GREMLIN Database
Q9HN08 - Thioredoxin reductase
UniProt: Q9HN08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 294 (254)
Sequences: 15138 (11068)
Seq/√Len: 694.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_V110_T4.8101.00
263_A277_L3.7071.00
152_D156_R3.6991.00
10_D33_D3.3011.00
134_E150_Y2.9821.00
35_V81_I2.8301.00
254_D257_F2.7671.00
33_D79_D2.6491.00
70_H74_E2.5771.00
99_V107_R2.5421.00
128_V131_S2.5361.00
185_V189_L2.4031.00
258_D288_S2.2991.00
259_A284_D2.2331.00
10_D111_D2.2171.00
12_V37_F2.1671.00
87_S101_E2.1291.00
204_A207_Y2.0981.00
21_C36_V2.0911.00
265_A270_A1.9621.00
99_V109_Y1.9381.00
89_D99_V1.9321.00
11_V32_L1.8781.00
86_E101_E1.8371.00
39_R84_T1.8361.00
97_G109_Y1.8341.00
41_N82_A1.8271.00
89_D101_E1.8161.00
11_V27_T1.8111.00
42_A66_R1.7901.00
28_A33_D1.7821.00
29_R76_A1.7281.00
35_V79_D1.7271.00
154_D188_C1.7141.00
84_T103_Q1.7101.00
251_A263_A1.7081.00
156_R160_D1.7021.00
134_E158_P1.6711.00
28_A78_C1.6701.00
213_E216_L1.6651.00
68_L266_I1.6621.00
102_T105_G1.6191.00
280_H285_H1.6141.00
163_Y188_C1.6141.00
155_G169_G1.5391.00
216_L220_W1.5301.00
91_P99_V1.4841.00
12_V100_V1.4781.00
63_P67_G1.4721.00
237_D240_L1.4661.00
156_R161_G1.4511.00
215_D218_G1.4401.00
269_R272_A1.4371.00
213_E217_S1.4371.00
170_Q173_A1.3911.00
81_I106_R1.3861.00
42_A70_H1.3841.00
86_E103_Q1.3781.00
101_E107_R1.3741.00
202_G205_P1.3661.00
9_R33_D1.3481.00
182_G186_A1.3331.00
129_G132_A1.3271.00
198_G201_E1.3261.00
128_V132_A1.3241.00
42_A63_P1.3171.00
132_A159_V1.3041.00
37_F108_V1.3031.00
63_P217_S1.3021.00
11_V112_T1.3021.00
208_D211_R1.2961.00
16_G38_D1.2921.00
88_V113_V1.2911.00
72_H75_T1.2851.00
65_L266_I1.2841.00
159_V162_L1.2781.00
200_P204_A1.2751.00
276_R279_D1.2711.00
286_I289_Y1.2451.00
283_D289_Y1.2391.00
81_I108_V1.2391.00
71_D75_T1.2321.00
151_A164_V1.2281.00
68_L72_H1.2261.00
96_T102_T1.2101.00
214_S218_G1.2011.00
126_P129_G1.1871.00
234_A237_D1.1761.00
71_D74_E1.1641.00
155_G185_V1.1611.00
149_A168_G1.1571.00
151_A169_G1.1441.00
14_V117_A1.1321.00
91_P95_D1.1311.00
203_V207_Y1.1301.00
9_R111_D1.1261.00
21_C73_A1.1241.00
228_E232_A1.1131.00
62_V250_A1.1121.00
64_T250_A1.1091.00
202_G207_Y1.1031.00
149_A164_V1.1011.00
13_I20_G1.1011.00
165_A185_V1.0971.00
150_Y158_P1.0921.00
208_D271_E1.0921.00
91_P97_G1.0851.00
208_D212_R1.0751.00
258_D287_E1.0751.00
216_L221_A1.0711.00
10_D35_V1.0701.00
226_W255_R1.0681.00
190_L194_K1.0571.00
16_G43_A1.0531.00
139_H146_F1.0491.00
254_D259_A1.0491.00
185_V188_C1.0451.00
70_H80_L1.0391.00
89_D107_R1.0351.00
10_D109_Y1.0271.00
137_D150_Y1.0271.00
90_R98_F1.0241.00
191_A196_A1.0211.00
91_P109_Y1.0111.00
65_L264_D1.0091.00
14_V113_V1.0011.00
137_D146_F0.9981.00
72_H76_A0.9961.00
233_E236_D0.9961.00
69_F266_I0.9901.00
42_A67_G0.9871.00
214_S219_E0.9801.00
102_T108_V0.9791.00
65_L248_L0.9771.00
202_G206_H0.9711.00
200_P203_V0.9691.00
184_H188_C0.9681.00
90_R97_G0.9671.00
226_W229_W0.9651.00
200_P207_Y0.9601.00
13_I114_L0.9591.00
14_V115_A0.9541.00
212_R215_D0.9521.00
67_G70_H0.9441.00
123_Y135_T0.9401.00
238_H241_D0.9391.00
72_H246_A0.9381.00
37_F81_I0.9381.00
68_L71_D0.9341.00
21_C205_P0.9331.00
217_S221_A0.9201.00
12_V108_V0.9191.00
20_G38_D0.9191.00
10_D32_L0.9091.00
199_Y207_Y0.9061.00
215_D219_E0.9001.00
98_F101_E0.8971.00
211_R219_E0.8951.00
72_H266_I0.8891.00
199_Y202_G0.8871.00
137_D170_Q0.8871.00
156_R163_Y0.8851.00
214_S222_D0.8851.00
36_V80_L0.8841.00
96_T101_E0.8831.00
96_T100_V0.8801.00
191_A194_K0.8761.00
63_P214_S0.8741.00
23_A26_F0.8721.00
140_G146_F0.8701.00
226_W256_T0.8701.00
27_T32_L0.8651.00
229_W233_E0.8621.00
251_A277_L0.8581.00
260_T277_L0.8571.00
236_D239_D0.8571.00
155_G188_C0.8541.00
11_V114_L0.8541.00
10_D110_T0.8531.00
10_D97_G0.8471.00
285_H289_Y0.8451.00
235_G238_H0.8441.00
25_V29_R0.8431.00
35_V110_T0.8421.00
155_G184_H0.8411.00
146_F173_A0.8381.00
186_A190_L0.8381.00
203_V206_H0.8361.00
24_G36_V0.8351.00
133_F159_V0.8321.00
190_L193_R0.8241.00
14_V85_V0.8221.00
43_A70_H0.8221.00
249_R265_A0.8211.00
97_G100_V0.8201.00
213_E220_W0.8171.00
99_V102_T0.8161.00
211_R215_D0.8161.00
217_S220_W0.8141.00
26_F30_Y0.8121.00
180_G183_A0.8091.00
75_T246_A0.8081.00
210_K213_E0.8061.00
37_F102_T0.8021.00
233_E237_D0.8021.00
25_V76_A0.7991.00
165_A189_L0.7981.00
24_G78_C0.7971.00
233_E238_H0.7961.00
232_A237_D0.7931.00
219_E223_R0.7851.00
153_A195_R0.7821.00
146_F150_Y0.7821.00
102_T106_R0.7811.00
126_P131_S0.7801.00
156_R159_V0.7801.00
279_D283_D0.7771.00
96_T99_V0.7751.00
133_F149_A0.7711.00
229_W232_A0.7671.00
222_D255_R0.7661.00
234_A238_H0.7661.00
180_G184_H0.7561.00
169_G181_N0.7541.00
28_A76_A0.7521.00
265_A273_G0.7521.00
232_A235_G0.7511.00
177_I181_N0.7501.00
252_H255_R0.7481.00
133_F158_P0.7481.00
225_R228_E0.7471.00
234_A240_L0.7451.00
224_D227_R0.7431.00
222_D256_T0.7421.00
123_Y168_G0.7411.00
156_R188_C0.7401.00
157_T164_V0.7401.00
135_T150_Y0.7391.00
183_A187_R0.7391.00
260_T281_I0.7371.00
126_P130_D0.7371.00
224_D255_R0.7361.00
193_R197_R0.7361.00
230_F234_A0.7351.00
198_G281_I0.7351.00
218_G222_D0.7341.00
43_A80_L0.7331.00
199_Y204_A0.7281.00
132_A135_T0.7261.00
126_P132_A0.7241.00
83_D104_D0.7221.00
209_W212_R0.7141.00
234_A239_D0.7111.00
97_G111_D0.7071.00
235_G239_D0.7051.00
73_A80_L0.7021.00
138_H150_Y0.7011.00
211_R216_L0.7001.00
154_D193_R0.7001.00
187_R192_D0.6981.00
228_E234_A0.6981.00
74_E79_D0.6961.00
220_W223_R0.6961.00
67_G71_D0.6951.00
210_K215_D0.6951.00
279_D285_H0.6931.00
202_G271_E0.6911.00
227_R231_A0.6891.00
73_A78_C0.6881.00
44_L69_F0.6861.00
62_V264_D0.6851.00
151_A155_G0.6841.00
220_W224_D0.6831.00
226_W232_A0.6821.00
61_D201_E0.6811.00
201_E211_R0.6811.00
61_D211_R0.6761.00
263_A281_I0.6741.00
88_V98_F0.6731.00
270_A273_G0.6731.00
227_R232_A0.6701.00
88_V115_A0.6701.00
200_P205_P0.6681.00
194_K197_R0.6671.00
38_D82_A0.6671.00
41_N63_P0.6671.00
25_V73_A0.6661.00
278_L282_D0.6661.00
216_L223_R0.6651.00
65_L68_L0.6641.00
239_D242_D0.6631.00
199_Y203_V0.6621.00
124_L130_D0.6621.00
228_E255_R0.6601.00
228_E231_A0.6601.00
165_A182_G0.6591.00
230_F236_D0.6581.00
230_F233_E0.6561.00
124_L129_G0.6551.00
254_D261_L0.6531.00
259_A286_I0.6521.00
132_A158_P0.6521.00
213_E221_A0.6491.00
164_V168_G0.6481.00
238_H242_D0.6441.00
247_A250_A0.6431.00
273_G276_R0.6401.00
201_E206_H0.6381.00
191_A195_R0.6371.00
227_R230_F0.6351.00
231_A237_D0.6341.00
226_W230_F0.6341.00
265_A274_A0.6321.00
231_A234_A0.6311.00
20_G39_R0.6301.00
214_S217_S0.6291.00
233_E239_D0.6261.00
35_V108_V0.6251.00
201_E207_Y0.6191.00
277_L281_I0.6181.00
228_E233_E0.6181.00
20_G116_A0.6181.00
10_D28_A0.6141.00
253_L287_E0.6131.00
212_R216_L0.6111.00
216_L219_E0.6041.00
164_V169_G0.6031.00
98_F113_V0.6011.00
235_G240_L0.6001.00
65_L69_F0.6001.00
97_G102_T0.5971.00
192_D195_R0.5961.00
29_R206_H0.5931.00
201_E204_A0.5931.00
63_P66_R0.5921.00
121_G146_F0.5911.00
109_Y112_T0.5901.00
8_R32_L0.5901.00
69_F73_A0.5881.00
236_D240_L0.5841.00
251_A254_D0.5811.00
232_A236_D0.5811.00
163_Y189_L0.5771.00
275_H278_L0.5751.00
43_A66_R0.5711.00
90_R95_D0.5681.00
91_P96_T0.5671.00
64_T68_L0.5671.00
257_F284_D0.5661.00
264_D277_L0.5631.00
192_D196_A0.5621.00
66_R70_H0.5611.00
222_D225_R0.5591.00
245_F268_E0.5571.00
129_G133_F0.5571.00
213_E218_G0.5561.00
281_I285_H0.5541.00
184_H196_A0.5541.00
18_P203_V0.5471.00
263_A274_A0.5431.00
209_W214_S0.5431.00
23_A114_L0.5411.00
98_F102_T0.5361.00
210_K274_A0.5361.00
226_W233_E0.5351.00
96_T103_Q0.5311.00
259_A281_I0.5291.00
231_A236_D0.5281.00
229_W234_A0.5251.00
223_R227_R0.5241.00
17_G118_W0.5241.00
88_V100_V0.5211.00
244_E268_E0.5201.00
223_R226_W0.5181.00
208_D215_D0.5160.99
68_L248_L0.5110.99
272_A276_R0.5100.99
84_T101_E0.5080.99
272_A275_H0.5060.99
231_A235_G0.5020.99
226_W237_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9082 100 0.307 Contact Map
3ladA 2 0.9014 100 0.308 Contact Map
1xdiA 3 0.9082 100 0.314 Contact Map
3urhA 2 0.9082 100 0.315 Contact Map
2yquA 2 0.9014 100 0.315 Contact Map
2wpfA 2 0.9116 100 0.319 Contact Map
1zmdA 4 0.9082 100 0.319 Contact Map
2hqmA 2 0.9116 100 0.323 Contact Map
3o0hA 2 0.9082 100 0.325 Contact Map
2r9zA 2 0.9116 100 0.325 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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