GREMLIN Database
Q9HN25 - Uncharacterized protein
UniProt: Q9HN25 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 269 (214)
Sequences: 2978 (2537)
Seq/√Len: 173.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_E212_A6.4771.00
132_N262_V3.3711.00
113_P175_R3.2161.00
106_T140_S3.0461.00
107_V242_V2.9881.00
195_S210_R2.7301.00
107_V139_L2.6251.00
170_A173_A2.5871.00
146_M229_A2.5661.00
117_H120_D2.5301.00
113_P160_F2.4911.00
119_Q123_A2.4371.00
193_I196_Y2.3681.00
98_P102_S2.3431.00
108_V144_R2.3161.00
160_F171_F2.2981.00
262_V266_G2.2521.00
133_F266_G2.1381.00
163_T209_V2.1331.00
130_N135_E2.0071.00
108_V142_V2.0051.00
258_Y262_V1.9921.00
54_G58_N1.9741.00
208_A212_A1.8751.00
95_V140_S1.8251.00
121_F240_F1.7991.00
55_C59_D1.7761.00
177_W200_E1.7441.00
55_C58_N1.7411.00
260_E263_E1.7341.00
155_G191_D1.7241.00
220_A224_Q1.7191.00
165_E218_Q1.7191.00
53_A57_S1.7161.00
147_A226_E1.7121.00
111_S143_Y1.7031.00
113_P157_V1.6611.00
97_G103_A1.6571.00
159_A209_V1.6521.00
165_E217_T1.6471.00
115_C118_C1.6251.00
204_E208_A1.5521.00
219_S223_S1.5141.00
150_A153_A1.5071.00
163_T167_N1.4871.00
166_R212_A1.4851.00
177_W181_N1.4831.00
165_E212_A1.4821.00
196_Y200_E1.4701.00
227_T230_K1.4491.00
161_E221_Q1.4461.00
163_T203_I1.4451.00
223_S227_T1.4341.00
56_L60_G1.4231.00
174_L178_V1.3921.00
145_N161_E1.3891.00
191_D214_A1.3871.00
158_H219_S1.3791.00
257_P260_E1.3611.00
42_T46_A1.3271.00
106_T142_V1.3101.00
174_L198_A1.3091.00
117_H236_S1.2871.00
107_V141_Y1.2741.00
177_W197_L1.2581.00
132_N258_Y1.2571.00
113_P145_N1.2541.00
211_T215_E1.2431.00
156_A178_V1.2291.00
114_S152_W1.2241.00
160_F178_V1.2191.00
128_K258_Y1.2121.00
41_L45_A1.2121.00
150_A154_T1.2061.00
89_G93_Q1.2051.00
98_P103_A1.2021.00
209_V213_A1.1901.00
143_Y171_F1.1841.00
166_R208_A1.1771.00
110_F228_A1.1621.00
181_N197_L1.1601.00
240_F261_F1.1541.00
227_T231_N1.1501.00
40_V44_T1.1441.00
206_P210_R1.1391.00
158_H218_Q1.1381.00
154_T158_H1.1261.00
122_E176_E1.1221.00
154_T223_S1.1141.00
196_Y199_S1.1031.00
161_E225_D1.0971.00
210_R214_A1.0931.00
145_N225_D1.0771.00
99_D102_S1.0761.00
120_D124_D1.0721.00
161_E222_V1.0711.00
126_F130_N1.0681.00
111_S175_R1.0681.00
114_S150_A1.0681.00
130_N134_I1.0591.00
146_M226_E1.0501.00
109_V240_F1.0480.99
121_F125_V1.0470.99
259_D263_E1.0420.99
239_G251_S1.0350.99
109_V141_Y1.0250.99
105_T243_A1.0230.99
114_S153_A1.0190.99
220_A223_S1.0170.99
256_K260_E1.0130.99
105_T265_A1.0120.99
207_E211_T0.9980.99
59_D62_G0.9970.99
152_W194_K0.9970.99
108_V241_V0.9930.99
57_S61_G0.9900.99
207_E210_R0.9890.99
163_T166_R0.9790.99
199_S206_P0.9750.99
145_N171_F0.9590.99
178_V194_K0.9570.99
122_E175_R0.9370.99
215_E218_Q0.9280.99
110_F232_A0.9220.99
105_T242_V0.9210.99
158_H213_A0.9060.99
97_G140_S0.9050.99
39_R43_A0.8990.98
160_F164_Y0.8970.98
119_Q182_P0.8970.98
103_A140_S0.8900.98
105_T139_L0.8900.98
216_R219_S0.8890.98
208_A211_T0.8890.98
133_F265_A0.8790.98
228_A232_A0.8770.98
47_A51_S0.8750.98
176_E180_S0.8660.98
144_R228_A0.8630.98
155_G194_K0.8620.98
127_P130_N0.8610.98
195_S214_A0.8590.98
158_H222_V0.8510.98
236_S239_G0.8500.98
126_F176_E0.8460.98
147_A222_V0.8460.98
49_S58_N0.8450.98
114_S185_V0.8360.98
96_L172_W0.8330.97
53_A58_N0.8250.97
185_V194_K0.8220.97
174_L209_V0.8190.97
159_A163_T0.8170.97
157_V222_V0.8170.97
257_P261_F0.8140.97
128_K133_F0.8100.97
148_F153_A0.8100.97
182_P185_V0.8090.97
57_S60_G0.8070.97
61_G65_Q0.8060.97
112_D153_A0.8050.97
122_E126_F0.8010.97
39_R42_T0.7950.97
166_R206_P0.7950.97
192_A196_Y0.7900.97
61_G64_S0.7880.96
110_F144_R0.7800.96
103_A106_T0.7780.96
149_V153_A0.7770.96
62_G65_Q0.7690.96
89_G92_A0.7630.96
123_A127_P0.7590.96
145_N160_F0.7570.96
117_H255_A0.7550.95
199_S210_R0.7460.95
59_D63_D0.7440.95
73_E76_G0.7430.95
63_D66_A0.7420.95
121_F129_L0.7420.95
261_F264_L0.7390.95
90_L93_Q0.7390.95
197_L201_T0.7380.95
87_A92_A0.7380.95
128_K132_N0.7320.95
107_V240_F0.7310.95
58_N61_G0.7290.95
91_D94_P0.7260.94
159_A174_L0.7230.94
93_Q142_V0.7220.94
251_S254_G0.7200.94
161_E165_E0.7180.94
190_G193_I0.7170.94
158_H216_R0.7160.94
191_D195_S0.7120.94
53_A56_L0.7070.94
148_F234_I0.7060.94
173_A201_T0.7030.93
234_I241_V0.7020.93
127_P132_N0.6980.93
95_V98_P0.6980.93
116_P182_P0.6970.93
93_Q110_F0.6910.93
126_F134_I0.6890.93
218_Q221_Q0.6870.93
125_V240_F0.6850.93
172_W175_R0.6850.93
252_F264_L0.6820.92
116_P120_D0.6820.92
163_T174_L0.6750.92
111_S172_W0.6740.92
174_L194_K0.6710.92
52_L55_C0.6700.92
167_N170_A0.6700.92
179_Y237_T0.6680.92
93_Q144_R0.6670.92
46_A56_L0.6670.92
203_I209_V0.6620.91
90_L94_P0.6600.91
89_G95_V0.6600.91
212_A218_Q0.6590.91
146_M234_I0.6530.91
60_G65_Q0.6500.90
163_T173_A0.6480.90
114_S188_D0.6470.90
194_K197_L0.6430.90
127_P258_Y0.6380.90
95_V99_D0.6360.90
162_E165_E0.6330.89
162_E213_A0.6320.89
260_E264_L0.6240.89
189_P192_A0.6240.89
152_W155_G0.6220.88
177_W180_S0.6180.88
51_S55_C0.6130.88
71_D74_T0.6110.88
80_S83_D0.6110.88
114_S149_V0.6090.87
56_L59_D0.6080.87
195_S206_P0.6080.87
151_P155_G0.6060.87
50_L53_A0.6030.87
217_T220_A0.6030.87
143_Y172_W0.6020.87
92_A95_V0.6010.87
170_A203_I0.5990.87
111_S179_Y0.5960.86
138_S266_G0.5910.86
42_T49_S0.5890.86
81_L84_H0.5870.85
94_P164_Y0.5860.85
155_G158_H0.5850.85
152_W189_P0.5840.85
198_A209_V0.5830.85
158_H165_E0.5830.85
104_D138_S0.5820.85
224_Q228_A0.5800.85
113_P176_E0.5750.84
38_R41_L0.5740.84
133_F139_L0.5740.84
174_L201_T0.5730.84
147_A225_D0.5710.84
155_G189_P0.5710.84
132_N136_P0.5710.84
79_A83_D0.5690.84
42_T45_A0.5690.84
159_A194_K0.5670.83
228_A231_N0.5670.83
223_S226_E0.5660.83
117_H254_G0.5650.83
166_R204_E0.5620.83
162_E218_Q0.5620.83
147_A154_T0.5610.83
159_A198_A0.5590.83
104_D136_P0.5580.82
138_S211_T0.5570.82
52_L56_L0.5570.82
46_A50_L0.5550.82
88_A92_A0.5530.82
126_F129_L0.5510.82
193_I197_L0.5500.82
191_D213_A0.5490.81
55_C60_G0.5470.81
98_P140_S0.5450.81
226_E229_A0.5430.81
48_A51_S0.5420.81
119_Q185_V0.5410.81
72_A75_T0.5390.80
76_G81_L0.5380.80
241_V251_S0.5380.80
232_A241_V0.5380.80
75_T79_A0.5360.80
60_G64_S0.5350.80
134_I141_Y0.5320.79
174_L203_I0.5310.79
107_V261_F0.5290.79
82_A85_P0.5280.79
38_R42_T0.5270.79
166_R209_V0.5260.79
148_F236_S0.5260.79
204_E207_E0.5240.78
210_R213_A0.5220.78
96_L126_F0.5210.78
252_F257_P0.5200.78
45_A57_S0.5180.78
87_A90_L0.5160.77
103_A143_Y0.5150.77
159_A213_A0.5150.77
160_F175_R0.5130.77
84_H88_A0.5120.77
152_W186_A0.5120.77
54_G57_S0.5120.77
110_F114_S0.5110.77
234_I239_G0.5110.77
216_R220_A0.5090.76
173_A176_E0.5090.76
157_V160_F0.5090.76
195_S199_S0.5060.76
96_L130_N0.5040.76
116_P122_E0.5030.76
111_S239_G0.5010.75
50_L55_C0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ghaA 1 0.6729 100 0.457 Contact Map
3bciA 1 0.5911 100 0.474 Contact Map
3f4sA 1 0.658 100 0.475 Contact Map
4z7xA 1 0.7212 100 0.481 Contact Map
3gmfA 1 0.6283 100 0.483 Contact Map
4ihuA 3 0.6766 100 0.494 Contact Map
4n30A 1 0.632 100 0.5 Contact Map
4pwoA 1 0.8587 100 0.501 Contact Map
5c00A 1 0.6989 100 0.515 Contact Map
3gn3A 3 0.6171 100 0.524 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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