GREMLIN Database
Q9HN19 - Methylaspartate ammonia-lyase
UniProt: Q9HN19 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 418 (406)
Sequences: 168 (91)
Seq/√Len: 4.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
344_A377_T4.1880.90
295_A325_D4.1190.89
105_D141_A3.7810.84
117_E134_S3.6000.81
200_E204_P3.4300.77
275_M290_L3.3330.75
364_T368_R3.2560.73
260_L269_L3.2230.72
312_R316_E3.1370.70
21_A278_G3.1300.70
284_I317_A2.9070.64
106_A141_A2.8720.63
284_I321_A2.8710.63
253_V275_M2.8540.62
322_G325_D2.7020.58
280_R317_A2.6460.56
196_F202_V2.6250.55
134_S338_L2.6000.55
70_A359_T2.5620.53
134_S336_G2.5380.53
170_G390_F2.4830.51
319_V352_T2.4580.50
113_A117_E2.4470.50
153_L240_L2.4180.49
261_R294_L2.3950.48
183_M347_C2.3670.47
319_V325_D2.3610.47
172_S183_M2.3240.46
170_G188_V2.3090.46
356_V379_A2.2450.44
210_V263_A2.0990.39
344_A379_A2.0970.39
191_L372_H2.0110.37
50_G361_N1.9830.36
340_S356_V1.9540.35
331_T359_T1.8990.34
317_A321_A1.8960.33
11_G52_A1.8890.33
278_G340_S1.8560.32
253_V303_I1.8450.32
187_R225_G1.8440.32
4_E102_V1.8380.32
165_P379_A1.8330.32
81_D309_C1.8300.32
55_V133_V1.8290.32
157_L342_R1.8230.32
14_G395_A1.8100.31
365_V368_R1.7880.31
8_A93_V1.7760.30
148_T151_R1.7440.29
295_A322_G1.7270.29
148_T379_A1.7210.29
171_Q195_L1.7210.29
301_V320_D1.7200.29
290_L303_I1.6740.28
81_D89_H1.6730.28
275_M303_I1.6630.27
117_E247_P1.6580.27
240_L271_I1.6520.27
154_A160_E1.6510.27
101_L137_L1.6340.27
162_A379_A1.6220.26
21_A277_A1.6130.26
77_A83_L1.5960.26
16_F32_M1.5830.26
73_Q176_R1.5690.25
179_G182_A1.5680.25
210_V240_L1.5610.25
389_G392_A1.5550.25
53_L129_V1.5540.25
73_Q195_L1.5480.25
325_D352_T1.5350.24
188_V302_D1.5340.24
73_Q171_Q1.5200.24
149_Q369_R1.5200.24
337_L377_T1.5140.24
18_D47_R1.5140.24
254_T257_V1.5130.24
82_P304_V1.5100.24
18_D73_Q1.4870.23
46_I125_L1.4790.23
320_D346_Y1.4760.23
145_R155_D1.4740.23
202_V243_L1.4730.23
14_G179_G1.4680.23
137_L243_L1.4620.23
291_R371_A1.4540.23
18_D176_R1.4520.23
2_R129_V1.4510.23
117_E245_G1.4470.22
33_A223_L1.4450.22
77_A374_A1.4360.22
9_T52_A1.4360.22
137_L166_V1.4330.22
5_R102_V1.4310.22
291_R325_D1.4290.22
95_G99_E1.4270.22
294_L322_G1.4230.22
18_D195_L1.4220.22
171_Q197_N1.4210.22
381_Q384_A1.4130.22
18_D171_Q1.4130.22
163_T379_A1.4040.22
74_Y171_Q1.4000.21
74_Y176_R1.3920.21
174_E182_A1.3890.21
176_R195_L1.3680.21
74_Y195_L1.3650.21
14_G336_G1.3630.21
46_I268_P1.3560.21
13_A50_G1.3540.21
138_V310_D1.3510.20
171_Q176_R1.3450.20
232_F267_Y1.3360.20
173_G360_C1.3350.20
293_G297_A1.3340.20
372_H404_T1.3290.20
116_V327_V1.3250.20
255_G297_A1.3210.20
159_T408_H1.3200.20
50_G169_F1.3160.20
196_F243_L1.3070.20
216_L234_V1.3040.20
174_E276_D1.3010.19
18_D74_Y1.2860.19
159_T378_D1.2850.19
169_F361_N1.2790.19
268_P302_D1.2760.19
154_A377_T1.2760.19
99_E315_V1.2720.19
57_V101_L1.2710.19
292_D298_G1.2670.19
73_Q360_C1.2640.19
71_A127_T1.2630.19
209_L216_L1.2630.19
257_V301_V1.2590.19
148_T404_T1.2520.19
15_F359_T1.2510.19
47_R73_Q1.2490.18
170_G394_Y1.2350.18
49_P107_A1.2300.18
46_I250_R1.2250.18
194_G234_V1.2130.18
154_A379_A1.2040.18
16_F316_E1.1950.17
171_Q388_M1.1940.17
23_I34_Y1.1900.17
52_A380_A1.1880.17
74_Y197_N1.1780.17
13_A361_N1.1720.17
162_A166_V1.1710.17
105_D137_L1.1680.17
174_E201_A1.1590.17
195_L360_C1.1570.17
232_F315_V1.1530.17
73_Q197_N1.1510.17
47_R176_R1.1510.17
110_A134_S1.1430.17
47_R74_Y1.1430.17
46_I208_R1.1380.16
18_D360_C1.1330.16
190_V381_Q1.1320.16
287_M305_A1.1280.16
3_I15_F1.1220.16
312_R315_V1.1120.16
154_A158_G1.1110.16
98_A119_L1.1100.16
270_Q302_D1.1060.16
73_Q173_G1.0940.16
173_G195_L1.0890.16
137_L170_G1.0860.16
162_A378_D1.0810.16
328_Q347_C1.0800.16
129_V337_L1.0790.16
81_D84_F1.0780.16
336_G361_N1.0740.15
212_Y308_W1.0730.15
18_D197_N1.0720.15
201_A355_Y1.0680.15
47_R173_G1.0670.15
2_R60_S1.0640.15
173_G215_W1.0630.15
369_R390_F1.0600.15
154_A266_P1.0590.15
336_G395_A1.0590.15
154_A356_V1.0560.15
368_R398_S1.0550.15
279_S282_A1.0460.15
261_R300_A1.0450.15
127_T130_R1.0440.15
18_D173_G1.0400.15
173_G176_R1.0280.15
106_A394_Y1.0250.15
216_L256_Y1.0250.15
20_Q47_R1.0200.15
32_M148_T1.0090.14
176_R360_C1.0080.14
176_R197_N1.0060.14
27_A34_Y1.0060.14
169_F355_Y0.9930.14
142_S392_A0.9930.14
270_Q381_Q0.9930.14
51_E86_A0.9930.14
108_C327_V0.9910.14
116_V129_V0.9880.14
344_A356_V0.9870.14
116_V329_V0.9840.14
98_A291_R0.9840.14
171_Q360_C0.9840.14
71_A169_F0.9830.14
182_A360_C0.9820.14
291_R319_V0.9800.14
46_I96_A0.9780.14
263_A290_L0.9770.14
267_Y325_D0.9770.14
124_G303_I0.9750.14
176_R388_M0.9730.14
175_Q178_R0.9700.14
2_R315_V0.9640.14
195_L388_M0.9630.14
137_L278_G0.9610.14
6_V57_V0.9540.14
149_Q372_H0.9480.14
11_G328_Q0.9470.14
118_S152_V0.9440.13
46_I155_D0.9400.13
263_A275_M0.9390.13
74_Y360_C0.9370.13
231_R270_Q0.9360.13
159_T315_V0.9330.13
55_V394_Y0.9330.13
169_F273_G0.9300.13
130_R336_G0.9290.13
109_V138_V0.9290.13
47_R397_V0.9280.13
220_A232_F0.9280.13
123_R207_V0.9270.13
356_V410_A0.9260.13
197_N388_M0.9260.13
174_E179_G0.9250.13
18_D388_M0.9230.13
47_R360_C0.9230.13
47_R197_N0.9220.13
215_W360_C0.9180.13
39_R61_D0.9140.13
23_I26_G0.9130.13
210_V259_E0.9130.13
47_R171_Q0.9100.13
24_T234_V0.9090.13
106_A112_N0.9080.13
47_R195_L0.9070.13
79_D138_V0.9070.13
150_T356_V0.9020.13
362_E385_K0.9010.13
148_T165_P0.9010.13
154_A163_T0.9010.13
46_I245_G0.9000.13
41_D377_T0.8960.13
74_Y173_G0.8960.13
378_D408_H0.8950.13
52_A124_G0.8950.13
226_D300_A0.8910.13
305_A328_Q0.8870.13
48_E239_M0.8850.13
97_V289_E0.8810.13
352_T373_V0.8800.13
74_Y388_M0.8780.13
53_L77_A0.8770.13
134_S141_A0.8750.12
257_V325_D0.8720.12
165_P267_Y0.8720.12
240_L291_R0.8710.12
39_R55_V0.8710.12
163_T408_H0.8690.12
65_V342_R0.8680.12
159_T340_S0.8680.12
334_V401_M0.8660.12
257_V290_L0.8660.12
79_D310_D0.8650.12
375_L404_T0.8630.12
5_R234_V0.8620.12
150_T375_L0.8620.12
258_R297_A0.8590.12
289_E329_V0.8540.12
355_Y360_C0.8530.12
169_F201_A0.8510.12
75_S127_T0.8510.12
213_L271_I0.8470.12
271_I353_R0.8470.12
96_A125_L0.8440.12
73_Q388_M0.8340.12
15_F174_E0.8340.12
179_G215_W0.8320.12
163_T329_V0.8310.12
31_G34_Y0.8300.12
49_P199_V0.8300.12
211_E214_D0.8280.12
292_D303_I0.8270.12
225_G250_R0.8260.12
360_C388_M0.8260.12
71_A195_L0.8250.12
180_A216_L0.8220.12
344_A378_D0.8190.12
12_V394_Y0.8140.12
133_V394_Y0.8130.12
160_E408_H0.8120.12
348_A380_A0.8120.12
47_R215_W0.8120.12
42_G283_Q0.8110.12
20_Q173_G0.8100.12
53_L93_V0.8060.12
267_Y340_S0.8040.12
165_P398_S0.8020.12
190_V323_A0.8010.12
177_R261_R0.7970.11
209_L212_Y0.7940.11
73_Q384_A0.7920.11
14_G369_R0.7910.11
297_A300_A0.7890.11
5_R410_A0.7880.11
172_S195_L0.7860.11
250_R293_G0.7860.11
173_G197_N0.7820.11
20_Q360_C0.7820.11
173_G179_G0.7810.11
50_G336_G0.7800.11
77_A304_V0.7800.11
73_Q215_W0.7800.11
23_I31_G0.7770.11
64_R213_L0.7770.11
31_G36_G0.7770.11
71_A273_G0.7750.11
388_M397_V0.7750.11
276_D397_V0.7740.11
109_V310_D0.7720.11
344_A408_H0.7710.11
20_Q176_R0.7680.11
57_V137_L0.7670.11
356_V377_T0.7650.11
112_N365_V0.7640.11
83_L309_C0.7630.11
360_C384_A0.7630.11
360_C397_V0.7620.11
102_V121_D0.7600.11
97_V133_V0.7580.11
50_G126_H0.7560.11
73_Q169_F0.7540.11
87_A265_A0.7540.11
45_R240_L0.7540.11
5_R98_A0.7540.11
294_L352_T0.7530.11
8_A13_A0.7510.11
290_L381_Q0.7480.11
127_T273_G0.7470.11
160_E356_V0.7460.11
126_H401_M0.7460.11
71_A171_Q0.7460.11
20_Q397_V0.7460.11
126_H361_N0.7450.11
20_Q276_D0.7440.11
101_L106_A0.7420.11
133_V271_I0.7410.11
133_V151_R0.7390.11
78_G331_T0.7390.11
51_E381_Q0.7390.11
73_Q276_D0.7380.11
213_L345_R0.7370.11
114_A369_R0.7360.11
171_Q384_A0.7350.11
96_A200_E0.7330.11
147_T152_V0.7330.11
205_D298_G0.7310.11
8_A406_A0.7310.11
8_A324_A0.7300.11
370_C374_A0.7290.11
13_A338_L0.7270.11
370_C379_A0.7230.11
17_F51_E0.7230.11
55_V78_G0.7220.11
12_V187_R0.7210.11
11_G329_V0.7200.11
174_E177_R0.7160.11
243_L390_F0.7130.10
217_S270_Q0.7130.10
136_A228_Y0.7130.10
73_Q174_E0.7130.10
189_G226_D0.7120.10
120_A380_A0.7080.10
97_V316_E0.7070.10
55_V331_T0.7050.10
13_A169_F0.7040.10
189_G245_G0.7030.10
354_A360_C0.7020.10
20_Q73_Q0.7020.10
117_E133_V0.6990.10
174_E195_L0.6990.10
133_V172_S0.6990.10
179_G390_F0.6970.10
193_H237_Y0.6970.10
145_R285_D0.6970.10
290_L301_V0.6970.10
47_R388_M0.6950.10
196_F341_G0.6930.10
268_P373_V0.6920.10
341_G379_A0.6900.10
368_R410_A0.6890.10
172_S176_R0.6840.10
220_A313_A0.6840.10
179_G360_C0.6830.10
319_V324_A0.6820.10
180_A360_C0.6820.10
195_L384_A0.6800.10
327_V375_L0.6790.10
371_A374_A0.6790.10
116_V134_S0.6760.10
312_R344_A0.6730.10
196_F396_A0.6730.10
6_V194_G0.6730.10
108_C111_D0.6720.10
62_G113_A0.6720.10
20_Q355_Y0.6720.10
246_P373_V0.6700.10
78_G182_A0.6680.10
254_T293_G0.6670.10
181_E353_R0.6660.10
62_G263_A0.6660.10
224_G246_P0.6660.10
220_A341_G0.6660.10
66_R134_S0.6640.10
129_V316_E0.6640.10
78_G388_M0.6630.10
48_E202_V0.6620.10
344_A371_A0.6610.10
224_G377_T0.6610.10
213_L264_A0.6600.10
112_N141_A0.6590.10
195_L215_W0.6590.10
182_A215_W0.6580.10
126_H169_F0.6550.10
153_L340_S0.6550.10
319_V322_G0.6550.10
52_A98_A0.6550.10
171_Q174_E0.6520.10
73_Q172_S0.6490.10
120_A250_R0.6480.10
281_E373_V0.6470.10
334_V339_E0.6450.10
126_H130_R0.6450.10
154_A312_R0.6450.10
5_R151_R0.6440.10
28_D121_D0.6400.10
3_I331_T0.6400.10
6_V152_V0.6390.10
57_V64_R0.6380.10
64_R118_S0.6350.10
166_V319_V0.6340.10
384_A388_M0.6340.10
114_A327_V0.6330.10
224_G298_G0.6330.10
177_R215_W0.6320.10
194_G288_A0.6310.10
27_A31_G0.6290.10
16_F185_L0.6280.10
50_G244_F0.6260.10
14_G149_Q0.6260.10
9_T56_E0.6250.09
334_V342_R0.6240.09
176_R215_W0.6240.09
185_L275_M0.6230.09
262_A295_A0.6220.09
270_Q353_R0.6210.09
144_A207_V0.6200.09
349_G352_T0.6150.09
173_G182_A0.6140.09
55_V70_A0.6130.09
147_T155_D0.6130.09
332_P366_S0.6110.09
35_A405_L0.6100.09
150_T189_G0.6100.09
106_A144_A0.6080.09
259_E262_A0.6070.09
240_L253_V0.6060.09
201_A276_D0.6050.09
262_A325_D0.6050.09
17_F75_S0.6050.09
182_A195_L0.6040.09
244_F256_Y0.6030.09
126_H309_C0.6030.09
202_V240_L0.6010.09
53_L125_L0.6010.09
78_G397_V0.6010.09
71_A176_R0.5990.09
232_F402_R0.5960.09
217_S368_R0.5940.09
200_E394_Y0.5930.09
71_A201_A0.5930.09
71_A74_Y0.5920.09
74_Y276_D0.5910.09
9_T58_V0.5900.09
65_V139_A0.5890.09
8_A61_D0.5880.09
118_S134_S0.5860.09
151_R220_A0.5830.09
151_R369_R0.5800.09
250_R356_V0.5800.09
276_D360_C0.5800.09
303_I373_V0.5780.09
18_D397_V0.5780.09
49_P183_M0.5780.09
155_D213_L0.5780.09
89_H273_G0.5770.09
208_R370_C0.5770.09
49_P347_C0.5770.09
149_Q179_G0.5770.09
43_Y142_S0.5760.09
209_L320_D0.5760.09
146_A282_A0.5760.09
371_A377_T0.5760.09
203_G206_G0.5740.09
156_A184_L0.5720.09
356_V373_V0.5720.09
173_G276_D0.5710.09
71_A256_Y0.5680.09
16_F116_V0.5660.09
74_Y384_A0.5660.09
197_N201_A0.5650.09
345_R351_D0.5630.09
189_G404_T0.5620.09
151_R240_L0.5620.09
157_L338_L0.5620.09
12_V172_S0.5620.09
213_L353_R0.5600.09
28_D313_A0.5600.09
152_V296_D0.5590.09
36_G79_D0.5570.09
154_A402_R0.5570.09
196_F397_V0.5560.09
70_A86_A0.5560.09
194_G380_A0.5540.09
232_F351_D0.5530.09
57_V259_E0.5530.09
245_G250_R0.5520.09
194_G286_A0.5510.09
105_D208_R0.5500.09
382_V398_S0.5470.09
55_V106_A0.5450.09
337_L364_T0.5450.09
197_N360_C0.5450.09
179_G381_Q0.5440.09
7_T58_V0.5440.09
250_R352_T0.5440.09
26_G31_G0.5430.09
63_R213_L0.5430.09
98_A382_V0.5420.09
298_G352_T0.5410.09
129_V327_V0.5410.09
102_V410_A0.5410.09
173_G355_Y0.5400.09
74_Y215_W0.5390.09
165_P378_D0.5380.09
126_H244_F0.5380.09
182_A354_A0.5380.09
64_R407_R0.5380.09
110_A352_T0.5380.09
147_T281_E0.5370.09
64_R405_L0.5350.09
74_Y172_S0.5340.09
14_G290_L0.5330.09
61_D243_L0.5300.09
69_C86_A0.5280.09
377_T408_H0.5280.09
18_D174_E0.5270.09
157_L395_A0.5260.08
265_A322_G0.5240.08
61_D261_R0.5240.08
277_A286_A0.5240.08
373_V404_T0.5240.08
148_T319_V0.5230.08
171_Q215_W0.5230.08
97_V267_Y0.5230.08
176_R276_D0.5220.08
41_D364_T0.5220.08
148_T232_F0.5210.08
173_G388_M0.5190.08
332_P383_L0.5160.08
11_G42_G0.5160.08
154_A404_T0.5150.08
174_E360_C0.5150.08
346_Y361_N0.5140.08
165_P368_R0.5140.08
31_G79_D0.5140.08
8_A284_I0.5130.08
127_T331_T0.5130.08
21_A25_A0.5120.08
183_M188_V0.5120.08
332_P362_E0.5100.08
46_I405_L0.5100.08
81_D127_T0.5100.08
196_F223_L0.5090.08
83_L91_A0.5080.08
312_R342_R0.5070.08
279_S375_L0.5060.08
168_V184_L0.5050.08
18_D215_W0.5050.08
113_A134_S0.5050.08
191_L283_Q0.5050.08
16_F231_R0.5050.08
10_P129_V0.5030.08
224_G375_L0.5000.08
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kkoA 2 0.9761 100 0.599 Contact Map
1kczA 2 0.9809 100 0.614 Contact Map
3otrA 2 0.8684 100 0.846 Contact Map
4mksA 3 0.8182 100 0.848 Contact Map
2pa6A 5 0.8517 100 0.849 Contact Map
3uj2A 3 0.8636 100 0.849 Contact Map
3tqpA 2 0.8349 100 0.85 Contact Map
2fymA 3 0.866 100 0.85 Contact Map
2akzA 2 0.8589 100 0.851 Contact Map
4ropA 3 0.8541 100 0.852 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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