GREMLIN Database
UPP - Uracil phosphoribosyltransferase
UniProt: Q9HN05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 227 (204)
Sequences: 3071 (1595)
Seq/√Len: 111.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_T62_E4.2221.00
116_G210_G4.0101.00
186_L190_D3.8321.00
180_S199_T3.5101.00
60_A67_E3.4391.00
58_F69_T3.3441.00
22_S70_G2.9921.00
154_M175_V2.8721.00
39_V97_K2.8541.00
185_L202_I2.6511.00
155_C191_Q2.6341.00
155_C187_R2.5631.00
158_L188_V2.4841.00
66_T204_D2.4831.00
32_V36_K2.4711.00
60_A69_T2.4351.00
58_F71_E2.3411.00
57_E72_R2.2401.00
159_D163_D2.2381.00
81_I144_A2.1971.00
187_R191_Q2.1911.00
46_G95_L2.1811.00
182_P186_L2.1721.00
9_A202_I2.1251.00
95_L176_L2.0041.00
62_E67_E1.9591.00
59_T72_R1.9581.00
162_T192_F1.9011.00
30_E33_S1.8721.00
175_V188_V1.8721.00
24_L38_L1.8061.00
18_K71_E1.7931.00
66_T213_V1.7871.00
65_L213_V1.7831.00
17_A41_L1.7741.00
159_D191_Q1.7421.00
11_V202_I1.7351.00
39_V93_E1.7321.00
57_E74_T1.7251.00
186_L189_G1.6141.00
182_P204_D1.6081.00
140_T172_D1.6051.00
207_T213_V1.5561.00
82_I105_G1.5371.00
185_L197_L1.5341.00
42_G91_F1.5131.00
48_E51_D1.4991.00
83_N89_T1.4841.00
53_A174_F1.4721.00
96_L104_Q1.4681.00
61_F68_T1.4621.00
43_R97_K1.4421.00
156_T159_D1.4251.00
20_T40_K1.4051.00
21_L200_V1.3731.00
204_D213_V1.3331.00
49_I176_L1.2930.99
112_D126_T1.2890.99
177_S199_T1.2870.99
81_I95_L1.2670.99
155_C159_D1.2630.99
38_L178_A1.2500.99
205_T213_V1.2440.99
158_L173_L1.2340.99
162_T194_D1.2190.99
174_F196_D1.2180.99
54_M79_V1.2160.99
50_I99_F1.2080.99
130_V160_H1.2030.99
160_H164_E1.2020.99
35_R96_L1.1970.99
29_T222_R1.1900.99
113_E209_D1.1830.99
107_I157_V1.1770.99
110_G126_T1.1750.99
45_S176_L1.1580.99
24_L37_G1.1580.99
78_D139_D1.1530.99
159_D192_F1.1480.99
109_A153_T1.1380.99
105_G132_L1.1340.99
105_G133_P1.1290.98
45_S49_I1.1280.98
80_V136_S1.1280.98
135_I139_D1.1130.98
183_D205_T1.0890.98
79_V139_D1.0740.98
55_E74_T1.0560.98
188_V197_L1.0540.98
41_L200_V1.0500.98
9_A185_L1.0460.97
10_H198_L1.0460.97
182_P205_T1.0400.97
9_A189_G1.0310.97
33_S36_K1.0290.97
130_V164_E1.0280.97
24_L41_L1.0200.97
203_D212_I1.0160.97
80_V141_V1.0080.97
160_H163_D1.0050.97
12_I17_A0.9930.97
82_I132_L0.9860.96
140_T174_F0.9850.96
46_G94_G0.9810.96
23_R72_R0.9760.96
171_E194_D0.9630.96
17_A44_I0.9610.96
50_I54_M0.9590.96
46_G81_I0.9530.96
89_T106_V0.9390.95
43_R98_A0.9360.95
56_T71_E0.9330.95
143_V161_V0.9280.95
158_L195_A0.9220.95
26_D61_F0.9110.94
75_G78_D0.9060.94
13_T18_K0.9040.94
156_T160_H0.9040.94
125_I152_S0.9000.94
155_C188_V0.8930.94
136_S141_V0.8860.94
205_T208_D0.8810.93
59_T70_G0.8600.93
90_P223_A0.8590.93
92_V106_V0.8530.92
20_T37_G0.8500.92
22_S72_R0.8500.92
141_V170_V0.8440.92
143_V158_L0.8360.91
174_F198_L0.8260.91
81_I99_F0.8250.91
49_I142_I0.8140.90
142_I174_F0.8140.90
161_V170_V0.8130.90
46_G49_I0.8110.90
12_I45_S0.8110.90
81_I92_V0.8080.90
172_D196_D0.8050.90
46_G98_A0.7920.89
21_L179_V0.7910.89
111_R147_M0.7800.88
111_R220_G0.7780.88
110_G129_Y0.7780.88
23_R33_S0.7750.88
39_V43_R0.7690.88
187_R190_D0.7670.88
112_D115_A0.7610.87
80_V105_G0.7480.86
116_G209_D0.7420.86
183_D186_L0.7420.86
87_A147_M0.7360.85
147_M212_I0.7340.85
199_T202_I0.7310.85
142_I176_L0.7240.84
92_V104_Q0.7240.84
38_L41_L0.7200.84
111_R218_D0.7190.84
79_V140_T0.7150.84
83_N144_A0.7140.84
189_G196_D0.7140.84
66_T205_T0.7130.83
42_G94_G0.7120.83
29_T33_S0.7080.83
141_V161_V0.7040.83
103_K139_D0.7030.83
63_T68_T0.7030.83
143_V157_V0.7000.82
188_V195_A0.7000.82
22_S61_F0.6950.82
170_V194_D0.6950.82
13_T51_D0.6940.82
162_T169_G0.6930.82
134_D137_E0.6920.82
108_S128_D0.6860.81
12_I199_T0.6850.81
189_G197_L0.6840.81
203_D214_P0.6840.81
23_R29_T0.6830.81
184_G206_L0.6810.81
25_R203_D0.6750.80
38_L223_A0.6720.80
140_T171_E0.6710.80
124_P187_R0.6710.80
10_H196_D0.6680.79
44_I47_Y0.6680.79
21_L201_A0.6650.79
75_G103_K0.6650.79
29_T64_P0.6640.79
89_T92_V0.6630.79
23_R37_G0.6630.79
39_V42_G0.6570.78
147_M153_T0.6560.78
93_E97_K0.6560.78
111_R146_P0.6530.78
177_S180_S0.6500.77
111_R153_T0.6500.77
28_T62_E0.6490.77
38_L42_G0.6470.77
109_A156_T0.6420.77
125_I156_T0.6410.76
61_F67_E0.6400.76
25_R214_P0.6400.76
79_V99_F0.6390.76
110_G125_I0.6380.76
152_S187_R0.6360.76
44_I98_A0.6340.76
80_V132_L0.6340.76
112_D124_P0.6320.75
26_D59_T0.6300.75
109_A160_H0.6270.75
211_Y219_A0.6270.75
38_L219_A0.6200.74
16_L98_A0.6180.74
192_F195_A0.6170.74
111_R149_A0.6110.73
92_V144_A0.6100.73
107_I130_V0.6090.73
124_P127_V0.6050.72
147_M216_L0.6050.72
185_L189_G0.6050.72
46_G176_L0.6050.72
183_D204_D0.6010.72
179_V201_A0.5970.71
40_K47_Y0.5930.71
9_A180_S0.5910.71
124_P152_S0.5900.70
12_I200_V0.5880.70
143_V188_V0.5870.70
158_L162_T0.5860.70
16_L44_I0.5860.70
159_D187_R0.5830.70
109_A127_V0.5820.69
125_I153_T0.5790.69
24_L49_I0.5790.69
64_P222_R0.5780.69
113_E152_S0.5770.69
17_A200_V0.5760.69
203_D215_G0.5720.68
212_I216_L0.5720.68
61_F70_G0.5700.68
214_P217_G0.5700.68
212_I218_D0.5690.68
30_E101_R0.5660.67
34_F219_A0.5650.67
124_P156_T0.5650.67
39_V46_G0.5640.67
87_A220_G0.5610.67
34_F87_A0.5600.66
147_M211_Y0.5580.66
98_A101_R0.5580.66
75_G139_D0.5550.66
107_I143_V0.5520.65
115_A152_S0.5500.65
87_A219_A0.5470.65
33_S174_F0.5450.64
154_M177_S0.5440.64
155_C192_F0.5440.64
49_I141_V0.5420.64
50_I73_V0.5420.64
36_K97_K0.5420.64
211_Y218_D0.5410.64
162_T173_L0.5370.63
80_V170_V0.5360.63
185_L199_T0.5350.63
38_L91_F0.5330.63
18_K201_A0.5320.63
178_A200_V0.5320.63
19_H73_V0.5320.63
196_D199_T0.5300.62
22_S26_D0.5280.62
43_R46_G0.5280.62
20_T44_I0.5280.62
159_D162_T0.5270.62
31_Q35_R0.5260.62
110_G131_K0.5250.61
87_A211_Y0.5230.61
153_T156_T0.5230.61
30_E103_K0.5230.61
18_K56_T0.5210.61
92_V95_L0.5200.61
192_F197_L0.5200.61
39_V223_A0.5200.61
47_Y94_G0.5200.61
47_Y225_R0.5170.60
143_V173_L0.5170.60
64_P133_P0.5160.60
153_T177_S0.5140.60
162_T195_A0.5120.60
193_P226_T0.5110.59
173_L195_A0.5100.59
39_V199_T0.5100.59
111_R221_D0.5090.59
19_H40_K0.5060.59
51_D98_A0.5060.59
146_P153_T0.5050.59
85_L89_T0.5040.58
207_T212_I0.5040.58
87_A212_I0.5030.58
83_N108_S0.5030.58
148_L180_S0.5020.58
59_T69_T0.5020.58
91_F178_A0.5010.58
170_V195_A0.5000.58
183_D210_G0.5000.58
146_P149_A0.5000.58
87_A149_A0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xttA 3 0.9383 100 0.27 Contact Map
3dmpA 4 0.9339 100 0.3 Contact Map
1bd3D 3 0.9471 100 0.301 Contact Map
2ehjA 3 0.9163 100 0.309 Contact Map
1o5oA 3 0.9251 100 0.315 Contact Map
1v9sA 3 0.9163 100 0.333 Contact Map
2e55A 3 0.9075 100 0.342 Contact Map
1i5eA 2 0.9163 100 0.395 Contact Map
3s5jB 2 0.815 99.8 0.755 Contact Map
1qb7A 2 0.8899 99.7 0.781 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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