GREMLIN Database
Q9HN16 - Uncharacterized protein
UniProt: Q9HN16 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 431 (368)
Sequences: 1679 (1346)
Seq/√Len: 70.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_L223_A5.3891.00
192_L224_L5.2151.00
61_E65_H4.5111.00
53_Y103_A4.2251.00
185_V219_T4.0361.00
111_N162_T3.7081.00
167_A190_A3.6011.00
62_A67_D3.4931.00
64_L95_A3.4191.00
191_A198_V3.1691.00
293_V316_G3.1331.00
68_P71_G3.0811.00
97_A102_T3.0561.00
215_V219_T2.8711.00
60_A93_P2.8651.00
86_V223_A2.8611.00
60_A92_V2.6061.00
60_A91_F2.5341.00
63_A231_F2.5081.00
121_L166_L2.4301.00
114_A166_L2.4251.00
98_G102_T2.4241.00
69_F88_V2.4211.00
118_L165_A2.3811.00
294_W298_R2.3311.00
284_L288_A2.2441.00
196_F328_Y2.1361.00
171_T187_I2.1361.00
222_G226_A2.1191.00
110_C163_L2.1141.00
214_G218_A2.1011.00
287_L291_P2.0511.00
83_Y161_D2.0371.00
161_D328_Y2.0051.00
314_V318_L1.9961.00
183_A209_A1.9671.00
199_V317_M1.9531.00
188_A219_T1.9261.00
262_A325_N1.9221.00
298_R302_T1.9161.00
297_A313_V1.8501.00
179_H183_A1.8421.00
262_A267_R1.8391.00
64_L96_A1.8341.00
116_L142_V1.8171.00
209_A212_A1.8171.00
184_G188_A1.8001.00
223_A227_G1.7611.00
114_A163_L1.7591.00
228_G235_A1.7231.00
84_P322_P1.7151.00
353_L357_A1.7081.00
124_H129_R1.7041.00
323_A327_L1.6951.00
352_L356_T1.6861.00
283_P287_L1.6671.00
197_P328_Y1.6600.99
160_V164_I1.6600.99
315_A402_G1.6580.99
199_V202_L1.6580.99
200_L314_V1.6190.99
55_A83_Y1.6110.99
235_A239_Y1.6100.99
179_H182_I1.6020.99
393_L396_A1.5800.99
82_V328_Y1.5690.99
81_Y87_A1.5650.99
82_V250_S1.5610.99
53_Y107_Q1.5610.99
356_T360_A1.5240.99
281_Y285_A1.5100.99
95_A98_G1.5010.99
106_I109_A1.5010.99
70_V81_Y1.4970.99
363_V366_A1.4940.99
309_T313_V1.4740.99
111_N163_L1.4680.99
63_A92_V1.4520.99
325_N328_Y1.4320.98
308_T311_L1.4290.98
83_Y194_K1.4270.98
154_A161_D1.4190.98
224_L227_G1.4160.98
218_A222_G1.4140.98
269_L274_G1.3950.98
227_G232_G1.3930.98
106_I110_C1.3810.98
163_L166_L1.3710.98
30_A33_G1.3660.98
161_D330_V1.3650.98
51_W79_V1.3490.98
232_G235_A1.3430.98
102_T106_I1.3400.98
191_A220_A1.3280.98
364_Q367_H1.3260.97
264_S267_R1.3200.97
60_A88_V1.3160.97
64_L92_V1.3100.97
192_L227_G1.3100.97
201_G216_A1.3070.97
143_G147_A1.2940.97
295_F299_R1.2930.97
411_T414_T1.2860.97
409_W412_I1.2850.97
166_L170_G1.2840.97
396_A399_P1.2750.97
57_H103_A1.2710.97
394_S397_S1.2650.97
262_A328_Y1.2590.97
216_A219_T1.2590.97
159_Q322_P1.2570.97
168_L171_T1.2460.96
117_G166_L1.2390.96
149_A326_A1.2390.96
215_V218_A1.2310.96
211_H215_V1.2280.96
323_A328_Y1.2260.96
205_V213_I1.2250.96
388_V391_P1.2240.96
56_Y59_A1.2190.96
118_L169_A1.2190.96
283_P290_A1.2140.96
56_Y91_F1.2140.96
107_Q163_L1.2110.96
25_V225_V1.2080.96
79_V318_L1.2070.96
189_A223_A1.2000.95
201_G210_W1.1960.95
407_L411_T1.1950.95
282_G286_L1.1840.95
55_A79_V1.1700.95
321_S331_Y1.1670.95
116_L120_A1.1660.95
59_A82_V1.1660.95
188_A220_A1.1630.95
30_A40_F1.1600.95
360_A364_Q1.1550.94
198_V202_L1.1460.94
296_V413_H1.1460.94
102_T105_A1.1340.94
100_W105_A1.1260.94
279_R283_P1.1250.94
182_I186_V1.1210.93
56_Y82_V1.1210.93
412_I415_A1.1150.93
292_A296_V1.1100.93
321_S325_N1.1090.93
117_G414_T1.1070.93
50_A104_F1.1020.93
204_L216_A1.1010.93
83_Y328_Y1.1000.93
266_Y270_S1.0920.93
117_G163_L1.0870.92
246_R249_V1.0870.92
308_T312_A1.0840.92
242_V249_V1.0790.92
237_I241_H1.0750.92
205_V210_W1.0750.92
56_Y83_Y1.0730.92
53_Y94_Q1.0640.92
189_A219_T1.0630.92
73_E76_L1.0620.91
28_W32_A1.0590.91
225_V228_G1.0570.91
357_A361_F1.0480.91
81_Y88_V1.0430.91
120_A124_H1.0410.91
204_L207_R1.0390.91
190_A197_P1.0310.90
358_A361_F1.0310.90
82_V246_R1.0270.90
159_Q194_K1.0260.90
361_F367_H1.0220.90
203_W309_T1.0210.90
119_A333_Y1.0200.90
93_P96_A1.0150.90
281_Y284_L1.0090.89
52_D194_K0.9940.89
324_S329_V0.9870.88
190_A196_F0.9870.88
293_V297_A0.9770.88
290_A294_W0.9750.88
119_A145_C0.9730.87
220_A224_L0.9630.87
285_A299_R0.9620.87
82_V249_V0.9610.87
195_V325_N0.9600.87
24_L36_V0.9590.87
86_V192_L0.9580.87
227_G249_V0.9570.87
402_G407_L0.9530.86
187_I264_S0.9530.86
89_A231_F0.9520.86
107_Q157_L0.9480.86
178_D183_A0.9470.86
154_A162_T0.9470.86
262_A327_L0.9430.86
149_A161_D0.9420.86
118_L166_L0.9420.86
295_F298_R0.9360.85
55_A82_V0.9340.85
232_G236_Y0.9320.85
228_G232_G0.9310.85
404_S407_L0.9290.85
88_V327_L0.9290.85
187_I216_A0.9260.85
91_F161_D0.9200.84
31_V38_V0.9190.84
410_C414_T0.9180.84
31_V40_F0.9160.84
82_V154_A0.9130.84
172_F310_Y0.9120.84
80_S84_P0.9090.84
81_Y327_L0.9090.84
59_A91_F0.9070.83
161_D324_S0.9060.83
167_A193_V0.8990.83
162_T166_L0.8990.83
50_A54_R0.8960.83
225_V229_L0.8930.82
161_D164_I0.8920.82
176_E179_H0.8860.82
393_L400_L0.8840.82
389_V398_V0.8820.82
387_A395_V0.8810.82
362_P365_P0.8800.82
169_A310_Y0.8790.81
386_L389_V0.8780.81
88_V323_A0.8760.81
294_W297_A0.8740.81
153_S157_L0.8720.81
143_G146_V0.8700.81
28_W35_L0.8690.81
160_V328_Y0.8680.81
161_D197_P0.8680.81
153_S326_A0.8670.81
140_L356_T0.8630.80
263_M271_Q0.8620.80
164_I190_A0.8620.80
25_V39_Y0.8600.80
246_R257_S0.8560.80
227_G235_A0.8490.79
117_G120_A0.8490.79
168_L198_V0.8470.79
74_T138_R0.8460.79
35_L39_Y0.8440.79
195_V199_V0.8430.79
32_A40_F0.8410.79
56_Y325_N0.8410.79
296_V410_C0.8400.78
73_E77_P0.8380.78
82_V327_L0.8370.78
406_V409_W0.8360.78
180_Q209_A0.8360.78
51_W80_S0.8300.78
79_V325_N0.8280.77
112_V155_L0.8250.77
28_W31_V0.8230.77
81_Y271_Q0.8230.77
70_V82_V0.8220.77
387_A391_P0.8190.77
86_V189_A0.8180.77
177_R182_I0.8170.77
389_V403_L0.8160.76
201_G213_I0.8130.76
59_A81_Y0.8100.76
68_P234_D0.8080.76
204_L213_I0.8060.76
80_S318_L0.8030.75
113_A226_A0.7990.75
187_I204_L0.7980.75
55_A80_S0.7970.75
56_Y331_Y0.7920.74
240_V244_A0.7910.74
94_Q103_A0.7900.74
181_G215_V0.7900.74
24_L27_F0.7870.74
161_D196_F0.7860.74
52_D328_Y0.7850.74
355_G360_A0.7840.74
56_Y328_Y0.7830.73
86_V191_A0.7830.73
212_A215_V0.7790.73
82_V325_N0.7780.73
388_V393_L0.7740.73
357_A364_Q0.7710.72
324_S327_L0.7710.72
82_V196_F0.7680.72
311_L314_V0.7660.72
262_A323_A0.7650.72
392_V395_V0.7640.72
204_L313_V0.7630.71
34_V42_V0.7590.71
149_A398_V0.7580.71
36_V42_V0.7560.71
402_G406_V0.7550.71
52_D325_N0.7550.71
342_L346_G0.7530.70
280_L284_L0.7520.70
168_L331_Y0.7480.70
23_R27_F0.7470.70
286_L297_A0.7430.69
292_A359_M0.7420.69
188_A192_L0.7420.69
79_V84_P0.7420.69
86_V197_P0.7400.69
283_P286_L0.7380.69
82_V195_V0.7360.69
351_L364_Q0.7330.68
56_Y80_S0.7320.68
314_V331_Y0.7310.68
97_A106_I0.7310.68
102_T167_A0.7310.68
362_P367_H0.7290.68
31_V100_W0.7290.68
56_Y197_P0.7280.68
116_L138_R0.7280.68
351_L358_A0.7270.68
195_V328_Y0.7270.68
403_L414_T0.7250.68
400_L409_W0.7210.67
197_P262_A0.7190.67
30_A34_V0.7190.67
138_R162_T0.7180.67
27_F217_V0.7170.67
181_G211_H0.7150.67
392_V396_A0.7140.66
238_R242_V0.7140.66
148_S151_V0.7140.66
33_G42_V0.7110.66
88_V196_F0.7110.66
122_T169_A0.7100.66
144_F358_A0.7080.66
387_A392_V0.7070.66
267_R321_S0.7050.65
202_L207_R0.7050.65
192_L220_A0.7030.65
204_L258_P0.7020.65
84_P399_P0.7020.65
159_Q325_N0.7000.65
196_F325_N0.7000.65
31_V35_L0.6990.65
280_L285_A0.6980.65
122_T175_L0.6970.65
296_V300_E0.6950.64
26_L29_S0.6940.64
135_D139_L0.6940.64
222_G225_V0.6920.64
104_F111_N0.6910.64
82_V245_A0.6910.64
239_Y246_R0.6870.63
401_L404_S0.6860.63
86_V188_A0.6840.63
218_A394_S0.6820.63
97_A213_I0.6810.63
307_L338_C0.6810.63
233_V359_M0.6810.63
84_P197_P0.6790.63
319_L399_P0.6790.63
80_S186_V0.6770.62
203_W213_I0.6770.62
56_Y238_R0.6770.62
61_E95_A0.6760.62
174_A182_I0.6740.62
160_V323_A0.6730.62
171_T183_A0.6690.61
74_T77_P0.6690.61
82_V248_R0.6680.61
386_L390_A0.6680.61
278_P282_G0.6660.61
361_F366_A0.6660.61
210_W214_G0.6660.61
80_S325_N0.6640.61
127_E308_T0.6640.61
168_L191_A0.6630.61
360_A365_P0.6620.61
204_L212_A0.6620.61
113_A241_H0.6610.60
250_S257_S0.6600.60
246_R250_S0.6580.60
264_S269_L0.6580.60
151_V333_Y0.6560.60
245_A248_R0.6500.59
26_L34_V0.6480.59
191_A201_G0.6470.59
292_A316_G0.6470.59
310_Y316_G0.6450.59
27_F31_V0.6450.59
56_Y159_Q0.6440.58
363_V367_H0.6430.58
308_T342_L0.6420.58
399_P402_G0.6420.58
66_G97_A0.6420.58
87_A238_R0.6410.58
248_R265_L0.6400.58
311_L338_C0.6390.58
51_W55_A0.6380.58
230_W285_A0.6380.58
171_T200_L0.6370.58
361_F414_T0.6360.57
265_L269_L0.6340.57
55_A325_N0.6330.57
326_A329_V0.6320.57
223_A235_A0.6300.57
66_G211_H0.6290.57
95_A103_A0.6280.57
190_A317_M0.6260.56
389_V392_V0.6250.56
357_A360_A0.6240.56
182_I306_R0.6240.56
90_L93_P0.6220.56
296_V405_A0.6200.56
96_A177_R0.6170.55
81_Y259_D0.6150.55
171_T190_A0.6140.55
196_F327_L0.6140.55
361_F364_Q0.6120.55
411_T415_A0.6100.54
72_I76_L0.6090.54
56_Y195_V0.6080.54
22_R119_A0.6080.54
262_A271_Q0.6070.54
59_A398_V0.6050.54
139_L143_G0.6040.54
299_R303_L0.6010.53
56_Y324_S0.6000.53
312_A318_L0.6000.53
36_V40_F0.5990.53
150_P271_Q0.5960.53
161_D334_F0.5960.53
265_L288_A0.5950.53
203_W206_F0.5930.52
35_L65_H0.5920.52
350_W365_P0.5910.52
199_V315_A0.5910.52
397_S400_L0.5890.52
365_P368_V0.5890.52
202_L205_V0.5860.51
136_I140_L0.5860.51
238_R249_V0.5860.51
223_A335_P0.5850.51
56_Y327_L0.5840.51
84_P184_G0.5830.51
359_M362_P0.5820.51
154_A210_W0.5800.51
81_Y325_N0.5790.51
286_L293_V0.5790.51
299_R302_T0.5780.51
107_Q111_N0.5780.51
396_A400_L0.5780.51
359_M414_T0.5770.50
111_N154_A0.5760.50
107_Q166_L0.5740.50
31_V37_P0.5720.50
35_L185_V0.5720.50
102_T113_A0.5710.50
98_G106_I0.5690.49
170_G174_A0.5690.49
313_V324_S0.5680.49
195_V327_L0.5680.49
208_R281_Y0.5670.49
94_Q107_Q0.5670.49
23_R26_L0.5660.49
25_V30_A0.5650.49
385_V388_V0.5640.49
348_E351_L0.5640.49
71_G221_T0.5630.49
265_L285_A0.5620.49
322_P328_Y0.5610.48
398_V401_L0.5600.48
222_G230_W0.5590.48
218_A221_T0.5590.48
61_E67_D0.5590.48
350_W362_P0.5570.48
135_D201_G0.5560.48
86_V328_Y0.5560.48
352_L360_A0.5560.48
305_D308_T0.5550.48
400_L404_S0.5550.48
221_T359_M0.5550.48
262_A321_S0.5520.47
52_D159_Q0.5510.47
227_G233_V0.5510.47
34_V44_A0.5500.47
218_A368_V0.5500.47
91_F141_V0.5500.47
218_A352_L0.5490.47
51_W324_S0.5480.47
220_A223_A0.5480.47
121_L124_H0.5470.47
217_V272_L0.5460.47
78_G290_A0.5460.47
176_E209_A0.5460.47
410_C415_A0.5440.46
29_S112_V0.5430.46
60_A63_A0.5430.46
35_L41_L0.5430.46
261_F326_A0.5430.46
168_L200_L0.5400.46
205_V208_R0.5390.46
352_L357_A0.5380.46
188_A322_P0.5360.45
214_G265_L0.5360.45
81_Y161_D0.5350.45
55_A331_Y0.5340.45
210_W358_A0.5340.45
52_D188_A0.5330.45
50_A111_N0.5330.45
274_G394_S0.5320.45
30_A39_Y0.5310.45
198_V201_G0.5290.45
29_S35_L0.5290.45
397_S405_A0.5280.44
111_N116_L0.5270.44
210_W213_I0.5270.44
191_A197_P0.5260.44
50_A271_Q0.5250.44
48_H156_G0.5250.44
86_V325_N0.5250.44
60_A309_T0.5250.44
89_A309_T0.5230.44
27_F39_Y0.5230.44
271_Q324_S0.5230.44
161_D329_V0.5220.44
55_A164_I0.5220.44
387_A393_L0.5210.44
26_L137_D0.5200.43
108_S155_L0.5200.43
170_G222_G0.5180.43
297_A301_H0.5170.43
341_Y345_G0.5160.43
322_P325_N0.5150.43
34_V40_F0.5150.43
395_V400_L0.5150.43
378_P397_S0.5130.43
266_Y279_R0.5120.43
406_V411_T0.5120.43
294_W355_G0.5100.42
213_I263_M0.5090.42
230_W336_L0.5080.42
214_G226_A0.5070.42
296_V406_V0.5060.42
188_A195_V0.5060.42
190_A323_A0.5060.42
391_P396_A0.5060.42
288_A357_A0.5050.42
197_P325_N0.5040.42
98_G404_S0.5030.41
68_P312_A0.5030.41
29_S142_V0.5020.41
30_A136_I0.5020.41
79_V82_V0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.7935 94.1 0.919 Contact Map
3rceA 1 0.8097 17.6 0.96 Contact Map
2kluA 1 0.1183 7.4 0.966 Contact Map
2l2tA 2 0.1021 3.3 0.971 Contact Map
3wt9A 1 0.3387 3.3 0.971 Contact Map
2jwaA 2 0.1021 3.1 0.972 Contact Map
4p02A 1 0.2947 3 0.972 Contact Map
4ogqG 1 0.0858 2.7 0.973 Contact Map
2k1eA 3 0.2251 2 0.974 Contact Map
2m20A 2 0.109 1.9 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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