GREMLIN Database
HIS7 - Imidazoleglycerol-phosphate dehydratase
UniProt: Q9HN13 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 196 (191)
Sequences: 2769 (1366)
Seq/√Len: 98.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_E16_D4.0741.00
80_F143_F3.4291.00
7_A20_T3.2991.00
105_A166_A2.9011.00
30_T54_T2.7121.00
140_W171_V2.7091.00
137_A158_E2.6841.00
153_C167_L2.5561.00
107_V170_G2.4841.00
106_S154_G2.4311.00
16_D58_D2.2981.00
9_T18_A2.2261.00
131_L136_A2.1831.00
81_S148_A2.1681.00
20_T54_T2.1491.00
120_D154_G2.0921.00
57_C72_V2.0861.00
97_R106_S2.0491.00
29_H46_A2.0271.00
128_V164_I2.0181.00
74_I146_H2.0071.00
107_V153_C2.0011.00
57_C68_T1.8981.00
138_H142_T1.8741.00
34_G39_D1.8691.00
25_G52_D1.7891.00
111_V149_V1.7651.00
136_A164_I1.7631.00
38_F69_V1.7591.00
121_G167_L1.6651.00
91_Q177_D1.6581.00
124_S160_A1.6511.00
30_T56_R1.6511.00
91_Q180_R1.6251.00
47_K192_T1.6141.00
137_A141_R1.6061.00
50_L184_R1.6061.00
32_D56_R1.5871.00
143_F171_V1.5551.00
84_V179_T1.5501.00
118_E156_D1.5331.00
27_G52_D1.4881.00
19_V55_V1.4831.00
88_R187_G1.4531.00
7_A18_A1.4131.00
36_G62_D1.4071.00
65_D135_M1.3920.99
38_F72_V1.3850.99
111_V175_V1.3430.99
9_T16_D1.3390.99
123_F164_I1.3330.99
44_A93_F1.3330.99
23_L179_T1.3310.99
90_I111_V1.3260.99
160_A163_E1.3230.99
95_D177_D1.3170.99
78_A146_H1.3110.99
105_A155_V1.2910.99
73_G138_H1.2860.99
69_V135_M1.2830.99
140_W153_C1.2810.99
143_F149_V1.2790.99
127_T130_G1.2670.99
26_D52_D1.2370.99
4_R24_D1.2340.99
34_G61_L1.2330.99
19_V79_A1.2230.99
65_D132_T1.2130.99
18_A56_R1.1870.98
35_I65_D1.1540.98
100_L108_V1.1530.98
134_R160_A1.1500.98
73_G142_T1.1370.98
29_H43_A1.1310.98
48_H172_G1.1170.98
78_A82_E1.1150.98
8_V75_A1.1140.98
155_V163_E1.1140.98
176_D179_T1.1070.97
105_A163_E1.1000.97
97_R108_V1.0940.97
124_S163_E1.0930.97
42_L53_V1.0930.97
13_A43_A1.0910.97
8_V82_E1.0910.97
81_S87_K1.0860.97
125_Q134_R1.0820.97
132_T135_M1.0810.97
5_T20_T1.0790.97
61_L65_D1.0760.97
176_D180_R1.0690.97
107_V171_V1.0610.97
73_G139_F1.0590.97
134_R159_N1.0440.96
95_D108_V1.0430.96
127_T132_T1.0420.96
19_V75_A1.0360.96
121_G155_V1.0350.96
5_T22_D1.0320.96
69_V131_L1.0180.96
105_A167_L1.0100.96
115_A145_T1.0080.95
33_T39_D1.0070.95
65_D130_G1.0040.95
45_F172_G0.9920.95
32_D58_D0.9730.95
33_T55_V0.9650.94
50_L185_R0.9570.94
140_W167_L0.9540.94
61_L68_T0.9490.94
99_P104_V0.9480.94
125_Q160_A0.9460.94
119_F136_A0.9450.94
33_T72_V0.9440.94
50_L176_D0.9340.93
98_V170_G0.9280.93
8_V79_A0.9190.93
153_C171_V0.9180.93
28_E52_D0.9170.93
155_V166_A0.9110.92
141_R145_T0.9100.92
51_F179_T0.9050.92
45_F175_V0.9050.92
103_A157_G0.9030.92
21_L80_F0.9000.92
112_S150_T0.8980.92
31_V43_A0.8900.91
123_F160_A0.8890.91
45_F49_G0.8850.91
44_A75_A0.8720.91
80_F175_V0.8710.91
36_G130_G0.8700.91
19_V76_L0.8530.90
117_Y144_A0.8500.89
119_F123_F0.8460.89
138_H141_R0.8460.89
157_G163_E0.8450.89
38_F139_F0.8440.89
111_V147_A0.8380.89
102_E150_T0.8370.89
144_A151_L0.8310.88
22_D52_D0.8230.88
126_P160_A0.8230.88
34_G68_T0.8220.88
106_S156_D0.8220.88
35_I61_L0.8210.88
45_F51_F0.8170.88
120_D156_D0.8130.87
176_D184_R0.8030.87
65_D127_T0.8010.87
132_T159_N0.7970.86
128_V160_A0.7920.86
32_D39_D0.7870.86
115_A148_A0.7860.85
135_M138_H0.7820.85
84_V90_I0.7810.85
51_F80_F0.7790.85
94_A174_A0.7780.85
142_T146_H0.7770.85
50_L190_P0.7770.85
46_A49_G0.7720.84
121_G163_E0.7630.84
55_V72_V0.7620.84
43_A62_D0.7570.83
103_A158_E0.7570.83
94_A177_D0.7520.83
104_V108_V0.7470.82
36_G61_L0.7440.82
45_F100_L0.7340.81
65_D128_V0.7290.81
46_A51_F0.7230.80
127_T134_R0.7210.80
46_A53_V0.7210.80
125_Q128_V0.7150.80
111_V150_T0.7130.79
116_V141_R0.7070.79
102_E158_E0.7050.79
103_A155_V0.7030.78
96_R177_D0.6990.78
132_T138_H0.6970.78
80_F149_V0.6970.78
21_L51_F0.6900.77
69_V139_F0.6800.76
105_A156_D0.6770.76
36_G57_C0.6770.76
155_V167_L0.6760.76
88_R189_T0.6710.75
128_V133_S0.6710.75
151_L171_V0.6690.75
109_V151_L0.6690.75
35_I130_G0.6690.75
49_G172_G0.6680.75
39_D62_D0.6670.75
117_Y121_G0.6670.75
76_L143_F0.6640.74
39_D61_L0.6600.74
9_T56_R0.6520.73
117_Y137_A0.6510.73
125_Q133_S0.6510.73
117_Y142_T0.6420.72
126_P132_T0.6390.72
91_Q176_D0.6340.71
65_D136_A0.6310.71
97_R154_G0.6250.70
37_F41_M0.6220.70
43_A47_K0.6220.70
180_R185_R0.6190.69
48_H173_R0.6130.68
31_V39_D0.6130.68
189_T195_D0.6120.68
35_I131_L0.6110.68
6_A82_E0.6110.68
8_V78_A0.6070.68
95_D106_S0.6060.68
126_P133_S0.6040.67
87_K113_G0.6040.67
38_F136_A0.6000.67
183_Q187_G0.5960.66
72_V75_A0.5950.66
38_F73_G0.5930.66
85_G90_I0.5920.66
125_Q132_T0.5860.65
161_H165_E0.5840.65
6_A83_A0.5820.64
185_R190_P0.5790.64
115_A146_H0.5790.64
97_R104_V0.5770.64
49_G176_D0.5760.64
44_A173_R0.5760.64
94_A111_V0.5750.64
185_R189_T0.5740.63
6_A75_A0.5740.63
107_V167_L0.5720.63
96_R173_R0.5710.63
119_F141_R0.5710.63
64_D129_G0.5700.63
80_F109_V0.5670.62
29_H172_G0.5670.62
13_A63_V0.5620.62
116_V137_A0.5610.62
19_V72_V0.5600.62
51_F175_V0.5580.61
38_F75_A0.5570.61
87_K90_I0.5530.61
76_L80_F0.5520.60
91_Q181_I0.5500.60
29_H52_D0.5500.60
142_T145_T0.5480.60
13_A194_G0.5480.60
37_F40_H0.5480.60
139_F143_F0.5460.60
152_H156_D0.5450.59
44_A107_V0.5430.59
40_H161_H0.5430.59
92_R110_D0.5430.59
108_V192_T0.5400.59
102_E152_H0.5390.59
108_V154_G0.5390.59
41_M168_F0.5360.58
38_F42_L0.5350.58
66_H71_D0.5340.58
162_H165_E0.5330.58
183_Q186_A0.5320.58
112_S196_L0.5280.57
123_F126_P0.5270.57
133_S160_A0.5250.57
177_D180_R0.5250.57
176_D185_R0.5240.57
63_V68_T0.5230.56
132_T160_A0.5230.56
103_A166_A0.5210.56
118_E141_R0.5210.56
129_G133_S0.5200.56
109_V192_T0.5160.55
98_V173_R0.5150.55
184_R187_G0.5130.55
75_A79_A0.5120.55
115_A144_A0.5120.55
6_A21_L0.5090.54
138_H158_E0.5090.54
44_A100_L0.5050.54
29_H47_K0.5040.54
21_L53_V0.5040.54
23_L83_A0.5030.54
42_L72_V0.5000.53
17_V57_C0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mu3A 6 0.9337 100 -0.012 Contact Map
4gquA 6 0.9337 100 -0.001 Contact Map
1rhyA 4 0.8929 100 0.001 Contact Map
2ae8A 5 0.8776 100 0.002 Contact Map
4jifA 2 0.4184 31.1 0.96 Contact Map
3p8cA 1 0.3316 8.2 0.969 Contact Map
4pwwA 2 0.2092 7 0.97 Contact Map
2c4wA 2 0.5 6.2 0.971 Contact Map
1sq1A 4 0.1888 5.2 0.972 Contact Map
4ob9A 2 0.2092 5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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