GREMLIN Database
GLME - Glutamate mutase epsilon subunit
UniProt: Q9HN20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 476 (388)
Sequences: 233 (157)
Seq/√Len: 8.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
270_E368_R6.3941.00
215_L228_I6.0361.00
246_L268_G5.4421.00
369_S430_D5.3891.00
224_I397_I4.2620.98
100_Y125_N3.5600.95
266_A364_E3.5580.95
83_G337_R3.2870.92
368_R397_I3.1020.89
201_T206_T3.1010.89
152_R192_Y2.9560.87
284_Q303_A2.9090.86
127_G161_G2.8940.85
211_P233_G2.8540.85
192_Y195_R2.7600.82
104_A125_N2.7170.81
76_Q138_V2.5830.78
224_I427_V2.5300.76
233_G272_L2.5060.76
223_S421_L2.3880.72
388_R392_A2.3700.71
76_Q80_E2.2400.67
183_L390_F2.2070.66
302_L305_A2.1630.64
248_Y260_A2.1370.63
424_F434_K2.1310.63
409_V427_V2.1290.63
233_G246_L2.1170.62
390_F395_L2.1120.62
226_I263_A2.0950.61
51_L55_E2.0950.61
272_L278_V2.0860.61
58_L86_L2.0490.59
226_I267_I2.0420.59
103_A134_V2.0070.58
261_V282_L1.9550.56
243_S399_F1.9520.56
59_C336_L1.9450.55
414_D420_R1.9150.54
243_S246_L1.9010.54
99_A102_K1.8600.52
270_E397_I1.8530.52
154_L207_I1.7660.48
178_T186_T1.7580.48
421_L437_H1.7470.47
79_D139_D1.7270.46
144_V267_I1.7240.46
233_G268_G1.6940.45
152_R359_E1.6910.45
280_T312_P1.6870.45
191_Q237_A1.6750.44
363_I387_V1.6710.44
85_D337_R1.6600.44
65_V329_A1.6210.42
268_G362_L1.6150.42
212_F390_F1.6060.42
124_V127_G1.5860.41
121_F127_G1.5680.40
166_F193_V1.5550.40
90_T147_G1.5550.40
144_V336_L1.5540.39
237_A276_V1.5460.39
271_Y431_D1.5400.39
381_D407_G1.5330.39
285_W407_G1.5300.39
167_E173_Y1.5160.38
68_L134_V1.5030.37
237_A274_D1.5010.37
94_Y381_D1.4940.37
55_E265_A1.4850.37
215_L239_Q1.4680.36
152_R196_L1.4620.36
98_N238_T1.4540.36
155_A166_F1.4530.36
269_A273_P1.4490.35
223_S427_V1.4370.35
104_A108_A1.4340.35
97_D367_V1.4140.34
286_M332_N1.3970.34
132_R162_G1.3870.33
244_V359_E1.3700.33
214_P218_T1.3670.32
94_Y368_R1.3630.32
158_T166_F1.3550.32
200_Y394_T1.3490.32
49_A108_A1.3410.32
164_Q186_T1.3380.31
291_R323_A1.3360.31
263_A392_A1.3270.31
172_T400_P1.3200.31
53_N276_V1.3160.31
172_T264_M1.3150.31
272_L276_V1.3140.31
276_V391_D1.3100.30
175_L183_L1.3040.30
227_A311_E1.2990.30
350_S429_L1.2850.30
101_E132_R1.2820.29
378_G385_G1.2800.29
150_D363_I1.2750.29
83_G336_L1.2740.29
100_Y303_A1.2730.29
186_T369_S1.2700.29
90_T250_Q1.2630.29
182_D436_I1.2590.29
408_D423_K1.2570.29
128_V187_I1.2410.28
348_E363_I1.2380.28
250_Q287_G1.2310.28
159_L253_N1.2300.28
56_A424_F1.2270.28
338_T372_D1.2270.28
57_V405_A1.2240.28
216_T258_V1.2230.27
189_Y237_A1.2200.27
234_L271_Y1.2170.27
75_L147_G1.2160.27
123_A158_T1.2080.27
314_K325_G1.2080.27
147_G250_Q1.2030.27
59_C343_L1.1980.27
68_L130_G1.1940.27
237_A272_L1.1940.27
89_T125_N1.1930.27
142_V357_D1.1920.26
276_V407_G1.1860.26
195_R202_E1.1850.26
182_D372_D1.1850.26
173_Y177_Y1.1850.26
388_R391_D1.1820.26
91_I127_G1.1720.26
45_K134_V1.1710.26
65_V134_V1.1680.26
49_A233_G1.1670.26
167_E177_Y1.1640.26
90_T287_G1.1630.26
233_G415_D1.1570.25
167_E332_N1.1530.25
119_N327_P1.1520.25
377_A394_T1.1480.25
303_A412_A1.1450.25
155_A158_T1.1440.25
144_V158_T1.1390.25
142_V323_A1.1380.25
167_E286_M1.1370.25
224_I303_A1.1370.25
147_G287_G1.1240.24
78_L121_F1.1180.24
62_R177_Y1.1160.24
359_E430_D1.1140.24
282_L306_T1.1100.24
226_I295_R1.1090.24
376_E391_D1.1050.24
100_Y124_V1.1040.24
282_L426_A1.1030.24
262_R350_S1.1010.24
384_R388_R1.1000.24
173_Y332_N1.0960.24
195_R253_N1.0950.24
77_H89_T1.0910.23
251_V319_S1.0910.23
78_L303_A1.0890.23
108_A433_T1.0850.23
270_E430_D1.0840.23
173_Y286_M1.0830.23
258_V309_L1.0790.23
198_G211_P1.0770.23
303_A407_G1.0770.23
160_A233_G1.0690.23
268_G278_V1.0680.23
52_E73_E1.0670.23
145_R177_Y1.0660.23
212_F374_V1.0660.23
196_L350_S1.0650.23
144_V166_F1.0610.23
136_R371_L1.0600.22
53_N387_V1.0480.22
304_G358_R1.0480.22
63_A214_P1.0460.22
223_S376_E1.0390.22
136_R253_N1.0350.22
391_D435_R1.0350.22
171_I390_F1.0340.22
249_G314_K1.0330.22
194_D197_C1.0300.22
184_E378_G1.0280.22
336_L343_L1.0270.22
107_L203_R1.0140.21
135_V326_V1.0110.21
86_L186_T1.0070.21
150_D237_A1.0050.21
82_G91_I1.0040.21
91_I397_I1.0020.21
129_E261_V1.0000.21
149_P209_R0.9970.21
160_A258_V0.9970.21
156_A408_D0.9960.21
47_F165_S0.9950.21
75_L250_Q0.9930.21
230_T310_V0.9930.21
271_Y399_F0.9880.20
239_Q412_A0.9840.20
72_V137_R0.9820.20
241_V406_A0.9740.20
345_M378_G0.9700.20
138_V338_T0.9660.20
136_R223_S0.9650.20
108_A233_G0.9630.20
259_A361_A0.9600.20
172_T336_L0.9580.20
271_Y364_E0.9570.20
166_F402_S0.9540.20
216_T394_T0.9540.20
298_G338_T0.9540.20
242_R275_S0.9520.20
146_H176_P0.9500.20
160_A391_D0.9490.19
65_V166_F0.9490.19
213_G332_N0.9420.19
91_I153_L0.9370.19
268_G429_L0.9360.19
164_Q413_R0.9320.19
367_V419_V0.9300.19
83_G333_A0.9300.19
90_T177_Y0.9240.19
153_L361_A0.9180.19
100_Y224_I0.9150.19
161_G206_T0.9060.18
127_G284_Q0.9060.18
263_A390_F0.9050.18
204_G215_L0.9030.18
150_D320_P0.9010.18
64_G327_P0.8990.18
48_A55_E0.8970.18
265_A433_T0.8960.18
373_A394_T0.8940.18
154_L238_T0.8880.18
191_Q426_A0.8870.18
183_L394_T0.8860.18
161_G363_I0.8850.18
150_D241_V0.8840.18
59_C340_D0.8840.18
62_R173_Y0.8840.18
368_R382_I0.8820.18
202_E388_R0.8790.18
154_L163_F0.8760.18
266_A360_Q0.8740.18
142_V438_R0.8720.18
167_E176_P0.8720.18
136_R409_V0.8700.18
91_I123_A0.8690.17
66_P298_G0.8670.17
128_V196_L0.8660.17
306_T310_V0.8650.17
153_L156_A0.8630.17
100_Y284_Q0.8620.17
392_A426_A0.8610.17
54_A293_E0.8590.17
231_I374_V0.8580.17
145_R173_Y0.8550.17
264_M377_A0.8550.17
144_V159_L0.8540.17
282_L310_V0.8500.17
177_Y327_P0.8490.17
181_Y185_T0.8450.17
62_R167_E0.8440.17
56_A129_E0.8400.17
159_L178_T0.8390.17
116_S282_L0.8380.17
93_S237_A0.8370.17
124_V153_L0.8370.17
81_E337_R0.8360.17
134_V354_D0.8330.17
246_L419_V0.8320.17
348_E420_R0.8310.17
97_D149_P0.8300.17
301_G415_D0.8200.16
145_R167_E0.8190.16
170_P225_A0.8150.16
127_G152_R0.8140.16
104_A185_T0.8120.16
64_G177_Y0.8120.16
173_Y176_P0.8120.16
197_C406_A0.8110.16
313_T397_I0.8110.16
231_I385_G0.8090.16
244_V426_A0.8060.16
133_E136_R0.8030.16
431_D435_R0.8020.16
121_F139_D0.8000.16
310_V313_T0.8000.16
338_T358_R0.7980.16
93_S186_T0.7960.16
156_A253_N0.7960.16
177_Y332_N0.7960.16
222_P390_F0.7950.16
304_G342_V0.7900.16
289_F359_E0.7900.16
273_P374_V0.7880.16
186_T212_F0.7880.16
144_V163_F0.7860.16
268_G316_I0.7860.16
160_A276_V0.7850.16
151_A224_I0.7850.16
74_L314_K0.7810.16
73_E271_Y0.7810.16
129_E160_A0.7800.15
47_F381_D0.7800.15
273_P423_K0.7790.15
374_V411_P0.7770.15
333_A337_R0.7760.15
163_F207_I0.7750.15
368_R388_R0.7750.15
315_V339_T0.7720.15
74_L283_H0.7700.15
422_L427_V0.7700.15
69_D423_K0.7680.15
121_F207_I0.7670.15
163_F381_D0.7670.15
347_D395_L0.7650.15
144_V377_A0.7640.15
263_A434_K0.7600.15
431_D434_K0.7600.15
99_A129_E0.7590.15
135_V166_F0.7570.15
321_Q405_A0.7570.15
268_G363_I0.7560.15
107_L155_A0.7540.15
202_E420_R0.7540.15
98_N178_T0.7510.15
198_G359_E0.7450.15
233_G403_D0.7440.15
177_Y213_G0.7430.15
317_T428_A0.7430.15
136_R344_R0.7420.15
73_E244_V0.7410.15
166_F406_A0.7400.15
338_T394_T0.7400.15
90_T316_I0.7390.15
208_N214_P0.7390.15
374_V389_A0.7380.15
78_L207_I0.7370.15
384_R391_D0.7350.15
62_R145_R0.7350.15
47_F328_T0.7340.15
233_G352_T0.7330.15
65_V135_V0.7330.15
258_V391_D0.7310.14
261_V310_V0.7290.14
58_L77_H0.7240.14
294_A413_R0.7200.14
53_N294_A0.7190.14
66_P321_Q0.7190.14
367_V374_V0.7180.14
202_E394_T0.7160.14
116_S399_F0.7160.14
292_D295_R0.7160.14
196_L408_D0.7150.14
190_W210_E0.7130.14
169_G210_E0.7130.14
168_G190_W0.7130.14
169_G190_W0.7130.14
168_G210_E0.7130.14
295_R367_V0.7130.14
227_A389_A0.7120.14
177_Y286_M0.7110.14
98_N154_L0.7100.14
268_G319_S0.7090.14
185_T229_V0.7070.14
243_S251_V0.7060.14
172_T225_A0.7030.14
150_D191_Q0.7010.14
158_T220_V0.7000.14
243_S418_R0.6990.14
422_L430_D0.6990.14
191_Q239_Q0.6980.14
355_G371_L0.6980.14
264_M400_P0.6960.14
366_S428_A0.6960.14
369_S433_T0.6940.14
52_E105_E0.6930.14
238_T381_D0.6920.14
127_G310_V0.6910.14
80_E274_D0.6880.14
132_R196_L0.6850.14
67_R123_A0.6850.14
396_D425_G0.6850.14
255_V354_D0.6840.14
277_T399_F0.6840.14
65_V298_G0.6830.14
160_A234_L0.6820.14
301_G342_V0.6800.13
127_G160_A0.6800.13
154_L411_P0.6800.13
173_Y260_A0.6790.13
150_D228_I0.6790.13
233_G357_D0.6780.13
303_A314_K0.6780.13
146_H167_E0.6770.13
104_A406_A0.6770.13
126_H157_V0.6760.13
227_A337_R0.6740.13
126_H391_D0.6720.13
270_E323_A0.6710.13
131_C247_G0.6700.13
63_A218_T0.6700.13
193_V427_V0.6690.13
93_S276_V0.6690.13
268_G323_A0.6670.13
121_F320_P0.6670.13
87_L236_A0.6670.13
78_L411_P0.6670.13
127_G157_V0.6670.13
283_H314_K0.6660.13
295_R317_T0.6660.13
213_G286_M0.6660.13
241_V368_R0.6630.13
282_L433_T0.6620.13
363_I388_R0.6600.13
320_P323_A0.6590.13
276_V377_A0.6590.13
367_V375_Y0.6540.13
82_G293_E0.6540.13
80_E363_I0.6520.13
250_Q316_I0.6520.13
90_T173_Y0.6500.13
61_P64_G0.6490.13
252_G413_R0.6480.13
78_L261_V0.6470.13
188_E191_Q0.6450.13
384_R420_R0.6450.13
90_T167_E0.6440.13
148_T209_R0.6440.13
56_A347_D0.6430.13
108_A185_T0.6430.13
63_A88_P0.6420.13
140_A343_L0.6420.13
311_E410_L0.6400.13
65_V413_R0.6390.13
155_A159_L0.6380.13
84_A337_R0.6370.13
73_E329_A0.6370.13
397_I422_L0.6340.13
382_I415_D0.6340.13
234_L388_R0.6320.13
233_G382_I0.6310.13
54_A196_L0.6310.13
246_L362_L0.6300.13
268_G324_V0.6300.13
97_D419_V0.6290.13
79_D277_T0.6280.13
184_E276_V0.6280.13
173_Y327_P0.6270.12
280_T313_T0.6270.12
125_N200_Y0.6240.12
64_G173_Y0.6240.12
163_F341_Q0.6230.12
368_R421_L0.6200.12
149_P252_G0.6180.12
164_Q359_E0.6180.12
172_T244_V0.6170.12
146_H173_Y0.6170.12
356_V374_V0.6150.12
81_E215_L0.6130.12
54_A253_N0.6130.12
153_L407_G0.6110.12
80_E84_A0.6100.12
44_H48_A0.6090.12
148_T154_L0.6080.12
147_G176_P0.6070.12
105_E114_D0.6070.12
70_E102_K0.6070.12
382_I421_L0.6070.12
134_V374_V0.6070.12
167_E327_P0.6060.12
309_L362_L0.6060.12
155_A246_L0.6050.12
226_I243_S0.6050.12
67_R321_Q0.6050.12
107_L193_V0.6030.12
212_F265_A0.6030.12
62_R90_T0.6020.12
128_V330_E0.6010.12
164_Q237_A0.6010.12
172_T229_V0.6000.12
114_D241_V0.5980.12
156_A414_D0.5970.12
271_Y372_D0.5940.12
91_I154_L0.5930.12
317_T335_G0.5910.12
163_F166_F0.5900.12
330_E397_I0.5900.12
239_Q337_R0.5890.12
293_E304_G0.5880.12
253_N413_R0.5880.12
185_T244_V0.5870.12
129_E377_A0.5870.12
341_Q365_R0.5830.12
101_E378_G0.5820.12
263_A307_A0.5800.12
103_A261_V0.5770.12
251_V317_T0.5770.12
304_G339_T0.5770.12
64_G167_E0.5750.12
224_I284_Q0.5730.12
217_G287_G0.5720.12
90_T149_P0.5720.12
154_L181_Y0.5720.12
80_E254_L0.5710.12
69_D409_V0.5700.11
99_A276_V0.5690.11
269_A277_T0.5690.11
293_E297_H0.5670.11
91_I246_L0.5670.11
294_A350_S0.5640.11
289_F304_G0.5640.11
172_T317_T0.5630.11
253_N414_D0.5620.11
398_P425_G0.5620.11
187_I217_G0.5620.11
289_F323_A0.5580.11
80_E126_H0.5570.11
52_E297_H0.5570.11
202_E380_G0.5540.11
108_A224_I0.5510.11
161_G412_A0.5500.11
153_L284_Q0.5500.11
51_L342_V0.5500.11
86_L373_A0.5500.11
334_A345_M0.5490.11
181_Y320_P0.5480.11
90_T145_R0.5460.11
79_D297_H0.5460.11
325_G331_S0.5460.11
341_Q399_F0.5450.11
82_G337_R0.5440.11
125_N192_Y0.5430.11
188_E205_V0.5430.11
159_L193_V0.5420.11
409_V430_D0.5400.11
415_D430_D0.5390.11
142_V161_G0.5380.11
292_D337_R0.5360.11
158_T267_I0.5340.11
73_E351_I0.5340.11
98_N299_V0.5340.11
121_F138_V0.5330.11
50_V93_S0.5320.11
100_Y117_E0.5320.11
88_P214_P0.5310.11
142_V421_L0.5310.11
294_A304_G0.5300.11
237_A289_F0.5300.11
130_G368_R0.5290.11
134_V258_V0.5290.11
107_L116_S0.5290.11
56_A266_A0.5270.11
181_Y238_T0.5270.11
268_G422_L0.5260.11
191_Q430_D0.5220.11
124_V388_R0.5210.11
62_R327_P0.5210.11
371_L387_V0.5190.11
200_Y349_Q0.5190.11
194_D209_R0.5190.11
217_G400_P0.5190.11
60_Q222_P0.5190.11
304_G424_F0.5180.11
153_L195_R0.5150.11
178_T409_V0.5150.11
84_A93_S0.5140.11
72_V414_D0.5100.11
319_S327_P0.5100.11
90_T94_Y0.5090.11
284_Q312_P0.5060.10
122_P322_E0.5060.10
96_R322_E0.5060.10
120_G322_E0.5060.10
139_D263_A0.5050.10
123_A152_R0.5040.10
49_A105_E0.5010.10
249_G325_G0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ccwB 2 0.9958 100 0.185 Contact Map
4xc8A 2 0.8739 96 0.968 Contact Map
2xijA 2 0.916 94.2 0.972 Contact Map
1reqB 1 0.8866 93.5 0.972 Contact Map
4r3uA 2 0.937 93.1 0.973 Contact Map
1reqA 1 0.9265 90.9 0.974 Contact Map
1aj0A 1 0.5 88.5 0.976 Contact Map
3kp1A 2 0.9055 87.3 0.976 Contact Map
2y5sA 2 0.4937 84 0.977 Contact Map
4hb7A 2 0.4559 76.9 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0117 seconds.