GREMLIN Database
Q9HN18 - Monoamine oxidase regulatory-like
UniProt: Q9HN18 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (156)
Sequences: 1014 (486)
Seq/√Len: 38.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_D158_Q3.6111.00
120_A161_E3.1211.00
36_D175_R3.0831.00
95_S155_T2.9801.00
50_T127_T2.9601.00
139_E174_K2.8661.00
115_D167_E2.7841.00
32_R41_D2.7831.00
136_S150_T2.7671.00
34_Y137_K2.7511.00
83_E123_F2.7171.00
129_F160_G2.6781.00
133_E152_E2.5701.00
126_D157_T2.5671.00
131_E154_R2.4281.00
133_E154_R2.3921.00
70_H88_G2.3081.00
74_A77_S2.2100.99
82_D123_F2.1300.99
98_M130_A2.0860.99
131_E156_Y2.0330.99
157_T161_E2.0160.99
51_V90_F2.0110.99
35_E175_R1.9600.99
44_K131_E1.9370.98
91_V155_T1.9080.98
90_F94_L1.7550.97
73_A84_R1.7420.97
65_N87_N1.6650.96
49_R55_D1.6240.95
130_A153_L1.5190.93
58_W61_N1.4360.91
63_T90_F1.4270.91
60_T65_N1.3760.89
73_A77_S1.3690.89
89_L118_H1.3350.88
109_A149_V1.3250.88
151_T170_P1.3240.88
152_E165_S1.2910.86
154_R162_L1.2830.86
95_S130_A1.2500.84
67_N70_H1.2200.83
33_F175_R1.2190.83
74_A82_D1.2150.83
53_E84_R1.2110.82
63_T87_N1.2030.82
48_G129_F1.2000.82
53_E57_V1.1980.82
63_T70_H1.1970.82
126_D163_V1.1960.82
140_S148_M1.1920.81
38_A41_D1.1830.81
39_V137_K1.1780.81
140_S171_M1.1760.80
93_A150_T1.1730.80
56_N64_M1.1730.80
51_V94_L1.1700.80
99_S132_S1.1660.80
148_M171_M1.1620.80
39_V175_R1.1590.79
107_A110_N1.1380.78
140_S144_P1.1110.76
56_N86_V1.0790.74
122_V128_L1.0640.73
38_A83_E1.0450.72
65_N86_V1.0330.71
56_N65_N1.0270.71
33_F176_G1.0110.69
114_D117_Q1.0060.69
107_A151_T1.0030.69
80_E85_L0.9930.68
58_W62_L0.9700.66
112_G117_Q0.9630.66
105_A164_L0.9500.65
51_V86_V0.9430.64
116_I166_L0.9380.64
35_E149_V0.9350.63
49_R88_G0.9320.63
35_E173_R0.9300.63
92_I113_Y0.9260.63
93_A114_D0.9010.60
64_M124_H0.8990.60
53_E58_W0.8930.60
42_V133_E0.8870.59
153_L166_L0.8840.59
162_L165_S0.8730.58
176_G179_D0.8640.57
115_D165_S0.8590.57
56_N124_H0.8580.57
63_T118_H0.8560.56
38_A137_K0.8500.56
54_T127_T0.8440.55
81_F121_P0.8410.55
78_G177_A0.8290.54
64_M96_V0.8250.54
89_L96_V0.8220.53
79_T82_D0.8200.53
138_R148_M0.8200.53
157_T163_V0.8140.53
73_A124_H0.8090.52
59_F87_N0.8090.52
100_V110_N0.8040.52
74_A129_F0.8040.52
77_S161_E0.8030.52
97_G109_A0.7950.51
35_E160_G0.7920.51
94_L128_L0.7900.50
37_F149_V0.7880.50
128_L163_V0.7880.50
49_R90_F0.7800.50
173_R179_D0.7780.49
56_N91_V0.7700.49
74_A78_G0.7690.49
84_R118_H0.7620.48
55_D121_P0.7590.48
65_N70_H0.7530.47
65_N72_N0.7530.47
33_F36_D0.7520.47
35_E174_K0.7500.47
129_F156_Y0.7490.47
132_S168_R0.7480.47
60_T87_N0.7430.46
27_A33_F0.7420.46
92_I96_V0.7370.46
140_S146_V0.7360.46
97_G112_G0.7340.45
29_W43_Y0.7320.45
34_Y147_G0.7290.45
59_F121_P0.7260.45
24_Q38_A0.7250.45
99_S168_R0.7220.44
107_A170_P0.7180.44
87_N90_F0.7150.44
73_A83_E0.7130.44
43_Y154_R0.7080.43
128_L157_T0.7070.43
67_N75_Y0.7060.43
97_G147_G0.7030.43
92_I116_I0.7030.43
119_H162_L0.7030.43
87_N118_H0.7030.43
69_M85_L0.7000.42
37_F104_S0.7000.42
42_V86_V0.6980.42
119_H124_H0.6950.42
45_H155_T0.6930.42
132_S151_T0.6930.42
75_Y79_T0.6920.42
31_G111_L0.6900.42
25_L44_K0.6900.42
39_V178_A0.6840.41
40_G133_E0.6830.41
135_L151_T0.6810.41
54_T57_V0.6760.40
119_H165_S0.6760.40
98_M151_T0.6750.40
95_S164_L0.6740.40
43_Y178_A0.6690.40
68_P75_Y0.6680.40
145_H174_K0.6640.39
74_A156_Y0.6640.39
111_L168_R0.6610.39
91_V128_L0.6600.39
64_M90_F0.6580.39
82_D94_L0.6570.39
36_D71_F0.6570.39
34_Y125_G0.6550.38
45_H48_G0.6520.38
91_V122_V0.6510.38
128_L156_Y0.6500.38
60_T71_F0.6480.38
35_E137_K0.6450.38
26_R44_K0.6430.37
53_E83_E0.6430.37
87_N96_V0.6420.37
65_N118_H0.6400.37
132_S153_L0.6400.37
39_V141_E0.6370.37
48_G127_T0.6300.36
122_V155_T0.6270.36
70_H121_P0.6240.36
114_D122_V0.6240.36
38_A159_D0.6200.36
61_N66_A0.6200.36
83_E124_H0.6190.35
158_Q163_V0.6100.35
34_Y141_E0.6090.35
52_T97_G0.6080.35
78_G104_S0.6060.34
28_G34_Y0.6020.34
55_D105_A0.6010.34
112_G122_V0.5950.33
45_H168_R0.5910.33
36_D50_T0.5890.33
119_H128_L0.5890.33
89_L105_A0.5870.33
84_R124_H0.5860.33
83_E159_D0.5800.32
57_V84_R0.5740.32
60_T70_H0.5740.32
76_A104_S0.5730.32
54_T58_W0.5710.32
135_L167_E0.5710.32
110_N168_R0.5710.32
91_V116_I0.5690.31
78_G136_S0.5670.31
61_N71_F0.5650.31
52_T57_V0.5620.31
52_T136_S0.5610.31
78_G175_R0.5550.30
67_N116_I0.5550.30
118_H164_L0.5530.30
115_D133_E0.5470.30
110_N113_Y0.5370.29
61_N77_S0.5360.29
150_T167_E0.5340.29
56_N70_H0.5310.29
138_R141_E0.5310.29
79_T156_Y0.5300.28
101_V105_A0.5300.28
59_F136_S0.5290.28
53_E124_H0.5290.28
78_G141_E0.5270.28
41_D77_S0.5240.28
72_N84_R0.5240.28
148_M158_Q0.5230.28
110_N170_P0.5220.28
47_Y144_P0.5200.28
41_D137_K0.5190.28
92_I168_R0.5160.27
74_A159_D0.5160.27
86_V173_R0.5090.27
37_F60_T0.5050.27
73_A138_R0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2bi0A 3 0.8702 100 0.398 Contact Map
1q6wA 6 0.7115 100 0.409 Contact Map
3exzA 2 0.6971 100 0.419 Contact Map
4e3eA 3 0.8413 100 0.424 Contact Map
4ffuA 6 0.774 100 0.426 Contact Map
3ir3A 2 0.6106 100 0.459 Contact Map
2c2iA 2 0.6875 100 0.47 Contact Map
4rv2B 2 0.6538 100 0.476 Contact Map
3k67A 2 0.7356 100 0.477 Contact Map
1iq6A 2 0.6394 100 0.479 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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