTSFTGAKPYDEFVELAGLSE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	269 (214)
Sequences:	2978 (2537)
Seq/√Len:	173.4

ECOLI - DSBA
BACSU - BDBD
HALSA - Q9HN25

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
162_E	212_A	6.477	1.00
132_N	262_V	3.371	1.00
113_P	175_R	3.216	1.00
106_T	140_S	3.046	1.00
107_V	242_V	2.988	1.00
195_S	210_R	2.730	1.00
107_V	139_L	2.625	1.00
170_A	173_A	2.587	1.00
146_M	229_A	2.566	1.00
117_H	120_D	2.530	1.00
113_P	160_F	2.491	1.00
119_Q	123_A	2.437	1.00
193_I	196_Y	2.368	1.00
98_P	102_S	2.343	1.00
108_V	144_R	2.316	1.00
160_F	171_F	2.298	1.00
262_V	266_G	2.252	1.00
133_F	266_G	2.138	1.00
163_T	209_V	2.133	1.00
130_N	135_E	2.007	1.00
108_V	142_V	2.005	1.00
258_Y	262_V	1.992	1.00
54_G	58_N	1.974	1.00
208_A	212_A	1.875	1.00
95_V	140_S	1.825	1.00
121_F	240_F	1.799	1.00
55_C	59_D	1.776	1.00
177_W	200_E	1.744	1.00
55_C	58_N	1.741	1.00
260_E	263_E	1.734	1.00
155_G	191_D	1.724	1.00
220_A	224_Q	1.719	1.00
165_E	218_Q	1.719	1.00
53_A	57_S	1.716	1.00
147_A	226_E	1.712	1.00
111_S	143_Y	1.703	1.00
113_P	157_V	1.661	1.00
97_G	103_A	1.657	1.00
159_A	209_V	1.652	1.00
165_E	217_T	1.647	1.00
115_C	118_C	1.625	1.00
204_E	208_A	1.552	1.00
219_S	223_S	1.514	1.00
150_A	153_A	1.507	1.00
163_T	167_N	1.487	1.00
166_R	212_A	1.485	1.00
177_W	181_N	1.483	1.00
165_E	212_A	1.482	1.00
196_Y	200_E	1.470	1.00
227_T	230_K	1.449	1.00
161_E	221_Q	1.446	1.00
163_T	203_I	1.445	1.00
223_S	227_T	1.434	1.00
56_L	60_G	1.423	1.00
174_L	178_V	1.392	1.00
145_N	161_E	1.389	1.00
191_D	214_A	1.387	1.00
158_H	219_S	1.379	1.00
257_P	260_E	1.361	1.00
42_T	46_A	1.327	1.00
106_T	142_V	1.310	1.00
174_L	198_A	1.309	1.00
117_H	236_S	1.287	1.00
107_V	141_Y	1.274	1.00
177_W	197_L	1.258	1.00
132_N	258_Y	1.257	1.00
113_P	145_N	1.254	1.00
211_T	215_E	1.243	1.00
156_A	178_V	1.229	1.00
114_S	152_W	1.224	1.00
160_F	178_V	1.219	1.00
128_K	258_Y	1.212	1.00
41_L	45_A	1.212	1.00
150_A	154_T	1.206	1.00
89_G	93_Q	1.205	1.00
98_P	103_A	1.202	1.00
209_V	213_A	1.190	1.00
143_Y	171_F	1.184	1.00
166_R	208_A	1.177	1.00
110_F	228_A	1.162	1.00
181_N	197_L	1.160	1.00
240_F	261_F	1.154	1.00
227_T	231_N	1.150	1.00
40_V	44_T	1.144	1.00
206_P	210_R	1.139	1.00
158_H	218_Q	1.138	1.00
154_T	158_H	1.126	1.00
122_E	176_E	1.122	1.00
154_T	223_S	1.114	1.00
196_Y	199_S	1.103	1.00
161_E	225_D	1.097	1.00
210_R	214_A	1.093	1.00
145_N	225_D	1.077	1.00
99_D	102_S	1.076	1.00
120_D	124_D	1.072	1.00
161_E	222_V	1.071	1.00
126_F	130_N	1.068	1.00
111_S	175_R	1.068	1.00
114_S	150_A	1.068	1.00
130_N	134_I	1.059	1.00
146_M	226_E	1.050	1.00
109_V	240_F	1.048	0.99
121_F	125_V	1.047	0.99
259_D	263_E	1.042	0.99
239_G	251_S	1.035	0.99
109_V	141_Y	1.025	0.99
105_T	243_A	1.023	0.99
114_S	153_A	1.019	0.99
220_A	223_S	1.017	0.99
256_K	260_E	1.013	0.99
105_T	265_A	1.012	0.99
207_E	211_T	0.998	0.99
59_D	62_G	0.997	0.99
152_W	194_K	0.997	0.99
108_V	241_V	0.993	0.99
57_S	61_G	0.990	0.99
207_E	210_R	0.989	0.99
163_T	166_R	0.979	0.99
199_S	206_P	0.975	0.99
145_N	171_F	0.959	0.99
178_V	194_K	0.957	0.99
122_E	175_R	0.937	0.99
215_E	218_Q	0.928	0.99
110_F	232_A	0.922	0.99
105_T	242_V	0.921	0.99
158_H	213_A	0.906	0.99
97_G	140_S	0.905	0.99
39_R	43_A	0.899	0.98
160_F	164_Y	0.897	0.98
119_Q	182_P	0.897	0.98
103_A	140_S	0.890	0.98
105_T	139_L	0.890	0.98
216_R	219_S	0.889	0.98
208_A	211_T	0.889	0.98
133_F	265_A	0.879	0.98
228_A	232_A	0.877	0.98
47_A	51_S	0.875	0.98
176_E	180_S	0.866	0.98
144_R	228_A	0.863	0.98
155_G	194_K	0.862	0.98
127_P	130_N	0.861	0.98
195_S	214_A	0.859	0.98
158_H	222_V	0.851	0.98
236_S	239_G	0.850	0.98
126_F	176_E	0.846	0.98
147_A	222_V	0.846	0.98
49_S	58_N	0.845	0.98
114_S	185_V	0.836	0.98
96_L	172_W	0.833	0.97
53_A	58_N	0.825	0.97
185_V	194_K	0.822	0.97
174_L	209_V	0.819	0.97
159_A	163_T	0.817	0.97
157_V	222_V	0.817	0.97
257_P	261_F	0.814	0.97
128_K	133_F	0.810	0.97
148_F	153_A	0.810	0.97
182_P	185_V	0.809	0.97
57_S	60_G	0.807	0.97
61_G	65_Q	0.806	0.97
112_D	153_A	0.805	0.97
122_E	126_F	0.801	0.97
39_R	42_T	0.795	0.97
166_R	206_P	0.795	0.97
192_A	196_Y	0.790	0.97
61_G	64_S	0.788	0.96
110_F	144_R	0.780	0.96
103_A	106_T	0.778	0.96
149_V	153_A	0.777	0.96
62_G	65_Q	0.769	0.96
89_G	92_A	0.763	0.96
123_A	127_P	0.759	0.96
145_N	160_F	0.757	0.96
117_H	255_A	0.755	0.95
199_S	210_R	0.746	0.95
59_D	63_D	0.744	0.95
73_E	76_G	0.743	0.95
63_D	66_A	0.742	0.95
121_F	129_L	0.742	0.95
261_F	264_L	0.739	0.95
90_L	93_Q	0.739	0.95
197_L	201_T	0.738	0.95
87_A	92_A	0.738	0.95
128_K	132_N	0.732	0.95
107_V	240_F	0.731	0.95
58_N	61_G	0.729	0.95
91_D	94_P	0.726	0.94
159_A	174_L	0.723	0.94
93_Q	142_V	0.722	0.94
251_S	254_G	0.720	0.94
161_E	165_E	0.718	0.94
190_G	193_I	0.717	0.94
158_H	216_R	0.716	0.94
191_D	195_S	0.712	0.94
53_A	56_L	0.707	0.94
148_F	234_I	0.706	0.94
173_A	201_T	0.703	0.93
234_I	241_V	0.702	0.93
127_P	132_N	0.698	0.93
95_V	98_P	0.698	0.93
116_P	182_P	0.697	0.93
93_Q	110_F	0.691	0.93
126_F	134_I	0.689	0.93
218_Q	221_Q	0.687	0.93
125_V	240_F	0.685	0.93
172_W	175_R	0.685	0.93
252_F	264_L	0.682	0.92
116_P	120_D	0.682	0.92
163_T	174_L	0.675	0.92
111_S	172_W	0.674	0.92
174_L	194_K	0.671	0.92
52_L	55_C	0.670	0.92
167_N	170_A	0.670	0.92
179_Y	237_T	0.668	0.92
93_Q	144_R	0.667	0.92
46_A	56_L	0.667	0.92
203_I	209_V	0.662	0.91
90_L	94_P	0.660	0.91
89_G	95_V	0.660	0.91
212_A	218_Q	0.659	0.91
146_M	234_I	0.653	0.91
60_G	65_Q	0.650	0.90
163_T	173_A	0.648	0.90
114_S	188_D	0.647	0.90
194_K	197_L	0.643	0.90
127_P	258_Y	0.638	0.90
95_V	99_D	0.636	0.90
162_E	165_E	0.633	0.89
162_E	213_A	0.632	0.89
260_E	264_L	0.624	0.89
189_P	192_A	0.624	0.89
152_W	155_G	0.622	0.88
177_W	180_S	0.618	0.88
51_S	55_C	0.613	0.88
71_D	74_T	0.611	0.88
80_S	83_D	0.611	0.88
114_S	149_V	0.609	0.87
56_L	59_D	0.608	0.87
195_S	206_P	0.608	0.87
151_P	155_G	0.606	0.87
50_L	53_A	0.603	0.87
217_T	220_A	0.603	0.87
143_Y	172_W	0.602	0.87
92_A	95_V	0.601	0.87
170_A	203_I	0.599	0.87
111_S	179_Y	0.596	0.86
138_S	266_G	0.591	0.86
42_T	49_S	0.589	0.86
81_L	84_H	0.587	0.85
94_P	164_Y	0.586	0.85
155_G	158_H	0.585	0.85
152_W	189_P	0.584	0.85
198_A	209_V	0.583	0.85
158_H	165_E	0.583	0.85
104_D	138_S	0.582	0.85
224_Q	228_A	0.580	0.85
113_P	176_E	0.575	0.84
38_R	41_L	0.574	0.84
133_F	139_L	0.574	0.84
174_L	201_T	0.573	0.84
147_A	225_D	0.571	0.84
155_G	189_P	0.571	0.84
132_N	136_P	0.571	0.84
79_A	83_D	0.569	0.84
42_T	45_A	0.569	0.84
159_A	194_K	0.567	0.83
228_A	231_N	0.567	0.83
223_S	226_E	0.566	0.83
117_H	254_G	0.565	0.83
166_R	204_E	0.562	0.83
162_E	218_Q	0.562	0.83
147_A	154_T	0.561	0.83
159_A	198_A	0.559	0.83
104_D	136_P	0.558	0.82
138_S	211_T	0.557	0.82
52_L	56_L	0.557	0.82
46_A	50_L	0.555	0.82
88_A	92_A	0.553	0.82
126_F	129_L	0.551	0.82
193_I	197_L	0.550	0.82
191_D	213_A	0.549	0.81
55_C	60_G	0.547	0.81
98_P	140_S	0.545	0.81
226_E	229_A	0.543	0.81
48_A	51_S	0.542	0.81
119_Q	185_V	0.541	0.81
72_A	75_T	0.539	0.80
76_G	81_L	0.538	0.80
241_V	251_S	0.538	0.80
232_A	241_V	0.538	0.80
75_T	79_A	0.536	0.80
60_G	64_S	0.535	0.80
134_I	141_Y	0.532	0.79
174_L	203_I	0.531	0.79
107_V	261_F	0.529	0.79
82_A	85_P	0.528	0.79
38_R	42_T	0.527	0.79
166_R	209_V	0.526	0.79
148_F	236_S	0.526	0.79
204_E	207_E	0.524	0.78
210_R	213_A	0.522	0.78
96_L	126_F	0.521	0.78
252_F	257_P	0.520	0.78
45_A	57_S	0.518	0.78
87_A	90_L	0.516	0.77
103_A	143_Y	0.515	0.77
159_A	213_A	0.515	0.77
160_F	175_R	0.513	0.77
84_H	88_A	0.512	0.77
152_W	186_A	0.512	0.77
54_G	57_S	0.512	0.77
110_F	114_S	0.511	0.77
234_I	239_G	0.511	0.77
216_R	220_A	0.509	0.76
173_A	176_E	0.509	0.76
157_V	160_F	0.509	0.76
195_S	199_S	0.506	0.76
96_L	130_N	0.504	0.76
116_P	122_E	0.503	0.76
111_S	239_G	0.501	0.75
50_L	55_C	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ghaA	1	0.6729	100	0.457	Contact Map
3bciA	1	0.5911	100	0.474	Contact Map
3f4sA	1	0.658	100	0.475	Contact Map
4z7xA	1	0.7212	100	0.481	Contact Map
3gmfA	1	0.6283	100	0.483	Contact Map
4ihuA	3	0.6766	100	0.494	Contact Map
4n30A	1	0.632	100	0.5	Contact Map
4pwoA	1	0.8587	100	0.501	Contact Map
5c00A	1	0.6989	100	0.515	Contact Map
3gn3A	3	0.6171	100	0.524	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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