GREMLIN Database
GMSS - Glutamate mutase sigma subunit
UniProt: Q9HN21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (128)
Sequences: 245 (159)
Seq/√Len: 14.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
118_F130_A3.3250.99
7_T35_T2.9990.97
73_C91_V2.9540.97
11_G62_V2.6310.94
39_L43_T2.6170.94
25_L124_F2.5050.93
25_L29_L2.1790.86
124_F130_A2.1560.85
61_L127_V2.0570.82
46_T79_Q2.0570.82
81_A85_V1.9720.80
77_H80_L1.9520.79
39_L42_Q1.9270.78
106_K110_E1.8900.77
96_A99_Q1.8470.75
45_K75_G1.7170.69
15_S44_A1.6950.68
26_D30_R1.6890.68
60_V120_A1.6790.67
26_D38_N1.6660.67
43_T48_F1.6580.66
60_V87_A1.6430.66
39_L118_F1.5700.62
28_A32_A1.5430.61
49_A79_Q1.5360.60
25_L32_A1.5360.60
13_I114_F1.5180.59
12_T41_A1.4970.58
77_H89_T1.4840.57
29_L124_F1.4810.57
37_H55_H1.4270.54
43_T69_A1.4100.53
44_A47_E1.4050.53
114_F122_T1.3590.51
45_K73_C1.3220.49
52_A60_V1.3210.49
124_F128_V1.3140.48
15_S42_Q1.3040.48
60_V81_A1.3030.48
10_L124_F1.2990.47
127_V130_A1.2760.46
8_V120_A1.2580.45
7_T37_H1.2560.45
63_S114_F1.2390.44
49_A60_V1.2190.43
71_Q114_F1.1870.41
60_V89_T1.1780.41
34_F59_A1.1740.41
10_L85_V1.1590.40
19_A41_A1.1450.39
124_F127_V1.1450.39
20_V94_N1.1420.39
25_L31_E1.1350.39
90_V116_R1.1260.38
7_T119_S1.1250.38
34_F101_D1.1120.38
49_A82_A1.1040.37
88_T115_D1.0920.37
53_A82_A1.0880.36
50_T121_Q1.0850.36
22_I80_L1.0810.36
88_T131_V1.0800.36
81_A108_R1.0790.36
70_Q131_V1.0750.36
91_V112_M1.0750.36
7_T131_V1.0700.35
39_L102_F1.0620.35
14_G76_L1.0590.35
77_H87_A1.0590.35
19_A31_E1.0230.33
23_T120_A1.0150.33
22_I25_L0.9980.32
12_T124_F0.9860.31
107_Q111_E0.9840.31
81_A84_G0.9760.31
74_A132_K0.9740.31
15_S43_T0.9550.30
58_D104_T0.9540.30
107_Q110_E0.9520.30
85_V108_R0.9490.30
91_V95_L0.9380.29
32_A107_Q0.9350.29
84_G129_D0.9320.29
21_G66_Y0.9280.29
32_A125_E0.9270.29
51_A59_A0.9240.29
10_L15_S0.9150.28
9_V34_F0.9140.28
14_G52_A0.9130.28
117_V125_E0.9120.28
37_H106_K0.9050.28
42_Q66_Y0.8990.27
58_D127_V0.8860.27
104_T107_Q0.8800.27
48_F76_L0.8790.27
64_S78_D0.8770.27
86_D101_D0.8710.26
97_V107_Q0.8570.26
26_D95_L0.8330.25
95_L108_R0.8330.25
14_G75_G0.8320.25
8_V29_L0.8230.24
54_D79_Q0.8140.24
6_P58_D0.8020.23
10_L51_A0.7850.23
42_Q47_E0.7850.23
59_A131_V0.7830.23
102_F106_K0.7830.23
23_T80_L0.7660.22
43_T47_E0.7580.22
15_S27_H0.7570.22
103_E133_T0.7480.21
68_H95_L0.7460.21
100_T107_Q0.7280.21
58_D63_S0.7270.21
68_H117_V0.7230.21
12_T51_A0.7170.20
42_Q90_V0.7160.20
41_A51_A0.7150.20
6_P88_T0.7120.20
56_D121_Q0.7060.20
84_G133_T0.7060.20
9_V41_A0.7040.20
69_A112_M0.7040.20
79_Q83_A0.6910.19
7_T58_D0.6880.19
6_P95_L0.6830.19
114_F118_F0.6770.19
32_A128_V0.6710.19
19_A120_A0.6670.19
29_L32_A0.6630.18
69_A96_A0.6620.18
107_Q115_D0.6590.18
35_T81_A0.6570.18
103_E108_R0.6540.18
76_L80_L0.6530.18
69_A99_Q0.6500.18
98_G122_T0.6490.18
17_A44_A0.6480.18
13_I91_V0.6410.18
25_L80_L0.6340.18
46_T111_E0.6320.17
62_V122_T0.6280.17
9_V86_D0.6220.17
128_V131_V0.6180.17
88_T126_A0.6170.17
43_T121_Q0.6160.17
65_L97_V0.6150.17
77_H99_Q0.6130.17
10_L127_V0.6110.17
45_K69_A0.6110.17
35_T85_V0.6070.17
88_T116_R0.6010.17
8_V89_T0.5990.16
66_Y109_F0.5960.16
84_G102_F0.5890.16
79_Q121_Q0.5890.16
29_L77_H0.5870.16
49_A81_A0.5860.16
39_L130_A0.5850.16
7_T127_V0.5830.16
62_V74_A0.5780.16
64_S98_G0.5770.16
48_F60_V0.5760.16
22_I96_A0.5720.16
97_V115_D0.5680.16
17_A65_L0.5610.15
30_R121_Q0.5610.15
17_A108_R0.5580.15
13_I63_S0.5520.15
86_D98_G0.5520.15
11_G20_V0.5460.15
123_G127_V0.5450.15
15_S88_T0.5420.15
72_D97_V0.5410.15
19_A112_M0.5350.15
21_G112_M0.5300.15
27_H30_R0.5240.14
32_A52_A0.5210.14
127_V131_V0.5200.14
70_Q120_A0.5180.14
116_R132_K0.5160.14
13_I52_A0.5160.14
125_E129_D0.5130.14
28_A128_V0.5120.14
32_A124_F0.5100.14
24_L96_A0.5080.14
23_T94_N0.5020.14
101_D104_T0.5010.14
75_G91_V0.5010.14
58_D129_D0.5000.14
25_L75_G0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1reqA 1 0.906 99.9 0.622 Contact Map
2xijA 2 0.906 99.9 0.626 Contact Map
1xrsB 2 0.8859 99.8 0.645 Contact Map
3kp1A 2 0.8792 99.8 0.65 Contact Map
4r3uC 1 0.8725 99.8 0.669 Contact Map
1reqB 1 0.8859 99.8 0.67 Contact Map
4xc8A 2 0.9732 99.7 0.68 Contact Map
3bulA 1 0.9799 99.7 0.694 Contact Map
3ezxA 2 0.8121 99.7 0.699 Contact Map
2i2xB 1 0.9262 99.7 0.702 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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