GREMLIN Database
HIS3 - Phosphoribosyl-AMP cyclohydrolase
UniProt: Q9HN23 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (104)
Sequences: 3221 (1828)
Seq/√Len: 179.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_T78_V2.5711.00
54_R67_E2.4751.00
56_H67_E2.2661.00
34_D106_E2.1491.00
79_D95_A2.1211.00
55_A92_Y2.0041.00
48_R51_T1.9841.00
41_A92_Y1.9751.00
77_S97_T1.9271.00
77_S95_A1.9171.00
38_L89_A1.8611.00
105_H110_H1.8521.00
64_E70_A1.8461.00
26_I38_L1.8121.00
43_R47_A1.8071.00
25_V41_A1.7981.00
33_R93_L1.7771.00
80_E112_T1.7741.00
80_E93_L1.7541.00
54_R77_S1.7421.00
27_A57_Y1.7401.00
47_A51_T1.7121.00
58_Y63_D1.6461.00
52_T56_H1.6061.00
48_R56_H1.5891.00
67_E70_A1.5641.00
31_D95_A1.5301.00
75_T97_T1.5301.00
55_A78_V1.5151.00
64_E71_T1.5091.00
24_A38_L1.4921.00
81_I92_Y1.4911.00
57_Y76_Q1.4831.00
15_H23_V1.4491.00
30_A79_D1.4461.00
96_Q99_G1.4131.00
25_V92_Y1.3831.00
54_R75_T1.3411.00
29_D106_E1.2801.00
82_R93_L1.2681.00
103_T110_H1.2431.00
48_R65_L1.2331.00
42_T45_A1.2001.00
39_A100_A1.1841.00
42_T65_L1.1841.00
13_A43_R1.1791.00
15_H18_D1.1701.00
48_R52_T1.1391.00
57_Y96_Q1.1171.00
24_A40_Y1.1151.00
87_G111_R1.0831.00
67_E75_T1.0671.00
48_R67_E1.0641.00
30_A93_L1.0561.00
24_A89_A1.0551.00
74_N99_G1.0541.00
52_T67_E1.0160.99
28_Q91_L1.0040.99
29_D95_A1.0000.99
76_Q94_V0.9860.99
25_V45_A0.9700.99
27_A94_V0.9510.99
30_A95_A0.9430.99
16_T19_G0.9270.99
74_N96_Q0.9200.99
96_Q100_A0.9200.99
17_D43_R0.9090.99
58_Y65_L0.9020.99
44_E47_A0.9020.99
44_E48_R0.9010.99
76_Q96_Q0.8860.98
42_T58_Y0.8780.98
84_D88_D0.8760.98
27_A55_A0.8690.98
82_R112_T0.8500.98
50_A81_I0.8260.98
32_S106_E0.8250.98
35_V91_L0.8200.97
83_V111_R0.8170.97
45_A65_L0.8140.97
16_T21_G0.8130.97
37_M89_A0.8060.97
54_R70_A0.8050.97
29_D96_Q0.8000.97
26_I35_V0.7700.96
105_H111_R0.7690.96
78_V92_Y0.7650.96
18_D21_G0.7530.96
46_V90_L0.7450.96
53_G77_S0.7440.96
15_H46_V0.7190.95
99_G105_H0.7080.94
55_A76_Q0.7050.94
82_R91_L0.7040.94
89_A109_F0.7000.94
76_Q100_A0.6950.94
28_Q93_L0.6900.93
46_V81_I0.6870.93
18_D40_Y0.6860.93
29_D34_D0.6840.93
34_D93_L0.6680.92
17_D46_V0.6670.92
19_G61_S0.6570.92
36_L94_V0.6460.91
58_Y64_E0.6330.90
59_S66_W0.6320.90
26_I91_L0.6310.90
15_H87_G0.6200.89
78_V109_F0.6170.89
74_N104_G0.6140.89
78_V81_I0.6080.88
15_H83_V0.6050.88
39_A85_C0.6020.88
99_G106_E0.6010.88
28_Q35_V0.5980.87
56_H65_L0.5920.87
14_G18_D0.5910.87
41_A45_A0.5880.86
83_V87_G0.5870.86
37_M66_W0.5870.86
55_A94_V0.5850.86
39_A55_A0.5840.86
110_H113_L0.5820.86
62_R66_W0.5810.86
16_T20_D0.5770.85
14_G111_R0.5770.85
27_A39_A0.5760.85
112_T115_G0.5750.85
37_M91_L0.5730.85
57_Y94_V0.5700.85
22_L60_R0.5680.85
112_T116_D0.5650.84
83_V110_H0.5610.84
37_M86_D0.5580.84
74_N98_G0.5570.83
82_R111_R0.5540.83
27_A92_Y0.5540.83
29_D32_S0.5510.83
21_G60_R0.5490.83
17_D23_V0.5480.82
34_D82_R0.5420.82
17_D20_D0.5410.82
45_A56_H0.5330.81
88_D109_F0.5310.80
81_I113_L0.5290.80
41_A49_T0.5210.79
14_G17_D0.5190.79
27_A76_Q0.5170.79
27_A33_R0.5150.78
103_T111_R0.5140.78
56_H70_A0.5130.78
15_H19_G0.5120.78
25_V33_R0.5090.78
41_A91_L0.5080.77
49_T55_A0.5070.77
44_E65_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zpsA 2 0.9535 100 0.086 Contact Map
1im3D 1 0.2946 15.2 0.949 Contact Map
2k8hA 1 0.6667 11.3 0.952 Contact Map
2j07A 2 0.8992 10 0.953 Contact Map
1yiiA 1 0.6512 8.6 0.954 Contact Map
1wywB 1 0.5814 8.4 0.955 Contact Map
3kydD 1 0.5039 8.1 0.955 Contact Map
2x4iA 2 0.3953 7.4 0.956 Contact Map
1v58A 2 0.3953 7.2 0.956 Contact Map
3ic4A 1 0.3643 7.1 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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