GREMLIN Database
HIS4 - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
UniProt: Q9HN14 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 242 (232)
Sequences: 5843 (3079)
Seq/√Len: 202.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_A120_I3.2281.00
142_E146_E2.5151.00
118_G162_L2.4901.00
23_V177_K2.4201.00
160_A195_I2.3861.00
113_T119_E2.3851.00
89_S92_D2.3431.00
158_R162_L2.3431.00
132_L156_A2.3241.00
130_V159_Y2.3061.00
41_T76_A2.2761.00
138_E147_G2.2641.00
41_T45_A2.1951.00
94_T98_D2.1251.00
18_Q32_T2.1231.00
232_T235_D2.1151.00
112_E142_E2.0961.00
42_D46_A2.0141.00
138_E151_D1.9841.00
207_D210_R1.9761.00
207_D211_A1.9741.00
178_Q230_N1.9281.00
138_E149_G1.8711.00
87_I96_L1.8681.00
44_V78_D1.8601.00
93_A128_V1.8461.00
67_A95_A1.8381.00
60_F145_T1.8351.00
120_I128_V1.8201.00
187_R191_D1.7771.00
169_F185_P1.7411.00
111_I141_V1.7211.00
160_A194_D1.6991.00
151_D154_A1.6981.00
94_T123_A1.6911.00
24_Q177_K1.6901.00
35_D38_D1.6441.00
90_A120_I1.6131.00
222_V226_L1.5921.00
210_R239_A1.5821.00
183_T211_A1.5701.00
35_D72_D1.5631.00
51_L79_V1.5531.00
46_A234_A1.5461.00
26_E29_T1.5411.00
206_V231_F1.5171.00
150_M158_R1.5021.00
222_V225_A1.4931.00
205_T208_D1.4871.00
66_N69_A1.4841.00
16_D57_D1.4781.00
103_R129_L1.4651.00
157_Q192_S1.4651.00
203_V212_L1.4601.00
158_R161_D1.4531.00
15_Q30_E1.4451.00
225_A231_F1.4431.00
131_S168_L1.4371.00
68_T71_E1.4341.00
106_L109_A1.4291.00
74_L81_V1.4001.00
210_R214_A1.3961.00
97_L127_G1.3941.00
115_D119_E1.3941.00
109_A116_I1.3861.00
90_A123_A1.3671.00
34_G39_A1.3571.00
231_F236_A1.3511.00
72_D75_D1.3501.00
10_P48_A1.3461.00
140_V147_G1.3351.00
190_V197_V1.3251.00
136_D151_D1.3231.00
9_L50_A1.3211.00
191_D216_G1.3201.00
137_G188_D1.3191.00
91_E94_T1.3171.00
208_D211_A1.2961.00
206_V239_A1.2871.00
118_G122_A1.2801.00
209_V225_A1.2681.00
171_D182_R1.2611.00
50_A103_R1.2601.00
53_L73_I1.2561.00
70_V83_V1.2341.00
7_T50_A1.2271.00
93_A104_V1.2231.00
115_D118_G1.1951.00
110_A130_V1.1911.00
42_D45_A1.1911.00
23_V29_T1.1841.00
209_V222_V1.1831.00
108_T112_E1.1821.00
234_A238_A1.1791.00
131_S170_T1.1771.00
213_E220_A1.1761.00
169_F189_L1.1741.00
90_A119_E1.1661.00
46_A232_T1.1641.00
156_A189_L1.1601.00
71_E75_D1.1601.00
71_E99_R1.1511.00
141_V146_E1.1371.00
134_A169_F1.1341.00
111_I150_M1.1271.00
188_D191_D1.1271.00
129_L168_L1.1241.00
153_V192_S1.1051.00
165_A196_P1.0851.00
181_V203_V1.0771.00
168_L221_V1.0731.00
33_Y228_E1.0711.00
7_T49_E1.0671.00
157_Q161_D1.0611.00
42_D229_G1.0481.00
188_D192_S1.0481.00
184_D187_R1.0451.00
112_E146_E1.0441.00
212_L220_A1.0361.00
167_I195_I1.0341.00
31_R228_E1.0331.00
6_F213_E1.0321.00
206_V236_A1.0321.00
134_A185_P1.0311.00
160_A193_V1.0271.00
130_V164_A1.0231.00
112_E141_V1.0201.00
235_D238_A1.0151.00
83_V96_L1.0131.00
19_V39_A1.0111.00
212_L217_A1.0101.00
183_T187_R1.0091.00
121_A125_S1.0021.00
166_G196_P1.0001.00
46_A233_L0.9931.00
134_A152_P0.9911.00
114_P158_R0.9831.00
50_A80_S0.9831.00
116_I120_I0.9811.00
190_V215_A0.9801.00
37_V69_A0.9791.00
152_P189_L0.9751.00
189_L197_V0.9721.00
211_A214_A0.9701.00
152_P156_A0.9670.99
74_L101_V0.9640.99
156_A193_V0.9630.99
186_V190_V0.9580.99
94_T124_Y0.9540.99
83_V101_V0.9310.99
187_R215_A0.9260.99
37_V72_D0.9210.99
121_A164_A0.9210.99
44_V77_T0.9190.99
50_A129_L0.9160.99
129_L166_G0.9130.99
64_R95_A0.9070.99
224_T228_E0.9060.99
43_W227_Y0.9040.99
206_V210_R0.9020.99
190_V217_A0.9020.99
39_A42_D0.8990.99
117_V130_V0.8940.99
154_A158_R0.8920.99
91_E95_A0.8900.99
59_A108_T0.8840.99
68_T72_D0.8830.99
95_A99_R0.8810.99
206_V235_D0.8710.99
153_V188_D0.8700.99
106_L120_I0.8700.99
70_V101_V0.8680.99
21_Q224_T0.8680.99
74_L102_D0.8670.99
41_T44_V0.8630.99
71_E95_A0.8610.99
26_E60_F0.8590.99
82_Q105_I0.8570.99
54_V168_L0.8540.99
141_V148_T0.8530.99
135_K173_D0.8500.99
49_E80_S0.8480.99
153_V157_Q0.8240.98
232_T236_A0.8230.98
203_V220_A0.8140.98
8_V222_V0.8140.98
93_A124_Y0.8040.98
64_R92_D0.8040.98
72_D76_A0.8040.98
153_V156_A0.8010.98
209_V231_F0.7980.98
135_K140_V0.7970.98
77_T80_S0.7920.98
190_V218_A0.7910.98
97_L124_Y0.7890.98
140_V172_V0.7880.98
80_S102_D0.7840.98
44_V79_V0.7800.98
23_V31_R0.7800.98
90_A124_Y0.7780.98
204_A208_D0.7770.98
205_T209_V0.7740.98
92_D95_A0.7710.97
183_T215_A0.7700.97
117_V159_Y0.7700.97
7_T219_G0.7650.97
15_Q57_D0.7640.97
111_I155_A0.7640.97
118_G158_R0.7580.97
191_D215_A0.7570.97
166_G218_A0.7560.97
134_A137_G0.7550.97
184_D188_D0.7550.97
174_V177_K0.7460.97
58_G65_A0.7430.97
37_V76_A0.7420.97
139_V155_A0.7350.97
126_D165_A0.7320.97
9_L198_I0.7230.96
54_V170_T0.7220.96
196_P218_A0.7170.96
23_V224_T0.7170.96
198_I219_G0.7160.96
67_A71_E0.7120.96
205_T230_N0.7080.96
152_P185_P0.7070.96
186_V197_V0.7060.96
174_V179_E0.7040.96
38_D42_D0.7030.96
48_A233_L0.7020.96
57_D62_G0.7010.96
160_A167_I0.6990.96
113_T116_I0.6990.96
157_Q160_A0.6960.95
64_R88_R0.6950.95
154_A157_Q0.6920.95
132_L155_A0.6920.95
103_R165_A0.6900.95
168_L198_I0.6880.95
6_F220_A0.6830.95
67_A96_L0.6790.95
102_D126_D0.6780.95
74_L99_R0.6680.94
209_V220_A0.6670.94
105_I168_L0.6650.94
136_D173_D0.6630.94
109_A113_T0.6620.94
73_I81_V0.6610.94
9_L129_L0.6600.94
130_V167_I0.6590.94
69_A73_I0.6530.94
61_E65_A0.6480.93
93_A97_L0.6480.93
90_A94_T0.6470.93
106_L117_V0.6470.93
215_A218_A0.6460.93
182_R185_P0.6440.93
71_E98_D0.6400.93
8_V220_A0.6390.93
189_L193_V0.6390.93
181_V204_A0.6380.93
65_A70_V0.6380.93
209_V236_A0.6370.93
122_A161_D0.6350.93
212_L215_A0.6330.93
38_D41_T0.6330.93
93_A106_L0.6320.92
95_A98_D0.6320.92
93_A127_G0.6320.92
186_V212_L0.6300.92
87_I106_L0.6300.92
87_I93_A0.6220.92
209_V226_L0.6200.92
226_L236_A0.6190.92
53_L81_V0.6160.92
102_D127_G0.6140.91
48_A236_A0.6140.91
88_R112_E0.6120.91
24_Q29_T0.6110.91
119_E122_A0.6100.91
156_A167_I0.6080.91
223_G227_Y0.5980.90
40_A73_I0.5970.90
21_Q175_E0.5960.90
141_V145_T0.5950.90
186_V217_A0.5950.90
18_Q30_E0.5940.90
121_A130_V0.5930.90
15_Q60_F0.5900.90
64_R96_L0.5890.90
9_L82_Q0.5870.89
150_M154_A0.5850.89
62_G66_N0.5830.89
137_G151_D0.5820.89
132_L139_V0.5820.89
109_A120_I0.5750.89
49_E237_Q0.5730.88
7_T218_A0.5710.88
57_D66_N0.5710.88
157_Q193_V0.5700.88
232_T238_A0.5680.88
103_R166_G0.5650.88
203_V222_V0.5640.88
14_M53_L0.5630.87
14_M69_A0.5630.87
186_V199_A0.5610.87
190_V216_G0.5600.87
83_V87_I0.5600.87
34_G42_D0.5590.87
91_E98_D0.5590.87
137_G185_P0.5580.87
233_L237_Q0.5550.87
166_G198_I0.5460.86
132_L159_Y0.5450.86
163_G195_I0.5410.85
176_G202_G0.5410.85
120_I124_Y0.5360.85
69_A81_V0.5360.85
209_V213_E0.5320.84
118_G161_D0.5300.84
181_V208_D0.5280.84
51_L73_I0.5270.84
9_L103_R0.5260.84
91_E119_E0.5260.84
22_L144_W0.5240.83
131_S198_I0.5240.83
199_A212_L0.5200.83
203_V209_V0.5200.83
170_T200_S0.5190.83
22_L25_G0.5180.83
229_G232_T0.5170.83
176_G180_G0.5160.83
64_R67_A0.5160.83
24_Q173_D0.5120.82
150_M155_A0.5110.82
70_V81_V0.5110.82
21_Q174_V0.5100.82
77_T81_V0.5090.82
63_A92_D0.5090.82
22_L107_G0.5080.82
204_A230_N0.5070.81
54_V131_S0.5060.81
36_P69_A0.5040.81
69_A72_D0.5040.81
126_D166_G0.5030.81
11_A221_V0.5030.81
96_L101_V0.5020.81
181_V209_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2agkA 1 0.8636 100 0.255 Contact Map
1jvnA 1 0.9587 100 0.286 Contact Map
1qo2A 1 0.9669 100 0.422 Contact Map
4gj1A 1 0.9215 100 0.445 Contact Map
2y88A 1 0.9793 100 0.462 Contact Map
4x2rA 1 0.9587 100 0.478 Contact Map
4u28A 1 0.9545 100 0.483 Contact Map
1thfD 2 0.9835 100 0.487 Contact Map
4evzA 1 0.9835 100 0.492 Contact Map
4axkA 1 0.9587 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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